{"id":"https://openalex.org/W2137578145","doi":null,"title":"Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas.","display_name":"Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas.","publication_year":1989,"publication_date":"1989-02-15","ids":{"openalex":"https://openalex.org/W2137578145","mag":"2137578145","pmid":"https://pubmed.ncbi.nlm.nih.gov/2643465"},"language":"en","primary_location":{"id":"pmid:2643465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2643465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A Balakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Balakrishnan","raw_affiliation_strings":["Cancer Research Laboratory, University of California, Berkeley 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory, University of California, Berkeley 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110188082","display_name":"Scott D. Cramer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Cramer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012885965","display_name":"Gautam Kumar Bandyopadhyay","orcid":"https://orcid.org/0000-0003-4347-6036","observed_orcids":["https://orcid.org/0000-0003-4347-6036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G K Bandyopadhyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088706447","display_name":"Walter T. Imagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Imagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048226930","display_name":"Jason Yang","orcid":"https://orcid.org/0000-0002-7156-5872","observed_orcids":["https://orcid.org/0000-0002-7156-5872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023444095","display_name":"Joel J. Elias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Elias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111632524","display_name":"Craig W. Beattie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Beattie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062440586","display_name":"Tapas K. Das Gupta","orcid":"https://orcid.org/0000-0001-6437-6320","observed_orcids":["https://orcid.org/0000-0001-6437-6320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T K Das Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114050238","display_name":"S. Nandi","orcid":"https://orcid.org/0009-0001-5887-999X","observed_orcids":["https://orcid.org/0009-0001-5887-999X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Nandi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9411,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.93939394,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"49","issue":"4","first_page":"857","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.44209998846054077,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.44209998846054077,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.11410000175237656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linoleate","display_name":"linoleate","score":0.8799999952316284},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9079999923706055},{"id":"https://openalex.org/keywords/breast-epithelial-cells","display_name":"breast epithelial cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fibroadenoma","display_name":"fibroadenoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.7269999980926514},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8370000123977661},{"id":"https://openalex.org/keywords/phospholipid-turnover","display_name":"phospholipid turnover","score":0.7889999747276306},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.8690000176429749},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.984000027179718},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9819999933242798},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8270000219345093},{"id":"https://openalex.org/keywords/collagen-gel-culture","display_name":"collagen gel culture","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6828368902206421},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6443710923194885},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.6388790607452393},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6127853989601135},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.4807884097099304},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4661836326122284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4481656551361084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37143296003341675},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3339451551437378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1969054937362671},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14530465006828308}],"mesh":[{"descriptor_ui":"D000232","descriptor_name":"Adenofibroma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2643465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2643465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2137578145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2643465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1513063003","https://openalex.org/W1598395017","https://openalex.org/W1629391151","https://openalex.org/W1922379936","https://openalex.org/W1947191366","https://openalex.org/W1958113960","https://openalex.org/W2005977562","https://openalex.org/W2012118931","https://openalex.org/W2013231447","https://openalex.org/W2021144709","https://openalex.org/W2030589383","https://openalex.org/W2040720266","https://openalex.org/W2040788523","https://openalex.org/W2075589691","https://openalex.org/W2115869249","https://openalex.org/W2146492926","https://openalex.org/W2152311269","https://openalex.org/W2158938248","https://openalex.org/W2276919550","https://openalex.org/W2434670030"],"related_works":["https://openalex.org/W1598395017","https://openalex.org/W54021026","https://openalex.org/W2085044058","https://openalex.org/W2012831582","https://openalex.org/W116477296","https://openalex.org/W2126372951","https://openalex.org/W1483518189","https://openalex.org/W2729442631","https://openalex.org/W2086967723","https://openalex.org/W2074705916"],"abstract_inverted_index":{"Human":[0],"breast":[1,7,93,115],"epithelial":[2,94,116,145],"cells":[3,67,95,117,146,160,186,216],"isolated":[4,68],"from":[5,69,147],"normal":[6,92,114,159,180,183,213],"tissues":[8],"of":[9,15,31,57,113,128,151,158,170,237],"premenopausal":[10],"women":[11],"demonstrated":[12],"direct":[13],"evidence":[14],"a":[16,41,100,125,167,219],"proliferative":[17,111],"effect":[18,178],"by":[19,53,98,108,124],"linoleate":[20],"(18:2":[21],"omega":[22,51,84,120,130,137,153,176],"6)":[23],"or":[24,86],"prostaglandin":[25],"E2":[26],"(PGE2)":[27],"in":[28,37,91,144,155,164,172,179,189,222,234],"the":[29,72,156,174,199,207,223],"presence":[30],"insulin":[32],"and":[33,135,184,194,201],"epidermal":[34,46,202],"growth":[35,47,59,79,90,203],"factor":[36,48],"serum-free":[38],"cultures":[39],"within":[40],"collagen":[42],"gel":[43],"matrix.":[44],"Neither":[45],"nor":[49],"18:2":[50,83,119,175],"6":[52,85,121,131,138,154,177],"itself":[54],"was":[55,96,122,161],"capable":[56],"stimulating":[58],"but":[60],"together":[61],"they":[62],"stimulated":[63],"proliferation":[64],"synergistically.":[65],"Epithelial":[66],"fibroadenomas":[70,165],"on":[71],"other":[73],"hand":[74],"failed":[75],"to":[76,82,118,132,139,191,198],"exhibit":[77],"any":[78],"stimulation":[80],"due":[81],"PGE2.":[87,109],"The":[88,110,149],"linoleate-stimulated":[89],"inhibited":[97],"indomethacin,":[99],"cyclooxygenase":[101],"inhibitor,":[102],"which":[103],"however":[104],"could":[105],"be":[106],"reversed":[107],"response":[112,190],"accompanied":[123],"greater":[126],"conversion":[127],"[14C]18:2":[129,152],"arachidonic":[133],"acid":[134],"[14C]20:4":[136],"prostaglandins":[140],"than":[141,163],"that":[142],"seen":[143],"fibroadenomas.":[148],"turnover":[150],"phospholipids":[157,171],"higher":[162],"indicating":[166],"possible":[168],"role":[169],"mediating":[173],"cells.":[181,238],"Both":[182],"fibroadenoma":[185,215],"can":[187],"proliferate":[188],"cholera":[192,229],"toxin":[193],"glucocorticoids":[195],"when":[196],"supplemented":[197],"insulin-":[200],"factor-containing":[204],"medium.":[205],"From":[206],"results":[208],"it":[209],"appears":[210],"that,":[211],"unlike":[212],"cells,":[214],"may":[217],"have":[218],"specific":[220],"defect":[221],"PGE2-responsive":[224],"cyclic":[225],"AMP-generating":[226],"mechanism":[227,231],"whereas":[228],"toxin-induced":[230],"is":[232],"operative":[233],"both":[235],"types":[236]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}