{"id":"https://openalex.org/W2137482117","doi":null,"title":"REGIONAL DIFFERENCES IN THE RESPONSE OF NEURAL STEM CELLS AND THEIR MICROENVIRONMENT TO IONIZING RADIATION","display_name":"REGIONAL DIFFERENCES IN THE RESPONSE OF NEURAL STEM CELLS AND THEIR MICROENVIRONMENT TO IONIZING RADIATION","publication_year":2009,"publication_date":"2009-05-14","ids":{"openalex":"https://openalex.org/W2137482117","mag":"2137482117"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/19631","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/19631","pdf_url":"http://hdl.handle.net/2077/19631","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/19631","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062292562","display_name":"Nina Hellstr\u00f6m Erkenstam","orcid":"https://orcid.org/0000-0002-4336-5419","observed_orcids":["https://orcid.org/0000-0002-4336-5419"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nina Hellstr\u00f6m Erkenstam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4336-5419","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062292562"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6240000128746033},{"id":"https://openalex.org/keywords/subventricular-zone","display_name":"subventricular zone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stem-cell-proliferation","display_name":"stem cell proliferation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/stem-cell-recovery","display_name":"stem cell recovery","score":0.7210000157356262},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.6679999828338623},{"id":"https://openalex.org/keywords/radiation-induced-inflammation","display_name":"radiation-induced inflammation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cranial-irradiation","display_name":"cranial irradiation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/radiation-shielding","display_name":"radiation shielding","score":0.4189999997615814},{"id":"https://openalex.org/keywords/postnatal-brain-development","display_name":"postnatal brain development","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7671757936477661},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7425037622451782},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7054042816162109},{"id":"https://openalex.org/C2777542384","wikidata":"https://www.wikidata.org/wiki/Q937403","display_name":"Subventricular zone","level":4,"score":0.584465503692627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5500187873840332},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.5144445896148682},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.47850409150123596},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.45694148540496826},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45474007725715637},{"id":"https://openalex.org/C200707615","wikidata":"https://www.wikidata.org/wiki/Q13652744","display_name":"Neuroepithelial cell","level":4,"score":0.4108119010925293},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.38858562707901},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38534215092658997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32325807213783264},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31058594584465027},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.290349543094635},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.10058581829071045},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08057498931884766},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/19631","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/19631","pdf_url":"http://hdl.handle.net/2077/19631","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2137482117","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/19631/1/gupea_2077_19631_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/19631","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/19631","pdf_url":"http://hdl.handle.net/2077/19631","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137482117.pdf","grobid_xml":"https://content.openalex.org/works/W2137482117.grobid-xml"},"referenced_works_count":140,"referenced_works":["https://openalex.org/W1515564094","https://openalex.org/W1551331657","https://openalex.org/W1590632482","https://openalex.org/W