{"id":"https://openalex.org/W2138232240","doi":"https://doi.org/10.1158/1078-0432.ccr-0155-3","title":"Identification of Necrosis-Associated Genes in Glioblastoma by cDNA Microarray Analysis","display_name":"Identification of Necrosis-Associated Genes in Glioblastoma by cDNA Microarray Analysis","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2138232240","doi":"https://doi.org/10.1158/1078-0432.ccr-0155-3","mag":"2138232240","pmid":"https://pubmed.ncbi.nlm.nih.gov/14734472"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-0155-3","doi":"https://doi.org/10.1158/1078-0432.ccr-0155-3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-0155-3","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/10/1/212/1950854/zdf00104000212.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/clincancerres/article-pdf/10/1/212/1950854/zdf00104000212.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072907410","display_name":"Shaan Mohammed Raza","orcid":"https://orcid.org/0000-0003-2722-2781","observed_orcids":["https://orcid.org/0000-0003-2722-2781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaan M. Raza","raw_affiliation_strings":["1Departments of Neurosurgery,2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Departments of Neurosurgery,2","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012403937","display_name":"Gregory N. Fuller","orcid":"https://orcid.org/0000-0001-9447-2647","observed_orcids":["https://orcid.org/0000-0001-9447-2647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory N. Fuller","raw_affiliation_strings":["Pathology, and3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, and3","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112141059","display_name":"Chang Hun Rhee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang Hun Rhee","raw_affiliation_strings":["Department of Neurosurgery, Korean Cancer Center Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Korean Cancer Center Hospital, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103967113","display_name":"Suyun Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suyun Huang","raw_affiliation_strings":["1Departments of Neurosurgery,2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Departments of Neurosurgery,2","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005194857","display_name":"Kenneth R. Hess","orcid":"https://orcid.org/0000-0003-1377-6070","observed_orcids":["https://orcid.org/0000-0003-1377-6070"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Hess","raw_affiliation_strings":["Biostatistics, Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, and4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, and4","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Pathology, and3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, and3","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091806633","display_name":"Raymond A. Sawaya","orcid":"https://orcid.org/0000-0002-6035-7939","observed_orcids":["https://orcid.org/0000-0002-6035-7939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond Sawaya","raw_affiliation_strings":["1Departments of Neurosurgery,2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Departments of Neurosurgery,2","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1434,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.92050329,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"212","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/ep4-receptor","display_name":"EP4 receptor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ras","display_name":"Ras","score":0.40799999237060547},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.875},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/procoagulant-activity","display_name":"procoagulant activity","score":0.925000011920929},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.7971795797348022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6384296417236328},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6378529071807861},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5489644408226013},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5483295917510986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.543245255947113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3564280569553375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19342902302742004},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18814516067504883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12495926022529602}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-0155-3","doi":"https://doi.org/10.1158/1078-0432.ccr-0155-3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-0155-3","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/10/1/212/1950854/zdf00104000212.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:14734472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14734472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-0155-3","doi":"https://doi.org/10.1158/1078-0432.ccr-0155-3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-0155-3","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/10/1/212/1950854/zdf00104000212.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6600000262260437}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308138","display_name":"Texas Higher Education Coordinating Board","ror":"https://ror.org/05as1qb59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138232240.pdf","grobid_xml":"https://content.openalex.org/works/W2138232240.