{"id":"https://openalex.org/W2138378181","doi":"https://doi.org/10.1152/ajpcell.00207.2015","title":"Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia","display_name":"Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia","publication_year":2015,"publication_date":"2015-08-26","ids":{"openalex":"https://openalex.org/W2138378181","doi":"https://doi.org/10.1152/ajpcell.00207.2015","mag":"2138378181","pmid":"https://pubmed.ncbi.nlm.nih.gov/26310815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4628936"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00207.2015","doi":"https://doi.org/10.1152/ajpcell.00207.2015","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpcell.00207.2015","pdf_url":"https://www.physiology.org/doi/pdf/10.1152/ajpcell.00207.2015","source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.physiology.org/doi/pdf/10.1152/ajpcell.00207.2015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003314533","display_name":"Muhammad Zaeem Noman","orcid":"https://orcid.org/0000-0002-1837-3097","observed_orcids":["https://orcid.org/0000-0002-1837-3097"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Muhammad Zaeem Noman","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078121805","display_name":"Meriem Hasmim","orcid":"https://orcid.org/0000-0002-7920-2443","observed_orcids":["https://orcid.org/0000-0002-7920-2443"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Meriem Hasmim","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027130214","display_name":"Yosra Messai","orcid":"https://orcid.org/0000-0002-4889-3544","observed_orcids":["https://orcid.org/0000-0002-4889-3544"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yosra Messai","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061975059","display_name":"St\u00e9phane Terry","orcid":"https://orcid.org/0000-0003-3089-7886","observed_orcids":["https://orcid.org/0000-0003-3089-7886"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Terry","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058317825","display_name":"Claudine Ki\u00e9da","orcid":"https://orcid.org/0000-0002-7573-029X","observed_orcids":["https://orcid.org/0000-0002-7573-029X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210118525","display_name":"Centre de Biophysique Mol\u00e9culaire","ror":"https://ror.org/02dpqcy73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118525","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claudine Kieda","raw_affiliation_strings":["Centre for Molecular Biophysics, Cell Recognition, and Glycobiology, UPR 4301 Centre National de la Recherche Scientifique, Orl\u00e9ans, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Biophysics, Cell Recognition, and Glycobiology, UPR 4301 Centre National de la Recherche Scientifique, Orl\u00e9ans, France; and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210118525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091343254","display_name":"Bassam Janji","orcid":"https://orcid.org/0000-0002-9763-0943","observed_orcids":["https://orcid.org/0000-0002-9763-0943"]},"institutions":[{"id":"https://openalex.org/I4210101141","display_name":"Luxembourg Institute of Health","ror":"https://ror.org/012m8gv78","country_code":"LU","type":"nonprofit","lineage":["https://openalex.org/I4210101141"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Bassam Janji","raw_affiliation_strings":["Laboratory of Experimental Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg","institution_ids":["https://openalex.org/I4210101141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045530749","display_name":"Salem Choua\u00efb","orcid":"https://orcid.org/0009-0007-3228-6882","observed_orcids":["https://orcid.org/0009-0007-3228-6882"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Salem Chouaib","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1186, Equipe Labellis\u00e9e Par La Ligue Contre Le Cancer, Gustave Roussy Campus, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210095243"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5045530749"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210095243"],"apc_list":null,"apc_paid":null,"fwci":2.3251,"has_fulltext":true,"cited_by_count":429,"citation_normalized_percentile":{"value":0.9174359,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"309","issue":"9","first_page":"C569","last_page":"C579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.20149999856948853,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08259999752044678,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.972000002861023},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.906000018119812},{"id":"https://openalex.org/keywords/immune-resistance","display_name":"immune