{"id":"https://openalex.org/W2138334178","doi":"https://doi.org/10.1093/mutage/ges008","title":"Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol","display_name":"Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol","publication_year":2012,"publication_date":"2012-03-09","ids":{"openalex":"https://openalex.org/W2138334178","doi":"https://doi.org/10.1093/mutage/ges008","mag":"2138334178","pmid":"https://pubmed.ncbi.nlm.nih.gov/22406526","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3382307"},"language":"en","primary_location":{"id":"doi:10.1093/mutage/ges008","doi":"https://doi.org/10.1093/mutage/ges008","is_oa":false,"landing_page_url":"https://doi.org/10.1093/mutage/ges008","pdf_url":null,"source":{"id":"https://openalex.org/S101337917","display_name":"Mutagenesis","issn_l":"0267-8357","issn":["0267-8357","1464-3804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3382307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062371918","display_name":"Silvia Balbo","orcid":"https://orcid.org/0000-0002-7686-0504","observed_orcids":["https://orcid.org/0000-0002-7686-0504"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. Balbo","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA. balbo006@umn.edu","Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA. balbo006@umn.edu","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Meng","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080267666","display_name":"Robin Bliss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. L. Bliss","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. A. Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Jensen","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071109008","display_name":"D. K. Hatsukami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. K. Hatsukami","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. S. Hecht","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062371918"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"],"apc_list":{"value":3162,"currency":"GBP","value_usd":4170},"apc_paid":null,"fwci":1.3889,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.80828289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"4","first_page":"485","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.8370000123977661},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.8600000143051147},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8100000023841858},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.40299999713897705},{"id":"https://openalex.org/keywords/peripheral-blood-granulocytes","display_name":"peripheral blood granulocytes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.46399998664855957},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/intra-individual-variability","display_name":"within-person variability","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C2777595113","wikidata":"https://www.wikidata.org/wiki/Q61457","display_name":"Acetaldehyde","level":3,"score":0.8677550554275513},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.7944284677505493},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.7393515110015869},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7168982625007629},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6205958127975464},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.5912144184112549},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5890913605690002},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.54423987865448},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5362927317619324},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4698083996772766},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46530041098594666},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4549944996833801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45358753204345703},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25397735834121704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18165838718414307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13294881582260132},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09477323293685913}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003849","descriptor_name":"Deoxyguanosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/mutage/ges008","doi":"https://doi.org/10.1093/mutage/ges008","is_oa":false,"landing_page_url":"https://doi.org/10.1093/mutage/ges008","pdf_url":null,"source":{"id":"https://openalex.org/S101337917","display_name":"Mutagenesis","issn_l":"0267-8357","issn":["0267-8357","1464-3804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2690421","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3382307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3382307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3382307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"Text"},{"id":"pmid:22406526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22406526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1013.3097","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1013.3097","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mutage.oxfordjournals.org/content/27/4/485.