{"id":"https://openalex.org/W2137384084","doi":null,"title":"Pathogenesis and treatment of chemical-induced lung injury","display_name":"Pathogenesis and treatment of chemical-induced lung injury","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2137384084","mag":"2137384084"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-52738","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52738","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52738","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063277324","display_name":"Elisabeth Wigenstam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elisabeth Wigenstam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063277324"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.32100000977516174,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.1429000049829483,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nitrogen-mustard","display_name":"nitrogen mustard","score":0.6679999828338623},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neutrophil-influx","display_name":"neutrophil influx","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8939999938011169},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9229999780654907},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7279999852180481},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.5170000195503235},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.47600001096725464},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2778670039","wikidata":"https://www.wikidata.org/wiki/Q414004","display_name":"Nitrogen mustard","level":4,"score":0.8475082516670227},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.7541170716285706},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.6915255784988403},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.67125004529953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5644693970680237},{"id":"https://openalex.org/C3019129585","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Skin irritation","level":2,"score":0.43389105796813965},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4165993928909302},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.4146851897239685},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3790995478630066},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3293371796607971},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2671670913696289},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.22338569164276123},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.16362130641937256},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.15229159593582153},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1491917371749878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12229904532432556}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-52738","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52738","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2137384084","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:506910/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-52738","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52738","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W91328212","https://openalex.org/W137194136","https://openalex.org/W141774154","https://openalex.org/W189583618","https://openalex.org/W202229671","https://openalex.org/W218521522","https://openalex.org/W300962634","https://openalex.org/W1028521357","https://openalex.org/W1499834471","https://openalex.org/W1513790751","https://openalex.org/W1517887571","https://openalex.org/W1522773084","https://openalex.org/W1557750365","https://openalex.org/W1557759394","https://openalex.org/W1560278958","https://openalex.org/W1572884481","https://openalex.org/W1583483795","https://openalex.org/W1603668575","https://openalex.org/W1651282701","https://openalex.org/W1717444875","https://openalex.org/W1745264954","https://openalex.org/W1786137152","https://openalex.org/W1872986951","https://openalex.org/W1895485518","https://openalex.org/W1964313477","https://openalex.org/W1965471051","https://openalex.org/W1965545860","https://openalex.org/W1970042812","https://openalex.org/W1970383148","https://openalex.org/W1972343698","https://openalex.org/W1973057402","https://openalex.org/W1973939