resistance","score":0.6629999876022339},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7670000195503235},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.9950000047683716},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8113981485366821},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.704454243183136},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6269667744636536},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5851773023605347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5440421104431152},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49495929479599},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.48133334517478943},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4635803699493408},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42373186349868774},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3936142325401306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16828450560569763},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1152/ajpcell.00207.2015","doi":"https://doi.org/10.1152/ajpcell.00207.2015","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpcell.00207.2015","pdf_url":"https://www.physiology.org/doi/pdf/10.1152/ajpcell.00207.2015","source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4033922","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4628936","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26310815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26310815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4628936","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4628936/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Cell Physiol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02072289v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02072289","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Physiology - Cell Physiology, 2015, 309 (9), pp.C569-C579. &#x27E8;10.1152/ajpcell.00207.2015&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1152/ajpcell.00207.2015","doi":"https://doi.org/10.1152/ajpcell.00207.2015","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpcell.00207.2015","pdf_url":"https://www.physiology.org/doi/pdf/10.1152/ajpcell.00207.2015","source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138378181.pdf","grobid_xml":"https://content.openalex.org/works/W2138378181.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W40998890","https://openalex.org/W621464006","https://openalex.org/W1499186714","https://openalex.org/W1505873322","https://openalex.org/W1518835034","https://openalex.org/W1544611835","https://openalex.org/W1661544713","https://openalex.org/W1778788621","https://openalex.org/W1799143857","https://openalex.org/W1888121068","https://openalex.org/W1964081206","https://openalex.org/W1964202506","https://openalex.org/W1969090863","https://openalex.org/W1969938369","https://openalex.org/W1970490725","https://openalex.org/W1970555184","https://openalex.org/W1970832400","https://openalex.org/W1970903764","https://openalex.org/W1973541913","https://openalex.org/W1973546677","https://openalex.org/W1974145039","https://openalex.org/W1974607014","https://openalex.org/W1976015720","https://openalex.org/W1976841472","https://openalex.org/W1977200909","https://openalex.org/W1978172515","https://openalex.org/W1979858258","https://openalex.org/W1980181119","https://openalex.org/W1986925527","https://openalex.org/W1986954791","https://openalex.org/W1989312464","https://openalex.org/W1989812120","https://openalex.org/W1996863944","https://openalex.org/W1998799674","https://openalex.org/W1999356404","https://openalex.org/W2000309603","https://openalex.org/W2000334113","https://openalex.org/W2001717792","https://openalex.org/W2003197676","https://openalex.org/W2004150448","https://openalex.org/W2004495270","https://openalex.org/W2005202415","https://openalex.org/W2005767172","https://openalex.org/W2006221512","https://openalex.org/W2009219530","https://openalex.org/W2010353217","https://openalex.org/W2011092598","https://openalex.org/W2012520088","https://openalex.org/W2013090484","https://openalex.org/W2014691022","https://openalex.org/W2017654880","https://openalex.org/W2019214729","https://openalex.org/W2019342806","https://openalex.org/W2019648143","https://openalex.org/W2020652289","https://openalex.org/W2022540958","https://openalex.org/W2023572006","https://openalex.org/W2029088626","https://openalex.