{"id":"https://openalex.org/W2138317215","doi":null,"title":"Evolution of the Virulent Primary Isolate, SIV/DeltaB670, in vivo,Implications for Study Design and Antiviral Therapies","display_name":"Evolution of the Virulent Primary Isolate, SIV/DeltaB670, in vivo,Implications for Study Design and Antiviral Therapies","publication_year":2007,"publication_date":"2007-01-05","ids":{"openalex":"https://openalex.org/W2138317215","mag":"2138317215"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10360","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/10360/1/taber_etd_2006.pdf","pdf_url":"https://d-scholarship.pitt.edu/10360/1/taber_etd_2006.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000740538","display_name":"Rachel Taber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachel Taber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000740538"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-evolution","display_name":"HIV evolution","score":0.7089999914169312},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.9110000133514404},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.6359999775886536},{"id":"https://openalex.org/keywords/viral-genotypes","display_name":"viral genotypes","score":0.5559999942779541},{"id":"https://openalex.org/keywords/gut-associated-lymphoid-tissue","display_name":"gut-associated lymphoid tissue","score":0.8629999756813049},{"id":"https://openalex.org/keywords/viral-reservoir","display_name":"viral reservoir","score":0.7820000052452087},{"id":"https://openalex.org/keywords/plasma-viral-load","display_name":"plasma viral load","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tissue-viral-load","display_name":"tissue viral load","score":0.8040000200271606},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7905129194259644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7160667777061462},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6585847735404968},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5580198168754578},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5381501913070679},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4955552816390991},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4901491105556488},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4628324806690216},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42259934544563293},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.4175138473510742},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.412556529045105},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2244969606399536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1942640244960785},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13847985863685608},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:10360","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/10360/1/taber_etd_2006.pdf","pdf_url":"https://d-scholarship.pitt.edu/10360/1/taber_etd_2006.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2138317215","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/10360/1/taber_etd_2006.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":323,"referenced_works":["https://openalex.org/W16961449","https://openalex.org/W20134117","https://openalex.org/W34672287","https://openalex.org/W36895208","https://openalex.org/W49920453","https://openalex.org/W78344578","https://openalex.org/W1484551801","https://openalex.org/W1489355333","https://openalex.org/W1490833013","https://openalex.org/W1497264521","https://openalex.org/W1497288508","https://openalex.org/W1503050157","https://openalex.org/W1520506879","https://openalex.org/W1522340644","https://openalex.org/W1544856836","https://openalex.org/W1545813846","https://openalex.org/W1546915777","https://openalex.org/W1549854676","https://openalex.org/W1562770126","https://openalex.org/W1563485932","https://openalex.org/W1564196488","https://openalex.org/W1581921347","https://openalex.org/W1582855350","https://openalex.org/W1585454314","https://openalex.org/W1587812553","https://openalex.org/W1596667011","https://openalex.org/W1596708165","https://openalex.org/W1601402644","https://openalex.org/W1602187312","https://openalex.org/W1606271020","https://openalex.org/W1627302258","https://openalex.org/W1633472206","https://openalex.org/W1639681517","https://openalex.org/W1655510925","https://openalex.org/W1656428876","https://openalex.org/W1677464321","https://openalex.org/W1735143085","https://openalex.org/W1753464271","https://openalex.org/W1763313231","https://openalex.org/W1782049572","https://openalex.org/W1808985647","https://openalex.org/W1847525633","https://openalex.org/W1854844842","https://openalex.org/W1903235978","https://openalex.org/W1924694638","https://openalex.org/W1938874210","https://openalex.org/W1951500076","https://openalex.org/W1954320464","https://openalex.org/W1964004218","https://openalex.org/W1965569618","https://openalex.org/W1965757034","https://openalex.org/W1966343819","https://openalex.org/W1967077761","https://openalex.org/W1967377083","https://openalex.org/W1969968206","https://openalex.org/W1972190162","https://openalex.org/W1972548566","https://openalex.org/W1972784970","https://openalex.org/W1973398091","https://openalex.org/W1974138678","https://openalex.org/W1974148103","https://openalex.org/W1974473728","https://openalex.org/W1976861903","https://openalex.org/W1977104590","https://openalex.org/W1977282539","https://openalex.org/W1979091614","https://openalex.org/W1979980949","https://openalex.org/W1981164507","https://openalex.org/W1981440980","https://openalex.org/W1981644527","https://openalex.org/W1981785785","https://openalex.org/W1982207482","https://openalex.org/W1982276846","https://openalex.org/W1985772041","https://openalex.org/W1986152436","https://openalex.org/W1986574361","https://openalex.org/W1987888541","https://openalex.org/W1987970975","https://openalex.org/W1990993204","https://openalex.org/W1991585318","https://openalex.org/W1992891916","https://openalex.org/W1993433621","https://openalex.org/W1993970697","https://openalex.org/W1994307941","https://openalex.org/W1995453338","https://openalex.org/W1996168633","https://openalex.org/W1996313031","https://openalex.org/W1997326614","https://openalex.org/W1997677784","https://openalex.org/W1997844736","https://openalex.org/W1999173680","https://openalex.org/W2000985920","https://openalex.org/W2001132089","https://openalex.org/W2001375348","https://openalex.org/W2001393597","https://openalex.org/W2002292720","https://openalex.org/W2005588470","https://openalex.org/W2005821645","https://openalex.org/W2005860294","https://openalex.org/W2005917147","https://openalex.org/W2006430661","https://openalex.org/W2007021820","https://openalex.org/W2007243487","https://openalex.org/W2008994596","https://openalex.org/W2009219530","https://openalex.org/W2009369926","https://openalex.org/W2011323997","https://openalex.org/W2011630381","https://openalex.org/W2011837112","https://openalex.org/W2012139740","https://openalex.org/W2012564250","https://openalex.org/W2014488064","https://openalex.org/W2015525697","https://openalex.org/W2016588190","https://openalex.org/W2020748808","https://openalex.org/W2021550859","https://openalex.org/W2021932640","https://openalex.org/W2022098233","https://openalex.org/W2022356718","https://openalex.org/W2022442231","https://openalex.org/W2023035407","https://openalex.org/W2023420720","https://openalex.org/W2024526881","https://openalex.org/W2024691000","https://openalex.org/W2024888854","https://openalex.org/W2025948021","https://openalex.org/W2026793457","https://openalex.org/W2026982369","https://openalex.org/W2028143521","https://openalex.org/W2028154433","https://openalex.org/W2028778392","https://openalex.org/W2029353650","https://openalex.org/W2030844138","https://openalex.org/W2031463355","https://openalex.org/W2034160159","https://openalex.org/W2039178901","https://openalex.org/W2041026285","https://openalex.org/W2041335447","https://openalex.org/W2041805971","https://openalex.org/W2042349682","https://openalex.org/W2042476299","https://openalex.org/W2042823677","https://openalex.org/W2042823706","https://openalex.org/W2042982138","https://openalex.org/W2044549799","https://openalex.org/W2045573880","https://openalex.org/W2046348452","https://openalex.org/W2046775341","https://openalex.org/W2048566257","https://openalex.org/W2048660375","https://openalex.org/W2048996787","https://openalex.org/W2048999843","https://openalex.org/W2052828684","https://openalex.org/W2052843309","https://openalex.org/W2053570917","https://openalex.org/W2054469024","https://openalex.org/W2055980006","https://openalex.org/W2056802413","https://openalex.org/W2057