{"id":"https://openalex.org/W2138166933","doi":"https://doi.org/10.1128/mcb.00208-09","title":"The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor","display_name":"The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor","publication_year":2010,"publication_date":"2010-04-05","ids":{"openalex":"https://openalex.org/W2138166933","doi":"https://doi.org/10.1128/mcb.00208-09","mag":"2138166933","pmid":"https://pubmed.ncbi.nlm.nih.gov/20368356","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2876522"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.00208-09","doi":"https://doi.org/10.1128/mcb.00208-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00208-09","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2876522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065550697","display_name":"Howard Donninger","orcid":"https://orcid.org/0000-0002-8589-1660","observed_orcids":["https://orcid.org/0000-0002-8589-1660"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Donninger","raw_affiliation_strings":["Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville","Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, KY 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068903139","display_name":"Luke B. Hesson","orcid":"https://orcid.org/0009-0003-4530-7663","observed_orcids":["https://orcid.org/0009-0003-4530-7663","https://orcid.org/0000-0002-7820-3102"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Luke Hesson","raw_affiliation_strings":["Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive","Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive, Edgbaston B15 2TT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive, Edgbaston B15 2TT, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039341486","display_name":"Michele D. Vos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Vos","raw_affiliation_strings":["Cell and Cancer Biology Branch, NCI","Cell and Cancer Biology Branch, NCI, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Cancer Biology Branch, NCI","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Cell and Cancer Biology Branch, NCI, Rockville, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009280962","display_name":"Kristin E. Beebe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Beebe","raw_affiliation_strings":["Cell and Cancer Biology Branch, NCI","Cell and Cancer Biology Branch, NCI, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Cancer Biology Branch, NCI","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Cell and Cancer Biology Branch, NCI, Rockville, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111878950","display_name":"Laura E. Gordon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Gordon","raw_affiliation_strings":["Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville","Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, Kentucky 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, Kentucky 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109152183","display_name":"David Sidransky","orcid":"https://orcid.org/0000-0003-4178-2072","observed_orcids":["https://orcid.org/0000-0003-4178-2072"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Sidransky","raw_affiliation_strings":["Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine","Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Wei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Wei Liu","raw_affiliation_strings":["Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine","Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Schlegel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Schlegel","raw_affiliation_strings":["Department of Pathology, University of Erlangen Nurnberg","Department of Pathology, University of Erlangen Nurnberg, 91054 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Erlangen Nurnberg","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Pathology, University of Erlangen Nurnberg, 91054 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072454939","display_name":"Shannon R. Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shannon Payne","raw_affiliation_strings":["Department of Pathology, University of Erlangen Nurnberg","Department of Pathology, University of Erlangen Nurnberg, 91054 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Erlangen Nurnberg","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Pathology, University of Erlangen Nurnberg, 91054 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108698366","display_name":"Arndt Hartmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87890613","display_name":"Epigenomics (Germany)","ror":"https://ror.org/0490dah44","country_code":"DE","type":"company","lineage":["https://openalex.org/I87890613"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arndt Hartmann","raw_affiliation_strings":["Epigenomics, Inc","Epigenomics, Inc., 1000 Seneca St., Ste. 300, Seattle, Washington 98101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenomics, Inc","institution_ids":["https://openalex.org/I87890613"]},{"raw_affiliation_string":"Epigenomics, Inc., 1000 Seneca St., Ste. 300, Seattle, Washington 98101","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073770568","display_name":"Farida Latif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Farida Latif","raw_affiliation_strings":["Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive","Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive, Edgbaston B15 2TT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive, Edgbaston B15 2TT, United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"last","author":{"id":null,"display_name":"Geoffrey J. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoffrey J. Clark","raw_affiliation_strings":["Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville","Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, Kentucky 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, Kentucky 40202","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":1.6923,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.83419796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"11","first_page":"2608","last_page":"2620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rassf2","display_name":"RASSF2","score":1.0},{"id":"https://openalex.org/keywords/par-4","display_name":"Par-4","score":0.9819999933242798},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tumor-suppressor-signaling","display_name":"tumor suppressor signaling","score":0.8519999980926514},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.5950000286102295},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7639999985694885},{"id":"https://openalex.org/keywords/ras-transformation","display_name":"Ras transformation","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9202704429626465},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8876185417175293},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7522315979003906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44506028294563293},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3453344404697418},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33442366123199463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32653942704200745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17423373460769653}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.00208-09","doi":"https://doi.org/10.1128/mcb.00208-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00208-09","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1921388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2876522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2876522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2876522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:20368356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20368356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/0fc879a8-3848-4f2e-b7db-751ae25b4434","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/0fc879a8-3848-4f2e-b7db-751ae25b4434","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Donninger, H, Hesson, L, Vos, M, Beebe, K, Gordon, L, Sidransky, D, Liu, JW, Schlegel, T, Payne, S, Hartmann, A, Latif, F & Clark, GJ 2010, 'The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor', Molecular and Cellular Biology, vol. 30, no. 11, pp. 2608-2620. https://doi.org/10.1128/MCB.00208-09","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1921388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2876522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6871870245","display_name":"Molecular Targets COBRE","funder_award_id":"P20RR018733","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1506218460","https://openalex.org/W1953337176","https://openalex.org/W1980432649","https://openalex.org/W1986406749","https://openalex.org/W1989823885","https://openalex.org/W1990578004","https://openalex.org/W2007662857","https://openalex.org/W2008167035","https://openalex.org/W2013304849","https://openalex.org/W2018676680","https://openalex.org/W2026433316","https://openalex.org/W2049186397","https://openalex.org/W2050474151","https://openalex.org/W2051073953","https://openalex.org/W2052333525","https://openalex.org/W2064372625","https://openalex.org/W2064478922","https://openalex.org/W2067224679","https://openalex.org/W2070342593","https://openalex.org/W2071126343","https://openalex.org/W2071630684","https://openalex.org/W2072975458","https://openalex.org/W2075821278","https://openalex.org/W2078085081","https://openalex.org/W2080719056","https://openalex.org/W2081602975","https://openalex.org/W2083695927","https://openalex.org/W2085012901","https://openalex.org/W2103173512","https://openalex.org/W2108973736","https://openalex.org/W2110211384","https://openalex.org/W2116117209","https://openalex.org/W2120556344","https://openalex.org/W2127492785","https://openalex.org/W2133841021","https://openalex.org/W2139526606","https://openalex.org/W2139597854","https://openalex.org/W2140258350","https://openalex.org/W2141286482","https://openalex.org/W2143296225","https://openalex.org/W2145103193","https://openalex.org/W2147977885","https://openalex.org/W2153961526","https://openalex.org/W2156656429","https://openalex.org/W2165639753","https://openalex.org/W2166921147","https://openalex.org/W2171791356","https://openalex.org/W2333279736","https://openalex.org/W4214918874","https://openalex.org/W4236713831"],"related_works":["https://openalex.org/W7098674281","https://openalex.org/W4206351889","https://openalex.org/W2064478922","https://openalex.org/W2052333525","https://openalex.org/W2038631211","https://openalex.org/W2300396214","https://openalex.org/W2510016347","https://openalex.org/W2007662857","https://openalex.org/W4244046996","https://openalex.org/W2107602530"],"abstract_inverted_index":{"RASSF2":[0,10,22,32,54,62,95,119,171],"is":[1,23,33,55,81,86,96,111],"a":[2,36,64,98,131,151,157],"novel":[3,152],"proapoptotic":[4],"effector":[5],"of":[6,9,16,21,51,53,93,103,124,154,156,170],"K-Ras.":[7],"Inhibition":[8],"expression":[11],"enhances":[12],"the":[13,70,89,106,109,121,140,166],"transforming":[14],"effects":[15,92],"K-Ras,":[17],"and":[18,66,85,101,160],"epigenetic":[19],"inactivation":[20,40,172],"frequently":[24],"detected":[25],"in":[26,126,176],"mutant":[27],"Ras-containing":[28],"primary":[29,177],"tumors.":[30,179],"Thus,":[31,137],"implicated":[34],"as":[35],"tumor":[37,77,128,142],"suppressor":[38,143],"whose":[39],"facilitates":[41],"transformation":[42],"by":[43,83],"disconnecting":[44],"apoptotic":[45,91],"responses":[46],"from":[47,105,147],"Ras.":[48],"The":[49],"mechanism":[50,132],"action":[52,155],"not":[56],"known.":[57],"Here":[58],"we":[59,138,149,161,173],"show":[60,117],"that":[61,118],"forms":[63],"direct":[65],"endogenous":[67],"complex":[68],"with":[69],"prostate":[71,127,178],"apoptosis":[72],"response":[73],"protein":[74],"4":[75],"(PAR-4)":[76],"suppressor.":[78],"This":[79],"interaction":[80],"regulated":[82],"K-Ras":[84],"essential":[87,112],"for":[88,113,133,165],"full":[90],"PAR-4.":[94],"primarily":[97],"nuclear":[99,122],"protein,":[100,159],"shuttling":[102],"PAR-4":[104,125],"cytoplasm":[107],"to":[108],"nucleus":[110],"its":[114,134],"function.":[115],"We":[116],"modulates":[120],"translocation":[123],"cells,":[129],"providing":[130],"biological":[135],"effects.":[136],"identify":[139,150],"first":[141],"signaling":[144],"pathway":[145],"emanating":[146],"RASSF2,":[148],"mode":[153],"RASSF":[158],"provide":[162],"an":[163],"explanation":[164],"extraordinarily":[167],"high":[168],"frequency":[169],"have":[174],"observed":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
