{"id":"https://openalex.org/W2137753678","doi":"https://doi.org/10.1002/pd.4182","title":"European Non\u2010Invasive Trisomy Evaluation (EU\u2010NITE) study: a multicenter prospective cohort study for non\u2010invasive fetal trisomy 21 testing","display_name":"European Non\u2010Invasive Trisomy Evaluation (EU\u2010NITE) study: a multicenter prospective cohort study for non\u2010invasive fetal trisomy 21 testing","publication_year":2013,"publication_date":"2013-06-23","ids":{"openalex":"https://openalex.org/W2137753678","doi":"https://doi.org/10.1002/pd.4182","mag":"2137753678","pmid":"https://pubmed.ncbi.nlm.nih.gov/23794121"},"language":"en","primary_location":{"id":"doi:10.1002/pd.4182","doi":"https://doi.org/10.1002/pd.4182","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pd.4182","pdf_url":null,"source":{"id":"https://openalex.org/S171405753","display_name":"Prenatal Diagnosis","issn_l":"0197-3851","issn":["0197-3851","1097-0223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal Diagnosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018706297","display_name":"E. J. T. Verweij","orcid":"https://orcid.org/0000-0002-9343-9957","observed_orcids":["https://orcid.org/0000-0002-9343-9957"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E. J. Verweij","raw_affiliation_strings":["Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091876255","display_name":"Bo Jacobsson","orcid":"https://orcid.org/0000-0001-5079-2374","observed_orcids":["https://orcid.org/0000-0001-5079-2374"]},"institutions":[{"id":"https://openalex.org/I1333353642","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19","country_code":"NO","type":"government","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"B. Jacobsson","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Norwegian Institute of Public Health Sahlgrenska University Hospital/\u00d6stra  Oslo Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Norwegian Institute of Public Health Sahlgrenska University Hospital/\u00d6stra  Oslo Norway","institution_ids":["https://openalex.org/I1333353642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030355855","display_name":"P. N. Adama van Scheltema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. A. van Scheltema","raw_affiliation_strings":["Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033037860","display_name":"Marjon Alina de Boer","orcid":"https://orcid.org/0000-0002-9386-649X","observed_orcids":["https://orcid.org/0000-0002-9386-649X"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. A. de Boer","raw_affiliation_strings":["Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023533163","display_name":"Mari\u00ebtte J.V. Hoffer","orcid":"https://orcid.org/0000-0002-1812-7670","observed_orcids":["https://orcid.org/0000-0002-1812-7670"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. J. V. Hoffer","raw_affiliation_strings":["Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062977298","display_name":"Desiree Hollemon","orcid":"https://orcid.org/0000-0003-4971-9334","observed_orcids":["https://orcid.org/0000-0003-4971-9334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Hollemon","raw_affiliation_strings":["Ariosa Diagnostics San Jose USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ariosa Diagnostics San Jose USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058254142","display_name":"Magnus Westgren","orcid":"https://orcid.org/0000-0003-1174-2184","observed_orcids":["https://orcid.org/0000-0003-1174-2184"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. Westgren","raw_affiliation_strings":["Karolinska Institute, Center of Fetal Medicine, Department of Obstetrics and Gynaecology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Center of Fetal Medicine, Department of Obstetrics and Gynaecology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Song","raw_affiliation_strings":["Ariosa Diagnostics San Jose USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ariosa Diagnostics San Jose USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038600846","display_name":"Dick Oepkes","orcid":"https://orcid.org/0000-0001-6989-1532","observed_orcids":["https://orcid.org/0000-0001-6989-1532"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"D. Oepkes","raw_affiliation_strings":["Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038600846"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":10.1195,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.98451446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"33","issue":"10","first_page":"996","last_page":"1001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-invasive-prenatal-testing","display_name":"non-invasive prenatal testing","score":0.9549999833106995},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cell-free-fetal-dna","display_name":"cell-free fetal DNA","score":0.9399999976158142},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5130000114440918},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.8786906003952026},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.598109781742096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5969637632369995},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.5837679505348206},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.5788474082946777},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5434028506278992},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.5393701791763306},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.494417667388916},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4921814501285553},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4661000967025757},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.45692017674446106},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4240188002586365},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.33865636587142944},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.331847608089447},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3289865553379059},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.29927635192871094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22518888115882874},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.209896057844162},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19904208183288574},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.06580471992492676},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014314","descriptor_name":"Trisomy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1002/pd.4182","doi":"https://doi.org/10.1002/pd.4182","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pd.4182","pdf_url":null,"source":{"id":"https://openalex.org/S171405753","display_name":"Prenatal