{"id":"https://openalex.org/W2137947730","doi":"https://doi.org/10.1074/jbc.m209241200","title":"Ca2+/cAMP Response Element-binding Protein (CREB)-dependent Activation of Per1 Is Required for Light-induced Signaling in the Suprachiasmatic Nucleus Circadian Clock","display_name":"Ca2+/cAMP Response Element-binding Protein (CREB)-dependent Activation of Per1 Is Required for Light-induced Signaling in the Suprachiasmatic Nucleus Circadian Clock","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2137947730","doi":"https://doi.org/10.1074/jbc.m209241200","mag":"2137947730","pmid":"https://pubmed.ncbi.nlm.nih.gov/12409294"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m209241200","doi":"https://doi.org/10.1074/jbc.m209241200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m209241200","pdf_url":"http://www.jbc.org/article/S0021925819311469/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819311469/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047752480","display_name":"Shelley A. Tischkau","orcid":"https://orcid.org/0000-0002-8016-6398","observed_orcids":["https://orcid.org/0000-0002-8016-6398"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley A. Tischkau","raw_affiliation_strings":["Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, B107 CLSL, 61801, USA","Departments of Cell and Structural Biology, Urbana, Illinois 61801","Neuroscience Program, University of Illinois at Urbana-Champaign, B107 CLSL, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, B107 CLSL, 61801, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Departments of Cell and Structural Biology, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Neuroscience Program, University of Illinois at Urbana-Champaign, B107 CLSL, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008686356","display_name":"Jennifer W. Mitchell","orcid":"https://orcid.org/0000-0003-0109-7185","observed_orcids":["https://orcid.org/0000-0003-0109-7185"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer W. Mitchell","raw_affiliation_strings":["Departments of Cell and Structural Biology, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell and Structural Biology, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055960402","display_name":"Sheue-Houy Tyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheue-Houy Tyan","raw_affiliation_strings":["Departments of Cell and Structural Biology, Urbana, Illinois 61801","Neuroscience Program, University of Illinois at Urbana-Champaign, B107 CLSL, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell and Structural Biology, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Neuroscience Program, University of Illinois at Urbana-Champaign, B107 CLSL, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014981127","display_name":"Gordon F. Buchanan","orcid":"https://orcid.org/0000-0003-2371-4455","observed_orcids":["https://orcid.org/0000-0003-2371-4455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon F. Buchanan","raw_affiliation_strings":["Departments of Molecular and Integrative Physiology, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular and Integrative Physiology, Urbana, Illinois 61801","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039332578","display_name":"Martha Ulbrick Gillette","orcid":"https://orcid.org/0000-0003-3645-2626","observed_orcids":["https://orcid.org/0000-0003-3645-2626"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martha U. Gillette","raw_affiliation_strings":["Departments of Cell and Structural Biology, Urbana, Illinois 61801","Departments of Molecular and Integrative Physiology, Urbana, Illinois 61801","Neuroscience Program, University of Illinois at Urbana-Champaign, B107 CLSL, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell and Structural Biology, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Departments of Molecular and Integrative Physiology, Urbana, Illinois 61801","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Program, University of Illinois at Urbana-Champaign, B107 CLSL, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039332578"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.9276,"has_fulltext":true,"cited_by_count":295,"citation_normalized_percentile":{"value":0.9831064,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"278","issue":"2","first_page":"718","last_page":"723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/per1","display_name":"Per1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8220000267028809},{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9430000185966492},{"id":"https://openalex.org/keywords/light-induced-phase-shift","display_name":"light-induced phase shift","score":0.847000002861023},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.8730000257492065},{"id":"https://openalex.org/keywords/retinohypothalamic-tract","display_name":"retinohypothalamic tract","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antisense-oligodeoxynucleotides","display_name":"antisense oligodeoxynucleotides","score":0.8140000104904175},{"id":"https://openalex.org/keywords/circadian-synchronization","display_name":"circadian synchronization","score":0.5889999866485596},{"id":"https://openalex.org/keywords/light-signaling","display_name":"light signaling","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2779317972","wikidata":"https://www.wikidata.org/wiki/Q1156516","display_name":"Suprachiasmatic