504223","https://openalex.org/W2059770652","https://openalex.org/W2060534902","https://openalex.org/W2060829964","https://openalex.org/W2061962974","https://openalex.org/W2063337242","https://openalex.org/W2063485002","https://openalex.org/W2064258123","https://openalex.org/W2064945443","https://openalex.org/W2065133594","https://openalex.org/W2065381303","https://openalex.org/W2065502408","https://openalex.org/W2067267322","https://openalex.org/W2067555129","https://openalex.org/W2067950821","https://openalex.org/W2068441823","https://openalex.org/W2070943659","https://openalex.org/W2073024759","https://openalex.org/W2073639989","https://openalex.org/W2074189989","https://openalex.org/W2077276848","https://openalex.org/W2077348914","https://openalex.org/W2079504777","https://openalex.org/W2080872140","https://openalex.org/W2081550246","https://openalex.org/W2081825634","https://openalex.org/W2082314789","https://openalex.org/W2082536602","https://openalex.org/W2083255836","https://openalex.org/W2085919513","https://openalex.org/W2086462809","https://openalex.org/W2087484510","https://openalex.org/W2088885588","https://openalex.org/W2090646713","https://openalex.org/W2091932385","https://openalex.org/W2092625183","https://openalex.org/W2093023493","https://openalex.org/W2093925037","https://openalex.org/W2094217534","https://openalex.org/W2094848995","https://openalex.org/W2097382368","https://openalex.org/W2098230823","https://openalex.org/W2098590425","https://openalex.org/W2098898129","https://openalex.org/W2098999499","https://openalex.org/W2100267080","https://openalex.org/W2100516254","https://openalex.org/W2102173284","https://openalex.org/W2103182811","https://openalex.org/W2103294053","https://openalex.org/W2103663071","https://openalex.org/W2103934951","https://openalex.org/W2103938894","https://openalex.org/W2104318155","https://openalex.org/W2104997862","https://openalex.org/W2105813980","https://openalex.org/W2106082651","https://openalex.org/W2106452966","https://openalex.org/W2106628454","https://openalex.org/W2109434501","https://openalex.org/W2109753398","https://openalex.org/W2111137043","https://openalex.org/W2111673257","https://openalex.org/W2112940179","https://openalex.org/W2113282092","https://openalex.org/W2114693995","https://openalex.org/W2114977840","https://openalex.org/W2116097076","https://openalex.org/W2117403896","https://openalex.org/W2117623876","https://openalex.org/W2117786107","https://openalex.org/W2117835204","https://openalex.org/W2118507973","https://openalex.org/W2122389576","https://openalex.org/W2122466054","https://openalex.org/W2123218483","https://openalex.org/W2123360068","https://openalex.org/W2124375095","https://openalex.org/W2124494452","https://openalex.org/W2124969212","https://openalex.org/W2125913713","https://openalex.org/W2126515754","https://openalex.org/W2127037021","https://openalex.org/W2128394497","https://openalex.org/W2129665077","https://openalex.org/W2130285456","https://openalex.org/W2130448025","https://openalex.org/W2130635171","https://openalex.org/W2131466396","https://openalex.org/W2133277136","https://openalex.org/W2133560947","https://openalex.org/W2134015637","https://openalex.org/W2136458755","https://openalex.org/W2137162710","https://openalex.org/W2137966586","https://openalex.org/W2138109360","https://openalex.org/W2138245470","https://openalex.org/W2139250164","https://openalex.org/W2140865115","https://openalex.org/W2141680152","https://openalex.org/W2142384567","https://openalex.org/W2142405752","https://openalex.org/W2143435033","https://openalex.org/W2144882745","https://openalex.org/W2145893333","https://openalex.org/W2146056675","https://openalex.org/W2146579948","https://openalex.org/W2146672876","https://openalex.org/W2147413871","https://openalex.org/W2149166876","https://openalex.org/W2149218498","https://openalex.org/W2149321099","https://openalex.org/W2149492547","https://openalex.org/W2149762607","https://openalex.org/W2149791183","https://openalex.org/W2150484278","https://openalex.org/W2151292912","https://openalex.org/W2152281378","https://openalex.org/W2154632774","https://openalex.org/W2155025120","https://openalex.org/W2156413944","https://openalex.org/W2157069655","https://openalex.org/W2157581317","https://openalex.org/W2158425153","https://openalex.org/W2158500407","https://