{"id":"https://openalex.org/W2138017682","doi":"https://doi.org/10.1096/fj.10-162263","title":"Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas","display_name":"Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas","publication_year":2010,"publication_date":"2010-07-19","ids":{"openalex":"https://openalex.org/W2138017682","doi":"https://doi.org/10.1096/fj.10-162263","mag":"2138017682","pmid":"https://pubmed.ncbi.nlm.nih.gov/20643906","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3229423"},"language":"en","primary_location":{"id":"doi:10.1096/fj.10-162263","doi":"https://doi.org/10.1096/fj.10-162263","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.10-162263","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3229423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062457545","display_name":"Gwendoline Van Goietsenoven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Gwendoline Van Goietsenoven","raw_affiliation_strings":["Laborarory of ToxicologyUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborarory of ToxicologyUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046389355","display_name":"Jenna Hutton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenna Hutton","raw_affiliation_strings":["Department of Molecular Genetics, Microbiology, and Immunology, University of Medicine, Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Microbiology, and Immunology, University of Medicine, Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079710986","display_name":"Jean\u2010Paul Becker","orcid":"https://orcid.org/0009-0003-2865-0734","observed_orcids":["https://orcid.org/0009-0003-2865-0734"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I4210140355","display_name":"VIB-VUB Center for Structural Biology","ror":"https://ror.org/03e84cm85","country_code":"BE","type":"facility","lineage":["https://openalex.org/I13469542","https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean\u2010Paul Becker","raw_affiliation_strings":["Laboratory for the Structure and Function of Biological MembranesCenter for Structural Biology and BioinformaticsUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for the Structure and Function of Biological MembranesCenter for Structural Biology and BioinformaticsUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I4210140355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080438465","display_name":"Benjamin Lallemand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Benjamin Lallemand","raw_affiliation_strings":["Laboratory of Bioanalytical Chemistry, Toxicology, and Applied ChemistryUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioanalytical Chemistry, Toxicology, and Applied ChemistryUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francis Robert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Francis Robert","raw_affiliation_strings":["Biochemistry Department, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113957992","display_name":"Florence Lefranc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Florence Lefranc","raw_affiliation_strings":["Department of Neurosurgery, Erasme University Hospital, Brussels, Belgium","Laborarory of Toxicology Universit\u00e9 Libre de Bruxelles  Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Erasme University Hospital, Brussels, Belgium","institution_ids":["https://openalex.org/I2802054198"]},{"raw_affiliation_string":"Laborarory of Toxicology Universit\u00e9 Libre de Bruxelles  Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012933847","display_name":"Christine Pirker","orcid":"https://orcid.org/0000-0001-7104-4404","observed_orcids":["https://orcid.org/0000-0001-7104-4404"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christine Pirker","raw_affiliation_strings":["Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029849111","display_name":"Guy Vandenbussche","orcid":"https://orcid.org/0000-0001-9592-2304","observed_orcids":["https://orcid.org/0000-0001-9592-2304"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I4210140355","display_name":"VIB-VUB Center for Structural Biology","ror":"https://ror.org/03e84cm85","country_code":"BE","type":"facility","lineage":["https://openalex.org/I13469542","https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guy Vandenbussche","raw_affiliation_strings":["Laboratory for the Structure and Function of Biological MembranesCenter for Structural Biology and BioinformaticsUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for the Structure and Function of Biological MembranesCenter for Structural Biology and BioinformaticsUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I4210140355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080190204","display_name":"Pierre Van