{"id":"https://openalex.org/W2137828581","doi":"https://doi.org/10.1200/jco.1994.12.6.1323","title":"Treatment of hepatocellular carcinoma: too many options?","display_name":"Treatment of hepatocellular carcinoma: too many options?","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2137828581","doi":"https://doi.org/10.1200/jco.1994.12.6.1323","mag":"2137828581","pmid":"https://pubmed.ncbi.nlm.nih.gov/8201395"},"language":"en","primary_location":{"id":"doi:10.1200/jco.1994.12.6.1323","doi":"https://doi.org/10.1200/jco.1994.12.6.1323","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1994.12.6.1323","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037875642","display_name":"Alan Paul Venook","orcid":"https://orcid.org/0000-0001-9749-6548","observed_orcids":["https://orcid.org/0000-0001-9749-6548"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A P Venook","raw_affiliation_strings":["Division of Hematology/Oncology, University of California, San Francisco 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, University of California, San Francisco 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037875642"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":9.064,"has_fulltext":false,"cited_by_count":199,"citation_normalized_percentile":{"value":0.98151652,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"6","first_page":"1323","last_page":"1334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.7099999785423279},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.6880000233650208},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.48399999737739563},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9089999794960022},{"id":"https://openalex.org/keywords/intra-arterial-infusion","display_name":"intra-arterial infusion","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lipiodol","display_name":"lipiodol","score":0.8159999847412109},{"id":"https://openalex.org/keywords/isolated-hepatic-perfusion","display_name":"isolated hepatic perfusion","score":0.9900000095367432},{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/conformal-radiotherapy","display_name":"conformal radiotherapy","score":1.0},{"id":"https://openalex.org/keywords/cryosurgery","display_name":"cryosurgery","score":0.9879999756813049},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.996999979019165},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9623280763626099},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7066574096679688},{"id":"https://openalex.org/C2778448856","wikidata":"https://www.wikidata.org/wiki/Q4205889","display_name":"Lipiodol","level":3,"score":0.49857354164123535},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4597158432006836},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44048359990119934},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.4379981458187103},{"id":"https://openalex.org/C2779864613","wikidata":"https://www.wikidata.org/wiki/Q16928295","display_name":"Percutaneous ethanol injection","level":4,"score":0.43786340951919556},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3584480285644531},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.34071844816207886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3262282609939575},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.23475664854049683},{"id":"https://openalex.org/C2777377203","wikidata":"https://www.wikidata.org/wiki/Q1809554","display_name":"Radiofrequency ablation","level":3,"score":0.1245114803314209},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.1994.12.6.1323","doi":"https://doi.org/10.1200/jco.1994.12.6.1323","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1994.12.6.1323","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:8201395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8201395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.550000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":119,"referenced_works":["https://openalex.org/W17151634","https://openalex.org/W172699111","https://openalex.org/W193328803","https://openalex.org/W202195286","https://openalex.org/W865643111","https://openalex.org/W1496296938","https://openalex.org/W1522619862","https://openalex.org/W1559225385","https://openalex.org/W1583533449","https://openalex.org/W1670652180","https://openalex.org/W1778822017","https://openalex.org/W1788361823","https://openalex.org/W1826412460","https://openalex.org/W1845252930","https://openalex.org/W1848028493","https://openalex.org/W1863577619","https://openalex.org/W1878603103","https://openalex.org/W1903855464","https://openalex.org/W1935387907","https://openalex.org/W1944710770","https://openalex.org/W1958840615","https://openalex.org/W1964989417","https://openalex.org/W1967390086","https://openalex.org/W1968252229","https://openalex.org/W1970890617","https://openalex.org/W1971209343","https://openalex.org/W1971734830","https://openalex.org/W1971992102","https://openalex.org/W1974486438","https://openalex.org/W1977650412","https://openalex.org/W1978012664","https://openalex.org/W1978157077","https://openalex.org/W1984728331","https://openalex.org/W1985499557","https://openalex.org/W1986451113","https://openalex.org/W1987555533","https://openalex.org/W1987978415","https://openalex.org/W1990163407","https://openalex.org/W1990464273","https://openalex.org/W1993988011","https://openalex.org/W1996909117","https://openalex.org/W1997869242","https://openalex.org/W2001048794","https://openalex.org/W2005