{"id":"https://openalex.org/W2137368340","doi":"https://doi.org/10.1093/nar/gkq028","title":"Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members","display_name":"Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members","publication_year":2010,"publication_date":"2010-02-16","ids":{"openalex":"https://openalex.org/W2137368340","doi":"https://doi.org/10.1093/nar/gkq028","mag":"2137368340","pmid":"https://pubmed.ncbi.nlm.nih.gov/20159993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887941"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkq028","doi":"https://doi.org/10.1093/nar/gkq028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq028","pdf_url":"https://academic.oup.com/nar/article-pdf/38/11/3760/11172104/gkq028.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/38/11/3760/11172104/gkq028.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101791245","display_name":"Huiwen Wang","orcid":"https://orcid.org/0000-0002-8699-7555","observed_orcids":["https://orcid.org/0000-0002-8699-7555"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiwen Wang","raw_affiliation_strings":["Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045307559","display_name":"Jill Molfenter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Molfenter","raw_affiliation_strings":["Department of Genetics, 2 Center for RNA Molecular Biology and 3 Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, 2 Center for RNA Molecular Biology and 3 Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101613283","display_name":"Hui Zhu","orcid":"https://orcid.org/0000-0003-0346-3935","observed_orcids":["https://orcid.org/0000-0003-0346-3935"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Zhu","raw_affiliation_strings":["Department of Genetics, 2 Center for RNA Molecular Biology and 3 Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, 2 Center for RNA Molecular Biology and 3 Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110910623","display_name":"Hua Jane Lou","orcid":"https://orcid.org/0009-0007-5924-4076","observed_orcids":["https://orcid.org/0009-0007-5924-4076"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hua Lou","raw_affiliation_strings":["Department of Genetics, 2 Center for RNA Molecular Biology and 3 Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, 2 Center for RNA Molecular Biology and 3 Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110910623"],"corresponding_institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":2.4425,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.89874384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"11","first_page":"3760","last_page":"3770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hud","display_name":"HUD","score":0.6019999980926514},{"id":"https://openalex.org/keywords/hu-protein","display_name":"HU protein","score":0.7429999709129333},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7919999957084656},{"id":"https://openalex.org/keywords/exon-inclusion","display_name":"exon inclusion","score":0.8159999847412109},{"id":"https://openalex.org/keywords/exon-6","display_name":"exon 6","score":0.7369999885559082},{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.9570000171661377},{"id":"https://openalex.org/keywords/splicing-enhancers","display_name":"splicing enhancers","score":0.9039999842643738},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pre-mrna-splicing-regulation","display_name":"pre-mRNA splicing regulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hubs","display_name":"hubs","score":0.8569999933242798},{"id":"https://openalex.org/keywords/huc","display_name":"HuC","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.9271442890167236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8304224014282227},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7627571225166321},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.7224719524383545},{"id":"https://openalex.org/C39917842","wikidata":"https://www.wikidata.org/wiki/Q1384125","display_name":"Exon trapping","level":5,"score":0.531091570854187},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.5027749538421631},{"id":"https://openalex.org/C2778776201","wikidata":"https://www.wikidata.org/wiki/Q3474283","display_name":"Exon skipping","level":5,"score":0.4876052439212799},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4576728343963623},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4380655288696289},{"id":"https://openalex.org/C190017056","wikidata":"https://www.wikidata.org/wiki/Q5420611","display_name":"Exon shuffling","level":5,"score":0.4341093897819519},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39712759852409363},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3703955113887787},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36196690797805786},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30697888135910034}],"mesh":[{"descriptor_ui":"D000067778","descriptor_name":"ELAV-Like Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000067779","descriptor_name":"ELAV-Like Protein 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051959","descriptor_name":"ELAV Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051959","descriptor_name":"ELAV Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1093/nar/gkq028","doi":"https://doi.org/10.1093/nar/gkq028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq028","pdf_url":"https://academic.oup.com/nar/article-pdf/38/11/3760/11172104/gkq028.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2887941","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887941","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:20159993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20159993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.5071","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.5071","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2010/02/16/nar.gkq028.full-text-lowres.