org/W2030020215","https://openalex.org/W2030634993","https://openalex.org/W2031626045","https://openalex.org/W2032244429","https://openalex.org/W2033364737","https://openalex.org/W2035396934","https://openalex.org/W2035978149","https://openalex.org/W2036511906","https://openalex.org/W2039075677","https://openalex.org/W2040401602","https://openalex.org/W2044484847","https://openalex.org/W2045247817","https://openalex.org/W2051588629","https://openalex.org/W2053353274","https://openalex.org/W2055169705","https://openalex.org/W2062783581","https://openalex.org/W2065779229","https://openalex.org/W2067680442","https://openalex.org/W2067969350","https://openalex.org/W2068971398","https://openalex.org/W2073548832","https://openalex.org/W2074991531","https://openalex.org/W2077230187","https://openalex.org/W2079124802","https://openalex.org/W2084939996","https://openalex.org/W2086402866","https://openalex.org/W2087377825","https://openalex.org/W2088571368","https://openalex.org/W2093921289","https://openalex.org/W2095510412","https://openalex.org/W2098342244","https://openalex.org/W2098539410","https://openalex.org/W2098674394","https://openalex.org/W2102085111","https://openalex.org/W2104300873","https://openalex.org/W2109424201","https://openalex.org/W2114154136","https://openalex.org/W2114503630","https://openalex.org/W2117398240","https://openalex.org/W2118655588","https://openalex.org/W2125184628","https://openalex.org/W2129321174","https://openalex.org/W2130529232","https://openalex.org/W2132564070","https://openalex.org/W2134053452","https://openalex.org/W2134361367","https://openalex.org/W2135656361","https://openalex.org/W2138272556","https://openalex.org/W2139595663","https://openalex.org/W2140088548","https://openalex.org/W2140741923","https://openalex.org/W2142644858","https://openalex.org/W2147070098","https://openalex.org/W2149360266","https://openalex.org/W2150678612","https://openalex.org/W2151170616","https://openalex.org/W2151713424","https://openalex.org/W2157005857","https://openalex.org/W2160915024","https://openalex.org/W2161184189","https://openalex.org/W2162812959","https://openalex.org/W2163889800","https://openalex.org/W2164164239","https://openalex.org/W2165426559","https://openalex.org/W2165805414","https://openalex.org/W2167458465","https://openalex.org/W2167640040","https://openalex.org/W2169798272","https://openalex.org/W2170682201","https://openalex.org/W2275872217","https://openalex.org/W2620406790","https://openalex.org/W3216091898"],"related_works":["https://openalex.org/W2583571120","https://openalex.org/W1553760529","https://openalex.org/W2003197676","https://openalex.org/W2463432841","https://openalex.org/W4404698311","https://openalex.org/W4282013377","https://openalex.org/W2770953850","https://openalex.org/W2883209651","https://openalex.org/W2921330079","https://openalex.org/W2074484141"],"abstract_inverted_index":{"The":[0],"tumor":[1,12,50,96],"microenvironment":[2,51],"is":[3],"a":[4,41],"complex":[5],"system,":[6],"playing":[7],"an":[8],"important":[9],"role":[10,38],"in":[11],"development":[13],"and":[14,24,52,59,62,88,91,107],"progression.":[15],"Besides":[16],"cellular":[17],"stromal":[18],"components,":[19],"extracellular":[20],"matrix":[21],"fibers,":[22],"cytokines,":[23],"other":[25],"metabolic":[26],"mediators":[27],"are":[28],"also":[29,72],"involved.":[30],"In":[31],"this":[32],"review":[33],"we":[34,99],"outline":[35,73],"the":[36,49],"potential":[37],"of":[39,44],"hypoxia,":[40],"major":[42],"feature":[43],"most":[45],"solid":[46],"tumors,":[47],"within":[48],"how":[53,74,92,101],"it":[54,93],"contributes":[55],"to":[56,66],"immune":[57,60,89,112],"resistance":[58],"suppression/tolerance":[61],"can":[63],"be":[64],"detrimental":[65],"antitumor":[67],"effector":[68],"cell":[69],"functions.":[70],"We":[71],"hypoxic":[75],"stress":[76],"influences":[77],"immunosuppressive":[78],"pathways":[79],"involving":[80],"macrophages,":[81],"myeloid-derived":[82],"suppressor":[83],"cells,":[84,87],"T":[85],"regulatory":[86],"checkpoints":[90],"may":[94],"confer":[95],"resistance.":[97],"Finally,":[98],"discuss":[100],"microenvironmental":[102],"hypoxia":[103],"poses":[104],"both":[105],"obstacles":[106],"opportunities":[108],"for":[109],"new":[110],"therapeutic":[111],"interventions.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":38},{"year":2025,"cited_by_count":39},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":46},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":63},{"year":2020,"cited_by_count":51},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
