{"id":"https://openalex.org/W2138070720","doi":"https://doi.org/10.1016/j.jamcollsurg.2006.05.124","title":"Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury","display_name":"Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury","publication_year":2006,"publication_date":"2006-08-29","ids":{"openalex":"https://openalex.org/W2138070720","doi":"https://doi.org/10.1016/j.jamcollsurg.2006.05.124","mag":"2138070720"},"language":"en","primary_location":{"id":"doi:10.1016/j.jamcollsurg.2006.05.124","doi":"https://doi.org/10.1016/j.jamcollsurg.2006.05.124","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2006.05.124","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010825727","display_name":"William E. Stansfield","orcid":"https://orcid.org/0000-0003-4421-4388","observed_orcids":["https://orcid.org/0000-0003-4421-4388"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Stansfield","raw_affiliation_strings":["University of North Carolina, Chapel Hill, NC","University of North Carolina, Chapel, Hill, NC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina, Chapel, Hill, NC#TAB#","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043461014","display_name":"Ashwani K. Bhardwaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashwani K. Bhardwaj","raw_affiliation_strings":["University of North Carolina, Chapel Hill, NC","University of North Carolina, Chapel, Hill, NC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina, Chapel, Hill, NC#TAB#","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107833967","display_name":"Mauricio Rojas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mauricio Rojas","raw_affiliation_strings":["University of North Carolina, Chapel Hill, NC","University of North Carolina, Chapel, Hill, NC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina, Chapel, Hill, NC#TAB#","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074041207","display_name":"Ruhang Tang","orcid":"https://orcid.org/0000-0003-4918-3525","observed_orcids":["https://orcid.org/0000-0003-4918-3525"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruhang Tang","raw_affiliation_strings":["University of North Carolina, Chapel Hill, NC","University of North Carolina, Chapel, Hill, NC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina, Chapel, Hill, NC#TAB#","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103146350","display_name":"Susan S. Smyth","orcid":"https://orcid.org/0000-0001-6840-7892","observed_orcids":["https://orcid.org/0000-0001-6840-7892","https://orcid.org/0000-0002-0651-1149"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan S. Smyth","raw_affiliation_strings":["University of North Carolina, Chapel Hill, NC","University of North Carolina, Chapel, Hill, NC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina, Chapel, Hill, NC#TAB#","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031493840","display_name":"Craig H. Selzman","orcid":"https://orcid.org/0000-0001-9218-4764","observed_orcids":["https://orcid.org/0000-0001-9218-4764"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig H. Selzman","raw_affiliation_strings":["University of North Carolina, Chapel Hill, NC","University of North Carolina, Chapel, Hill, NC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina, Chapel, Hill, NC#TAB#","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.2316,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64089194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"203","issue":"3","first_page":"S48","last_page":"S48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9819999933242798},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.956340491771698},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6657809019088745},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.6220289468765259},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5961445569992065},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5775833129882812},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5013651847839355},{"id":"https://openalex.org/C3017461755","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Myocardial ischemia","level":3,"score":0.49609336256980896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46704500913619995},{"id":"https://openalex.org/C2911020856","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Myocardial Reperfusion Injury","level":4,"score":0.4432261884212494},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.20116129517555237}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jamcollsurg.2006.05.124","doi":"https://doi.org/10.1016/j.jamcollsurg.2006.05.124","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2006.05.124","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4250100779","https://openalex.org/W1965521743","https://openalex.org/W4247637715","https://openalex.org/W2171383829","https://openalex.org/W2165501561","https://openalex.org/W2017534437","https://openalex.org/W2514700526","https://openalex.org/W2048458080","https://openalex.org/W7204190416","https://openalex.org/W2130702272"],"abstract_inverted_index":{"Stansfield,":[0],"William":[1],"E.":[2],"MD;":[3,7,10],"Bhardwaj,":[4],"Ashwani":[5],"K.":[6],"Rojas,":[8],"Mauricio":[9],"Tang,":[11],"Ruhang":[12],"PhD;":[13,18],"Smyth,":[14],"Susan":[15],"S.":[16],"MD,":[17],"Selzman,":[19],"Craig":[20],"H.":[21],"MD":[22],"Author":[23],"Information":[24]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}