{"id":"https://openalex.org/W2137329239","doi":"https://doi.org/10.1110/ps.051378905","title":"Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton\u2010gated channels","display_name":"Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton\u2010gated channels","publication_year":2005,"publication_date":"2005-06-30","ids":{"openalex":"https://openalex.org/W2137329239","doi":"https://doi.org/10.1110/ps.051378905","mag":"2137329239","pmid":"https://pubmed.ncbi.nlm.nih.gov/15987885","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2279311"},"language":"en","primary_location":{"id":"doi:10.1110/ps.051378905","doi":"https://doi.org/10.1110/ps.051378905","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.051378905","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.051378905","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.051378905","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043651054","display_name":"Benjamin Chagot","orcid":"https://orcid.org/0000-0002-9153-0060","observed_orcids":["https://orcid.org/0000-0002-9153-0060"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Chagot","raw_affiliation_strings":["Architecture et Fonction des Macromol\u00e9cules Biologiques, Centre National de le Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6098, Universit\u00e9s d'Aix-Marseille I and II, Marseille Cedex 20, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Architecture et Fonction des Macromol\u00e9cules Biologiques, Centre National de le Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6098, Universit\u00e9s d'Aix-Marseille I and II, Marseille Cedex 20, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109167388","display_name":"Pierre Escoubas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Escoubas","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS UMR 6097, Valbonne, France","Institut de Pharmacologie Mol\u00e9culaire et Cellulaire / CNRS UMR 6097, Valbonne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS UMR 6097, Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]},{"raw_affiliation_string":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire / CNRS UMR 6097, Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004506292","display_name":"Sylvie Diochot","orcid":"https://orcid.org/0000-0002-0128-3167","observed_orcids":["https://orcid.org/0000-0002-0128-3167"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Diochot","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS UMR 6097, Valbonne, France","Institut de Pharmacologie Mol\u00e9culaire et Cellulaire / CNRS UMR 6097, Valbonne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS UMR 6097, Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]},{"raw_affiliation_string":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire / CNRS UMR 6097, Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C\u00e9dric Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Bernard","raw_affiliation_strings":["Architecture et Fonction des Macromole\u0301 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unite\u0301 Mixte de Recherche (UMR) 6098 and Universite\u0301s d'Aix-Marseille I and II,Marseille Cedex 20, France","Architecture et Fonction des Macromol\u00e9 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 6098 and Universit\u00e9s d'Aix\u2010Marseille I and II,Marseille Cedex 20, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Architecture et Fonction des Macromole\u0301 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unite\u0301 Mixte de Recherche (UMR) 6098 and Universite\u0301s d'Aix-Marseille I and II,Marseille Cedex 20, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"Architecture et Fonction des Macromol\u00e9 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 6098 and Universit\u00e9s d'Aix\u2010Marseille I and II,Marseille Cedex 20, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068045779","display_name":"Michel Lazdunski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Lazdunski","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS UMR 6097, Valbonne, France","Institut de Pharmacologie Mol\u00e9culaire et Cellulaire / CNRS UMR 6097, Valbonne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS UMR 6097, Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]},{"raw_affiliation_string":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire / CNRS UMR 6097, Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110135591","display_name":"Herv\u00e9 Darbon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Herv\u00e9 Darbon","raw_affiliation_strings":["Architecture et Fonction des Macromole\u0301 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unite\u0301 Mixte de Recherche (UMR) 6098 and Universite\u0301s d'Aix-Marseille I and II,Marseille Cedex 20, France","AFMB, CNRS UMR 6098 and Universit\u00e9s d'Aix\u2010Marseille