{"id":"https://openalex.org/W2138368396","doi":"https://doi.org/10.1161/01.hyp.26.1.199","title":"Transforming Growth Factor-\u03b21 Expression and Phenotypic Modulation in the Kidney of Hypertensive Rats","display_name":"Transforming Growth Factor-\u03b21 Expression and Phenotypic Modulation in the Kidney of Hypertensive Rats","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W2138368396","doi":"https://doi.org/10.1161/01.hyp.26.1.199","mag":"2138368396","pmid":"https://pubmed.ncbi.nlm.nih.gov/7541781"},"language":"en","primary_location":{"id":"doi:10.1161/01.hyp.26.1.199","doi":"https://doi.org/10.1161/01.hyp.26.1.199","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.26.1.199","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108506894","display_name":"Akinori Hamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinori Hamaguchi","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111666613","display_name":"Shokei Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shokei Kim","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071085125","display_name":"Kensuke Ohta","orcid":"https://orcid.org/0009-0008-5620-7090","observed_orcids":["https://orcid.org/0009-0008-5620-7090"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kensuke Ohta","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113814660","display_name":"Keiko Yagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Yagi","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048257986","display_name":"Tokihito Yukimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tokihito Yukimura","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017952469","display_name":"Katsuyuki Miura","orcid":"https://orcid.org/0000-0002-2646-9582","observed_orcids":["https://orcid.org/0000-0002-2646-9582"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyuki Miura","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108493416","display_name":"Taneo Fukuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taneo Fukuda","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100834250","display_name":"Hiroshi Iwao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Iwao","raw_affiliation_strings":["From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Osaka City University Medical School, and the Department of Drug Safety Research (T.F.), Eisai Co, Ltd, Gifu, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I317356780"],"apc_list":null,"apc_paid":null,"fwci":5.3831,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.96362687,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"26","issue":"1","first_page":"199","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9860000014305115},{"id":"https://openalex.org/keywords/stroke-prone-spontaneously-hypertensive-rats","display_name":"stroke-prone spontaneously hypertensive rats","score":0.9789999723434448},{"id":"https://openalex.org/keywords/renal-gene-expression","display_name":"renal gene expression","score":0.7360000014305115},{"id":"https://openalex.org/keywords/glomerular-cells","display_name":"glomerular cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.921999990940094},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tubular-atrophy","display_name":"tubular atrophy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cilazapril","display_name":"cilazapril","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":1.0},{"id":"https://openalex.org/keywords/urinary-albumin-excretion","display_name":"urinary albumin excretion","score":0.9129999876022339},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2911077047","wikidata":"https://www.wikidata.org/wiki/Q1434446","display_name":"Nephrosclerosis","level":3,"score":0.7561389207839966},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7387778162956238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.716405987739563},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.6223934292793274},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5373787879943848},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5280015468597412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47722676396369934},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4293728470802307},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.41541337966918945},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2849541902542114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26753485202789307},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0757792592048645}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009400","descriptor_name":"Nephrosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009400","descriptor_name":"Nephrosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017315","descriptor_name":"Cilazapril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017315","descriptor_name":"Cilazapril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.hyp.26.1.199","doi":"https