{"id":"https://openalex.org/W2138044238","doi":"https://doi.org/10.1158/1055-9965.epi-08-0262","title":"Circulating 2-Hydroxy- and 16\u03b1-Hydroxy Estrone Levels and Risk of Breast Cancer among Postmenopausal Women","display_name":"Circulating 2-Hydroxy- and 16\u03b1-Hydroxy Estrone Levels and Risk of Breast Cancer among Postmenopausal Women","publication_year":2008,"publication_date":"2008-08-01","ids":{"openalex":"https://openalex.org/W2138044238","doi":"https://doi.org/10.1158/1055-9965.epi-08-0262","mag":"2138044238","pmid":"https://pubmed.ncbi.nlm.nih.gov/18708395","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2562592"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-08-0262","doi":"https://doi.org/10.1158/1055-9965.epi-08-0262","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-0262","pdf_url":"https://aacrjournals.org/cebp/article-pdf/17/8/2029/2268600/2029.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cebp/article-pdf/17/8/2029/2268600/2029.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014551852","display_name":"A. Heather Eliassen","orcid":"https://orcid.org/0000-0002-3961-6609","observed_orcids":["https://orcid.org/0000-0002-3961-6609"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Heather Eliassen","raw_affiliation_strings":["1Channing Laboratory, Department of Medicine, and","3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Channing Laboratory, Department of Medicine, and","institution_ids":[]},{"raw_affiliation_string":"3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003924876","display_name":"Stacey A. Missmer","orcid":"https://orcid.org/0000-0003-3147-6768","observed_orcids":["https://orcid.org/0000-0003-3147-6768"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey A. Missmer","raw_affiliation_strings":["1Channing Laboratory, Department of Medicine, and","2Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School and","3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Channing Laboratory, Department of Medicine, and","institution_ids":[]},{"raw_affiliation_string":"2Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School and","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054091966","display_name":"Shelley S. Tworoger","orcid":"https://orcid.org/0000-0002-6986-7046","observed_orcids":["https://orcid.org/0000-0002-6986-7046"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley S. Tworoger","raw_affiliation_strings":["1Channing Laboratory, Department of Medicine, and","3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Channing Laboratory, Department of Medicine, and","institution_ids":[]},{"raw_affiliation_string":"3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008373933","display_name":"Susan E. Hankinson","orcid":"https://orcid.org/0000-0001-9155-3767","observed_orcids":["https://orcid.org/0000-0001-9155-3767"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Hankinson","raw_affiliation_strings":["1Channing Laboratory, Department of Medicine, and","3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Channing Laboratory, Department of Medicine, and","institution_ids":[]},{"raw_affiliation_string":"3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9084,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.94334038,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"8","first_page":"2029","last_page":"2035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.05660000070929527,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-hydroxyestrone","display_name":"2-hydroxyestrone","score":0.8949999809265137},{"id":"https://openalex.org/keywords/16alpha-hydroxyestrone","display_name":"16\u03b1-hydroxyestrone","score":0.9350000023841858},{"id":"https://openalex.org/keywords/estrogen-metabolites","display_name":"estrogen metabolites","score":0.8510000109672546},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9760000109672546},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9980000257492065},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-tumors","display_name":"estrogen receptor-negative tumors","score":0.6349999904632568},{"id":"https://openalex.org/keywords/circulating-estrogen","display_name":"circulating estrogen","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nurses-health-study","display_name":"Nurses' Health Study","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.5540000200271606},{"id":"https://openalex.org/keywords/breast-cancer-prevention","display_name":"breast cancer prevention","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.968307614326477},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7332002520561218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6686322093009949},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6608541011810303},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5667951703071594},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.547150731086731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5407135486602783},{"id":"https://openalex.org/C2779149875","wikidata":"https://www.wikidata.org/wiki/Q5401864","display_name":"Estrone sulfate","level":4,"score":0.4616794288158417},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4552712142467499},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.44723936915397644},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38433003425598145}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/1055-9965.epi-08-0262","doi":"https://doi.org/10.1158/1055-9965.epi-08-0262","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-0262","pdf_url":"https://aacrjournals.org/cebp/article-pdf/17/8/2029/2268600/2029.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},{"id":"pmid:18708395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18708395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2562592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2562592","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.epi-08-0262","doi":"https://doi.org/10.1158/1055-9965.epi-08-0262","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-0262","pdf_url":"https://aacrjournals.org/cebp/article-pdf/17/8/2029/2268600/2029.