Antwerpen","orcid":"https://orcid.org/0000-0002-4934-8863","observed_orcids":["https://orcid.org/0000-0002-4934-8863"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pierre Van Antwerpen","raw_affiliation_strings":["Laboratory of Pharmaceutical ChemistryInstitute of PharmacyUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutical ChemistryInstitute of PharmacyUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052002042","display_name":"Antonio Evidente","orcid":"https://orcid.org/0000-0001-9110-1656","observed_orcids":["https://orcid.org/0000-0001-9110-1656"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Evidente","raw_affiliation_strings":["Dipartimento di Scienze del Suolo, della Pianta, dell'Ambiente e delle Produzioni Animali, Universita di Napoli Federico II, Portici, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze del Suolo, della Pianta, dell'Ambiente e delle Produzioni Animali, Universita di Napoli Federico II, Portici, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043913136","display_name":"Walter Berger","orcid":"https://orcid.org/0000-0003-0014-1658","observed_orcids":["https://orcid.org/0000-0003-0014-1658"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Walter Berger","raw_affiliation_strings":["Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082932007","display_name":"Martine Pr\u00e9vost","orcid":"https://orcid.org/0000-0003-3144-7828","observed_orcids":["https://orcid.org/0000-0003-3144-7828"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I4210140355","display_name":"VIB-VUB Center for Structural Biology","ror":"https://ror.org/03e84cm85","country_code":"BE","type":"facility","lineage":["https://openalex.org/I13469542","https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Martine Pr\u00e9vost","raw_affiliation_strings":["Laboratory for the Structure and Function of Biological MembranesCenter for Structural Biology and BioinformaticsUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for the Structure and Function of Biological MembranesCenter for Structural Biology and BioinformaticsUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I4210140355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003180767","display_name":"Jerry Pelletier","orcid":"https://orcid.org/0000-0003-1963-6466","observed_orcids":["https://orcid.org/0000-0003-1963-6466"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jerry Pelletier","raw_affiliation_strings":["Biochemistry Department, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102917329","display_name":"Robert Kiss A","orcid":"https://orcid.org/0000-0003-0692-3191","observed_orcids":["https://orcid.org/0000-0003-0692-3191","https://orcid.org/0000-0003-0209-3004","https://orcid.org/0000-0002-2879-6325"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Robert Kiss","raw_affiliation_strings":["Laborarory of ToxicologyUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborarory of ToxicologyUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054710367","display_name":"Terri Goss Kinzy","orcid":"https://orcid.org/0000-0003-1394-9226","observed_orcids":["https://orcid.org/0000-0003-1394-9226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terri Goss Kinzy","raw_affiliation_strings":["Department of Molecular Genetics, Microbiology, and Immunology, University of Medicine, Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Microbiology, and Immunology, University of Medicine, Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009000319","display_name":"Alexander Kornienko","orcid":"https://orcid.org/0000-0003-2041-7367","observed_orcids":["https://orcid.org/0000-0003-2041-7367"]},"institutions":[{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kornienko","raw_affiliation_strings":["Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico, USA","institution_ids":["https://openalex.org/I207123951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110518019","display_name":"V\u00e9ronique Mathieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Mathieu","raw_affiliation_strings":["Laborarory of ToxicologyUniversit\u00e9 Libre de Bruxelles Brussels Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborarory of ToxicologyUniversit\u00e9 Libre de Bruxelles Brussels Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5102917329"],"corresponding_institution_ids":["https://openalex.org/I132053463"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":4.7551,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.95727324,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"24","issue":"11","first_page":"4575","last_page":"4584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.10209999978542328,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.10209999978542328,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elongation-factor-1-alpha","display_name":"elongation factor 