{"id":"https://openalex.org/W2138170387","doi":null,"title":"Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats.","display_name":"Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats.","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W2138170387","mag":"2138170387","pmid":"https://pubmed.ncbi.nlm.nih.gov/6861121"},"language":"en","primary_location":{"id":"pmid:6861121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6861121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111418889","display_name":"Leonard A. Sauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Sauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108445496","display_name":"Robert T. Dauchy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R T Dauchy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0119,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.85949749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"8","first_page":"3497","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ketone-body-utilization","display_name":"ketone body utilization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/acetoacetate","display_name":"acetoacetate","score":0.9340000152587891},{"id":"https://openalex.org/keywords/beta-hydroxybutyrate","display_name":"beta-hydroxybutyrate","score":1.0},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.8690000176429749},{"id":"https://openalex.org/keywords/glutamine-utilization","display_name":"glutamine utilization","score":0.7689999938011169},{"id":"https://openalex.org/keywords/lactic-acid","display_name":"lactic acid","score":0.7630000114440918},{"id":"https://openalex.org/keywords/amino-acid-usage","display_name":"amino acid utilization","score":0.875},{"id":"https://openalex.org/keywords/morris-hepatoma","display_name":"Morris hepatoma","score":0.6079999804496765},{"id":"https://openalex.org/keywords/walker-carcinosarcoma","display_name":"Walker carcinosarcoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fasting-state","display_name":"fasting state","score":0.6520000100135803},{"id":"https://openalex.org/keywords/arteriovenous-differences","display_name":"arteriovenous differences","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tumor-growth-rate","display_name":"tumor growth rate","score":0.42500001192092896},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.40799999237060547},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.8779773712158203},{"id":"https://openalex.org/C31532488","wikidata":"https://www.wikidata.org/wiki/Q746183","display_name":"Ketone bodies","level":3,"score":0.8707596063613892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5925153493881226},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.585005521774292},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.5836279988288879},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5702142715454102},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47405216097831726},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.45842495560646057},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.413467675447464},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3569909334182739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33411359786987305},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32324886322021484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2481098175048828},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090","descriptor_name":"Acetoacetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007657","descriptor_name":"Ketone Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011915","descriptor_name":"Rats, Inbred BUF","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012513","descriptor_name":"Sarcoma, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020155","descriptor_name":"3-Hydroxybutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6861121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6861121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2138170387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6861121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W129491327","https://openalex.org/W1593311419","https://openalex.org/W1599545708","https://openalex.org/W1621686172","https://openalex.org/W1851485599","https://openalex.org/W1983671706","https://openalex.org/W2044518726","https://openalex.org/W2084260408","https://openalex.org/W2123071260","https://openalex.org/W2346403854"],"related_works":["https://openalex.org/W2129858875","https://openalex.org/W2312900171","https://openalex.org/W1538021355","https://openalex.org/W169152339","https://openalex.org/W2424331457","https://openalex.org/W2152119541","https://openalex.org/W2412540356","https://openalex.org/W2128700288","https://openalex.org/W2128991243","https://openalex.org/W2309200910"],"abstract_inverted_index":{"Arteriovenous":[0],"differences":[1],"for":[2,32,87,206,349],"acetoacetate,":[3,123],"beta-hydroxybutyrate,":[4],"glucose,":[5],"lactic":[6,383],"acid,":[7],"and":[8,10,21,23,37,52,70,89,102,135,157,175,203,220,238,253,262,266,374],"glutamine":[9,158,204,242,267],"other":[11],"amino":[12,325],"acids":[13,326],"were":[14,48,65,75,91,171,185,190,212,329],"measured":[15],"across":[16],"Morris":[17],"hepatomas":[18],"5123C,":[19],"7777,":[20],"7288CTCF":[22],"Walker":[24],"sarcocarcinoma":[25],"256":[26],"in":[27,29,40,141,159,209,268,271,287,352,357],"vivo":[28],"rats":[30,47,167,211,275,354],"fasted":[31,45,165,210,272,288,353],"2":[33],"days.":[34],"The":[35,83,153,198,322,343],"acetoacetate":[36,88,134],"beta-hydroxybutyrate":[38,90,139],"concentrations":[39,154],"arterial":[41,143,161,300,310,323],"whole":[42,162],"blood":[43,144,163],"of":[44,73,81,119,130,132,137,155,164,182,196,201,235,240,255,257,260,264,363,370,372,382],"tumor-bearing":[46,166],"0.52":[49],"+/-":[50,54,93,104,173,177,214,222],"0.06":[51],"1.82":[53],"0.19":[55],"mM":[56],"(S.E.,":[57],"n":[58,99,110],"=":[59,100,111,169],"38),":[60],"respectively.":[61,117,232],"Both":[62],"ketone":[63,364],"bodies":[64],"utilized":[66,126,186,281,330],"by":[67,284,359,366,380],"the":[68,71,79,120,133,138,142,151,160,194,236,241,245,258,299,309],"tumors,":[69],"rates":[72,80,86,188,195,200,259,332],"utilization":[74,85,205,263,305,371,381],"directly":[76,191],"related":[77],"to":[78,97,108,193,218,226,244,319,337],"supply.":[82,197],"mean":[84,199],"13.9":[92],"2.9":[94],"(range,":[95,106,216,224],"0":[96,107,225],"64;":[98],"30)":[101],"24.7":[103],"4.4":[105],"145;":[109],"38)":[112,170],"nmol/min/g":[113,228,339],"tumor":[114,229,340,350],"wet":[115,230,341],"weight,":[116,231],"Eight":[118],"tumors":[121,208,246,269,285],"produced":[122,294],"presumably":[124],"from":[125,335],"beta-hydroxybutyrate.":[127],"An":[128],"average":[129],"52%":[131],"30%":[136],"carried":[140],"was":[145,247,292,313],"removed":[146],"during":[147],"one":[148],"pass":[149],"through":[150],"tumors.":[152],"glucose":[156,202,237,265,373],"(n":[168],"6.55":[172],"0.3":[174],"0.76":[176],"0.02":[178],"mM,":[179],"respectively;":[180],"both":[181],"these":[183,278],"substrates":[184,279],"at":[187,331],"that":[189,277,333,346],"proportional":[192],"all":[207],"101":[213],"11":[215],"3":[217,320],"313)":[219],"8.2":[221],"1.1":[223],"25.1)":[227],"Thirty-six":[233],"%":[234],"25%":[239],"supplied":[243],"utilized.":[248],"Comparison":[249],"(by":[250],"linear":[251],"regression":[252],"analysis":[254],"covariance)":[256],"supply":[261],"growing":[270,286],"versus":[273],"fed":[274],"indicated":[276],"are":[280],"more":[282],"efficiently":[283],"animals.":[289],"Lactic":[290],"acid":[291],"either":[293],"or":[295,304,315],"utilized,":[296],"depending":[297],"on":[298],"whole-blood":[301,324],"concentration.":[302],"Production":[303],"occurred,":[306],"respectively,":[307],"when":[308],"lactate":[311],"concentration":[312],"less":[314],"greater":[316],"than":[317],"1":[318,336],"mM.":[321],"(except":[327],"glutamine)":[328],"ranged":[334],"4":[338],"weight.":[342],"results":[344],"indicate":[345],"energy":[347],"production":[348],"growth":[351],"is":[355],"supported,":[356],"part,":[358],"an":[360,367],"increased":[361,368],"availability":[362],"bodies,":[365],"efficiency":[369],"glutamine,":[375],"and,":[376],"under":[377],"certain":[378],"circumstances,":[379],"acid.":[384]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}