{"id":"https://openalex.org/W2138308571","doi":"https://doi.org/10.3109/08923979709038535","title":"Evaluation of the Immunotoxicity of Benzoporphyrin Derivative (Bpd-Ma) in Mice","display_name":"Evaluation of the Immunotoxicity of Benzoporphyrin Derivative (Bpd-Ma) in Mice","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2138308571","doi":"https://doi.org/10.3109/08923979709038535","mag":"2138308571","pmid":"https://pubmed.ncbi.nlm.nih.gov/9049661"},"language":"en","primary_location":{"id":"doi:10.3109/08923979709038535","doi":"https://doi.org/10.3109/08923979709038535","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923979709038535","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082045547","display_name":"John Douglas Waterfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Douglas Waterfield","raw_affiliation_strings":["Department of Oral Biology, Faculty of Dentistry, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, Faculty of Dentistry, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032666199","display_name":"Maureen Fairhurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maureen Fairhurst","raw_affiliation_strings":["Department of Oral Biology, Faculty of Dentistry, 2199 Wesbrook Mall, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, Faculty of Dentistry, 2199 Wesbrook Mall, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076582788","display_name":"Elizabeth M. Waterfield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth M. Waterfield","raw_affiliation_strings":["Quadralogic Technologies Inc., 520 West 6th Avenue, Vancouver, BC, Canada, V5Z 4H5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quadralogic Technologies Inc., 520 West 6th Avenue, Vancouver, BC, Canada, V5Z 4H5","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040635701","display_name":"Kenneth C. Norbury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth C. Norbury","raw_affiliation_strings":["Quadralogic Technologies Inc., 520 West 6th Avenue, Vancouver, BC, Canada, V5Z 4H5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quadralogic Technologies Inc., 520 West 6th Avenue, Vancouver, BC, Canada, V5Z 4H5","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4246,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63042128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"1","first_page":"89","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzoporphyrin-derivative","display_name":"benzoporphyrin derivative","score":0.8840000033378601},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.871999979019165},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.597000002861023},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-mediated-lympholysis","display_name":"cell-mediated lympholysis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sheep-red-blood-cells","display_name":"sheep red blood cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/t-cell-dependent-antigens","display_name":"T-dependent antigens","score":0.9160000085830688},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.375}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6868239641189575},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5515282154083252},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.5017268657684326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4959047734737396},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47257864475250244},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.44046974182128906},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4371703565120697},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4107184410095215},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.4103071689605713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3318555951118469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23438766598701477},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08591187000274658},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007117","descriptor_name":"Immunization, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008805","descriptor_name":"Mice, Inbred A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08923979709038535","doi":"https://doi.org/10.3109/08923979709038535","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923979709038535","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},{"id":"pmid:9049661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9049661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and immunotoxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W171793030","https://openalex.org/W197781038","https://openalex.org/W309283610","https://openalex.org/W611347588","https://openalex.org/W1762282947","https://openalex.org/W1993933168","https://openalex.org/W2002136180","https://openalex.org/W2052260254","https://openalex.org/W2086064383","https://openalex.org/W2090749980","https://openalex.org/W2091210609","https://openalex.org/W2092984684","https://openalex.org/W2093403267","https://openalex.org/W2116144604","https://openalex.org/W2183385134","https://openalex.org/W2396847665","https://openalex.org/W2467951181","https://openalex.org/W3011668247"],"related_works":["https://openalex.org/W1997295076","https://openalex.org/W2013336304","https://openalex.org/W1977867008","https://openalex.org/W2065930100","https://openalex.org/W1996071538","https://openalex.org/W2034992220","https://openalex.org/W2110561382","https://openalex.org/W2299469024","https://openalex.org/W2059106104","https://openalex.org/W2042721569"],"abstract_inverted_index":{"Photodynamic":[0],"therapy":[1],"has":[2],"been":[3],"shown":[4],"to":[5,70,80,92,117],"selectively":[6],"eliminate":[7],"activated":[8],"lymphocytes":[9],"in":[10,21,110,114],"a":[11,96,118],"number":[12],"of":[13,33,48,108,121],"experimental":[14],"situations.":[15],"These":[16],"findings":[17],"have":[18],"important":[19],"implications":[20],"therapies":[22],"involving":[23],"selective":[24],"immunomodulation.":[25],"In":[26,84],"this":[27],"study":[28],"we":[29],"report":[30],"the":[31,37,60,66,76,105,122],"effects":[32],"intravenous":[34],"dosing":[35],"with":[36],"photosensitizer":[38],"benzoporphyrin":[39],"derivative-monoacid":[40],"A(BPD)":[41],"on":[42,55,99],"normal":[43],"immunological":[44],"function.":[45],"Therapeutic":[46],"doses":[47],"BPD":[49,88,109],"and":[50],"light":[51],"had":[52,95],"no":[53],"effect":[54,98,107],"natural":[56],"killer":[57],"cell":[58],"activity,":[59],"mixed":[61],"lymphocyte":[62],"reaction,":[63],"cell-mediated":[64,100],"lympholysis,":[65],"primary":[67,106],"immune":[68,123],"response":[69,79],"sheep":[71],"red":[72],"blood":[73],"cells,":[74],"or":[75],"secondary":[77],"memory":[78],"T":[81],"cell-dependent":[82],"antigens.":[83],"non-light":[85],"treated":[86],"controls,":[87],"at":[89],"concentrations":[90],"up":[91],"10-fold":[93],"higher":[94],"limited":[97],"lympholysis.":[101],"We":[102],"conclude":[103],"that":[104],"several":[111],"therapeutic":[112],"modalities":[113],"not":[115],"due":[116],"generalized":[119],"suppression":[120],"system.":[124]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
