{"id":"https://openalex.org/W21374956","doi":null,"title":"Regulation of insulin action at the cellular level.","display_name":"Regulation of insulin action at the cellular level.","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W21374956","mag":"21374956","pmid":"https://pubmed.ncbi.nlm.nih.gov/2043221"},"language":"en","primary_location":{"id":"pmid:2043221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2043221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of internal medicine. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108466757","display_name":"Peter L\u00f6nnroth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"P L\u00f6nnroth","raw_affiliation_strings":["Department of Internal Medicine, Sahlgrenska Hospital, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sahlgrenska Hospital, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108466757"],"corresponding_institution_ids":["https://openalex.org/I2801112325"],"apc_list":null,"apc_paid":null,"fwci":0.445,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.52901674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"735","issue":null,"first_page":"23","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-action","display_name":"insulin action","score":0.8569999933242798},{"id":"https://openalex.org/keywords/insulin-receptor-tyrosine-kinase","display_name":"insulin receptor tyrosine kinase","score":0.8050000071525574},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7519999742507935},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":1.0},{"id":"https://openalex.org/keywords/glucose-transporter-translocation","display_name":"glucose transporter translocation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8539999723434448},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.800000011920929},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":1.0},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9779999852180481},{"id":"https://openalex.org/keywords/counterregulatory-hormones","display_name":"counterregulatory hormones","score":0.9900000095367432},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.5799999833106995},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7818664312362671},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.772003173828125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6659963130950928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6564991474151611},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6362046003341675},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.49256354570388794},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.4764678478240967},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4746181070804596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4237407147884369},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3625510334968567},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3213944733142853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2520660161972046}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2043221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2043221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of internal medicine. Supplement","raw_type":"Journal Article"},{"id":"mag:21374956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2043221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106172355","https://openalex.org/W3119743465","https://openalex.org/W70384554","https://openalex.org/W2330691842","https://openalex.org/W2098521500","https://openalex.org/W2188944942","https://openalex.org/W2015399755","https://openalex.org/W1984202169","https://openalex.org/W2763635492","https://openalex.org/W2011165643"],"abstract_inverted_index":{"Insulin":[0,96],"regulates":[1],"cellular":[2,52],"metabolic":[3,148],"reactions":[4],"by":[5],"its":[6],"action":[7,70],"on":[8],"the":[9,15,21,24,28,36,43,58,63,69,84,147],"plasma":[10],"membrane,":[11],"intracellular":[12],"enzymes":[13],"and":[14,68,90,112,121,138,150],"nucleus.":[16],"The":[17,39],"first":[18],"stage":[19],"in":[20,49,79,98,128,146,155],"propagation":[22],"of":[23,30,65,71,83,92,152],"insulin":[25,31,59,85,129,153],"signal":[26],"is":[27,54,122],"coupling":[29],"to":[32,117],"specific":[33],"receptors":[34],"at":[35],"cell":[37],"surface.":[38],"exact":[40],"mechanism":[41,46],"whereby":[42],"transmembrane":[44],"signalling":[45],"(s)":[47],"results":[48],"different":[50],"insulin-mediated":[51],"effects":[53],"not":[55],"known.":[56],"However,":[57],"receptor":[60],"tyrosine":[61],"kinase,":[62],"expression":[64],"second":[66],"messengers,":[67],"protein":[72],"kinase":[73],"C":[74],"may,":[75],"either":[76],"individually":[77],"or":[78],"combination,":[80],"mediate":[81],"some":[82],"effects,":[86],"such":[87,101,131],"as":[88,102,132],"translocation":[89],"activation":[91],"glucose":[93,140],"transporter":[94],"proteins.":[95],"resistance":[97,154],"clinical":[99],"conditions":[100],"insulin-dependent":[103],"diabetes":[104,108],"mellitus":[105,109],"(IDDM),":[106],"non-insulin-dependent":[107],"(NIDDM),":[110],"hypertension":[111],"obesity":[113],"may":[114],"be":[115],"acquired":[116],"a":[118],"large":[119],"extent,":[120],"thus":[123],"partially":[124],"reversible.":[125],"Regulatory":[126],"factors":[127],"sensitivity,":[130],"free":[133],"fatty":[134],"acids,":[135],"counterregulatory":[136],"hormones":[137],"blood":[139],"level,":[141],"play":[142],"an":[143],"important":[144],"role":[145],"control":[149],"pathogenesis":[151],"man.":[156]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
