{"id":"https://openalex.org/W2138163973","doi":"https://doi.org/10.1158/0008-5472.can-05-3404","title":"Identification of Candidate Alkylator-Induced Cancer Susceptibility Genes by Whole Genome Scanning in Mice","display_name":"Identification of Candidate Alkylator-Induced Cancer Susceptibility Genes by Whole Genome Scanning in Mice","publication_year":2006,"publication_date":"2006-05-15","ids":{"openalex":"https://openalex.org/W2138163973","doi":"https://doi.org/10.1158/0008-5472.can-05-3404","mag":"2138163973","pmid":"https://pubmed.ncbi.nlm.nih.gov/16707424"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-05-3404","doi":"https://doi.org/10.1158/0008-5472.can-05-3404","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-3404","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069393942","display_name":"Timothy S. Fenske","orcid":"https://orcid.org/0000-0001-7069-0025","observed_orcids":["https://orcid.org/0000-0001-7069-0025"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy S. Fenske","raw_affiliation_strings":["1Internal Medicine, Departments of","Department of Internal Medicine Washington University School of Medicine St. Louis Missouri 63110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine Washington University School of Medicine St. Louis Missouri 63110 USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068824166","display_name":"Christine M. McMahon","orcid":"https://orcid.org/0000-0001-9745-9595","observed_orcids":["https://orcid.org/0000-0001-9745-9595"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine McMahon","raw_affiliation_strings":["5Department of Pathology, Division of Molecular Diagnostics, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Pathology, Division of Molecular Diagnostics, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037765444","display_name":"Deepa Edwin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepa Edwin","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029334607","display_name":"Joseph C. Jarvis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph C. Jarvis","raw_affiliation_strings":["2Anatomy and Neurobiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Anatomy and Neurobiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087500022","display_name":"James M. Cheverud","orcid":"https://orcid.org/0000-0001-7651-863X","observed_orcids":["https://orcid.org/0000-0001-7651-863X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James M. Cheverud","raw_affiliation_strings":["2Anatomy and Neurobiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Anatomy and Neurobiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090650559","display_name":"Matthew J. Minn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Minn","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037454036","display_name":"Vikram Mathews","orcid":"https://orcid.org/0000-0001-9417-2353","observed_orcids":["https://orcid.org/0000-0001-9417-2353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vikram Mathews","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019090106","display_name":"Molly A. Bogue","orcid":"https://orcid.org/0000-0001-6624-9261","observed_orcids":["https://orcid.org/0000-0001-6624-9261"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly A. Bogue","raw_affiliation_strings":["4The Jackson Laboratory, Bar Harbor, Maine; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4The Jackson Laboratory, Bar Harbor, Maine; and","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004832167","display_name":"Michael A. Province","orcid":"https://orcid.org/0000-0001-6102-774X","observed_orcids":["https://orcid.org/0000-0001-6102-774X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Province","raw_affiliation_strings":["3Biostatistics, Washington University School of Medicine, St. Louis, Missouri;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Biostatistics, Washington University School of Medicine, St. Louis, Missouri;","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011034688","display_name":"Howard L. McLeod","orcid":"https://orcid.org/0000-0002-9004-9232","observed_orcids":["https://orcid.org/0000-0002-9004-9232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard L. McLeod","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056921013","display_name":"Timothy Aaron Graubert","orcid":"https://orcid.org/0000-0002-7710-1171","observed_orcids":["https://orcid.org/0000-0002-7710-1171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy A. Graubert","raw_affiliation_strings":["1Internal Medicine, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Internal Medicine, Departments of","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7812,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.85561798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":"10","first_page":"5029","last_page":"5038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.28610000014305115,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-malignancies","display_name":"secondary malignancies","score":0.765999972820282},{"id":"https://openalex.org/keywords/cancer-susceptibility-genes","display_name":"cancer susceptibility genes","score":0.7639999985694885},{"id":"https://openalex.org/keywords/n-nitroso-n-ethylurea","display_name":"N-nitroso-N-ethylurea","score":0.984000027179718},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.6890000104904175},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.8090000152587891},{"id":"https://openalex.org/keywords/qtl-mapping","display_name":"QTL