1733539716","https://openalex.org/W1787524943","https://openalex.org/W1847277954","https://openalex.org/W1859730138","https://openalex.org/W1861988602","https://openalex.org/W1875709550","https://openalex.org/W1927523013","https://openalex.org/W1928214378","https://openalex.org/W1928834579","https://openalex.org/W1936643702","https://openalex.org/W1959902108","https://openalex.org/W1965681567","https://openalex.org/W1965933264","https://openalex.org/W1965976131","https://openalex.org/W1967556157","https://openalex.org/W1969225564","https://openalex.org/W1970369805","https://openalex.org/W1971004772","https://openalex.org/W1972729587","https://openalex.org/W1974791004","https://openalex.org/W1980499453","https://openalex.org/W1983226940","https://openalex.org/W1984437024","https://openalex.org/W1987604172","https://openalex.org/W1988135514","https://openalex.org/W1990646544","https://openalex.org/W1990853114","https://openalex.org/W1994145084","https://openalex.org/W1994169350","https://openalex.org/W1994938808","https://openalex.org/W1995188451","https://openalex.org/W1999927211","https://openalex.org/W2002161951","https://openalex.org/W2003861928","https://openalex.org/W2004590336","https://openalex.org/W2005994473","https://openalex.org/W2014386715","https://openalex.org/W2014940168","https://openalex.org/W2015627353","https://openalex.org/W2016851798","https://openalex.org/W2018855387","https://openalex.org/W2020277172","https://openalex.org/W2021345772","https://openalex.org/W2022372660","https://openalex.org/W2025828736","https://openalex.org/W2028307977","https://openalex.org/W2031482209","https://openalex.org/W2031809301","https://openalex.org/W2037411373","https://openalex.org/W2037914328","https://openalex.org/W2040371729","https://openalex.org/W2050689607","https://openalex.org/W2051021067","https://openalex.org/W2054113947","https://openalex.org/W2054121698","https://openalex.org/W2054552572","https://openalex.org/W2055301723","https://openalex.org/W2056272654","https://openalex.org/W2056963133","https://openalex.org/W2057377682","https://openalex.org/W2061089834","https://openalex.org/W2061211083","https://openalex.org/W2062386682","https://openalex.org/W2063466545","https://openalex.org/W2065737043","https://openalex.org/W2066679122","https://openalex.org/W2067161293","https://openalex.org/W2067856703","https://openalex.org/W2068251212","https://openalex.org/W2068387575","https://openalex.org/W2070306500","https://openalex.org/W2070444599","https://openalex.org/W2071181288","https://openalex.org/W2072809430","https://openalex.org/W2073390876","https://openalex.org/W2074717269","https://openalex.org/W2076415360","https://openalex.org/W2078284356","https://openalex.org/W2078504009","https://openalex.org/W2079156156","https://openalex.org/W2079356804","https://openalex.org/W2082121882","https://openalex.org/W2083194463","https://openalex.org/W2083947354","https://openalex.org/W2085250497","https://openalex.org/W2085256528","https://openalex.org/W2085408461","https://openalex.org/W2085729372","https://openalex.org/W2087690085","https://openalex.org/W2088897382","https://openalex.org/W2089204174","https://openalex.org/W2090836465","https://openalex.org/W2092245844","https://openalex.org/W2094978516","https://openalex.org/W2096136751","https://openalex.org/W2098137179","https://openalex.org/W2099250398","https://openalex.org/W2102108000","https://openalex.org/W2108398194","https://openalex.org/W2108966597","https://openalex.org/W2109120242","https://openalex.org/W2111034473","https://openalex.org/W2114303594","https://openalex.org/W2117523148","https://openalex.org/W2119301405","https://openalex.org/W2120417150","https://openalex.org/W2123350568","https://openalex.org/W2125874180","https://openalex.org/W2132504992","https://openalex.org/W2139861763","https://openalex.org/W2145235967","https://openalex.org/W2145956680","https://openalex.org/W2146045918","https://openalex.org/W2146394305","https://openalex.org/W2147909291","https://openalex.org/W2148239264","https://openalex.org/W2148348488","https://openalex.org/W2150143842","https://openalex.org/W2150813685","https://openalex.org/W2151400960","https://openalex.org/W2151551770","https://openalex.org/W2152112132","https://