{"id":"https://openalex.org/W2137874745","doi":"https://doi.org/10.1164/rccm.200605-699oc","title":"Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury","display_name":"Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury","publication_year":2006,"publication_date":"2006-05-25","ids":{"openalex":"https://openalex.org/W2137874745","doi":"https://doi.org/10.1164/rccm.200605-699oc","mag":"2137874745","pmid":"https://pubmed.ncbi.nlm.nih.gov/16728713"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.200605-699oc","doi":"https://doi.org/10.1164/rccm.200605-699oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200605-699oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060789059","display_name":"Eileen N. Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Eileen N. Ogawa","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836964","display_name":"Akitoshi Ishizaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Akitoshi Ishizaka","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040109724","display_name":"Sadatomo Tasaka","orcid":"https://orcid.org/0000-0003-4861-4143","observed_orcids":["https://orcid.org/0000-0003-4861-4143"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Sadatomo Tasaka","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031532603","display_name":"Hidefumi Koh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hidefumi Koh","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Ueno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroshi Ueno","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043528593","display_name":"Fumimasa Amaya","orcid":"https://orcid.org/0000-0003-2934-0845","observed_orcids":["https://orcid.org/0000-0003-2934-0845"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Fumimasa Amaya","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002934466","display_name":"Masahito Ebina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masahito Ebina","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102808901","display_name":"Shingo Yamada","orcid":"https://orcid.org/0000-0001-9488-668X","observed_orcids":["https://orcid.org/0000-0001-9488-668X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shingo Yamada","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018102095","display_name":"Yosuke Funakoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yosuke Funakoshi","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042945460","display_name":"Junko Soejima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Junko Soejima","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038214218","display_name":"Kiyoshi Moriyama","orcid":"https://orcid.org/0000-0002-0387-5406","observed_orcids":["https://orcid.org/0000-0002-0387-5406"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kiyoshi Moriyama","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064119742","display_name":"Toru Kotani","orcid":"https://orcid.org/0000-0001-9504-0061","observed_orcids":["https://orcid.org/0000-0001-9504-0061"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toru Kotani","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059872950","display_name":"Satoru Hashimoto","orcid":"https://orcid.org/0000-0002-6726-9966","observed_orcids":["https://orcid.org/0000-0002-6726-9966"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Satoru Hashimoto","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081302173","display_name":"Hiroshi Morisaki","orcid":"https://orcid.org/0000-0002-2790-2093","observed_orcids":["https://orcid.org/0000-0002-2790-2093"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroshi Morisaki","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102795262","display_name":"Edward H Abraham","orcid":"https://orcid.org/0000-0002-4429-2389","observed_orcids":["https://orcid.org/0000-0002-4429-2389"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Edward Abraham","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063877976","display_name":"Junzo Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808"]},{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4387152237","display_name":"Shino-Test Corporation","ror":"https://ror.org/02zfbyq93","country_code":null,"type":"company","lineage":["https://openalex.org/I4387152237"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Junzo Takeda","raw_affiliation_strings":["Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medicine, University of Alabama, Birmingham, Alabama","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I32389192","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]},{"raw_affiliation_string":"Departments of Anesthesiology and Medicine, School of Medicine, Keio University; Department of Anesthesiology and Intensive Care, Tokyo Women's Medical University Daini Hospital, Tokyo; Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto; Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai; Central Institute, Shino-Test Corporation, Kanagawa; Ono Pharmaceutical Co. Ltd., Osaka, Japan; and","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I203951103","https://openalex.org/I40677808","https://openalex.org/I4210136522","https://openalex.org/I4387152237"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.7762,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.97493705,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"174","issue":"4","first_page":"400","last_page":"407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ventilator-induced-lung-injury","display_name":"ventilator-induced lung injury","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"tidal volume","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8119999766349792},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9570000171661377},{"id":"https://openalex.org/keywords/anti-hmgb1-antibody","display_name":"anti-HMGB1 