nucleus","level":3,"score":0.9257066249847412},{"id":"https://openalex.org/C2780360009","wikidata":"https://www.wikidata.org/wiki/Q15326762","display_name":"PER1","level":5,"score":0.9245138168334961},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7397845983505249},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.6098561882972717},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.5800997614860535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5256116390228271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4869502782821655},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.411212682723999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36910387873649597},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3663116693496704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3560420274734497},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.270211398601532},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1761012077331543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12893521785736084},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12215474247932434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06873354315757751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m209241200","doi":"https://doi.org/10.1074/jbc.m209241200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m209241200","pdf_url":"http://www.jbc.org/article/S0021925819311469/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12409294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12409294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m209241200","doi":"https://doi.org/10.1074/jbc.m209241200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m209241200","pdf_url":"http://www.jbc.org/article/S0021925819311469/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1715136076","display_name":null,"funder_award_id":"NS 22155","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1818327238","display_name":null,"funder_award_id":"NS11158","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3456245448","display_name":null,"funder_award_id":"R01 NS022155","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3593617728","display_name":"CELLULAR REGULATORS OF CIRCADIAN TIMING","funder_award_id":"R01HL067007","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8232299208","display_name":null,"funder_award_id":"MH12351","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8367386748","display_name":null,"funder_award_id":"HL67007","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8979640065","display_name":null,"funder_award_id":"NS10170","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137947730.pdf","grobid_xml":"https://content.openalex.org/works/W2137947730.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W150521681","https://openalex.org/W190033692","https://openalex.org/W1500623730","https://openalex.org/W1580590749","https://openalex.org/W1612131882","https://openalex.org/W1617798422","https://openalex.org/W1629086938","https://openalex.org/W1744822607","https://openalex.org/W1816777554","https://openalex.org/W1970355769","https://openalex.org/W1975146102","https://openalex.org/W1989896982","https://openalex.org/W1992182952","https://openalex.org/W1998448534","https://openalex.org/W2002388054","https://openalex.org/W2006824515","https://openalex.org/W2009850542","https://openalex.org/W2011400731","https://openalex.org/W2013132252","https://openalex.org/W2016027614","https://openalex.org/W2021229976","https://openalex.org/W2021654192","https://openalex.org/W2024228896","https://openalex.org/W2028606580","https://openalex.org/W2029227663","https://openalex.org/W2030118774","https://openalex.org/W2032656475","https://openalex.org/W2037010800","https://openalex.org/W2040964766","https://openalex.org/W2048466060","https://openalex.org/W2053326555","https://openalex.org/W2054433088","https://openalex.org/W2057522076","https://openalex.org/W2060431752","https://openalex.org/W2065192885","https://openalex.org/W2083673419","https://openalex.org/W2085904808","https://openalex.org/W2090816060","https://openalex.org/W2096819583","https://openalex.org/W2098438454","https://openalex.org/W2101600063","https://openalex.org/W2102048968","https://openalex.org/W2120187370","https://openalex.org/W2123194197","https://openalex.org/W2123981584","https://openalex.org/W2130179391","https://openalex.org/W2130807836","https://openalex.org/W2136983368","https://openalex.org/W2145330934","https://openalex.org/W2151468131","https://openalex.org/W2152014997"],"related_works":["https://openalex.org/W2207461195","https://openalex.org/W2054493393","https://openalex.org/W2184435628","https://openalex.org/W4226502556","https://openalex.org/W4255715816","https://openalex.org/W3028896300","https://openalex.org/W138931492","https://openalex.org/W2025223801","https://openalex.org/W2012509672","https://openalex.org/W2152248062"],"abstract_inverted_index":{"Light":[0],"is":[1],"a":[2,51],"prominent":[3],"stimulus":[4],"that":[5],"synchronizes":[6],"endogenous":[7],"circadian":[8,34,127],"rhythmicity":[9],"to":[10],"environmental":[11],"light/dark":[12],"cycles.":[13],"Nocturnal":[14],"light":[15],"elevates":[16],"mRNA":[17],"of":[18,33,101,115,125],"the":[19,47,59,69,96,116,126],"Period1":[20],"(Per1)":[21],"gene":[22],"and":[23,42,80,110],"induces":[24],"long":[25],"term":[26],"state":[27],"changes,":[28],"expressed":[29],"as":[30],"phase":[31,44,66,91,123],"shifts":[32],"rhythms.":[35],"The":[36],"cellular":[37],"mechanism":[38],"for":[39],"Per1":[40,79,102,111],"elevation":[41],"light-induced":[43,90],"advance":[45,124],"in":[46,68,93],"suprachiasmatic":[48],"nucleus":[49],"(SCN),":[50],"process":[52],"initiated":[53],"primarily":[54],"by":[55,74],"glutamatergic":[56],"neurotransmission":[57,121],"from":[58],"retinohypothalamic":[60],"tract,":[61],"was":[62],"examined.":[63],"Glutamate":[64],"(GLU)-induced":[65],"advances":[67,92],"rat":[70],"SCN":[71],"were":[72],"blocked":[73,89,98],"antisense":[75],"oligodeoxynucleotide":[76],"(ODN)":[77],"against":[78],"Ca(2+)/cAMP":[81,105],"response":[82,106],"element":[83],"(CRE)-decoy":[84],"ODN.":[85],"CRE-decoy":[86,97],"ODN":[87],"also":[88],"vivo.":[94],"Furthermore,":[95],"GLU-induced":[99],"accumulation":[100],"mRNA.":[103],"Thus,":[104],"element-binding":[107],"protein":[108],"(CREB)":[109],"are":[112],"integral":[113],"components":[114],"pathway":[117],"transducing":[118],"light-stimulated":[119],"GLU":[120],"into":[122],"clock.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}