{"id":"https://openalex.org/W2138370775","doi":"https://doi.org/10.1158/1055-9965.epi-10-0892","title":"Generalizability and Epidemiologic Characterization of Eleven Colorectal Cancer GWAS Hits in Multiple Populations","display_name":"Generalizability and Epidemiologic Characterization of Eleven Colorectal Cancer GWAS Hits in Multiple Populations","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2138370775","doi":"https://doi.org/10.1158/1055-9965.epi-10-0892","mag":"2138370775","pmid":"https://pubmed.ncbi.nlm.nih.gov/21071539","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081784"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-10-0892","doi":"https://doi.org/10.1158/1055-9965.epi-10-0892","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-10-0892","pdf_url":"https://aacrjournals.org/cebp/article-pdf/20/1/70/2272549/70.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cebp/article-pdf/20/1/70/2272549/70.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108112466","display_name":"Jing He","orcid":"https://orcid.org/0000-0002-8369-2414","observed_orcids":["https://orcid.org/0000-0002-8369-2414"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing He","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016405051","display_name":"Lynne Ross Wilkens","orcid":"https://orcid.org/0000-0001-8408-4536","observed_orcids":["https://orcid.org/0000-0001-8408-4536"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne R. Wilkens","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046710077","display_name":"Daniel O. Stram","orcid":"https://orcid.org/0000-0001-7099-9022","observed_orcids":["https://orcid.org/0000-0001-7099-9022"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel O. Stram","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104546118","display_name":"Laurence N. Kolonel","orcid":"https://orcid.org/0000-0002-2246-1970","observed_orcids":["https://orcid.org/0000-0002-2246-1970"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence N. Kolonel","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111890042","display_name":"Brian E. Henderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian E. Henderson","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072047782","display_name":"Anna H. Wu","orcid":"https://orcid.org/0000-0003-0546-902X","observed_orcids":["https://orcid.org/0000-0003-0546-902X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna H. Wu","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053074659","display_name":"Lo\u0131\u0308c Le Marchand","orcid":"https://orcid.org/0000-0001-5013-980X","observed_orcids":["https://orcid.org/0000-0001-5013-980X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loic Le Marchand","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063459619","display_name":"Christopher A. Haiman","orcid":"https://orcid.org/0000-0002-0097-9971","observed_orcids":["https://orcid.org/0000-0002-0097-9971"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher A. Haiman","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California; and 2Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063459619"],"corresponding_institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4210117038","https://openalex.org/I4390039246"],"apc_list":null,"apc_paid":null,"fwci":6.7196,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.97726717,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"70","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/genetic-risk-variants","display_name":"genetic risk variants","score":0.781000018119812},{"id":"https://openalex.org/keywords/multiethnic-population","display_name":"multi-ethnic population","score":0.6460000276565552},{"id":"https://openalex.org/keywords/8q24","display_name":"8q24","score":0.8399999737739563},{"id":"https://openalex.org/keywords/11q23","display_name":"11q23","score":0.972000002861023},{"id":"https://openalex.org/keywords/tumor-subsite","display_name":"tumor subsite","score":0.7089999914169312},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.6660000085830688},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7820000052452087},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9710000157356262},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6929594278335571},{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.653671383857727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5068579316139221},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.49875903129577637},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4955979585647583},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46900153160095215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46428194642066956},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.45622143149375916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34336668252944946},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3025359511375427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24113214015960693},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.16390705108642578},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.08953642845153809},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08694633841514587}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1055-9965.epi-10-0892","doi":"https://doi.org/10.1158/1055-9965.epi-10-0892","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-10-0892","pdf_url":"https://aacrjournals.org/cebp/article-pdf/20/1/70/2272549/70.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},{"id":"pmid:21071539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21071539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2256078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081784","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3081784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081784","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.epi-10-0892","doi":"https://doi.org/10.1158/1055-9965.epi-10-0892","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-10-0892","pdf_url":"https://aacrjournals.org/cebp/article-pdf/20/1/70/2272549/70.