920135","https://openalex.org/W2005997839","https://openalex.org/W2009435220","https://openalex.org/W2013122817","https://openalex.org/W2016774731","https://openalex.org/W2016891318","https://openalex.org/W2017674461","https://openalex.org/W2019104206","https://openalex.org/W2019731647","https://openalex.org/W2021733978","https://openalex.org/W2025081773","https://openalex.org/W2026972790","https://openalex.org/W2027302786","https://openalex.org/W2027514832","https://openalex.org/W2029987761","https://openalex.org/W2031306493","https://openalex.org/W2032493223","https://openalex.org/W2037480365","https://openalex.org/W2038770487","https://openalex.org/W2040428205","https://openalex.org/W2040660791","https://openalex.org/W2042839553","https://openalex.org/W2042916800","https://openalex.org/W2045133364","https://openalex.org/W2047288163","https://openalex.org/W2047603023","https://openalex.org/W2048020052","https://openalex.org/W2048858416","https://openalex.org/W2049716577","https://openalex.org/W2050116020","https://openalex.org/W2051339192","https://openalex.org/W2051400596","https://openalex.org/W2055642315","https://openalex.org/W2058527046","https://openalex.org/W2061475241","https://openalex.org/W2065726661","https://openalex.org/W2067022034","https://openalex.org/W2067582810","https://openalex.org/W2068285495","https://openalex.org/W2071282740","https://openalex.org/W2078369365","https://openalex.org/W2079755093","https://openalex.org/W2081131676","https://openalex.org/W2082376162","https://openalex.org/W2083604374","https://openalex.org/W2083752334","https://openalex.org/W2084460882","https://openalex.org/W2085664147","https://openalex.org/W2110180872","https://openalex.org/W2122710683","https://openalex.org/W2124596640","https://openalex.org/W2133756116","https://openalex.org/W2141582057","https://openalex.org/W2143081307","https://openalex.org/W2150988923","https://openalex.org/W2165286908","https://openalex.org/W2172003798","https://openalex.org/W2222478893","https://openalex.org/W2227845872","https://openalex.org/W2303351071","https://openalex.org/W2313891666","https://openalex.org/W2330134488","https://openalex.org/W2332011447","https://openalex.org/W2334978547","https://openalex.org/W2395530443","https://openalex.org/W2407894156","https://openalex.org/W2409386207","https://openalex.org/W2410041194","https://openalex.org/W2410782913","https://openalex.org/W2414348221","https://openalex.org/W2415948142","https://openalex.org/W2427410027","https://openalex.org/W2517087097","https://openalex.org/W2594704915","https://openalex.org/W2947872708","https://openalex.org/W4300033449"],"related_works":["https://openalex.org/W2059163822","https://openalex.org/W2065662140","https://openalex.org/W2026544313","https://openalex.org/W2051824309","https://openalex.org/W2164642122","https://openalex.org/W2763250844","https://openalex.org/W3035496831","https://openalex.org/W17449346","https://openalex.org/W2354726628","https://openalex.org/W2071841994"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2],"attempts":[3],"to":[4,11,77,117,135,147,176],"review":[5,31],"the":[6,33,144,164],"therapeutic":[7],"interventions":[8],"being":[9,179],"used":[10],"treat":[12],"patients":[13,46],"with":[14],"hepatocellular":[15],"carcinoma":[16],"(HCC).":[17],"DESIGN:":[18],"An":[19],"English":[20],"language":[21],"literature":[22],"search,":[23],"including":[24,63],"abstracts":[25],"and":[26,29,47,71,89,108,121,154,163],"original":[27],"articles,":[28,37],"a":[30,51,97],"of":[32,35,61,133,166],"bibliographies":[34],"such":[36,105],"was":[38],"conducted.":[39],"RESULTS:":[40],"Surgery":[41],"is":[42,56,143,151],"possible":[43],"in":[44,49,58,126,138],"few":[45,139],"curative":[48,125],"only":[50],"small":[52],"percentage.":[53],"Conventional":[54],"chemotherapy":[55],"ineffective":[57],"HCC.":[59,148],"Modifications":[60],"chemotherapy,":[62],"intraarterial":[64],"infusion,":[65],"chemoembolization,":[66],"lipiodol,":[67],"styrene-maleic":[68],"acid-neocarzinostatin":[69],"(SMANCS),":[70],"isolated":[72],"hepatic":[73],"perfusion,":[74],"have":[75,82,92,112],"led":[76],"improved":[78],"tumor":[79],"responses,":[80],"but":[81],"not":[83,113],"materially":[84],"affected":[85],"patient":[86,101,161],"outcome.":[87,102],"Radioimmunotherapy":[88],"conformal":[90],"radiotherapy":[91],"had":[93],"no":[94],"more":[95],"than":[96],"marginal":[98],"impact":[99,171],"on":[100,172,186],"Surgical":[103,149],"innovations":[104],"as":[106],"cryosurgery":[107],"percutaneous":[109],"alcohol":[110],"injection":[111],"yet":[114],"been":[115],"shown":[116],"offer":[118],"any":[119],"advantage,":[120],"liver":[122],"transplantation,":[123],"while":[124,155],"some":[127],"patients,":[128],"requires":[129],"an":[130],"enormous":[131],"expenditure":[132],"resources":[134],"achieve":[136],"cure":[137,150],"patients.":[140],"CONCLUSION:":[141],"Prevention":[142],"ideal":[145],"approach":[146],"rarely":[152],"possible,":[153],"numerous":[156],"therapies":[157],"may":[158],"palliate":[159],"symptoms,":[160],"selection":[162],"lack":[165],"randomized":[167],"studies":[168],"make":[169],"their":[170],"median":[173],"survival":[174],"difficult":[175],"assess.":[177],"Patients":[178],"treated":[180],"for":[181],"HCC":[182],"should":[183],"be":[184],"enrolled":[185],"treatment":[187],"protocols":[188],"testing":[189],"multimodality":[190],"or":[191],"new":[192],"strategies.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}