{"id":"https://openalex.org/W2138199510","doi":"https://doi.org/10.1200/jco.2008.18.6585","title":"Targeting Polo-Like Kinase: Learning Too Little Too Late?","display_name":"Targeting Polo-Like Kinase: Learning Too Little Too Late?","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W2138199510","doi":"https://doi.org/10.1200/jco.2008.18.6585","mag":"2138199510","pmid":"https://pubmed.ncbi.nlm.nih.gov/18955441"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2008.18.6585","doi":"https://doi.org/10.1200/jco.2008.18.6585","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2008.18.6585","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.18.6585?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.18.6585?role=tab","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072116005","display_name":"David Olmos","orcid":"https://orcid.org/0000-0002-7003-4826","observed_orcids":["https://orcid.org/0000-0002-7003-4826"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Olmos","raw_affiliation_strings":["The Drug Development Unit, Royal Marsden National Health Services Foundation Trust and The Institute of Cancer Research, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Drug Development Unit, Royal Marsden National Health Services Foundation Trust and The Institute of Cancer Research, Surrey, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016475369","display_name":"Charles Swanton","orcid":"https://orcid.org/0000-0002-4299-3018","observed_orcids":["https://orcid.org/0000-0002-4299-3018"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charles Swanton","raw_affiliation_strings":["Cancer Research UK Translational Cancer Therapeutics Laboratory, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Translational Cancer Therapeutics Laboratory, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann de Bono","raw_affiliation_strings":["The Drug Development Unit, Royal Marsden National Health Services Foundation Trust and The Institute of Cancer Research, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Drug Development Unit, Royal Marsden National Health Services Foundation Trust and The Institute of Cancer Research, Surrey, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"34","first_page":"5497","last_page":"5499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polo-like-kinase","display_name":"Polo-like kinase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5040000081062317},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8250432014465332},{"id":"https://openalex.org/C84815855","wikidata":"https://www.wikidata.org/wiki/Q7225885","display_name":"Polo-like kinase","level":4,"score":0.6129299998283386},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4409904181957245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3191448152065277},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1941688060760498},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13815924525260925},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.09554004669189453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.2008.18.6585","doi":"https://doi.org/10.1200/jco.2008.18.6585","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2008.18.6585","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.18.6585?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:18955441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18955441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Editorial"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1487517","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1487517/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF CLINICAL ONCOLOGY , 26 (34) pp. 5497-5499. (2008)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1200/jco.2008.18.6585","doi":"https://doi.org/10.1200/jco.2008.18.6585","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2008.18.6585","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.18.6585?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308982","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138199510.pdf","grobid_xml":"https://content.openalex.org/works/W2138199510.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1516211547","https://openalex.org/W1549144603","https://openalex.org/W1976023782","https://openalex.org/W1982304115","https://openalex.org/W1985638918","https://openalex.org/W2004109623","https://openalex.org/W2012921486","https://openalex.org/W2015507005","https://openalex.org/W2020411912","https://openalex.org/W2020431095","https://openalex.org/W2021246859","https://openalex.org/W2023146897","https://openalex.org/W2025540821","https://openalex.org/W2029108033","https://openalex.org/W2036292773","https://openalex.org/W2051000382","https://openalex.org/W2053738387","https://openalex.org/W2083625674","https://openalex.org/W2099629020","https://openalex.org/W2116853366","https://openalex.org/W2127019295","https://openalex.org/W2127766269","https://openalex.org/W2130968156","https://openalex.org/W2161354534","https://openalex.org/W2168282983","https://openalex.org/W2268888900","https://openalex.org/W4244636407"],"related_works":["https://openalex.org/W2976913341","https://openalex.org/W2538055630","https://openalex.org/W4401150250","https://openalex.org/W3014669242","https://openalex.org/W1975776530","https://openalex.org/W1969659005","https://openalex.org/W7135893176","https://openalex.org/W4327904206","https://openalex.org/W3041259603","https://openalex.org/W6902021127"],"abstract_inverted_index":{"David":[0],"Olmos,":[1],"The":[2,14,40,52],"Drug":[3,41],"Development":[4,42],"Unit,":[5,43],"Royal":[6,44],"Marsden":[7,45],"National":[8,46],"Health":[9,47],"Services":[10,48],"Foundation":[11,49],"Trust":[12,50],"and":[13,51],"Institute":[15,53],"of":[16,54],"Cancer":[17,24,28,55],"Research,":[18,56],"Surrey,":[19,57],"United":[20,35,58],"Kingdom":[21,36,59],"Charles":[22],"Swanton,":[23],"Research":[25,32],"UK":[26],"Translational":[27],"Therapeutics":[29],"Laboratory,":[30],"London":[31],"Institute,":[33],"London,":[34],"Johann":[37],"de":[38],"Bono,":[39]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}