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G151562090","display_name":null,"funder_award_id":"CA-49449","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G259397354","display_name":"Biochemical Markers in the nurses' Health Study Cohort","funder_award_id":"5r01ca049449-18","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3965309116","display_name":"Dietary and Hormonal Determinants of Cancer in Women","funder_award_id":"P01CA087969","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G459566519","display_name":null,"funder_award_id":"R01\u2010CA049449","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7141723403","display_name":"Nutritional Epidemiology of Cancer Education and Career Development Program","funder_award_id":"R25CA098566","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7725448993","display_name":"Biochemical Markers in the Nurses? Health Study Cohort","funder_award_id":"U01CA049449","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138044238.pdf","grobid_xml":"https://content.openalex.org/works/W2138044238.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1203690880","https://openalex.org/W1511930757","https://openalex.org/W1514900303","https://openalex.org/W1560531206","https://openalex.org/W1577465777","https://openalex.org/W1951670987","https://openalex.org/W1952381273","https://openalex.org/W1969456163","https://openalex.org/W1971545670","https://openalex.org/W1973947446","https://openalex.org/W1975949315","https://openalex.org/W1983038564","https://openalex.org/W1987332115","https://openalex.org/W1989292079","https://openalex.org/W1990862723","https://openalex.org/W1991172419","https://openalex.org/W1995588804","https://openalex.org/W1995954745","https://openalex.org/W2001732788","https://openalex.org/W2001984564","https://openalex.org/W2007331274","https://openalex.org/W2012345238","https://openalex.org/W2012963101","https://openalex.org/W2013142209","https://openalex.org/W2014936614","https://openalex.org/W2022696181","https://openalex.org/W2024859916","https://openalex.org/W2028325343","https://openalex.org/W2028691872","https://openalex.org/W2031505687","https://openalex.org/W2034584551","https://openalex.org/W2036402179","https://openalex.org/W2040017782","https://openalex.org/W2043506998","https://openalex.org/W2047687060","https://openalex.org/W2050400259","https://openalex.org/W2054339472","https://openalex.org/W2057180130","https://openalex.org/W2058484311","https://openalex.org/W2060439544","https://openalex.org/W2069430339","https://openalex.org/W2075107592","https://openalex.org/W2083440063","https://openalex.org/W2085374835","https://openalex.org/W2090560500","https://openalex.org/W2098872781","https://openalex.org/W2100690704","https://openalex.org/W2105073560","https://openalex.org/W2105087123","https://openalex.org/W2111829340","https://openalex.org/W2119237938","https://openalex.org/W2119577260","https://openalex.org/W2122100237","https://openalex.org/W2122908256","https://openalex.org/W2127845722","https://openalex.org/W2130343048","https://openalex.org/W2130958872","https://openalex.org/W2133570742","https://openalex.org/W2138597496","https://openalex.org/W2153216542","https://openalex.org/W2160687899","https://openalex.org/W2163151567","https://openalex.org/W2168251468","https://openalex.org/W2207936381","https://openalex.org/W2338597756","https://openalex.org/W2412734901","https://openalex.org/W2414835970","https://openalex.org/W2464908612","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2118156630","https://openalex.org/W4242770208","https://openalex.org/W2955871838","https://openalex.org/W4401910129","https://openalex.org/W1971545670","https://openalex.org/W2163151567","https://openalex.org/W53016809","https://openalex.org/W2111829340","https://openalex.org/W1983038564","https://openalex.org/W7095789672"],"abstract_inverted_index":{"Circulating":[0],"estrogens":[1],"are":[2,15,30],"associated":[3,103],"with":[4,104,164,186,226,239,246,256],"breast":[5,33,91,105],"cancer":[6,34,92,106],"risk":[7,93,107,148],"in":[8,51,263],"postmenopausal":[9,71],"women.":[10],"Given":[11],"that":[12,24],"estrogen":[13,28,165],"metabolites":[14,29,141],"potentially":[16],"both":[17],"mitogenic":[18],"and":[19,59,65,77,124,179,229,249],"genotoxic,":[20],"it":[21],"is":[22],"possible":[23],"plasma":[25],"levels":[26],"of":[27],"related":[31],"to":[32,53,147,260],"risk.":[35],"We":[36],"conducted":[37],"a":[38],"prospective,":[39],"nested":[40],"case-control":[41],"study":[42],"within":[43],"the":[44,139,180,222,230,235,250],"Nurses'":[45],"Health":[46],"Study.":[47],"Blood":[48],"samples,":[49],"collected":[50],"1989":[52],"1990,":[54],"were":[55,83,101,160,174],"assayed":[56],"for":[57,90,121,133,176,200,214],"2-OH":[58,96,122,177,201,227,247],"16alpha-OH":[60,98,134,240],"estrone":[61,99,123,178,182,228,232,248,252],"among":[62,162,184,254],"340":[63],"cases":[64],"677":[66],"matched":[67],"controls":[68],"not":[69,220],"taking":[70],"hormones.":[72],"Multivariate":[73],"relative":[74],"risks":[75],"(RR)":[76],"95%":[78,115,127,151,191,205],"confidence":[79],"intervals":[80],"(95%":[81],"CI)":[82],"calculated":[84],"by":[85],"conditional":[86],"logistic":[87],"regression,":[88],"adjusting":[89],"factors.":[94],"Neither":[95],"nor":[97],"concentrations":[100],"significantly":[102],"overall":[108,149],"(top":[109],"versus":[110],"bottom":[111],"quartile:":[112],"RR,":[113,125,203],"1.19;":[114],"CI,":[116,128,152,192,206],"0.80-1.79;":[117],"P(trend)":[118,130,154,194,208],"=":[119,131,155,195,198,209,212],"0.40":[120],"1.04;":[126],"0.71-1.53;":[129],"0.81":[132],"estrone).":[135,216],"The":[136,242],"ratio":[137,183,233,253],"between":[138],"two":[140],"(2-OH:16alpha-OH":[142],"estrone)":[143],"was":[144],"similarly":[145],"unrelated":[146],"(1.30;":[150],"0.87-1.95;":[153],"0.35).":[156],"Although":[157],"no":[158],"associations":[159,173,225,245],"detected":[161],"women":[163,185,255],"receptor":[166,168],"(ER)-positive/progesterone":[167],"(PR)-positive":[169],"tumors,":[170],"significant":[171,243],"positive":[172,237,244],"observed":[175],"2-OH:16alpha-OH":[181,215,231],"ER-negative/PR-negative":[187,257],"tumors":[188,258],"(RR,":[189],"3.65;":[190],"1.23-10.81;":[193],"0.01;":[196],"P(heterogeneity)":[197,211],"0.02":[199],"estrone;":[202],"3.70;":[204],"1.24-11.09;":[207],"0.004;":[210],"0.005":[213],"These":[217],"data":[218],"do":[219],"support":[221],"hypothesized":[223,236],"inverse":[224],"or":[234],"association":[238],"estrone.":[241],"2-OH:16-OH":[251],"needs":[259],"be":[261],"replicated":[262],"future":[264],"studies.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}