://doi.org/10.1161/01.hyp.26.1.199","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.26.1.199","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:7541781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7541781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1481283361","https://openalex.org/W1500454592","https://openalex.org/W1586163533","https://openalex.org/W1599392598","https://openalex.org/W1865845936","https://openalex.org/W1970433419","https://openalex.org/W1993402154","https://openalex.org/W1993851092","https://openalex.org/W1995700570","https://openalex.org/W1996023328","https://openalex.org/W1998156838","https://openalex.org/W2004043215","https://openalex.org/W2005165360","https://openalex.org/W2007105731","https://openalex.org/W2012008369","https://openalex.org/W2013346489","https://openalex.org/W2014501553","https://openalex.org/W2027785852","https://openalex.org/W2027957168","https://openalex.org/W2029624507","https://openalex.org/W2039359299","https://openalex.org/W2045832382","https://openalex.org/W2049655783","https://openalex.org/W2051819610","https://openalex.org/W2066679122","https://openalex.org/W2067023576","https://openalex.org/W2072558376","https://openalex.org/W2077969109","https://openalex.org/W2078663145","https://openalex.org/W2081165103","https://openalex.org/W2091321868","https://openalex.org/W2116911322","https://openalex.org/W2136898798","https://openalex.org/W2139839934","https://openalex.org/W2141283516","https://openalex.org/W2149482537","https://openalex.org/W2165830726","https://openalex.org/W2263697545","https://openalex.org/W2282726004","https://openalex.org/W2320100878","https://openalex.org/W2402642083","https://openalex.org/W2411266928","https://openalex.org/W2461169750","https://openalex.org/W2465842772","https://openalex.org/W2469961807","https://openalex.org/W2912155580","https://openalex.org/W3030237074","https://openalex.org/W4237236725"],"related_works":["https://openalex.org/W2061746819","https://openalex.org/W2365937626","https://openalex.org/W1898907328","https://openalex.org/W1992499058","https://openalex.org/W2079228972","https://openalex.org/W2079845284","https://openalex.org/W2327092418","https://openalex.org/W2079136430","https://openalex.org/W2031552278","https://openalex.org/W2355605317"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"reported":[3],"that":[4],"renal":[5,57,87,101],"mRNA":[6,60,92],"levels":[7],"for":[8],"transforming":[9,42,70,88,110,220],"growth":[10,43,71,89,111,221],"factor-beta":[11,44,72,90,112,222],"1,":[12],"fibronectin,":[13],"and":[14,39,46,74,126,155,206,225,230,240],"collagens":[15],"were":[16,106,128,183],"increased":[17,186,193],"in":[18,49,114,119,131,135,143,152,162,174,181,219],"32-week-old":[19],"stroke-prone":[20],"spontaneously":[21],"hypertensive":[22],"rats":[23,98],"(SHRSP)":[24],"with":[25,55,96,185,204],"severe":[26],"nephrosclerosis.":[27],"To":[28],"elucidate":[29],"the":[30,50,82,192,209,217,226],"mechanism":[31],"of":[32,41,52,69,84,104,140,166,171,195,202,211,236,242],"hypertension-induced":[33],"nephrosclerosis,":[34],"we":[35],"examined":[36],"gene":[37],"expression":[38,139,224],"localization":[40,68],"1":[45,73,91,113,223],"cellular":[47,75,227],"phenotype":[48,76],"kidney":[51,83],"25-week-old":[53,85],"SHRSP":[54,105,115,132,182,203],"moderate":[56],"damage.":[58],"Renal":[59],"was":[61,77,93,116,149,160,231],"measured":[62],"by":[63,79,191,233],"Northern":[64],"blot":[65],"analysis.":[66],"The":[67],"determined":[78],"immunohistochemistry.":[80],"In":[81],"SHRSP,":[86,167],"elevated":[94],"compared":[95],"Wistar-Kyoto":[97],"(WKY),":[99],"whereas":[100],"collagen":[102],"mRNAs":[103],"not":[107],"increased.":[108],"Immunoreactive":[109],"mainly":[117],"localized":[118],"glomerular":[120,133],"cells.":[121,200],"Furthermore,":[122,176],"alpha-smooth":[123],"muscle":[124,146],"actin":[125,147],"desmin":[127],"significantly":[129],"expressed":[130,161],"cells,":[134,154],"contrast":[136],"to":[137,213],"negligible":[138],"these":[141,172,178],"proteins":[142,173],"WKY.":[144,175],"alpha-Smooth":[145],"staining":[148,170],"also":[150],"observed":[151],"interstitial":[153],"vimentin,":[156],"another":[157],"phenotypic":[158,179,228],"marker,":[159],"atrophic":[163],"tubular":[164],"cells":[165],"despite":[168],"no":[169],"all":[177],"changes":[180],"associated":[184],"cell":[187,197,243],"proliferation,":[188],"as":[189],"shown":[190],"number":[194],"proliferating":[196],"nuclear":[198],"antigen-positive":[199],"Treatment":[201],"cilazapril":[205],"nifedipine":[207],"(from":[208],"age":[210],"13":[212],"25":[214],"weeks)":[215],"prevented":[216],"increase":[218],"modulation":[229],"accompanied":[232],"a":[234],"reduction":[235],"urinary":[237],"albumin":[238],"excretion":[239],"inhibition":[241],"proliferation.(ABSTRACT":[244],"TRUNCATED":[245],"AT":[246],"250":[247],"WORDS)":[248]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}