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1020.3894","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1020.3894","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mutage.oxfordjournals.org/content/early/2012/03/09/mutage.ges008.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2690421","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3382307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1660561155","display_name":null,"funder_award_id":"ES-11297","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7926442213","display_name":"DNA Adducts of the Carcinogen Acetaldehyde","funder_award_id":"R01ES011297","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000895342","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA077598","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G956063283","display_name":null,"funder_award_id":"CA-77598","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W48418913","https://openalex.org/W204207906","https://openalex.org/W1915306531","https://openalex.org/W1983241312","https://openalex.org/W2000064888","https://openalex.org/W2007271767","https://openalex.org/W2020177224","https://openalex.org/W2032904838","https://openalex.org/W2035043537","https://openalex.org/W2058748287","https://openalex.org/W2062566080","https://openalex.org/W2075287906","https://openalex.org/W2086758182","https://openalex.org/W2086979806","https://openalex.org/W2092699918","https://openalex.org/W2093088645","https://openalex.org/W2108931268","https://openalex.org/W2135455427","https://openalex.org/W2141972694","https://openalex.org/W2149985882","https://openalex.org/W2159657105","https://openalex.org/W2164985539","https://openalex.org/W2599538934","https://openalex.org/W2903596047"],"related_works":["https://openalex.org/W7097428807","https://openalex.org/W2056334497","https://openalex.org/W7100428902","https://openalex.org/W2149985882","https://openalex.org/W1983241312","https://openalex.org/W1978401222","https://openalex.org/W2741490936","https://openalex.org/W2328888667","https://openalex.org/W2495149445","https://openalex.org/W2135455427"],"abstract_inverted_index":{"Alcohol":[0],"consumption":[1,126,143],"is":[2,25,56],"an":[3,67],"established":[4],"risk":[5],"factor":[6],"for":[7,85,145,160],"cancers":[8],"of":[9,23,42,74,97,101,111,127,130,155,235,251,269],"the":[10,20,57,95,146,249,257],"head":[11],"and":[12,16,50,72,99,137,176,185,187,217,261],"neck,":[13],"colorectum,":[14],"liver":[15],"female":[17],"breast.":[18],"Acetaldehyde,":[19],"primary":[21],"metabolite":[22],"ethanol,":[24],"suspected":[26],"to":[27,37,139,246],"play":[28],"a":[29,83,158,267],"major":[30,58],"role":[31],"in":[32,40,48,61,114,209,218,238,254],"alcohol-related":[33,87],"carcinogenesis.":[34,51,88],"Acetaldehyde":[35],"binds":[36],"DNA":[38,44,76,115,180],"resulting":[39],"formation":[41,98],"adducts.":[43],"adducts":[45],"are":[46,91,231,244],"involved":[47],"mutagenesis":[49],"N":[52,102,112,188,197,210,252],"(2)-Ethylidenedeoxyguanosine":[53],"(N":[54],"(2)-ethylidene-dGuo)":[55],"adduct":[59,237],"formed":[60],"this":[62,75,236],"reaction.":[63],"Studies":[64],"have":[65],"shown":[66],"association":[68],"between":[69],"alcohol":[70,105,142,156,166],"drinking":[71],"levels":[73,110],"adduct,":[77],"suggesting":[78],"its":[79,193,263],"potential":[80,264],"use":[81,265],"as":[82,192,266],"biomarker":[84],"studying":[86],"However,":[89,222],"there":[90,223,230],"no":[92],"reports":[93],"on":[94],"kinetics":[96],"repair":[100],"(2)-ethylidene-dGuo":[103,113,189,211,253],"after":[104,125,177,214],"consumption.":[106],"Therefore,":[107],"we":[108],"investigated":[109],"from":[116,141,183],"human":[117],"peripheral":[118,239],"blood":[119,165,240,255],"cells":[120],"at":[121,171],"several":[122,172],"time":[123,173],"points":[124,174],"increasing":[128,164],"doses":[129,154,216],"alcohol.":[131],"Ten":[132],"healthy":[133],"non-smokers":[134],"were":[135,151,212],"recruited":[136],"asked":[138],"abstain":[140],"except":[144],"study":[147],"doses.":[148],"The":[149],"subjects":[150],"given":[152],"measured":[153],"once":[157],"week":[159],"3":[161],"weeks,":[162],"targeting":[163],"levels.":[167],"Blood":[168],"was":[169,181,190,224],"collected":[170],"before":[175],"each":[178],"dose,":[179],"isolated":[182],"granulocytes":[184],"lymphocytes":[186],"quantified":[191],"NaBH(3)CN":[194],"reduction":[195],"product":[196],"(":[198],"2":[199],")-ethyldeoxyguanosine":[200],"by":[201],"liquid":[202],"chromatography-electrospray":[203],"ionisation-tandem":[204],"mass":[205],"spectrometry.":[206],"Significant":[207],"increases":[208],"observed":[213],"all":[215],"both":[219],"cell":[220],"types.":[221],"substantial":[225],"intraindividual":[226],"variability,":[227],"indicating":[228],"that":[229],"other":[232],"important":[233],"sources":[234],"DNA.":[241],"Further":[242],"studies":[243],"needed":[245],"better":[247],"understand":[248],"origins":[250],"cells,":[256],"exposures":[258],"it":[259],"reflects,":[260],"thus":[262],"marker":[268],"alcohol's":[270],"genotoxic":[271],"effects.":[272]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
