{"id":"https://openalex.org/W2137334802","doi":"https://doi.org/10.1161/hc2601.090987","title":"Isoproterenol Activates Extracellular Signal\u2013Regulated Protein Kinases in Cardiomyocytes Through Calcineurin","display_name":"Isoproterenol Activates Extracellular Signal\u2013Regulated Protein Kinases in Cardiomyocytes Through Calcineurin","publication_year":2001,"publication_date":"2001-07-03","ids":{"openalex":"https://openalex.org/W2137334802","doi":"https://doi.org/10.1161/hc2601.090987","mag":"2137334802","pmid":"https://pubmed.ncbi.nlm.nih.gov/11435346"},"language":"en","primary_location":{"id":"doi:10.1161/hc2601.090987","doi":"https://doi.org/10.1161/hc2601.090987","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hc2601.090987","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053743858","display_name":"Yunzeng Zou","orcid":"https://orcid.org/0000-0003-1310-969X","observed_orcids":["https://orcid.org/0000-0003-1310-969X"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yunzeng Zou","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Yunzeng Zou From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]},{"raw_affiliation_string":"Yunzeng Zou From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065533956","display_name":"Atsushi Yao","orcid":"https://orcid.org/0000-0002-4968-068X","observed_orcids":["https://orcid.org/0000-0002-4968-068X"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Yao","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Atsushi Yao From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Atsushi Yao From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046657725","display_name":"Weidong Zhu","orcid":"https://orcid.org/0000-0001-7180-6210","observed_orcids":["https://orcid.org/0000-0001-7180-6210"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Weidong Zhu","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Weidong Zhu From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]},{"raw_affiliation_string":"Weidong Zhu From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109202511","display_name":"Sumiyo Kudoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumiyo Kudoh","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Sumiyo Kudoh From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Sumiyo Kudoh From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035729104","display_name":"Yukio Hiroi","orcid":"https://orcid.org/0000-0001-5088-7656","observed_orcids":["https://orcid.org/0000-0001-5088-7656"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio Hiroi","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Yukio Hiroi From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]},{"raw_affiliation_string":"Yukio Hiroi From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111786969","display_name":"Masaki Shimoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Shimoyama","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Masaki Shimoyama From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Masaki Shimoyama From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062656418","display_name":"Hiroki Uozumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Uozumi","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Hiroki Uozumi From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Hiroki Uozumi From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026286537","display_name":"Osami Kohmoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osami Kohmoto","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Osami Kohmoto From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Osami Kohmoto From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008683011","display_name":"Toshiyuki Takahashi","orcid":"https://orcid.org/0000-0003-1627-8624","observed_orcids":["https://orcid.org/0000-0003-1627-8624"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Takahashi","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Toshiyuki Takahashi From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]},{"raw_affiliation_string":"Toshiyuki Takahashi From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089304014","display_name":"Futoshi Shibasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Futoshi Shibasaki","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Futoshi Shibasaki From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Futoshi Shibasaki From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113946000","display_name":"Ryozo Nagai","orcid":"https://orcid.org/0000-0002-0911-7868","observed_orcids":["https://orcid.org/0000-0002-0911-7868"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryozo Nagai","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Ryozo Nagai From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Ryozo Nagai From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110826271","display_name":"Yoshio Yazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Yazaki","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Yoshio Yazaki From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]},{"raw_affiliation_string":"Yoshio Yazaki From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057781163","display_name":"Issei Komuro","orcid":"https://orcid.org/0000-0002-0714-7182","observed_orcids":["https://orcid.org/0000-0002-0714-7182"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Issei Komuro","raw_affiliation_strings":["From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","Department of Medicine II, Saitama Medical School, Saitama (O.K.)","Issei Komuro From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.); Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo (A.Y., W.Z., S.K., Y.H., M.S., H.U., T.T., R.N., Y.Y.); Department of Medicine II, Saitama Medical School, Saitama (O.K.); and Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210098918","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Medicine II, Saitama Medical School, Saitama (O.K.)","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Issei Komuro From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba (Y.Z., I.K.)","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science, Tokyo (F.S.), Japan","institution_ids":["https://openalex.org/I4210098918"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.424,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.96019485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"104","issue":"1","first_page":"102","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase","display_name":"extracellular signal-regulated kinase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9399999976158142},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8759999871253967},{"id":"https://openalex.org/keywords/calcium-induced-calcium-release","display_name":"calcium-induced calcium release","score":0.8429999947547913},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.703000009059906},{"id":"https://openalex.org/keywords/shc","display_name":"Shc","score":0.8180000185966492},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/z-band","display_name":"Z-band","score":0.6179999709129333},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.9660528898239136},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.6840682029724121},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6533118486404419},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6171827912330627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5394604206085205},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5369223356246948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49157246947288513},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45606744289398193},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4458944797515869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4251802861690521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3038600981235504},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071425","descriptor_name":"Src Homology 2 Domain-Containing, Transforming Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055765","descriptor_name":"Shc Signaling Adaptor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065095","descriptor_name":"Calcineurin Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/hc2601.090987","doi":"https://doi.org/10.1161/hc2601.090987","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hc2601.090987","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:11435346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11435346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"mag:2886522584","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.104.1.102?related-urls=yes&legid=circulationaha%3B104%2F1%2F102&legid=circulationaha%3B104%2F1%2F102&cited-by=yes","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1490838779","https://openalex.org/W1784820495","https://openalex.org/W1875111347","https://openalex.org/W1963942415","https://openalex.org/W1967412797","https://openalex.org/W1968672667","https://openalex.org/W1970579406","https://openalex.org/W1971072760","https://openalex.org/W1973896710","https://openalex.org/W1991163286","https://openalex.org/W1998299402","https://openalex.org/W2004412852","https://openalex.org/W2013056080","https://openalex.org/W2013576776","https://openalex.org/W2013741078","https://openalex.org/W2017583361","https://openalex.org/W2023758830","https://openalex.org/W2024400260","https://openalex.org/W2024880145","https://openalex.org/W2040097492","https://openalex.org/W2046075244","https://openalex.org/W2058031690","https://openalex.org/W2061405398","https://openalex.org/W2069983225","https://openalex.org/W2078381037","https://openalex.org/W2082547186","https://openalex.org/W2086449586","https://openalex.org/W2112583647","https://openalex.org/W2115792693","https://openalex.org/W2118634133","https://openalex.org/W2136546365","https://openalex.org/W2144630422","https://openalex.org/W2153937354","https://openalex.org/W2156433522","https://openalex.org/W2158034990","https://openalex.org/W2178451514","https://openalex.org/W2334499091","https://openalex.org/W2414363519"],"related_works":["https://openalex.org/W1518466260","https://openalex.org/W2363800098","https://openalex.org/W2136546365","https://openalex.org/W2389648055","https://openalex.org/W2374274115","https://openalex.org/W2078381037","https://openalex.org/W2333323416","https://openalex.org/W7156796506","https://openalex.org/W2001741403","https://openalex.org/W2418036801"],"abstract_inverted_index":{"BACKGROUND:":[0],"Extracellular":[1],"signal-regulated":[2],"kinases":[3],"(ERKs)":[4],"and":[5,27,43,123,126,140,154,160],"calcineurin":[6,26,79,132,147,159],"have":[7],"been":[8],"reported":[9],"to":[10,94],"play":[11],"important":[12],"roles":[13],"in":[14,29,37,81,87,97,150,188],"the":[15,23,44,88,99,103,109,151,163,178],"development":[16],"of":[17,40,50,56,64,72,90,105,113,131,137,158,173,186],"cardiac":[18],"hypertrophy.":[19],"We":[20],"examined":[21],"here":[22],"relation":[24],"between":[25],"ERKs":[28,36,73,96,161,187],"cardiomyocytes.":[30,189],"METHODS":[31],"AND":[32],"RESULTS:":[33],"Isoproterenol":[34,92,115],"activated":[35,128,169],"cultured":[38,82,100],"cardiomyocytes":[39,83,101],"neonatal":[41],"rats,":[42],"activation":[45,71,185],"was":[46,74,148],"abolished":[47],"by":[48,78,170,177],"chelation":[49],"extracellular":[51],"Ca(2+)":[52,58,66,118,175,180],"with":[53,60,68],"EGTA,":[54],"blockade":[55],"L-type":[57],"channels":[59],"nifedipine,":[61],"or":[62,102],"depletion":[63],"intracellular":[65,117,174],"stores":[67],"thapsigargin.":[69],"Isoproterenol-induced":[70],"also":[75,133],"significantly":[76],"suppressed":[77],"inhibitors":[80],"as":[84,86],"well":[85],"hearts":[89,104],"mice.":[91],"failed":[93],"activate":[95],"either":[98],"mice":[106],"that":[107,146],"overexpress":[108],"dominant":[110],"negative":[111],"mutant":[112],"calcineurin.":[114,129],"elevated":[116],"levels":[119,176],"at":[120],"both":[121],"systolic":[122],"diastolic":[124],"phases":[125],"dose-dependently":[127],"Inhibition":[130],"attenuated":[134],"isoproterenol-stimulated":[135],"phosphorylation":[136],"Src,":[138],"Shc,":[139],"Raf-1":[141],"kinase.":[142],"The":[143],"immunocytochemistry":[144],"revealed":[145],"localized":[149],"Z":[152],"band,":[153],"isoproterenol":[155],"induced":[156],"translocation":[157],"into":[162],"nucleus.":[164],"CONCLUSIONS:":[165],"Calcineurin,":[166],"which":[167],"is":[168],"marked":[171],"elevation":[172],"Ca(2+)-induced":[179],"release":[181],"mechanism,":[182],"regulates":[183],"isoproterenol-induced":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}