openalex.org/W2159225279","https://openalex.org/W2160215815","https://openalex.org/W2162314119","https://openalex.org/W2162533720","https://openalex.org/W2162650424","https://openalex.org/W2163779744","https://openalex.org/W2164903312","https://openalex.org/W2165037788","https://openalex.org/W2165895151","https://openalex.org/W2166374206","https://openalex.org/W2166670687","https://openalex.org/W2166942539","https://openalex.org/W2168225362","https://openalex.org/W2168620139","https://openalex.org/W2168776079","https://openalex.org/W2169283888","https://openalex.org/W2169623461","https://openalex.org/W2169657665","https://openalex.org/W2169847792","https://openalex.org/W2171871646","https://openalex.org/W2172271424","https://openalex.org/W2260935208","https://openalex.org/W2313306782","https://openalex.org/W2315098267","https://openalex.org/W2316541311","https://openalex.org/W2318289184","https://openalex.org/W2321998793","https://openalex.org/W2322579223","https://openalex.org/W2327503296","https://openalex.org/W2333399282","https://openalex.org/W2334860476","https://openalex.org/W2335496717","https://openalex.org/W2342220526","https://openalex.org/W2395808804","https://openalex.org/W2399076815","https://openalex.org/W2416350659","https://openalex.org/W2426282611","https://openalex.org/W3044574244","https://openalex.org/W4294294271","https://openalex.org/W4313342455"],"related_works":["https://openalex.org/W4399677590","https://openalex.org/W1999173680","https://openalex.org/W2126110357","https://openalex.org/W2116684687","https://openalex.org/W2179998662","https://openalex.org/W2559785427","https://openalex.org/W4388346580","https://openalex.org/W3045147521","https://openalex.org/W2263584512","https://openalex.org/W2790893406"],"abstract_inverted_index":{"Antiretroviral":[0],"drug":[1,55],"treatments":[2],"and":[3,59,178,218],"vaccine":[4,93],"strategies":[5],"are":[6],"hampered":[7],"by":[8,213],"the":[9,12,24,35,66,77,101,112,121,128,146,185],"ability":[10],"of":[11,26,37,47,145,160,181],"HIV":[13],"to":[14,18,76,108,124,136,224],"generate":[15],"variants":[16],"able":[17],"evade":[19],"their":[20,192],"protective":[21],"effects.":[22],"Understanding":[23],"effects":[25],"these":[27],"interventions":[28],"on":[29,188,207],"virus":[30,74,82,114,138,169,176,193,209,221],"evolution":[31,116,210],"could":[32,98],"aid":[33],"in":[34,44,111,199,211],"design":[36],"targeted":[38],"antiviral":[39,54],"strategies.":[40],"We":[41,63,140,164],"addressed":[42],"this":[43,87,153],"a":[45,156],"cohort":[46],"SIV":[48],"infected":[49],"non-human":[50],"primates":[51],"given":[52],"short-term":[53],"treatment":[56],"(ART)":[57],"with":[58,173],"without":[60],"DNA":[61],"vaccinations.":[62],"hypothesized":[64,142],"that":[65,72,100,143,166,190,215],"most":[67,129],"potent":[68],"therapies":[69],"(e.g.":[70],"those":[71],"suppress":[73],"burden":[75,194],"greatest":[78],"degree)":[79],"would":[80],"limit":[81],"evolution.":[83],"Our":[84,202],"results":[85,97,203],"supported":[86],"hypothesis.":[88],"There":[89],"was":[90,104],"no":[91],"apparent":[92],"effect":[94],"however.":[95],"These":[96],"indicate":[99],"immune":[102],"response":[103],"not":[105,197],"strong":[106],"enough":[107],"induce":[109],"changes":[110],"global":[113],"population,":[115],"must":[117],"be":[118,125,225],"monitored":[119],"at":[120],"epitope":[122],"level":[123],"revealed,":[126],"or":[127],"informative":[130],"time":[131],"points":[132],"were":[133,171],"unavailable":[134],"due":[135],"low":[137],"burdens.":[139],"additionally":[141],"infection":[144],"gut":[147],"associated":[148,172],"lymphoid":[149,186],"tissue":[150,175],"may":[151],"render":[152],"organ":[154],"as":[155],"reservoir":[157],"for":[158],"expression":[159],"unique":[161],"viral":[162],"genotypes.":[163,182],"demonstrated":[165],"high":[167,174],"plasma":[168],"loads":[170,177],"wide":[179],"dissemination":[180],"In":[183],"contrast,":[184],"tissues":[187],"animlals":[189],"controlled":[191],"contained":[195],"genotypes":[196],"expressed":[198],"other":[200],"organs.":[201],"have":[204],"important":[205],"implications":[206],"studying":[208],"vivo":[212],"demonstrating":[214],"large":[216],"populations":[217],"potentially":[219],"numerous":[220],"genes":[222],"need":[223],"analyzed.":[226]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}