{"id":"https://openalex.org/W2137990944","doi":"https://doi.org/10.1186/1756-8722-3-8","title":"From basic research to clinical development of MEK1/2 inhibitors for cancer therapy","display_name":"From basic research to clinical development of MEK1/2 inhibitors for cancer therapy","publication_year":2010,"publication_date":"2010-02-11","ids":{"openalex":"https://openalex.org/W2137990944","doi":"https://doi.org/10.1186/1756-8722-3-8","mag":"2137990944","pmid":"https://pubmed.ncbi.nlm.nih.gov/20149254","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2830959"},"language":"en","primary_location":{"id":"doi:10.1186/1756-8722-3-8","doi":"https://doi.org/10.1186/1756-8722-3-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-8722-3-8","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-3-8","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-3-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012432110","display_name":"Christophe Fr\u00e9min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christophe Fr\u00e9min","raw_affiliation_strings":["Institut de Recherche en Immunologie et Canc\u00e9rologie and Department of Pharmacology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3C 3J7, Canada","Institut de Recherche en Immunologie et Canc\u00e9rologie and Departments of Pharmacology and Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche en Immunologie et Canc\u00e9rologie and Department of Pharmacology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3C 3J7, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Institut de Recherche en Immunologie et Canc\u00e9rologie and Departments of Pharmacology and Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085198110","display_name":"Sylvain Meloche","orcid":"https://orcid.org/0000-0002-6201-7786","observed_orcids":["https://orcid.org/0000-0002-6201-7786"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sylvain Meloche","raw_affiliation_strings":["Institut de Recherche en Immunologie et Canc\u00e9rologie and Departments of Pharmacology and Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, H3C 3J7, Canada","Institut de Recherche en Immunologie et Canc\u00e9rologie and Departments of Pharmacology and Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche en Immunologie et Canc\u00e9rologie and Departments of Pharmacology and Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, H3C 3J7, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Institut de Recherche en Immunologie et Canc\u00e9rologie and Departments of Pharmacology and Molecular Biology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085198110"],"corresponding_institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":2.2664,"has_fulltext":true,"cited_by_count":249,"citation_normalized_percentile":{"value":0.91620402,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"1","first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.7350000143051147},{"id":"https://openalex.org/keywords/raf-mutations","display_name":"RAF mutations","score":0.9800000190734863},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-activation","display_name":"receptor tyrosine kinase activation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/clinical-drug-development","display_name":"clinical development","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6136608123779297},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6018781065940857},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5903989672660828},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5531411170959473},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5317493677139282},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5311822891235352},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.520026683807373},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5183040499687195},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48243698477745056},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.46165546774864197},{"id":"https://openalex.org/C2778366672","wikidata":"https://www.wikidata.org/wiki/Q5957687","display_name":"Hyperactivation","level":2,"score":0.429823637008667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4276845157146454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40978533029556274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3124261498451233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24987778067588806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1960088610649109},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11149978637695312}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048370","descriptor_name":"MAP Kinase Kinase 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1756-8722-3-8","doi":"https://doi.org/10.1186/1756-8722-3-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-8722-3-8","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-3-8","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1909873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2830959","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2830959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2830959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hematol Oncol","raw_type":"Text"},{"id":"pmid:20149254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20149254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:96111efe968a4115b5e0ebf0de0f5a50","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/96111efe968a4115b5e0ebf0de0f5a50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology & Oncology, Vol 3, Iss 1, p 8 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1756-8722-3-8","doi":"https://doi.org/10.1186/1756-8722-3-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-8722-3-8","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/1756-8722-3-8","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311169","display_name":"Cancer Research Society","ror":"https://ror.org/00t38a349"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137990944.pdf","grobid_xml":"https://content.openalex.org/works/W2137990944.