{"id":"https://openalex.org/W2138145147","doi":"https://doi.org/10.1634/theoncologist.9-3-302","title":"Advances in Chemoprevention of Head and Neck Cancer","display_name":"Advances in Chemoprevention of Head and Neck Cancer","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2138145147","doi":"https://doi.org/10.1634/theoncologist.9-3-302","mag":"2138145147","pmid":"https://pubmed.ncbi.nlm.nih.gov/15169985"},"language":"en","primary_location":{"id":"doi:10.1634/theoncologist.9-3-302","doi":"https://doi.org/10.1634/theoncologist.9-3-302","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.9-3-302","pdf_url":"https://academic.oup.com/oncolo/article-pdf/9/3/302/41844835/oncolo_9_3_302.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/oncolo/article-pdf/9/3/302/41844835/oncolo_9_3_302.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087448211","display_name":"John C. Rhee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Rhee","raw_affiliation_strings":["Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059710197","display_name":"Fadlo Raja Khuri","orcid":"https://orcid.org/0000-0002-8638-7618","observed_orcids":["https://orcid.org/0000-0002-8638-7618"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fadlo R. Khuri","raw_affiliation_strings":["Winship Cancer Institute, Emory University, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010399375","display_name":"Dong Moon Shin","orcid":"https://orcid.org/0000-0002-8245-4174","observed_orcids":["https://orcid.org/0000-0002-8245-4174"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dong M. Shin","raw_affiliation_strings":["Winship Cancer Institute, Emory University, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010399375"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"],"apc_list":{"value":3852,"currency":"USD","value_usd":3852},"apc_paid":null,"fwci":1.0473,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.72649573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"3","first_page":"302","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9610000252723694},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.9620000123977661},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/second-primary-tumors","display_name":"second primary tumors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oral-premalignant-lesions","display_name":"oral potentially malignant disorders","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dose-and-duration-of-therapy","display_name":"dose and duration of therapy","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9301937818527222},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5639647841453552},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5489910840988159},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5449409484863281},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5187159180641174},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4803382158279419},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4742618799209595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47288861870765686},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.45027250051498413},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.42451706528663635},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27876558899879456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1634/theoncologist.9-3-302","doi":"https://doi.org/10.1634/theoncologist.9-3-302","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.9-3-302","pdf_url":"https://academic.oup.com/oncolo/article-pdf/9/3/302/41844835/oncolo_9_3_302.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmid:15169985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15169985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1634/theoncologist.9-3-302","doi":"https://doi.org/10.1634/theoncologist.9-3-302","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.9-3-302","pdf_url":"https://academic.oup.com/oncolo/article-pdf/9/3/302/41844835/oncolo_9_3_302.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138145147.pdf","grobid_xml":"https://content.openalex.org/works/W2138145147.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W61798423","https://openalex.org/W100397332","https://openalex.org/W1553189784","https://openalex.org/W1581824974","https://openalex.org/W1586491683","https://openalex.org/W1608150289","https://openalex.org/W1808230316","https://openalex.org/W1848388241","https://openalex.org/W1855308453","https://openalex.org/W1964099867","https://openalex.org/W1964678619","https://openalex.org/W1965979849","https://openalex.org/W1966165057","https://openalex.org/W1973129455","https://openalex.org/W1975070503","https://openalex.org/W1976358642","https://openalex.org/W1979631363","https://openalex.org/W1980670095","https://openalex.org/W1983137421","https://openalex.org/W1991725525","https://openalex.org/W1991949008","https://openalex.org/W1992544851","https://openalex.org/W2003377506","https://openalex.org/W2004794022","https