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W94897181","https://openalex.org/W95949650","https://openalex.org/W96805545","https://openalex.org/W315516960","https://openalex.org/W1496218110","https://openalex.org/W1500509176","https://openalex.org/W1510734879","https://openalex.org/W1544252040","https://openalex.org/W1603077759","https://openalex.org/W1624769216","https://openalex.org/W1875292783","https://openalex.org/W1954576125","https://openalex.org/W1967550651","https://openalex.org/W1967720639","https://openalex.org/W1968258391","https://openalex.org/W1973108687","https://openalex.org/W1977383354","https://openalex.org/W1978506520","https://openalex.org/W1980556333","https://openalex.org/W1983511319","https://openalex.org/W1984167260","https://openalex.org/W1984417766","https://openalex.org/W1984570403","https://openalex.org/W1986085718","https://openalex.org/W1997473787","https://openalex.org/W2004028022","https://openalex.org/W2004485044","https://openalex.org/W2006340617","https://openalex.org/W2009031504","https://openalex.org/W2010677999","https://openalex.org/W2011702013","https://openalex.org/W2013979525","https://openalex.org/W2015441766","https://openalex.org/W2019112133","https://openalex.org/W2019163723","https://openalex.org/W2019673607","https://openalex.org/W2024384404","https://openalex.org/W2026895465","https://openalex.org/W2033563519","https://openalex.org/W2033677434","https://openalex.org/W2041742410","https://openalex.org/W2049141864","https://openalex.org/W2054757039","https://openalex.org/W2057271298","https://openalex.org/W2057715598","https://openalex.org/W2058776743","https://openalex.org/W2061751929","https://openalex.org/W2064815099","https://openalex.org/W2074194154","https://openalex.org/W2077747679","https://openalex.org/W2078232348","https://openalex.org/W2078602449","https://openalex.org/W2080863182","https://openalex.org/W2086008721","https://openalex.org/W2086144679","https://openalex.org/W2089843401","https://openalex.org/W2099542450","https://openalex.org/W2102895007","https://openalex.org/W2103339073","https://openalex.org/W2120299678","https://openalex.org/W2120513402","https://openalex.org/W2125639187","https://openalex.org/W2126177388","https://openalex.org/W2127162209","https://openalex.org/W2160307820","https://openalex.org/W2167569025","https://openalex.org/W2168109780","https://openalex.org/W2169920833","https://openalex.org/W2233809722","https://openalex.org/W2296074182","https://openalex.org/W2327972260","https://openalex.org/W2346259730","https://openalex.org/W2402964295","https://openalex.org/W2412863312","https://openalex.org/W2418610767","https://openalex.org/W2442946835"],"related_works":["https://openalex.org/W2933852390","https://openalex.org/W2097486055","https://openalex.org/W4385564284","https://openalex.org/W4401715113","https://openalex.org/W2740058783","https://openalex.org/W4288039537","https://openalex.org/W2616070469","https://openalex.org/W4237471665","https://openalex.org/W4403298604","https://openalex.org/W2066255429"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1,22],"the":[2,30,40,50,53,119,153,182,229,236,253,268,275,299,364],"field":[3],"of":[4,12,29,32,37,55,70,97,112,121,129,167,184,233,235,252,290,301,333,346,357,367],"cancer":[5],"research,":[6],"there":[7],"has":[8,57,351],"been":[9,58],"a":[10,35,89,340],"paucity":[11],"interest":[13,72],"in":[14,102,137,162,228,284,308,317,339,369],"necrosis,":[15],"whereas":[16],"studies":[17,372],"focusing":[18],"on":[19],"apoptosis":[20],"abound.":[21],"neuro-oncology,":[23],"this":[24,285],"is":[25,68],"particularly":[26,292],"surprising":[27],"because":[28,289],"importance":[31,74],"necrosis":[33,56,83,122,158,168,197,213,222,242,260],"as":[34,165],"hallmark":[36],"glioblastoma":[38],"(GBM),":[39],"most":[41,44,154],"malignant":[42],"and":[43,49,73,78,215,244,274,310,313,355,379],"common":[45],"primary":[46],"brain":[47],"tumor,":[48],"fact":[51],"that":[52,175,360],"degree":[54,120],"shown":[59],"to":[60,64,75,82,93,148,305,314,376],"be":[61,306,315,374],"inversely":[62],"related":[63,81],"patient":[65],"survival.":[66],"It":[67],"therefore":[69],"considerable":[71],"identify":[76],"genes":[77,101,131,151,177,188,208,217,238,254,304,354],"gene":[79,358],"products":[80,300],"formation.":[84],"EXPERIMENTAL":[85],"DESIGN:":[86],"We":[87],"used":[88,147],"nylon":[90],"cDNA":[91,347],"microarray":[92,349],"analyze":[94],"mRNA":[95],"expression":[96,115,128,136,231,257,348,359],"588":[98],"universal":[99],"cellular":[100],"15":[103],"surgically":[104],"resected":[105],"human":[106],"GBM":[107,243,334],"samples":[108,139],"with":[109,118,134,157,181,192,212,221,263,331],"varying":[110],"degrees":[111],"necrosis.":[113,185],"Gene":[114],"was":[116,132,146],"correlated":[117,211,220],"using":[123],"rank":[124],"correlation":[125,156,180,295,330],"coefficients.":[126],"The":[127,171,344],"identified":[130,352],"compared":[133],"their":[135,291],"tissue":[138],"from":[140],"5":[141],"anaplastic":[142,245],"astrocytomas":[143],"(AAs).":[144],"Immunostaining":[145],"determine":[149],"whether":[150],"showing":[152],"positive":[155],"were":[159,209,218,225,287],"increasingly":[160],"expressed":[161],"tumor":[163,196],"tissues,":[164],"grade":[166,240,261,318],"increased.":[169],"RESULTS:":[170],"hybridization":[172],"results":[173],"indicated":[174],"26":[176,187,237],"showed":[178,298,328],"significant":[179,226,329],"amount":[183],"All":[186],"had":[189,255],"functions":[190],"associated":[191],"either":[193],"Ras,":[194],"Akt,":[195],"factor":[198,201],"alpha,":[199],"nuclear":[200],"kappaB,":[202],"apoptosis,":[203],"procoagulation,":[204],"or":[205],"hypoxia.":[206],"Nine":[207],"positively":[210],"grade,":[214],"17":[216],"negatively":[219],"grade.":[223],"There":[224],"differences":[227],"median":[230],"levels":[232],"3":[234],"between":[239],"III":[241,262,319],"astrocytoma":[246],"(AA)":[247],"samples;":[248],"all":[249],"but":[250,321],"1":[251,273],"elevated":[256],"when":[258],"comparing":[259],"AA":[264],"samples.":[265],"Two":[266],"factors,":[267],"ephrin":[269],"type":[270],"A":[271],"receptor":[272,278],"prostaglandin":[276],"E(2)":[277],"EP4":[279],"subtype,":[280],"not":[281,322],"previously":[282],"considered":[283],"context,":[286],"highlighted":[288],"high":[293],"(positive)":[294],"coefficients;":[296],"immunostaining":[297],"these":[302,381],"two":[303,325],"localized":[307],"perinecrotic":[309],"necrotic":[311],"regions":[312],"overexpressed":[316],"GBMs,":[320],"AAs.":[323],"These":[324],"molecules":[326],"also":[327],"survival":[332],"patients":[335],"(P":[336],"=":[337],"0.0034)":[338],"combined":[341],"model.":[342],"CONCLUSIONS:":[343],"application":[345],"analysis":[350],"specific":[353],"patterns":[356],"may":[361],"help":[362],"elucidate":[363],"molecular":[365],"basis":[366],"necrogenesis":[368],"GBM.":[370],"Additional":[371],"will":[373],"required":[375],"further":[377],"investigate":[378],"confirm":[380],"findings.":[382]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-22T09:42:04.148104","created_date":"2016-06-24T00:00:00"}
