{"id":"https://openalex.org/W2137571007","doi":"https://doi.org/10.3844/ajptsp.2009.12.16","title":"The Effects of Recombinant Human Erythropoietin and Tamoxifen on Growth and Angiogenesis of Mammary Tumor in Sprague-Dawley Rat","display_name":"The Effects of Recombinant Human Erythropoietin and Tamoxifen on Growth and Angiogenesis of Mammary Tumor in Sprague-Dawley Rat","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2137571007","doi":"https://doi.org/10.3844/ajptsp.2009.12.16","mag":"2137571007"},"language":"en","primary_location":{"id":"doi:10.3844/ajptsp.2009.12.16","doi":"https://doi.org/10.3844/ajptsp.2009.12.16","is_oa":false,"landing_page_url":"https://doi.org/10.3844/ajptsp.2009.12.16","pdf_url":null,"source":{"id":"https://openalex.org/S151847409","display_name":"American Journal of Pharmacology and Toxicology","issn_l":"1557-4962","issn":["1557-4962","1557-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697006","host_organization_name":"Science Publications","host_organization_lineage":["https://openalex.org/P4322697006"],"host_organization_lineage_names":["Science Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Pharmacology and Toxicology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2137571007"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088875682","display_name":"A.K. Sairah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.K. Sairah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Rasedee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Rasedee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"O. Sheikh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Sheikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R. Rozita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Rozita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077860978","display_name":"Nagi Ahmed Abdullah Al-Haj","orcid":"https://orcid.org/0000-0002-4972-9703","observed_orcids":["https://orcid.org/0000-0002-4972-9703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagi ALHaj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4367,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66785279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":"1","first_page":"12","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-human-erythropoietin","display_name":"recombinant human erythropoietin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":1.0},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.781000018119812},{"id":"https://openalex.org/keywords/erythropoietin-receptor","display_name":"erythropoietin receptor","score":0.8899999856948853},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.7953619360923767},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7198396325111389},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.6896727085113525},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6240915060043335},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5604628920555115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47449278831481934},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4650716781616211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3912249207496643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3904002904891968},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36101555824279785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3086003065109253},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26260244846343994},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.12737718224525452},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09654080867767334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08639472723007202}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3844/ajptsp.2009.12.16","doi":"https://doi.org/10.3844/ajptsp.2009.12.16","is_oa":false,"landing_page_url":"https://doi.org/10.3844/ajptsp.2009.12.16","pdf_url":null,"source":{"id":"https://openalex.org/S151847409","display_name":"American Journal of Pharmacology and Toxicology","issn_l":"1557-4962","issn":["1557-4962","1557-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697006","host_organization_name":"Science Publications","host_organization_lineage":["https://openalex.org/P4322697006"],"host_organization_lineage_names":["Science Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Pharmacology and Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.917.95","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.917.95","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thescipub.com/PDF/ajptsp.2009.12.16.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W189180901","https://openalex.org/W1973170846","https://openalex.org/W1988897496","https://openalex.org/W2075780259","https://openalex.org/W2168376799"],"related_works":["https://openalex.org/W2040855599","https://openalex.org/W2041948708","https://openalex.org/W148978380","https://openalex.org/W3165668627","https://openalex.org/W2984222685","https://openalex.org/W1982265866","https://openalex.org/W2572605004","https://openalex.org/W2058132654","https://openalex.org/W2043938664","https://openalex.org/W1575993157"],"abstract_inverted_index":{"Abstract:":[0],"Problem":[1],"statement:":[2],"Erythropoietin":[3],"receptor":[4],"(EPOR)":[5],"has":[6,25],"been":[7],"detected":[8],"in":[9,18,144],"breast":[10],"cancer":[11,19],"cells":[12],"and":[13,22,49,55,83,92,104,107,116,132,165,193],"speculated":[14],"to":[15,42,65,109,156,178],"be":[16],"involved":[17],"growth,":[20],"viability":[21],"angiogenesis.":[23],"This":[24,38],"risen":[26],"suspicious":[27],"that":[28,152],"EPO":[29],"administration":[30],"may":[31],"enhance":[32],"the":[33,44,53,128,145,157,161,174],"severity":[34],"of":[35,46,57,94,130,147,150,163,188,195],"cancer.":[36],"Approach:":[37],"study":[39],"was":[40,96,100],"undertaken":[41],"determine":[43],"effects":[45],"rHuEPO,":[47],"Tamoxifen":[48,82,166,179],"their":[50],"combination":[51,85,162],"on":[52],"growth":[54,146],"angiogenesis":[56],"mammary":[58,67,148],"tumor.":[59],"Female":[60],"Sprague-Dawley":[61],"rats":[62,151],"were":[63,86,125],"induced":[64],"develop":[66],"tumor":[68,133,149,171,185],"through":[69],"xenograft":[70],"technique":[71],"by":[72],"inoculating":[73],"6x105":[74],"LCM":[75],"2388":[76],"cells.":[77],"Results:":[78],"Recombinant":[79],"human":[80],"erythropoietin,":[81],"Tamoxifen-rHuEPO":[84],"administered":[87],"weekly":[88,103],"for":[89,111,136],"four":[90],"weeks":[91],"size":[93,176],"tumors":[95],"measured":[97],"weekly.":[98],"Blood":[99],"also":[101],"collected":[102],"serum":[105,189],"separated":[106],"subjected":[108],"ELISA":[110],"Matrix":[112],"Metalloproteinases":[113],"2":[114],"(MMP-2)":[115],"Vascular":[117],"Endothelial":[118],"Growth":[119],"Factor":[120],"(VEGF),":[121],"quantification.":[122],"The":[123],"animals":[124],"sacrificed":[126],"at":[127],"end":[129],"experiment":[131],"masses":[134],"excised":[135],"histopathological":[137],"analysis.":[138],"Results":[139],"showed":[140,182,199],"no":[141],"significance":[142],"difference":[143],"received":[153],"rHuEPO":[154,164,196],"compared":[155,177],"control":[158],"rats.":[159],"Interestingly,":[160],"produced":[167],"approximately":[168],"90":[169],"%":[170,184],"regression":[172],"from":[173],"initial":[175],"alone":[180],"which":[181],"70":[183],"regression.":[186],"Quantification":[187],"angiogenic":[190],"factors,":[191],"MMP2":[192],"VEGF":[194],"treatment":[197],"group":[198],"lower":[200],"concentrations":[201]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