1-alpha","score":0.9399999976158142},{"id":"https://openalex.org/keywords/elongation-factors","display_name":"elongation factors","score":0.7269999980926514},{"id":"https://openalex.org/keywords/narciclasine","display_name":"narciclasine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/actin-bundling","display_name":"actin bundling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/drug-binding","display_name":"drug binding","score":0.43799999356269836},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.6230000257492065},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.4970000088214874},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.6370000243186951},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7580000162124634},{"id":"https://openalex.org/keywords/xenograft-survival","display_name":"xenograft survival","score":0.597000002861023},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C139124968","wikidata":"https://www.wikidata.org/wiki/Q126252","display_name":"Elongation factor","level":5,"score":0.641022801399231},{"id":"https://openalex.org/C2781465977","wikidata":"https://www.wikidata.org/wiki/Q420314","display_name":"Lycorine","level":3,"score":0.6214724779129028},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5978628396987915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5141201615333557},{"id":"https://openalex.org/C2910425318","wikidata":"https://www.wikidata.org/wiki/Q150708","display_name":"Amaryllidaceae Alkaloids","level":3,"score":0.4925766587257385},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45447713136672974},{"id":"https://openalex.org/C2778105851","wikidata":"https://www.wikidata.org/wiki/Q155848","display_name":"Amaryllidaceae","level":2,"score":0.4391656816005707},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42570245265960693},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32631736993789673},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26605719327926636},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.15732425451278687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13538908958435059},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.07574799656867981},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006912","descriptor_name":"Hydroxyquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010617","descriptor_name":"Phenanthridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019668","descriptor_name":"Liliaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020648","descriptor_name":"Peptide Elongation Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1096/fj.10-162263","doi":"https://doi.org/10.1096/fj.10-162263","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.10-162263","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3229423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3229423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},{"id":"pmid:20643906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20643906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:ir.library.illinoisstate.edu:fpbiosci-1104","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3229423","pdf_url":null,"source":{"id":"https://openalex.org/S4377196502","display_name":"ISU Red - Research and eData (Illinois State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47301684","host_organization_name":"Illinois State University","host_organization_lineage":["https://openalex.org/I47301684"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications \u2013 Biological Sciences","raw_type":"text"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/67950","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/67950","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The FASEB journal, 24 (11","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3229423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3229423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6631610734","display_name":"Regulators of Translation Elongation Factor eEF1A","funder_award_id":"R01GM057483","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320313928","display_name":"Institut national de la recherche