mapping","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.9789999723434448},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6460000276565552},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6373361349105835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5846535563468933},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5642774105072021},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5335032939910889},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5159193277359009},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5025935173034668},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.45600569248199463},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4349954128265381},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4019165635108948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3383268713951111},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.323731392621994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2636454999446869},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2413770854473114}],"mesh":[{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003043","descriptor_name":"Cocarcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005038","descriptor_name":"Ethylnitrosourea","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-05-3404","doi":"https://doi.org/10.1158/0008-5472.can-05-3404","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-3404","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:16707424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16707424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.527.5336","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.527.5336","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thalamus.wustl.edu/cheverudlab/publications/2006/Fenske_ETAL_CancerRes_66.pdf","raw_type":"text"},{"id":"pmh:oai:mouseion.jax.org:stfb2000_2009-2331","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/cgi/content/abstract/66/10/5029","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2000 - 2009","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8740538426","display_name":"Genomics Of Acute Myeloid Leukemia.","funder_award_id":"P01CA101937","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W2287952","https://openalex.org/W20143477","https://openalex.org/W148383583","https://openalex.org/W186964312","https://openalex.org/W1527524859","https://openalex.org/W1546962148","https://openalex.org/W1598625800","https://openalex.org/W1758507682","https://openalex.org/W1833833181","https://openalex.org/W1940615461","https://openalex.org/W1964895626","https://openalex.org/W1975829266","https://openalex.org/W1986799406","https://openalex.org/W1996796031","https://openalex.org/W1999412878","https://openalex.org/W2000441481","https://openalex.org/W2005039507","https://openalex.org/W2012298749","https://openalex.org/W2016127034","https://openalex.org/W2026828087","https://openalex.org/W2027056052","https://openalex.org/W2029036246","https://openalex.org/W2053411933","https://openalex.org/W2059222505","https://openalex.org/W2069798708","https://openalex.org/W2072467180","https://openalex.org/W2072630890","https://openalex.org/W2074444579","https://openalex.org/W2083345304","https://openalex.org/W2086588218","https://openalex.org/W2087022717","https://openalex.org/W2089415609","https://openalex.org/W2092109202","https://openalex.org/W2095554696","https://openalex.org/W2097861097","https://openalex.org/W2108539626","https://openalex.org/W2129849858","https://openalex.org/W2130711576","https://openalex.org/W2137333518","https://openalex.org/W2146366952","https://openalex.org/W2153883696","https://openalex.org/W2155302763","https://openalex.org/W2159401492","https://openalex.org/W2169278972","https://openalex.org/W2171673991","https://openalex.org/W2338057729","https://openalex.org/W2489592867","https://openalex.org/W4245587302","https://openalex.org/W7075739058"],"related_works":["https://openalex.org/W7097636481","https://openalex.org/W2587724352","https://openalex.org/W6958769815","https://openalex.org/W6976843698","https://openalex.org/W6920877554","https://openalex.org/W1967141979","https://openalex.org/W2594957841","https://openalex.org/W1991814251","https://openalex.org/W2063414913","https://openalex.org/W2095374215"],"abstract_inverted_index":{"Secondary":[0],"malignancies":[1,151],"are":[2,27],"a":[3,38,60,88,129],"serious":[4],"adverse":[5],"consequence":[6],"of":[7,12,41,65,78,91,112,187],"alkylator":[8],"chemotherapy.":[9],"The":[10],"risk":[11],"developing":[13],"an":[14],"alkylator-associated":[15,189],"malignancy":[16],"is":[17,200],"influenced":[18,201],"by":[19,202],"genetic":[20,25],"background,":[21],"although":[22],"the":[23,52,66,133,193],"relevant":[24],"factors":[26],"poorly":[28],"understood.":[29],"To":[30],"screen":[31],"for":[32,132],"novel":[33,181],"susceptibility":[34,127,196],"factors,":[35],"we":[36],"established":[37],"mouse":[39,182],"model":[40,183],"alkylator-induced":[42],"malignancy.":[43],"We":[44],"exposed":[45],"mice":[46,75,102],"from":[47],"20":[48],"inbred":[49],"strains":[50,67],"to":[51,197,209],"prototypical":[53],"alkylating":[54],"agent,":[55],"N-nitroso-N-ethylurea":[56],"(ENU).":[57],"ENU":[58],"was":[59,128],"potent":[61],"carcinogen":[62],"in":[63,72,83,95],"many":[64,185],"tested,":[68],"inducing":[69],"140":[70],"tumors":[71,94],"240":[73,96],"ENU-treated":[74],"(66%":[76],"incidence":[77,90],"at":[79],"least":[80],"one":[81],"tumor":[82,113,136],"evaluable":[84],"mice),":[85],"compared":[86],"with":[87,172],"background":[89],"8%":[92],"spontaneous":[93],"strain-,":[97],"age-,":[98],"and":[99,123,149,166,177,191],"sex-matched":[100],"control":[101],"(relative":[103],"risk,":[104],"8.4;":[105],"P":[106],"<":[107],"0.0001).":[108],"A":[109],"wide":[110],"variety":[111],"histologies":[114],"were":[115],"noted,":[116],"including":[117],"epithelial":[118],"carcinomas,":[119],"soft":[120],"tissue":[121],"sarcomas,":[122],"hematopoietic":[124],"tumors.":[125],"Cancer":[126],"heritable":[130],"trait":[131,156],"most":[134],"common":[135],"types,":[137],"lung":[138,173,175],"adenocarcinoma":[139],"(H(2)":[140,146,152],"=":[141,147,153],"0.25),":[142],"T":[143],"cell":[144],"lymphoma":[145,178],"0.19),":[148],"myeloid":[150],"0.10).":[154],"Quantitative":[155],"locus":[157],"mapping":[158],"identified":[159],"regions":[160],"on":[161],"chromosomes":[162],"3,":[163],"6,":[164],"9,":[165],"15":[167],"containing":[168],"candidate":[169],"genes":[170],"associated":[171],"adenoma,":[174],"carcinoma,":[176],"susceptibility.":[179],"This":[180],"recapitulates":[184],"features":[186],"human":[188],"cancer":[190],"supports":[192],"hypothesis":[194],"that":[195,205],"this":[198],"syndrome":[199],"inherited":[203],"polymorphisms":[204],"could":[206],"be":[207],"used":[208],"make":[210],"informed":[211],"clinical":[212],"treatment":[213],"decisions.":[214]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}