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.4387","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.4387","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9d/e3/Nucleic_Acids_Res_2010_Jun_16_38(11)_3760-3770.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.920.3176","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.920.3176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/38/11/3760.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.925.2892","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.925.2892","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2010/02/16/nar.gkq028.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:nar:38/11/3760","doi":null,"is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/38/11/3760","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/nar/gkq028","doi":"https://doi.org/10.1093/nar/gkq028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq028","pdf_url":"https://academic.oup.com/nar/article-pdf/38/11/3760/11172104/gkq028.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1345579560","display_name":"Hu proteins as novel splicing regulators in neurons","funder_award_id":"R56NS049103","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2325668992","display_name":"Hu proteins as novel splicing regulators in neurons","funder_award_id":"R01NS049103","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G30229433","display_name":"Typhoon Trio Variable Mode Imager For Use In Multi-User Facility","funder_award_id":"S10RR024536","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4898479253","display_name":null,"funder_award_id":"NS-049103","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137368340.pdf","grobid_xml":"https://content.openalex.org/works/W2137368340.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1514379483","https://openalex.org/W1829380772","https://openalex.org/W1927844679","https://openalex.org/W1964170234","https://openalex.org/W1964906901","https://openalex.org/W1965557392","https://openalex.org/W1973614363","https://openalex.org/W1979613763","https://openalex.org/W1998938482","https://openalex.org/W2001889965","https://openalex.org/W2011920499","https://openalex.org/W2020081155","https://openalex.org/W2026671856","https://openalex.org/W2028987099","https://openalex.org/W2033305072","https://openalex.org/W2035261316","https://openalex.org/W2035869111","https://openalex.org/W2038617558","https://openalex.org/W2041506786","https://openalex.org/W2052070792","https://openalex.org/W2053998703","https://openalex.org/W2055930249","https://openalex.org/W2056172652","https://openalex.org/W2056200986","https://openalex.org/W2064492560","https://openalex.org/W2069192087","https://openalex.org/W2073387857","https://openalex.org/W2073654740","https://openalex.org/W2087225941","https://openalex.org/W2091129822","https://openalex.org/W2093620389","https://openalex.org/W2093625208","https://openalex.org/W2097779331","https://openalex.org/W2104957429","https://openalex.org/W2109936378","https://openalex.org/W2110141158","https://openalex.org/W2115122534","https://openalex.org/W2134339178","https://openalex.org/W2150107170","https://openalex.org/W2151045225","https://openalex.org/W2152689225","https://openalex.org/W2154799292","https://openalex.org/W2155804510","https://openalex.org/W2158978257","https://openalex.org/W2170375626","https://openalex.org/W2183024399","https://openalex.org/W2338708163","https://openalex.org/W2747576034"],"related_works":["https://openalex.org/W7096306631","https://openalex.org/W2095192259","https://openalex.org/W3160925199","https://openalex.org/W1571370152","https://openalex.org/W1973614363","https://openalex.org/W2107278624","https://openalex.org/W2061217906","https://openalex.org/W2028987099","https://openalex.org/W1964170234","https://openalex.org/W2203796204"],"abstract_inverted_index":{"The":[0,18],"Hu":[1,22,44,59,108,148,161,178,191],"RNA-binding":[2],"protein":[3,109],"family":[4],"consists":[5],"of":[6,35,48,63,69,79,140,147,172,190],"four":[7],"members:":[8],"HuR/A,":[9],"HuB,":[10],"HuC":[11],"and":[12,86,121,127,185],"HuD.":[13,123],"HuR":[14],"expression":[15],"is":[16],"widespread.":[17],"other":[19],"three":[20],"neuron-specific":[21],"proteins":[23,45,60,149,162,179,192],"play":[24],"an":[25,64],"important":[26],"role":[27,189],"in":[28,155],"neuronal":[29],"differentiation":[30],"through":[31],"modulating":[32],"multiple":[33],"processes":[34],"RNA":[36],"metabolism.":[37],"In":[38],"the":[39,49,55,70,77,170,187],"splicing":[40,157,183,194],"events":[41],"examined":[42],"previously,":[43],"promote":[46,61,163],"skipping":[47],"alternative":[50,65],"exons.":[51],"Here,":[52],"we":[53],"report":[54],"first":[56],"example":[57],"where":[58],"inclusion":[62,117,167],"exon,":[66],"exon":[67,98,115,130,141,151,165],"6":[68,99,116,131,142,152,166],"HuD":[71,97,129,164],"pre-mRNA.":[72],"Sequence":[73],"alignment":[74],"analysis":[75],"indicates":[76,159],"presence":[78],"several":[80],"conserved":[81,106],"AU-rich":[82,136],"sequences":[83,137],"both":[84],"upstream":[85],"downstream":[87,139],"to":[88,112],"this":[89,119],"alternatively":[90],"spliced":[91],"exon.":[92],"We":[93],"generated":[94],"a":[95],"human":[96],"mini-gene":[100],"reporter":[101,120],"construct":[102],"that":[103,134,160,177],"includes":[104],"these":[105],"sequences.":[107],"over-expression":[110],"led":[111],"significantly":[113],"increased":[114],"from":[118],"endogenous":[122],"Studies":[124],"using":[125],"truncated":[126],"mutant":[128],"reporters":[132],"demonstrate":[133,176],"two":[135],"located":[138],"are":[143],"important.":[144],"RNAi":[145],"knockdown":[146],"decreased":[150],"inclusion.":[153],"An":[154],"vitro":[156],"assay":[158],"directly":[168],"at":[169],"level":[171],"splicing.":[173],"Our":[174],"studies":[175],"can":[180],"function":[181],"as":[182,193],"enhancers":[184],"expand":[186],"functional":[188],"regulators.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}