scientifique","ror":"https://ror.org/04td37d32"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1488083143","https://openalex.org/W1526675316","https://openalex.org/W1558276741","https://openalex.org/W1965098419","https://openalex.org/W1970473512","https://openalex.org/W1970812803","https://openalex.org/W1974851340","https://openalex.org/W1974865265","https://openalex.org/W1980313235","https://openalex.org/W1984183951","https://openalex.org/W1991191399","https://openalex.org/W1991471340","https://openalex.org/W1992579613","https://openalex.org/W2010489527","https://openalex.org/W2011874398","https://openalex.org/W2022602911","https://openalex.org/W2029789860","https://openalex.org/W2031187947","https://openalex.org/W2032598681","https://openalex.org/W2032860349","https://openalex.org/W2033060132","https://openalex.org/W2033293438","https://openalex.org/W2039988307","https://openalex.org/W2049692147","https://openalex.org/W2050906569","https://openalex.org/W2051917121","https://openalex.org/W2058028915","https://openalex.org/W2058815073","https://openalex.org/W2061842004","https://openalex.org/W2065954413","https://openalex.org/W2067465277","https://openalex.org/W2067605044","https://openalex.org/W2072009964","https://openalex.org/W2074611001","https://openalex.org/W2075540776","https://openalex.org/W2075981998","https://openalex.org/W2078888969","https://openalex.org/W2079118647","https://openalex.org/W2085017455","https://openalex.org/W2088288204","https://openalex.org/W2089494333","https://openalex.org/W2094041171","https://openalex.org/W2102377211","https://openalex.org/W2114956112","https://openalex.org/W2149080572","https://openalex.org/W2151409808","https://openalex.org/W2152315800","https://openalex.org/W2171166843","https://openalex.org/W2399409396"],"related_works":["https://openalex.org/W1619153708","https://openalex.org/W6989925206","https://openalex.org/W2094041171","https://openalex.org/W7097097653","https://openalex.org/W2512718972","https://openalex.org/W4401053474","https://openalex.org/W3014549893","https://openalex.org/W2801356018","https://openalex.org/W4322761613","https://openalex.org/W2765966668"],"abstract_inverted_index":{"ABSTRACT":[0],"Melanomas":[1],"display":[2],"poor":[3],"response":[4],"rates":[5],"to":[6,14,64,105,138,155,167,180,192,253],"adjuvant":[7],"therapies":[8],"because":[9],"of":[10,32,59,62,87,144,196,206,245],"their":[11,60,95,197],"intrinsic":[12],"resistance":[13,22,63],"proapoptotic":[15,65],"stimuli.":[16,66],"This":[17],"study":[18],"indicates":[19],"that":[20,151,174],"such":[21],"can":[23],"be":[24],"overcome,":[25],"at":[26,130],"least":[27],"partly,":[28],"through":[29],"the":[30,85,203],"targeting":[31,99],"eEF1A":[33,98,160,186,246],"elongation":[34,170],"factor":[35,171],"with":[36,100,247],"narciclasine,":[37],"an":[38],"Amaryllidaceae":[39,248],"isocarbostyril":[40],"controlling":[41],"plant":[42],"growth.":[43],"Narciclasine":[44],"displays":[45],"IC":[46],"50":[47],"growth":[48],"inhibitory":[49],"values":[50],"between":[51],"30\u2013100":[52],"nM":[53,176],"in":[54,94,113,161],"melanoma":[55,92],"cell":[56,69],"lines,":[57],"irrespective":[58],"levels":[61],"Normal":[67],"noncancerous":[68],"lines":[70],"are":[71],"much":[72],"less":[73],"affected.":[74],"At":[75],"nontoxic":[76],"doses,":[77],"narciclasine":[78,101,152,177],"also":[79],"significantly":[80],"improves":[81],"(":[82],"P":[83],"=0.004)":[84],"survival":[86],"mice":[88],"bearing":[89],"metastatic":[90],"apoptosis\u2010resistant":[91],"xenografts":[93],"brain.":[96],"The":[97],"(50":[102],"nM)":[103],"leads":[104],"1":[106],")":[107,118],"marked":[108],"actin":[109,168,183],"cytoskeleton":[110],"disorganization,":[111],"resulting":[112],"cytokinesis":[114],"impairment,":[115],"and":[116,123,142,158,173,199],"2":[117],"protein":[119],"synthesis":[120],"impairment":[121],"(elongation":[122],"initiation":[124],"steps),":[125],"whereas":[126],"apoptosis":[127],"is":[128,178,187],"induced":[129],"higher":[131],"doses":[132],"only":[133],"(\u2265200":[134],"nM).":[135],"In":[136],"addition":[137],"molecular":[139],"docking":[140],"validation":[141],"identification":[143],"potential":[145,190],"binding":[146],"sites,":[147],"we":[148],"biochemically":[149],"confirmed":[150],"directly":[153],"binds":[154],"human":[156],"recombinant":[157],"yeast\u2010purified":[159],"a":[162,189,251],"nanomolar":[163],"range,":[164],"but":[165],"not":[166],"or":[169],"2,":[172],"5":[175],"sufficient":[179],"impair":[181],"eEF1A\u2010related":[182],"bundling":[184],"activity.":[185],"thus":[188],"target":[191],"combat":[193,254],"melanomas":[194],"regardless":[195],"apoptosis\u2010sensitivity,":[198],"this":[200],"finding":[201],"reconciles":[202],"pleiotropic":[204],"cytostatic":[205],"narciclasine.\u2014Van":[207],"Goietsenoven,":[208],"G.,":[209,223],"Hutton,":[210],"J.,":[211,234],"Becker,":[212],"J.\u2010P.,":[213],"Lallemand,":[214],"B.,":[215],"Robert,":[216],"F.,":[217,219],"Lefranc,":[218],"Pirker,":[220],"C.,":[221],"Vandenbussche,":[222],"Van":[224],"Antwerpen,":[225],"P.,":[226],"Evidente,":[227],"A.,":[228,241],"Berger,":[229],"W.,":[230],"Prevost,":[231],"M.,":[232],"Pelletier,":[233],"Kiss,":[235],"R.,":[236],"Goss":[237],"Kinzy,":[238],"T.,":[239],"Kornienko,":[240],"Mathieu,":[242],"V.":[243],"Targeting":[244],"isocarbostyrils":[249],"as":[250],"strategy":[252],"melanomas.":[255],"FASEB":[256],"J":[257],".":[258],"24,":[259],"4575\u20134584":[260],"(2010).":[261],"www.fasebj.org":[262]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}