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1798569254","display_name":null,"funder_award_id":"CA63464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3100084882","display_name":"GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS","funder_award_id":"U01CA063464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3205575695","display_name":null,"funder_award_id":"N01\u2010PC035137","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3627917228","display_name":"Multiethnic Cohort Study of Diet and Cancer","funder_award_id":"R37CA054281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G392579417","display_name":"WS No. 12 Patterns of Care DX Year 2008","funder_award_id":"n01pc35137-18-0-2","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4276576992","display_name":"Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & Colo","funder_award_id":"5r01ca132839-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4344742353","display_name":"MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER","funder_award_id":"R01CA054281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4724959105","display_name":null,"funder_award_id":"R01-CA132839","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5554126587","display_name":"AROMATIC AMINES AND COLON CANCER RISK--GENETICS","funder_award_id":"R01CA060987","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5648774847","display_name":"Genetic Susceptibility to Cancer in Multiethnic Cohorts","funder_award_id":"R01CA063464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5654214539","display_name":null,"funder_award_id":"CA 54281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G667355291","display_name":null,"funder_award_id":"N01-PC-35 137","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7649984715","display_name":"Diet, Genetic Susceptibility and Colorectal Neoplasia","funder_award_id":"R01CA072520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8790823546","display_name":null,"funder_award_id":"CA132839","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138370775.pdf","grobid_xml":"https://content.openalex.org/works/W2138370775.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1968006026","https://openalex.org/W1977632740","https://openalex.org/W1988370082","https://openalex.org/W1988966853","https://openalex.org/W1991460649","https://openalex.org/W1993561195","https://openalex.org/W2021654829","https://openalex.org/W2022481980","https://openalex.org/W2023474682","https://openalex.org/W2027350554","https://openalex.org/W2039478109","https://openalex.org/W2046771886","https://openalex.org/W2054552261","https://openalex.org/W2057276264","https://openalex.org/W2074718000","https://openalex.org/W2100729170","https://openalex.org/W2106054679","https://openalex.org/W2122039687","https://openalex.org/W2131923400","https://openalex.org/W2140882931","https://openalex.org/W2148655495","https://openalex.org/W2149561548","https://openalex.org/W2157752701","https://openalex.org/W2157885410","https://openalex.org/W2161355153","https://openalex.org/W2164382475","https://openalex.org/W2164752398","https://openalex.org/W2168272873","https://openalex.org/W2169446852","https://openalex.org/W2170823667","https://openalex.org/W2185984956","https://openalex.org/W2262867447"],"related_works":["https://openalex.org/W2904355662","https://openalex.org/W6925456534","https://openalex.org/W2758092636","https://openalex.org/W2336919895","https://openalex.org/W2154340576","https://openalex.org/W2165918430","https://openalex.org/W2036263970","https://openalex.org/W2887697718","https://openalex.org/W1982845633","https://openalex.org/W2027330816"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genome-wide":[1],"association":[2],"studies":[3],"(GWAS)":[4],"in":[5,61,102,123,139,155,169,181,214,221,256],"populations":[6,157,223],"of":[7,19,28,65,76,114,149,188,201,247,252],"European":[8,77,124],"ancestry":[9],"have":[10],"identified":[11],"several":[12],"loci":[13,122,135],"that":[14,209],"confer":[15],"an":[16,111],"increased":[17,112],"risk":[18,33,113,138,150,154,220],"colorectal":[20],"cancer":[21],"(CRC).":[22],"METHODS:":[23],"We":[24,106,178],"studied":[25],"the":[26,29,103,108,117,131,182,202,210,228,245,249],"generalizability":[27],"associations":[30,109,129,183],"with":[31,110,136,218],"11":[32],"variants":[34,212],"for":[35,92,116,199,238],"CRC":[36,67,93],"on":[37,152],"8q23":[38],"(rs16892766),":[39],"8q24":[40,132],"(rs6983267),":[41],"9p24":[42],"(rs719725),":[43],"10p14":[44],"(rs10795668),":[45],"11q23":[46,119],"(rs3802842),":[47],"14q22":[48],"(rs4444235),":[49],"15q13":[50,121],"(rs4779584),":[51],"16q22":[52],"(rs9929218),":[53],"18q21":[54],"(rs4939827),":[55],"19q13":[56],"(rs10411210),":[57],"and":[58,72,85,88,94,120,126,133,196,227,258],"20p12":[59,134],"(rs961253)":[60],"a":[62],"multiethnic":[63],"sample":[64],"2,472":[66],"cases,":[68],"839":[69],"adenoma":[70,95],"cases":[71],"4,466":[73],"controls":[74],"comprised":[75],"American,":[78,80,84],"African":[79,140],"Native":[81],"Hawaiian,":[82],"Japanese":[83,170,225],"Latino":[86],"men":[87],"women.":[89],"Because":[90],"findings":[91],"were":[96],"similar,":[97],"we":[98,143],"combined":[99],"both":[100],"groups":[101,233],"analyses.":[104],"RESULTS:":[105],"confirmed":[107],"CRC/adenoma":[115,137,153,189,219],"8q24,":[118],"Americans,":[125,226],"observed":[127],"significant":[128,146],"between":[130],"Americans.":[141],"Moreover,":[142],"found":[144,179],"statistically":[145],"cumulative":[147],"effects":[148,255],"alleles":[151],"all":[156],"(odds":[158],"ratio":[159],"[OR]":[160],"per":[161],"allele":[162],"=":[163,173,176],"1.07-1.09,":[164],"P":[165,175],"\u2264":[166],"0.039)":[167],"except":[168,224],"Americans":[171],"(OR":[172],"1.01,":[174],"0.52).":[177],"heterogeneity":[180],"by":[184,235],"tumor":[185],"subsite,":[186],"age":[187],"onset,":[190],"sex,":[191],"body":[192],"mass":[193],"index":[194],"(BMI),":[195],"smoking":[197],"status":[198],"some":[200,239],"variants.":[203,240],"CONCLUSIONS:":[204],"These":[205,242],"results":[206,243],"provide":[207],"evidence":[208],"known":[211],"are":[213],"aggregate":[215],"significantly":[216],"associated":[217],"multiple":[222],"influences":[229],"may":[230],"differ":[231],"across":[232],"defined":[234],"clinicopathological":[236],"characteristics":[237],"IMPACT:":[241],"underline":[244],"importance":[246],"studying":[248],"epidemiologic":[250],"architecture":[251],"these":[253],"genetic":[254],"large":[257],"diverse":[259],"populations.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}