I and II, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France; fax: +33 (0)4\u201091\u201016\u201045\u201036","Architecture et Fonction des Macromol\u00e9 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 6098 and Universit\u00e9s d'Aix\u2010Marseille I and II,Marseille Cedex 20, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Architecture et Fonction des Macromole\u0301 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unite\u0301 Mixte de Recherche (UMR) 6098 and Universite\u0301s d'Aix-Marseille I and II,Marseille Cedex 20, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"AFMB, CNRS UMR 6098 and Universit\u00e9s d'Aix\u2010Marseille I and II, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France; fax: +33 (0)4\u201091\u201016\u201045\u201036","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"Architecture et Fonction des Macromol\u00e9 cules Biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 6098 and Universit\u00e9s d'Aix\u2010Marseille I and II,Marseille Cedex 20, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110135591"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.8259,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.67220398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"8","first_page":"2003","last_page":"2010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.07249999791383743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asic3","display_name":"ASIC3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/acid-sensing-ion-channels","display_name":"acid-sensing ion channels","score":0.9710000157356262},{"id":"https://openalex.org/keywords/peptide-toxins","display_name":"peptide toxins","score":0.6890000104904175},{"id":"https://openalex.org/keywords/anthopleura-elegantissima","display_name":"Anthopleura elegantissima","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sea-anemone-venom","display_name":"sea anemone venom","score":0.9319999814033508},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.5519999861717224},{"id":"https://openalex.org/keywords/toxin-specificity","display_name":"toxin specificity","score":0.5170000195503235},{"id":"https://openalex.org/keywords/herg-channel","display_name":"hERG","score":0.9330000281333923},{"id":"https://openalex.org/keywords/electrostatic-surface","display_name":"electrostatic surface","score":0.550000011920929},{"id":"https://openalex.org/keywords/pain-transduction","display_name":"pain transduction","score":0.6039999723434448},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C143928317","wikidata":"https://www.wikidata.org/wiki/Q4222244","display_name":"Acid-sensing ion channel","level":4,"score":0.7477926015853882},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7038127183914185},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.678650438785553},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.6622188091278076},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.619537353515625},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5362915396690369},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.4642549157142639},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4600420594215393},{"id":"https://openalex.org/C85641259","wikidata":"https://www.wikidata.org/wiki/Q290042","display_name":"Turn (biochemistry)","level":2,"score":0.4517003893852234},{"id":"https://openalex.org/C113241181","wikidata":"https://www.wikidata.org/wiki/Q24784174","display_name":"Ankyrin repeat","level":3,"score":0.4307297468185425},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35713738203048706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3274712562561035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2319183349609375},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15574252605438232},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.14301660656929016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07660171389579773},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003064","descriptor_name":"Cnidarian Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026941","descriptor_name":"Sodium Channel Blockers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062565","descriptor_name":"Acid Sensing Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1110/ps.051378905","doi":"https://doi.org/10.1110/ps.051378905","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.051378905","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.051378905","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2279311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2279311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:15987885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15987885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00091075v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00091075","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Protein Science, 2005, 14, pp.2003-2010","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-01636767v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01636767","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Protein Science, 2005, 14 (8), pp.2003-2010. &#x27E8;10.1110/ps.051378905&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1110/ps.051378905","doi":"https://doi.org/10.1110/ps.051378905","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.051378905","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.051378905","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137329239.pdf","grobid_xml":"https://content.openalex.org/works/W2137329239.