{"id":"https://openalex.org/W2137720141","doi":null,"title":"Plasma lipoprotein(a) levels and LDL-cholesterol lowering response to statin therapy in patients with heterozygous familial hypercholesterolemia.","display_name":"Plasma lipoprotein(a) levels and LDL-cholesterol lowering response to statin therapy in patients with heterozygous familial hypercholesterolemia.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2137720141","mag":"2137720141","pmid":"https://pubmed.ncbi.nlm.nih.gov/16951279"},"language":"en","primary_location":{"id":"pmid:16951279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16951279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"George Miltiadous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Miltiadous","raw_affiliation_strings":["Department of Internal Medicine, Medical School, University of Ioannina, Ioannina 451 10, Greece","University of Ioannina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Medical School, University of Ioannina, Ioannina 451 10, Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"University of Ioannina","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090286008","display_name":"Vasilios G. Saougos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vasilios Saougos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019040009","display_name":"Marios A. Cariolou","orcid":"https://orcid.org/0000-0002-5882-6935","observed_orcids":["https://orcid.org/0000-0002-5882-6935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marios Cariolou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056379080","display_name":"Moses Elisaf","orcid":"https://orcid.org/0000-0003-0505-078X","observed_orcids":["https://orcid.org/0000-0003-0505-078X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moses S Elisaf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"36","issue":"3","first_page":"353","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.9750000238418579},{"id":"https://openalex.org/keywords/heterozygous-familial-hypercholesterolemia","display_name":"heterozygous familial hypercholesterolemia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.9089999794960022},{"id":"https://openalex.org/keywords/statin-response","display_name":"statin response","score":0.6330000162124634},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.6520000100135803},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.8897557258605957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.748100996017456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7300031185150146},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.6500014066696167},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5922325253486633},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5239579677581787},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5064100027084351},{"id":"https://openalex.org/C2776104379","wikidata":"https://www.wikidata.org/wiki/Q21112670","display_name":"Lipoprotein(a)","level":4,"score":0.44961825013160706},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.41232770681381226}],"mesh":[{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017270","descriptor_name":"Lipoprotein(a)","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16951279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16951279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.499.1425","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.499.1425","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.annclinlabsci.org/content/36/3/353.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1979754520","https://openalex.org/W2000125537","https://openalex.org/W2025139957","https://openalex.org/W2048500853","https://openalex.org/W2129166365","https://openalex.org/W2167994535","https://openalex.org/W2185638699","https://openalex.org/W3153594880"],"related_works":["https://openalex.org/W2344450815","https://openalex.org/W4226179925","https://openalex.org/W2021730434","https://openalex.org/W2134826755","https://openalex.org/W2025164307","https://openalex.org/W2995591678","https://openalex.org/W2059272048","https://openalex.org/W4411881029","https://openalex.org/W2081164285","https://openalex.org/W1992857228"],"abstract_inverted_index":{"Familial":[0],"hypercholesterolemia":[1],"(FH)":[2],"is":[3,17],"characterised":[4],"by":[5],"elevated":[6],"plasma":[7,50,93],"LDL-cholesterol":[8,37,98],"levels":[9,52,75,95],"and":[10,31,96],"premature":[11],"ischemic":[12],"heart":[13],"disease.":[14],"Statin":[15],"therapy":[16,59,81,103],"mandatory":[18],"in":[19,24,40,60,82,104],"order":[20],"to":[21],"prevent":[22],"atherosclerosis":[23],"patients":[25,41,61,83,106],"with":[26,42,62,84,107],"heterozygous":[27,43,85,108],"FH.":[28,44,86,109],"Both":[29],"genetic":[30],"environmental":[32],"factors":[33],"affect":[34,54],"the":[35,55,71,77,97],"statin-induced":[36],"lowering":[38,99],"effect":[39,72,100],"Recently":[45],"published":[46],"data":[47,67],"suggest":[48],"that":[49],"lipoprotein(a)":[51,74,94],"may":[53],"efficacy":[56,78],"of":[57,73,79,101],"statin":[58,80,102],"nephrotic":[63],"syndrome.":[64],"However,":[65],"no":[66],"are":[68],"available":[69],"concerning":[70],"on":[76],"This":[87],"report":[88],"demonstrates":[89],"negative":[90],"correlation":[91],"between":[92],"49":[105]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-27T00:00:00"}