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W282039557","https://openalex.org/W1494491432","https://openalex.org/W1511031451","https://openalex.org/W1528756081","https://openalex.org/W1572526443","https://openalex.org/W1589959819","https://openalex.org/W1644484251","https://openalex.org/W1756746580","https://openalex.org/W1965414206","https://openalex.org/W1966260349","https://openalex.org/W1967400782","https://openalex.org/W1971915141","https://openalex.org/W1974024530","https://openalex.org/W1976385326","https://openalex.org/W1983833034","https://openalex.org/W1989480480","https://openalex.org/W1990065094","https://openalex.org/W1991053141","https://openalex.org/W1991738330","https://openalex.org/W1998809668","https://openalex.org/W2001521752","https://openalex.org/W2001999652","https://openalex.org/W2004136952","https://openalex.org/W2009642188","https://openalex.org/W2009925333","https://openalex.org/W2010598092","https://openalex.org/W2010685617","https://openalex.org/W2012871013","https://openalex.org/W2018896819","https://openalex.org/W2022473934","https://openalex.org/W2030578954","https://openalex.org/W2031885286","https://openalex.org/W2034269086","https://openalex.org/W2035079756","https://openalex.org/W2035936653","https://openalex.org/W2036614475","https://openalex.org/W2037267209","https://openalex.org/W2037838528","https://openalex.org/W2041098455","https://openalex.org/W2041811289","https://openalex.org/W2047182549","https://openalex.org/W2049171090","https://openalex.org/W2049291806","https://openalex.org/W2050422354","https://openalex.org/W2055288483","https://openalex.org/W2059192510","https://openalex.org/W2059852645","https://openalex.org/W2061345986","https://openalex.org/W2062657417","https://openalex.org/W2062821569","https://openalex.org/W2064129448","https://openalex.org/W2070686081","https://openalex.org/W2070800665","https://openalex.org/W2077321849","https://openalex.org/W2080686146","https://openalex.org/W2086262311","https://openalex.org/W2088293068","https://openalex.org/W2091364041","https://openalex.org/W2094583929","https://openalex.org/W2100847793","https://openalex.org/W2106119346","https://openalex.org/W2113693365","https://openalex.org/W2114950222","https://openalex.org/W2116787167","https://openalex.org/W2117852040","https://openalex.org/W2118106910","https://openalex.org/W2118188078","https://openalex.org/W2119236236","https://openalex.org/W2120492882","https://openalex.org/W2122051507","https://openalex.org/W2122231684","https://openalex.org/W2122757669","https://openalex.org/W2123541095","https://openalex.org/W2123885531","https://openalex.org/W2127150495","https://openalex.org/W2129400742","https://openalex.org/W2129429534","https://openalex.org/W2130044807","https://openalex.org/W2134757689","https://openalex.org/W2136745780","https://openalex.org/W2136833729","https://openalex.org/W2137047957","https://openalex.org/W2145725580","https://openalex.org/W2146181034","https://openalex.org/W2149717151","https://openalex.org/W2153084734","https://openalex.org/W2156509877","https://openalex.org/W2157016650","https://openalex.org/W2157540307","https://openalex.org/W2162147795","https://openalex.org/W2163188200","https://openalex.org/W2166568854","https://openalex.org/W2166624257","https://openalex.org/W2167006963","https://openalex.org/W2205509090","https://openalex.org/W2214705274","https://openalex.org/W2225512902","https://openalex.org/W2246017419","https://openalex.org/W2246856492","https://openalex.org/W2273990438","https://openalex.org/W2301163078","https://openalex.org/W2514915228","https://openalex.org/W2589963821","https://openalex.org/W2598765111","https://openalex.org/W4249688612"],"related_works":["https://openalex.org/W1974091059","https://openalex.org/W1848470479","https://openalex.org/W2013658947","https://openalex.org/W1837139339","https://openalex.org/W1980160555","https://openalex.org/W4303432239","https://openalex.org/W2223921723","https://openalex.org/W2011826559","https://openalex.org/W2789608969","https://openalex.org/W2073996882"],"abstract_inverted_index":{"The":[0],"Ras-dependent":[1],"Raf/MEK/ERK1/2":[2],"mitogen-activated":[3],"protein":[4],"(MAP)":[5],"kinase":[6],"signaling":[7],"pathway":[8,23,52],"is":[9,24],"a":[10,31],"major":[11],"regulator":[12],"of":[13,21,33,36,49,62,65,85,89,99,102],"cell":[14],"proliferation":[15],"and":[16,107],"survival.":[17],"Not":[18],"surprisingly,":[19],"hyperactivation":[20],"this":[22,68],"frequently":[25],"observed":[26],"in":[27,43,105],"human":[28],"malignancies":[29],"as":[30,56],"result":[32],"aberrant":[34],"activation":[35],"receptor":[37],"tyrosine":[38],"kinases":[39],"or":[40,45],"gain-of-function":[41],"mutations":[42],"RAS":[44],"RAF":[46],"genes.":[47],"Components":[48],"the":[50,60,73,79,82,90,96],"ERK1/2":[51,91],"are":[53],"therefore":[54],"viewed":[55],"attractive":[57],"candidates":[58],"for":[59,81],"development":[61,84],"targeted":[63],"therapies":[64],"cancer.":[66],"In":[67],"article,":[69],"we":[70],"briefly":[71],"review":[72],"basic":[74],"research":[75],"that":[76],"has":[77],"laid":[78],"groundwork":[80],"clinical":[83,100],"small":[86],"molecules":[87],"inhibitors":[88,104],"pathway.":[92],"We":[93],"then":[94],"present":[95],"current":[97],"state":[98],"evaluation":[101],"MEK1/2":[103],"cancer":[106],"discuss":[108],"challenges":[109],"ahead.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":30}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}