Diagnosis","issn_l":"0197-3851","issn":["0197-3851","1097-0223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal Diagnosis","raw_type":"journal-article"},{"id":"pmid:23794121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23794121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal diagnosis","raw_type":"Evaluation Study"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2990279","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/102687","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Prenatal Diagnosis, 33(10), 996 - 1001","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940753444102711","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/102687","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Prenatal Diagnosis, Vol. 33, no. 10, p. 996-1001","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/102687","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/102687","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"33","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/01a4e5e4-26db-48c0-9d2d-2728a50335da","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/pages/publications/84884982181","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Verweij, E J, Jacobsson, B, van Scheltema, P A, de Boer, M A, Hoffer, M J V, Hollemon, D, Westgren, M, Song, K & Oepkes, D 2013, 'European Non-Invasive Trisomy Evaluation (EU-NITE) study : A multicenter prospective cohort study for non-invasive fetal trisomy 21 testing', Prenatal diagnosis, vol. 33, no. 10, pp. 996-1001. https://doi.org/10.1002/pd.4182","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2990279","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/102687","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Prenatal Diagnosis","raw_type":"Article / Letter to editor"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/c2a66481-d017-4075-a746-3176f2b37ec9","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/c2a66481-d017-4075-a746-3176f2b37ec9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Prenatal Diagnosis, 33(10), 996 - 1001. John Wiley and Sons Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1976295767","https://openalex.org/W1984290204","https://openalex.org/W1986028580","https://openalex.org/W1995188045","https://openalex.org/W2015487852","https://openalex.org/W2015893684","https://openalex.org/W2034507453","https://openalex.org/W2049706382","https://openalex.org/W2050974511","https://openalex.org/W2057180173","https://openalex.org/W2069687969","https://openalex.org/W2075791178","https://openalex.org/W2078927009","https://openalex.org/W2100977485","https://openalex.org/W2108641027","https://openalex.org/W2134164600","https://openalex.org/W2171812329","https://openalex.org/W2172268977","https://openalex.org/W4256561866"],"related_works":["https://openalex.org/W2130056558","https://openalex.org/W1984290204","https://openalex.org/W2132238722","https://openalex.org/W2317645718","https://openalex.org/W3124434451","https://openalex.org/W2527092924","https://openalex.org/W2120987862","https://openalex.org/W2343579303","https://openalex.org/W2091829473","https://openalex.org/W2944262096"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,23,33,51,79,110,116,155,178],"performance":[4],"of":[5,12,62,100,169,187],"a":[6,30,60,67,121],"directed":[7,167],"non-invasive":[8,163],"prenatal":[9,164],"testing":[10,165],"method":[11],"cell-free":[13,170],"DNA":[14,171],"analysis":[15],"for":[16,72,144,184],"fetal":[17,73,188],"trisomy":[18],"21":[19,92],"(T21)":[20],"by":[21],"shipping":[22],"whole":[24],"blood":[25,83,174],"samples":[26,54,175],"from":[27,48],"Europe":[28],"to":[29,59,78,173],"laboratory":[31],"in":[32,66,127,134],"USA.":[34],"METHODS:":[35],"A":[36],"European":[37,158],"multicenter":[38,159],"prospective,":[39],"consecutive":[40],"cohort":[41],"study":[42,119,160],"was":[43,87,107,125,132,139],"performed":[44],"enrolling":[45],"pregnant":[46],"women":[47],"Sweden":[49],"and":[50,75,149],"Netherlands.":[52],"Blood":[53],"were":[55],"drawn":[56],"just":[57],"prior":[58],"planned":[61],"invasive":[63],"diagnostic":[64],"procedure":[65],"population":[68],"at":[69],"increased":[70],"risk":[71,96,99,186],"T21":[74,122,145],"then":[76],"shipped":[77,176],"USA":[80],"without":[81],"any":[82],"processing.":[84],"Chromosome-selective":[85],"sequencing":[86,168],"carried":[88],"out":[89],"on":[90],"chromosome":[91],"with":[93],"reporting":[94],"high":[95],"or":[97,103],"low":[98],"T21.":[101,189],"Karyotyping":[102],"rapid":[104],"aneuploidy":[105],"detection":[106],"used":[108],"as":[109],"clinical":[111],"reference":[112],"standard.":[113],"RESULTS:":[114],"Of":[115],"520":[117],"eligible":[118],"subjects,":[120],"test":[123],"result":[124,143],"obtained":[126],"504/520":[128],"(96.9%).":[129],"Risk":[130],"assessment":[131],"accurate":[133,183],"503/504":[135],"subjects":[136],"(99.8%).":[137],"There":[138],"one":[140],"false":[141],"negative":[142],"(sensitivity":[146],"17/18,":[147],"94.4%,":[148],"specificity":[150],"100%).":[151],"CONCLUSION:":[152],"This":[153],"is":[154,181],"first":[156],"prospective":[157],"showing":[161],"that":[162],"using":[166],"applied":[172],"across":[177],"Atlantic":[179],"Ocean,":[180],"highly":[182],"assessing":[185]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}