{"id":"https://openalex.org/W2138106705","doi":"https://doi.org/10.1152/ajpheart.00038.2009","title":"\u03b2-Adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cells","display_name":"\u03b2-Adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cells","publication_year":2009,"publication_date":"2009-04-25","ids":{"openalex":"https://openalex.org/W2138106705","doi":"https://doi.org/10.1152/ajpheart.00038.2009","mag":"2138106705","pmid":"https://pubmed.ncbi.nlm.nih.gov/19395557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2716097"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00038.2009","doi":"https://doi.org/10.1152/ajpheart.00038.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00038.2009","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2716097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113873586","display_name":"Einsley Marie Janowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Einsley Janowski","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047258062","display_name":"Regina M. Day","orcid":"https://orcid.org/0000-0003-0822-8993","observed_orcids":["https://orcid.org/0000-0003-0822-8993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Regina Day","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108347229","display_name":"Alexander S. Kraev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Kraev","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111715744","display_name":"John Roder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C. Roder","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087577548","display_name":"Lars Nilausen Cleemann","orcid":"https://orcid.org/0000-0001-5840-7477","observed_orcids":["https://orcid.org/0000-0001-5840-7477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars Cleemann","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021316321","display_name":"Martin Morad","orcid":"https://orcid.org/0000-0002-9054-0195","observed_orcids":["https://orcid.org/0000-0002-9054-0195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Morad","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2157,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67079007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"296","issue":"6","first_page":"H1994","last_page":"H2006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.3662000000476837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.24729999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-ca2-exchanger","display_name":"Na+/Ca2+ exchanger","score":0.9210000038146973},{"id":"https://openalex.org/keywords/beta-adrenergic-regulation","display_name":"beta-adrenergic regulation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/squalus-acanthias","display_name":"Squalus acanthias","score":0.9649999737739563},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49282196164131165},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4688096344470978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46654701232910156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.453457772731781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4504960775375366},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4272429347038269},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41967537999153137},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.41877421736717224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39265406131744385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25550854206085205},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19276437163352966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048251","descriptor_name":"Squalus acanthias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpheart.00038.2009","doi":"https://doi.org/10.1152/ajpheart.00038.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00038.2009","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2716097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2716097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Heart Circ Physiol","raw_type":"Text"},{"id":"pmid:19395557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19395557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2716097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2716097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Heart Circ Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1743050008","display_name":null,"funder_award_id":"R01 HL16152","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3230396157","display_name":"Electrophysiology of Neonatal and Adult Heart","funder_award_id":"5r01hl016152-38","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7053428282","display_name":"HGF Signaling in Pulmonary