217","https://openalex.org/W1976051917","https://openalex.org/W1976459300","https://openalex.org/W1977967985","https://openalex.org/W1980265413","https://openalex.org/W1982376300","https://openalex.org/W1982483409","https://openalex.org/W1983805610","https://openalex.org/W1984808204","https://openalex.org/W1985354520","https://openalex.org/W1985371429","https://openalex.org/W1987911729","https://openalex.org/W1992230297","https://openalex.org/W1992905570","https://openalex.org/W1993934464","https://openalex.org/W1994656151","https://openalex.org/W1995357195","https://openalex.org/W1995731966","https://openalex.org/W1996904887","https://openalex.org/W1997933750","https://openalex.org/W1998437621","https://openalex.org/W1999319544","https://openalex.org/W2000933179","https://openalex.org/W2001516113","https://openalex.org/W2001796665","https://openalex.org/W2002211843","https://openalex.org/W2002467106","https://openalex.org/W2003259342","https://openalex.org/W2004657857","https://openalex.org/W2004965438","https://openalex.org/W2005432265","https://openalex.org/W2006249161","https://openalex.org/W2008417116","https://openalex.org/W2009980769","https://openalex.org/W2010800806","https://openalex.org/W2013114941","https://openalex.org/W2014963245","https://openalex.org/W2018172685","https://openalex.org/W2018521741","https://openalex.org/W2025138300","https://openalex.org/W2028991215","https://openalex.org/W2030295027","https://openalex.org/W2034914625","https://openalex.org/W2036326871","https://openalex.org/W2036327819","https://openalex.org/W2037065932","https://openalex.org/W2037142666","https://openalex.org/W2040012543","https://openalex.org/W2042740706","https://openalex.org/W2043546340","https://openalex.org/W2046076918","https://openalex.org/W2046818057","https://openalex.org/W2049271826","https://openalex.org/W2051545628","https://openalex.org/W2053388673","https://openalex.org/W2056699335","https://openalex.org/W2058451534","https://openalex.org/W2060845714","https://openalex.org/W2061203364","https://openalex.org/W2063132102","https://openalex.org/W2063700930","https://openalex.org/W2071318509","https://openalex.org/W2075858546","https://openalex.org/W2076452049","https://openalex.org/W2076712592","https://openalex.org/W2076889715","https://openalex.org/W2078316516","https://openalex.org/W2079893720","https://openalex.org/W2081406906","https://openalex.org/W2081748503","https://openalex.org/W2082741854","https://openalex.org/W2083661423","https://openalex.org/W2084304195","https://openalex.org/W2085451664","https://openalex.org/W2086237867","https://openalex.org/W2090631453","https://openalex.org/W2090919511","https://openalex.org/W2092085734","https://openalex.org/W2093949724","https://openalex.org/W2094235282","https://openalex.org/W2095862705","https://openalex.org/W2097884684","https://openalex.org/W2098296430","https://openalex.org/W2098734814","https://openalex.org/W2099342380","https://openalex.org/W2099445482","https://openalex.org/W2099675490","https://openalex.org/W2100289338","https://openalex.org/W2102265675","https://openalex.org/W2102345655","https://openalex.org/W2102508479","https://openalex.org/W2103440850","https://openalex.org/W2103536061","https://openalex.org/W2104071939","https://openalex.org/W2106067268","https://openalex.org/W2108244474","https://openalex.org/W2108247884","https://openalex.org/W2111189439","https://openalex.org/W2117172636","https://openalex.org/W2117839847","https://openalex.org/W2119964587","https://openalex.org/W2120805219","https://openalex.org/W2121464855","https://openalex.org/W2121701189","https://openalex.org/W2123062776","https://openalex.org/W2134460916","https://openalex.org/W2143645698","https://openalex.org/W2144974667","https://openalex.org/W2147450860","https://openalex.org/W2147993424","https://openalex.org/W2152065366","https://openalex.org/W2154023242","https://openalex.org/W2154746915","https://openalex.org/W2157022248","https://openalex.org/W2160601823","https://openalex.org/W2161629451","https://openalex.org/W2164619145","https://openalex.org/W2165275387","https://openalex.org/W2166607989","https://openalex.org/W2166691652","https://openalex.org/W2265160193","https://openalex.org/W2268494761","https://openalex.org/W2295402402","https://openalex.org/W2312492751","https://openalex.org/W2313837936","https://openalex.org/W2346038399","https://openalex.org/W2439658448","https://openalex.org/W3097326077","https://openalex.org/W3133268475"],"related_works":["https://openalex.org/W2075664437","https://openalex.org/W2000933729","https://openalex.org/W1982690971","https://openalex.org/W2056304428","https://openalex.org/W3021896673","https://openalex.org/W2036108169","https://openalex.org/W2511916519","https://openalex.org/W2070832048","https://openalex.org/W2808838674","https://openalex.org/W2775692904"],"abstract_inverted_index":{"Inhalation":[0],"of":[1,37,126,144,179,187,200,215,221,310,326,336],"chemical":[2,66],"substances":[3],"can":[4,160],"cause":[5],"irritation":[6],"to":[7,20,39,85,92,119,167,236,247,292,305],"airways":[8],"and":[9,56,71,97,133,137,227,230,256,259,328],"in":[10,77,90,114,197,264,323],"high":[11],"doses":[12],"acute":[13,30,43,95,150,225],"airway":[14,31,57,67,151,260,312],"injury.":[15,100,296],"When":[16],"mice":[17,244,267],"are":[18],"exposed":[19,246],"the":[21,40,72,75,111,120,124,127,156,180,185,188,198,208,224,238,302,308],"alkylating":[22],"nitrogen":[23],"mustard":[24],"analogue":[25],"melphalan":[26],"they":[27,192],"develop":[28],"an":[29,279],"inflammation":[32,68,152],"with":[33,105,250,288,301],"a":[34,62,78,164,172,194,219,269],"rapid":[35],"influx":[36,118],"neutrophils":[38],"lungs.":[41],"The":[42],"phase":[44],"is":[45,122,135,147,214,290],"followed":[46],"by":[47,52,205],"long-term":[48,201],"respiratory":[49],"complications":[50],"characterized":[51],"bronchitis,":[53],"lung":[54,145,202,232,257,295],"fibrosis,":[55],"hyperreactivity.":[58],"In":[59,149,234],"this":[60,324,331],"thesis,":[61],"mouse":[63],"model":[64],"for":[65,241],"was":[69,262,299],"established":[70],"effects":[73,96],"on":[74],"lungs":[76,121],"time":[79,240,254],"span":[80],"from":[81],"6":[82],"hours":[83],"up":[84],"3":[86],"months":[87],"were":[88,245],"investigated":[89],"order":[91,235],"study":[93],"both":[94],"possible":[98,165],"chronic":[99,294],"We":[101,183,314],"find":[102,237],"that":[103,155,278,316,330],"treatment":[104],"corticosteroids,":[106],"e.g.":[107],"dexamethasone,":[108],"effectively":[109],"blocks":[110],"inflammatory":[112,181],"reaction":[113],"several":[115],"ways:":[116],"Neutrophil":[117],"diminished,":[123],"expression":[125],"proinflammatory":[128],"cytokines":[129],"interleukin":[130],"(IL)":[131],"-6":[132],"IL-1b":[134],"decreased":[136],"edema":[138],"formation":[139],"as":[140,142,163,171,191],"well":[141],"development":[143],"fibrosis":[146],"mitigated.":[148],"we":[153,276],"show":[154,184],"antioxidant":[157],"vitamin":[158],"E":[159],"be":[161,335],"used":[162],"complement":[166],"corticosteroids":[168],"but":[169],"not":[170],"replacement":[173],"since":[174],"it":[175],"causes":[176],"insufficient":[177],"downregulation":[178],"response.":[182],"importance":[186,217],"T":[189,211],"lymphocytes":[190],"play":[193],"prominent":[195],"role":[196],"pathogenesis":[199,309],"injuries":[203],"caused":[204],"melphalan.":[206],"Especially":[207],"minor":[209],"gd":[210],"cell":[212],"subset":[213],"major":[216],"orchestrating":[218],"number":[220],"responses":[222],"including":[223],"cytokine":[226],"neutrophil":[228],"response":[229],"late-phase":[231],"fibrosis.":[233],"critical":[239],"dexamethasone":[242,251,289],"treatment,":[243,281],"melphalan,":[248],"treated":[249],"at":[252],"specific":[253],"points":[255],"physiology":[258],"reactivity":[261],"measured":[263],"anaesthetized,":[265],"tracheostomized":[266],"using":[268],"small":[270],"animal":[271],"ventilator.":[272],"From":[273],"these":[274],"results":[275],"conclude":[277],"early":[280],"i.e.":[282],"within":[283],"one":[284],"hour":[285],"after":[286],"exposure,":[287],"needed":[291],"prevent":[293],"This":[297],"thesis":[298],"undertaken":[300],"main":[303],"goal":[304],"better":[306],"understand":[307],"melphalan-induced":[311],"inflammation.":[313],"believe":[315],"our":[317],"findings":[318],"have":[319],"shed":[320],"new":[321],"light":[322],"area":[325],"research":[327],"hope":[329],"increased":[332],"knowledge":[333],"may":[334],"future":[337],"clinical":[338],"use.":[339]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}