{"id":"https://openalex.org/W2138237342","doi":"https://doi.org/10.1002/gepi.20636","title":"Evaluation of an approximation method for assessment of overall significance of multiple\u2010dependent tests in a genomewide association study","display_name":"Evaluation of an approximation method for assessment of overall significance of multiple\u2010dependent tests in a genomewide association study","publication_year":2011,"publication_date":"2011-10-17","ids":{"openalex":"https://openalex.org/W2138237342","doi":"https://doi.org/10.1002/gepi.20636","mag":"2138237342","pmid":"https://pubmed.ncbi.nlm.nih.gov/22006681","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3268180"},"language":"en","primary_location":{"id":"doi:10.1002/gepi.20636","doi":"https://doi.org/10.1002/gepi.20636","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gepi.20636","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3268180","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107834048","display_name":"Valentina Moskvina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Valentina Moskvina","raw_affiliation_strings":["MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom. MoskvinaV1@cf.ac.uk","MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom. MoskvinaV1@cf.ac.uk","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108093042","display_name":"Colm T. O'Dushlaine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colm O'Dushlaine","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051460895","display_name":"Shaun Purcell","orcid":"https://orcid.org/0000-0002-7402-5812","observed_orcids":["https://orcid.org/0000-0002-7402-5812"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaun Purcell","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030438682","display_name":"Nick J. Craddock","orcid":"https://orcid.org/0000-0003-2171-0610","observed_orcids":["https://orcid.org/0000-0003-2171-0610"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Craddock","raw_affiliation_strings":["MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028228908","display_name":"Peter Holmans","orcid":"https://orcid.org/0000-0003-0870-9412","observed_orcids":["https://orcid.org/0000-0003-0870-9412"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Holmans","raw_affiliation_strings":["MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059458620","display_name":"Michael C. O\u2019Donovan","orcid":"https://orcid.org/0000-0001-7073-2379","observed_orcids":["https://orcid.org/0000-0001-7073-2379"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael C. O'Donovan","raw_affiliation_strings":["MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5107834048"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.1985,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.87915342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"35","issue":"8","first_page":"861","last_page":"866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9169999957084656},{"id":"https://openalex.org/keywords/fisher-s-method","display_name":"Fisher's method","score":0.699999988079071},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8740000128746033},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8640000224113464},{"id":"https://openalex.org/keywords/permutation-tests","display_name":"permutation tests","score":0.4230000078678131},{"id":"https://openalex.org/keywords/type-i-error-rate","display_name":"type I error rate","score":0.8119999766349792},{"id":"https://openalex.org/keywords/plink","display_name":"PLINK","score":0.5460000038146973},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.8189269304275513},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.6872099041938782},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.606476366519928},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.5736249685287476},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.5595206022262573},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5238766074180603},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5067446827888489},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.5007531642913818},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.49734213948249817},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4274464249610901},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.4246123433113098},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3884657621383667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36879923939704895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3653450012207031},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35953277349472046},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3574126660823822},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3556134104728699},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2075081467628479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18021979928016663},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/gepi.20636","doi":"https://doi.org/10.1002/gepi.20636","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gepi.20636","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},{"id":"pmid:22006681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22006681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic epidemiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2512946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3268180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3268180","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3268180","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Genet Epidemiol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.715.1446","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.715.1446","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://research.mssm.edu/statgen/library/moskvina-2011-setscreen.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2512946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3268180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3125097226","display_name":"White Matter Abnormalities in Schizophrenia","funder_award_id":"P50MH066392","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1972028609","https://openalex.org/W1989012909","https://openalex.org/W2003283154","https://openalex.org/W2008047653","https://openalex.org/W2011593178","https://openalex.org/W2023171821","https://openalex.org/W2050161506","https://openalex.org/W2056641564","https://openalex.org/W2069877263","https://openalex.org/W2073116379","https://openalex.org/W2089175718","https://openalex.org/W2098597355","https://openalex.org/W2129245687","https://openalex.org/W2161633633","https://openalex.org/W2330978860","https://openalex.org/W4233262837"],"related_works":["https://openalex.org/W7100962405","https://openalex.org/W1989804913","https://openalex.org/W2155177033","https://openalex.org/W2055795617","https://openalex.org/W1997570142","https://openalex.org/W2098213860","https://openalex.org/W1975709333","https://openalex.org/W1963934696","https://openalex.org/W2011550781","https://openalex.org/W2003283154"],"abstract_inverted_index":{"We":[0,63,116,151],"describe":[1],"implementation":[2],"of":[3,11,28,35,71,81,86,113,126,181,185,203],"a":[4,38,42,48,68,76,84,170,179,194],"set-based":[5],"method":[6,66,89,155],"to":[7,67,101,110,141,159,166,197],"assess":[8],"the":[9,33,53,102,111,139,154,200],"significance":[10,105],"findings":[12],"from":[13],"genomewide":[14],"association":[15],"study":[16],"data.":[17],"Our":[18],"method,":[19],"implemented":[20],"in":[21,47,79,119,199],"PLINK,":[22],"is":[23,44,156,175],"based":[24],"on":[25],"theoretical":[26],"approximation":[27],"Fisher's":[29],"statistics":[30],"such":[31],"that":[32,50,95,118,153],"combination":[34],"P-vales":[36],"at":[37,178],"gene":[39],"or":[40,56,99],"across":[41],"pathway":[43],"carried":[45],"out":[46],"manner":[49],"accounts":[51],"for":[52,83,132],"correlation":[54,78],"structure,":[55],"linkage":[57,135],"disequilibrium,":[58],"between":[59],"single":[60],"nucleotide":[61],"polymorphisms.":[62],"compare":[64],"our":[65],"permutation-based":[69,167],"product":[70],"P-values":[72],"approach":[73],"and":[74,162,191],"show":[75,117,152],"typical":[77],"excess":[80],"0.98":[82],"number":[85],"comparisons.":[87],"The":[88],"gives":[90],"Type":[91],"I":[92],"error":[93],"rates":[94],"are":[96,128],"less":[97],"than":[98],"equal":[100],"corresponding":[103],"nominal":[104],"levels,":[106],"making":[107],"it":[108],"robust":[109,158],"effects":[112],"false":[114],"positives.":[115],"broadly":[120],"similar":[121],"populations,":[122],"reference":[123],"data":[124,189,205],"sets":[125,190],"markers":[127],"an":[129],"appropriate":[130],"substrate":[131],"deriving":[133],"marker-marker":[134],"disequilibrium":[136],"(LD),":[137],"negating":[138],"need":[140],"access":[142],"individual":[143],"level":[144],"genotypes,":[145],"greatly":[146],"facilitating":[147],"its":[148],"generic":[149],"applicability.":[150],"thus":[157],"LD-associated":[160],"bias":[161],"has":[163],"equivalent":[164],"performance":[165],"methods,":[168],"with":[169],"significantly":[171,186],"shorter":[172],"runtime.":[173],"This":[174],"particularly":[176],"relevant":[177],"time":[180],"increasing":[182],"public":[183],"availability":[184],"larger":[187],"genetic":[188],"should":[192],"go":[193],"long":[195],"way":[196],"assist":[198],"rapid":[201],"analysis":[202],"these":[204],"sets.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