Remodeling","funder_award_id":"5r01hl073929-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G975359632","display_name":null,"funder_award_id":"R01 HL-73929","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332504","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W196095620","https://openalex.org/W1850486727","https://openalex.org/W1914136440","https://openalex.org/W1966880718","https://openalex.org/W1991220984","https://openalex.org/W1993855997","https://openalex.org/W1997033006","https://openalex.org/W2006036490","https://openalex.org/W2006583262","https://openalex.org/W2014655613","https://openalex.org/W2020165702","https://openalex.org/W2027827595","https://openalex.org/W2028093318","https://openalex.org/W2028914697","https://openalex.org/W2030781430","https://openalex.org/W2032781215","https://openalex.org/W2033187129","https://openalex.org/W2036377020","https://openalex.org/W2039999201","https://openalex.org/W2040647365","https://openalex.org/W2044948576","https://openalex.org/W2046924202","https://openalex.org/W2059201211","https://openalex.org/W2072908173","https://openalex.org/W2082208569","https://openalex.org/W2088982504","https://openalex.org/W2095753590","https://openalex.org/W2097858715","https://openalex.org/W2099654084","https://openalex.org/W2112810806","https://openalex.org/W2127926880","https://openalex.org/W2130068784","https://openalex.org/W2144226165","https://openalex.org/W2145076651","https://openalex.org/W2155354600","https://openalex.org/W2158784210","https://openalex.org/W2167324624","https://openalex.org/W2335815721","https://openalex.org/W4236653206","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1980824744","https://openalex.org/W2145076651","https://openalex.org/W1997033006","https://openalex.org/W4214867184","https://openalex.org/W1989959217","https://openalex.org/W1993208368","https://openalex.org/W2103105155","https://openalex.org/W2130068784","https://openalex.org/W2072482237","https://openalex.org/W1997066597"],"abstract_inverted_index":{"The":[0,59],"function,":[1],"regulation,":[2],"and":[3,56,77,83,89,102,138,147,186,189,204,225],"molecular":[4,30,51,232],"structure":[5],"of":[6,22,39,50,118,123,136,143,153,174,183,197],"the":[7,35,48,144,154,175,184,194,198,229],"cardiac":[8,24,45,61,206],"Na(+)/Ca(2+)":[9],"exchangers":[10],"(NCXs)":[11],"vary":[12],"significantly":[13],"among":[14],"vertebrates.":[15],"We":[16,213],"previously":[17],"reported":[18],"that":[19,215],"beta-adrenergic":[20,121,217],"suppression":[21,142,182],"amphibian":[23],"NCX1.1":[25],"is":[26,219,226],"associated":[27],"with":[28,141,163,172,202],"specific":[29],"motifs.":[31,233],"Here":[32],"we":[33],"investigated":[34],"bimodal,":[36],"cAMP-dependent":[37],"regulation":[38,131,135,218],"spiny":[40],"dogfish":[41],"shark":[42,60,79,126,165,170,223],"(Squalus":[43],"acanthias)":[44],"NCX,":[46,171],"exploring":[47],"effects":[49],"structure,":[52],"host":[53],"cell":[54],"environment,":[55],"ionic":[57],"milieu.":[58],"NCX":[62,127,224],"sequence":[63],"(GenBank":[64],"accession":[65],"no.":[66],"DQ":[67],"068478)":[68],"revealed":[69],"two":[70],"novel":[71,176],"proline/alanine-rich":[72],"amino":[73],"acid":[74],"insertions.":[75],"Wild-type":[76],"mutant":[78,169],"NCXs":[80],"were":[81,94],"cloned":[82,124,222],"expressed":[84],"in":[85,110,221],"mammalian":[86],"cells":[87,208],"(HEK-293":[88],"FlpIn-293),":[90],"where":[91],"their":[92],"activities":[93],"measured":[95],"as":[96,133],"Ni(2+)-sensitive":[97],"Ca(2+)":[98,119,190],"fluxes":[99],"(fluo":[100],"4)":[101],"membrane":[103,115],"(Na(+)/Ca(2+)":[104],"exchange)":[105],"currents":[106,188],"evoked":[107],"by":[108],"changes":[109],"extracellular":[111],"Na(+)":[112],"concentration":[113],"and/or":[114],"potential.":[116],"Regardless":[117],"buffering,":[120],"stimulation":[122],"wild-type":[125],"consistently":[128],"produced":[129,180],"bimodal":[130,195,216],"(defined":[132],"differential":[134],"Ca(2+)-efflux":[137,155],"-influx":[139],"pathways),":[140],"Ca(2+)-influx":[145],"mode":[146],"either":[148],"no":[149,210],"change":[150],"or":[151],"enhancement":[152],"mode,":[156],"closely":[157],"resembling":[158],"results":[159],"from":[160],"parallel":[161],"experiments":[162,201],"native":[164],"cardiomyocytes.":[166],"In":[167],"contrast,":[168],"deletion":[173],"region":[177],"2":[178],"insertion,":[179],"equal":[181],"inward":[185],"outward":[187],"fluxes,":[191],"thereby":[192],"abolishing":[193],"nature":[196],"regulation.":[199,212],"Control":[200],"nontransfected":[203],"dog":[205],"NCX-expressing":[207],"showed":[209],"cAMP":[211],"conclude":[214],"retained":[220],"dependent":[227],"on":[228],"shark's":[230],"unique":[231]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