antibody","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.953000009059906},{"id":"https://openalex.org/keywords/microvascular-permeability","display_name":"microvascular permeability","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.8870000243186951},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.9394010305404663},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8110600709915161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7621655464172363},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7301009893417358},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6678370237350464},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.4515326917171478},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4425343871116638},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43282318115234375},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4140545427799225},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3913075923919678},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35815924406051636},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2279607355594635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20737534761428833}],"mesh":[{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1164/rccm.200605-699oc","doi":"https://doi.org/10.1164/rccm.200605-699oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200605-699oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:16728713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16728713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.8279","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.8279","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajrccm.atsjournals.org/content/174/4/400.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1967623294","https://openalex.org/W1983405778","https://openalex.org/W1992217737","https://openalex.org/W1995593745","https://openalex.org/W1996207798","https://openalex.org/W2004266769","https://openalex.org/W2005121187","https://openalex.org/W2008848433","https://openalex.org/W2017407356","https://openalex.org/W2028294482","https://openalex.org/W2029068688","https://openalex.org/W2033088713","https://openalex.org/W2044887713","https://openalex.org/W2048519644","https://openalex.org/W2050165422","https://openalex.org/W2059217150","https://openalex.org/W2062082715","https://openalex.org/W2087957246","https://openalex.org/W2099764303","https://openalex.org/W2107305239","https://openalex.org/W2112822465","https://openalex.org/W2128426645","https://openalex.org/W2135374161","https://openalex.org/W2140103530","https://openalex.org/W2144585115","https://openalex.org/W2146807706","https://openalex.org/W2158095695","https://openalex.org/W2161568523","https://openalex.org/W2164714222","https://openalex.org/W2167412896","https://openalex.org/W2167743972","https://openalex.org/W2171028311","https://openalex.org/W2227906064","https://openalex.org/W2409888801","https://openalex.org/W2597070792","https://openalex.org/W4234847617"],"related_works":["https://openalex.org/W1978256486","https://openalex.org/W1490007860","https://openalex.org/W2097236514","https://openalex.org/W3137999900","https://openalex.org/W2002001129","https://openalex.org/W2365473896","https://openalex.org/W1541957757","https://openalex.org/W3083272915","https://openalex.org/W4312195781","https://openalex.org/W2101775523"],"abstract_inverted_index":{"RATIONALE:":[0],"Proinflammatory":[1],"cytokines":[2],"play":[3],"an":[4],"important":[5],"role":[6],"in":[7,36,125,130,134,147,154,181,196],"ventilator-induced":[8],"lung":[9,24,76],"injury":[10],"(VILI).":[11],"High-mobility":[12],"group":[13],"box-1":[14],"(HMGB1)":[15],"is":[16,34],"a":[17,88,93],"macrophage-derived":[18],"proinflammatory":[19],"cytokine":[20],"that":[21,32,187],"can":[22],"cause":[23],"injury.":[25],"OBJECTIVES:":[26],"This":[27],"study":[28],"tested":[29],"the":[30,49,59,65,111,131,135,148,171,193,197],"hypothesis":[31],"HMGB1":[33,63,124,146,161,188],"released":[35],"intact":[37],"lungs":[38,155],"ventilated":[39,83,156],"with":[40,87,104,157],"large":[41,94,114,132,158],"Vt.":[42,97,159],"A":[43,53],"second":[44],"objective":[45,55],"was":[46,56,99],"to":[47,57],"identify":[48],"source":[50],"of":[51,61,68,107,113,123,145,150,177,192,199],"HMGB1.":[52],"third":[54],"examine":[58],"effects":[60],"blocking":[62],"on":[64],"subsequent":[66],"development":[67,198],"VILI.":[69,200],"METHODS:":[70],"Bronchoalveolar":[71],"lavage":[72],"fluid":[73],"(BALF)":[74],"and":[75,140,152,167,174],"tissues":[77],"were":[78,127],"obtained":[79,101],"from":[80,102],"rabbits":[81,103],"mechanically":[82],"for":[84],"4":[85],"h":[86],"small":[89,136],"(8":[90],"ml/kg)":[91,96],"versus":[92],"(30":[95],"BALF":[98,126],"also":[100],"intratracheal":[105],"instillation":[106],"anti-HMGB1":[108],"antibody":[109],"before":[110],"initiation":[112],"Vt":[115,137],"ventilation.":[116],"MEASUREMENTS":[117],"AND":[118],"MAIN":[119],"RESULTS:":[120],"The":[121],"concentrations":[122,176],"fivefold":[128],"higher":[129],"than":[133],"group.":[138],"Immunohistochemistry":[139],"immunofluorescence":[141],"studies":[142],"revealed":[143],"expression":[144],"cytoplasm":[149],"macrophages":[151],"neutrophils":[153],"Blocking":[160],"improved":[162],"oxygenation,":[163],"limited":[164],"microvascular":[165],"permeability":[166],"neutrophil":[168],"influx":[169],"into":[170],"alveolar":[172],"lumen,":[173],"decreased":[175],"tumor":[178],"necrosis":[179],"factor-alpha":[180],"BALF.":[182],"CONCLUSIONS:":[183],"These":[184],"observations":[185],"suggest":[186],"could":[189],"be":[190],"one":[191],"deteriorating":[194],"factors":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