://openalex.org/W2011663093","https://openalex.org/W2021996848","https://openalex.org/W2022298741","https://openalex.org/W2028259306","https://openalex.org/W2030129038","https://openalex.org/W2030714746","https://openalex.org/W2034303744","https://openalex.org/W2036363901","https://openalex.org/W2037887091","https://openalex.org/W2039759959","https://openalex.org/W2046668563","https://openalex.org/W2056780782","https://openalex.org/W2069706185","https://openalex.org/W2072566577","https://openalex.org/W2074267550","https://openalex.org/W2076133729","https://openalex.org/W2076408164","https://openalex.org/W2077277471","https://openalex.org/W2080710975","https://openalex.org/W2087082455","https://openalex.org/W2093446050","https://openalex.org/W2097584581","https://openalex.org/W2102714041","https://openalex.org/W2108197743","https://openalex.org/W2109694492","https://openalex.org/W2111627225","https://openalex.org/W2113408403","https://openalex.org/W2115372159","https://openalex.org/W2116861117","https://openalex.org/W2122712858","https://openalex.org/W2138209396","https://openalex.org/W2139230093","https://openalex.org/W2140252749","https://openalex.org/W2141647078","https://openalex.org/W2142661339","https://openalex.org/W2143578354","https://openalex.org/W2146447599","https://openalex.org/W2148122132","https://openalex.org/W2151782814","https://openalex.org/W2160625004","https://openalex.org/W2162171882","https://openalex.org/W2164584016","https://openalex.org/W2168731357","https://openalex.org/W2193027574","https://openalex.org/W2271717367","https://openalex.org/W2314876271","https://openalex.org/W2315403385","https://openalex.org/W2317242858","https://openalex.org/W2327972628","https://openalex.org/W2330709704","https://openalex.org/W2332251422","https://openalex.org/W2336169581","https://openalex.org/W2339318589","https://openalex.org/W2394818201","https://openalex.org/W2406213538","https://openalex.org/W2416763102","https://openalex.org/W2418629436","https://openalex.org/W4233621581","https://openalex.org/W6675965455","https://openalex.org/W6677825531","https://openalex.org/W6681211271","https://openalex.org/W6681761019"],"related_works":["https://openalex.org/W1979631363","https://openalex.org/W2409526153","https://openalex.org/W2090000105","https://openalex.org/W2566866636","https://openalex.org/W2113302452","https://openalex.org/W2082054250","https://openalex.org/W2472602874","https://openalex.org/W2084513298","https://openalex.org/W2021063529","https://openalex.org/W2410320269"],"abstract_inverted_index":{"Abstract":[0],"Learning":[1],"Objectives":[2],"After":[3],"completing":[4],"this":[5],"course,":[6],"the":[7,14,32,46,97,157,164,194],"reader":[8],"will":[9],"be":[10,143],"able":[11],"to:":[12],"Describe":[13],"mechanism":[15],"of":[16,18,54,83,110,152,199],"carcinogenesis":[17],"head":[19,158,177],"and":[20,27,38,44,50,63,92,112,124,133,149,159,170,178,192,197],"neck":[21,64,179],"cancer.":[22],"Explain":[23],"chemoprevention":[24,181],"with":[25,72,86,187],"retinoids":[26,138,188],"other":[28,171],"chemopreventive":[29],"compounds.":[30],"Discuss":[31],"published":[33],"data":[34],"including":[35],"phase":[36,39],"II":[37],"III":[40],"randomized":[41],"trials.":[42],"Access":[43],"take":[45],"CME":[47],"test":[48],"online":[49],"receive":[51],"1":[52,58],"hour":[53],"AMA":[55],"PRA":[56],"category":[57],"credit":[59],"at":[60,106],"CME.TheOncologist.com":[61],"Head":[62],"squamous":[65],"cell":[66],"carcinoma":[67],"is":[68,120],"a":[69,73],"devastating":[70],"disease":[71],"poor":[74],"outcome":[75],"in":[76,96,130,150,156,175],"advanced":[77],"stages,":[78],"accounting":[79],"for":[80],"approximately":[81],"3%":[82],"all":[84],"malignancies,":[85],"an":[87,107,121],"estimated":[88,103],"37,200":[89],"new":[90,190],"cases":[91],"11,000":[93],"deaths":[94],"annually":[95],"U.S.":[98],"Second":[99],"primary":[100,154],"tumors":[101,155],"are":[102,113],"to":[104,116,142],"occur":[105],"annual":[108],"rate":[109],"3%\u201310%":[111],"significant":[114],"threats":[115],"long-term":[117],"survivors.":[118],"Chemoprevention":[119],"appealing":[122],"strategy,":[123],"its":[125],"success":[126],"has":[127],"been":[128,140],"demonstrated":[129],"breast":[131],"cancer":[132,180],"familial":[134],"adenomatous":[135],"polyposis.":[136],"High-dose":[137],"have":[139],"shown":[141],"active":[144],"against":[145],"oral":[146],"premalignant":[147],"lesions":[148],"prevention":[151],"second":[153],"neck.":[160],"New":[161],"targets":[162],"include":[163,183],"epidermal":[165],"growth":[166],"factor":[167],"receptor,":[168],"cyclooxygenase-2,":[169],"molecular":[172],"targets.":[173],"Challenges":[174],"future":[176],"investigations":[182],"achieving":[184],"long-lasting":[185],"efficacy":[186],"and/or":[189],"agents,":[191],"determining":[193],"optimal":[195],"dose":[196],"duration":[198],"therapy":[200],"while":[201],"maintaining":[202],"acceptable":[203],"toxicities.":[204]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}