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1491642680","https://openalex.org/W1967255925","https://openalex.org/W1972459558","https://openalex.org/W1975459052","https://openalex.org/W1978354972","https://openalex.org/W1985095190","https://openalex.org/W1986872525","https://openalex.org/W1988455380","https://openalex.org/W2000948557","https://openalex.org/W2006221802","https://openalex.org/W2006294085","https://openalex.org/W2016772559","https://openalex.org/W2046091222","https://openalex.org/W2047283239","https://openalex.org/W2070671106","https://openalex.org/W2078091344","https://openalex.org/W2080587028","https://openalex.org/W2085779087","https://openalex.org/W2088981699","https://openalex.org/W2092433412","https://openalex.org/W2092744441","https://openalex.org/W2093700493","https://openalex.org/W2094106297","https://openalex.org/W2100095444","https://openalex.org/W2104024569","https://openalex.org/W2106315897","https://openalex.org/W2113047946","https://openalex.org/W2113869859","https://openalex.org/W2127116852","https://openalex.org/W2127623881","https://openalex.org/W2137745009","https://openalex.org/W2139755116","https://openalex.org/W2149464160","https://openalex.org/W2168058467","https://openalex.org/W2949250147"],"related_works":["https://openalex.org/W1260817","https://openalex.org/W2111941517","https://openalex.org/W2167331514","https://openalex.org/W2071473924","https://openalex.org/W1981515148","https://openalex.org/W7096369293","https://openalex.org/W1996614162","https://openalex.org/W3019536860","https://openalex.org/W2006294085","https://openalex.org/W4211121140"],"abstract_inverted_index":{"Acid-sensing":[0],"ion":[1,138,210],"channels":[2,7,103],"(ASIC)":[3],"are":[4,93],"proton-gated":[5],"sodium":[6],"that":[8,96],"have":[9],"been":[10,31],"implicated":[11],"in":[12,18,85,176,203],"pain":[13],"transduction":[14],"associated":[15],"with":[16,95,128,157],"acidosis":[17],"inflamed":[19],"or":[20],"ischemic":[21],"tissues.":[22],"APETx2,":[23,118,151],"a":[24,44,63,69,113,145,201],"peptide":[25,46,81],"toxin":[26,114],"effector":[27,100],"of":[28,36,62,68,91,97,101,131,135,188],"ASIC3,":[29],"has":[30],"purified":[32],"from":[33],"an":[34],"extract":[35],"the":[37,75,107,121,129,132,158,189,204],"sea":[38],"anemone":[39],"Anthopleura":[40],"elegantissima.":[41],"APETx2":[42,92],"is":[43,173],"42-amino-acid":[45],"cross-linked":[47],"by":[48,57],"three":[49],"disulfide":[50],"bridges.":[51],"Its":[52],"three-dimensional":[53],"structure,":[54],"as":[55],"determined":[56],"conventional":[58],"two-dimensional":[59],"1H-NMR,":[60],"consists":[61],"compact":[64],"disulfide-bonded":[65],"core":[66],"composed":[67],"four-stranded":[70],"beta-sheet.":[71],"It":[72],"belongs":[73],"to":[74,106,111,117,143],"disulfide-rich":[76],"all-beta":[77],"structural":[78,89],"family":[79],"encompassing":[80,152],"toxins":[82],"commonly":[83],"found":[84],"animal":[86],"venoms.":[87],"The":[88],"characteristics":[90,134],"compared":[94],"PcTx1,":[98],"another":[99],"ASIC":[102],"but":[104],"specific":[105],"ASIC1a":[108],"subtype":[109],"and":[110,165,171,182,196],"APETx1,":[112],"structurally":[115],"related":[116],"which":[119],"targets":[120],"HERG":[122],"potassium":[123],"channel.":[124],"Structural":[125],"comparisons,":[126],"coupled":[127],"analysis":[130],"electrostatic":[133],"these":[136,208],"various":[137],"channel":[139,147],"effectors,":[140],"led":[141],"us":[142],"suggest":[144],"putative":[146],"interaction":[148],"surface":[149,169],"for":[150,207],"its":[153],"N":[154],"terminus":[155],"together":[156],"type":[159,190],"I-beta":[160],"turn":[161,192],"connecting":[162,193],"beta-strands":[163,194],"III":[164],"IV.":[166],"This":[167],"basic":[168],"(R31":[170],"R17)":[172],"also":[174,199],"rich":[175],"aromatic":[177],"residues":[178],"(Y16,":[179],"F15,":[180],"Y32,":[181],"F33).":[183],"An":[184],"additional":[185],"region":[186],"made":[187],"II'-beta":[191],"I":[195],"II":[197],"could":[198],"play":[200],"role":[202],"specificity":[205],"observed":[206],"different":[209],"effectors.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