openalex.org/W2152120625","https://openalex.org/W2152794331","https://openalex.org/W2154104720","https://openalex.org/W2154908600","https://openalex.org/W2157548945","https://openalex.org/W2158628168","https://openalex.org/W2162020808","https://openalex.org/W2162716161","https://openalex.org/W2165867905","https://openalex.org/W2166261688","https://openalex.org/W2166625995","https://openalex.org/W2168945089","https://openalex.org/W2169529166","https://openalex.org/W2170899083","https://openalex.org/W2417171523"],"related_works":["https://openalex.org/W1990646544","https://openalex.org/W1985301079","https://openalex.org/W2909938262","https://openalex.org/W3184925595","https://openalex.org/W1853178570","https://openalex.org/W2331716068","https://openalex.org/W2334223087","https://openalex.org/W4251277328","https://openalex.org/W2912701360","https://openalex.org/W2898007795"],"abstract_inverted_index":{"Radiation":[0],"therapy":[1],"is":[2,49],"one":[3],"of":[4,47,62,70,110,126,236,251,274,285],"the":[5,45,58,63,66,71,105,147,152,161,190,199,212,249,252,258,264,271,283],"most":[6,42],"effective":[7],"tools":[8],"for":[9,221],"treating":[10],"malignant":[11],"tumors;":[12],"however,":[13],"cranial":[14],"irradiation":[15,290],"often":[16],"results":[17],"in":[18,54,100,137,146,169,198,211,241,257,263],"intellectual":[19],"impairment":[20],"and":[21,28,65,78,107,117,231,281],"cognitive":[22],"deficits,":[23],"such":[24],"as":[25,142,144],"impaired":[26],"learning":[27],"memory.":[29],"Ionizing":[30],"radiation":[31,112,191],"generates":[32],"DNA":[33],"damage,":[34],"causing":[35],"proliferative":[36,88],"cells":[37,91,116,176,182,277],"to":[38,85,95,134,184,225,248,278,291],"undergo":[39],"apoptosis.":[40],"In":[41,188],"brain":[43],"regions,":[44,57],"generation":[46],"neurons":[48,81],"complete":[50],"at":[51,129],"birth.":[52],"However,":[53],"two":[55,153],"discrete":[56],"granule":[59],"cell":[60,75,140,155,171,228,254],"layer":[61],"hippocampus":[64],"subventricular":[67],"zone":[68],"(SVZ)":[69],"lateral":[72],"ventricle,":[73],"stem":[74,115,139,154,170,175,181,227,238,253,276],"continuously":[76],"proliferate":[77],"generate":[79],"new":[80],"throughout":[82],"life.":[83],"Due":[84],"their":[86,118],"high":[87],"capacity,":[89],"these":[90,237,268],"are":[92],"particularly":[93],"vulnerable":[94],"ionizing":[96,111,279],"radiation.":[97],"\\nThe":[98],"studies":[99],"this":[101,287],"thesis":[102],"focused":[103],"on":[104,113],"immediate":[106,195],"late":[108],"effects":[109],"neural":[114],"microenvironment.":[119],"We":[120],"found":[121],"that":[122],"a":[123,166],"single":[124],"dose":[125],"6":[127],"Gy":[128],"postnatal":[130,200],"day":[131],"9":[132],"leads":[133],"long-lasting":[135],"decreases":[136],"both":[138],"proliferation,":[141],"well":[143],"neurogenesis,":[145],"adult":[148],"rat.":[149],"Even":[150],"though":[151],"regions":[156],"were":[157,177],"equally":[158],"affected":[159],"by":[160],"initial":[162],"radiation,":[163,280],"there":[164],"was":[165,203,261],"differential":[167],"response":[168,197],"recovery.":[172],"While":[173],"hippocampal":[174,275],"long-term":[178],"affected;":[179],"SVZ":[180,243],"seemed":[183],"recover":[185],"with":[186],"time.":[187],"addition,":[189],"injury":[192],"caused":[193],"an":[194],"inflammatory":[196],"brain,":[201],"which":[202,260],"not":[204,215],"sustained":[205],"into":[206],"adulthood.":[207],"Interestingly,":[208],"irradiated":[209,242],"microglia":[210,244],"SVZ,":[213,259],"but":[214],"hippocampus,":[216],"upregulated":[217],"several":[218],"genes":[219,240],"coding":[220],"growth":[222],"factors":[223],"known":[224],"promote":[226],"maintenance,":[229],"proliferation":[230],"survival.":[232],"The":[233],"specific":[234],"upregulation":[235],"cell-related":[239],"could":[245],"potentially":[246],"contribute":[247],"recovery":[250],"population":[255],"seen":[256],"lacking":[262],"hippocampus.":[265],"Taken":[266],"together,":[267],"data":[269],"demonstrate":[270],"pronounced":[272],"susceptibility":[273],"highlight":[282],"importance":[284],"shielding":[286],"structure":[288],"from":[289],"minimize":[292],"functional":[293],"consequences.":[294]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
