{"id":"https://openalex.org/W2137294173","doi":"https://doi.org/10.7314/apjcp.2014.15.22.9611","title":"Clinical Utility of Haptoglobin in Combination with CEA, NSE and CYFRA21-1 for Diagnosis of Lung Cancer","display_name":"Clinical Utility of Haptoglobin in Combination with CEA, NSE and CYFRA21-1 for Diagnosis of Lung Cancer","publication_year":2014,"publication_date":"2014-12-18","ids":{"openalex":"https://openalex.org/W2137294173","doi":"https://doi.org/10.7314/apjcp.2014.15.22.9611","mag":"2137294173","pmid":"https://pubmed.ncbi.nlm.nih.gov/25520076"},"language":"en","primary_location":{"id":"doi:10.7314/apjcp.2014.15.22.9611","doi":"https://doi.org/10.7314/apjcp.2014.15.22.9611","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2014.15.22.9611","pdf_url":"http://koreascience.or.kr:80/article/JAKO201405458144820.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://koreascience.or.kr:80/article/JAKO201405458144820.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100382530","display_name":"Bing Wang","orcid":"https://orcid.org/0000-0002-9038-9878","observed_orcids":["https://orcid.org/0000-0002-9038-9878"]},"institutions":[{"id":"https://openalex.org/I4210118317","display_name":"81th Hospital of PLA","ror":"https://ror.org/02xxx6w64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118317"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Wang","raw_affiliation_strings":["Department of Clinical Lab, the 81th Hospital of PLA, Nanjing, China E-mail : mapleqh@126.com","Department of Clinical Lab, the 81th Hospital of PLA, Nanjing, China E-mail :"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Lab, the 81th Hospital of PLA, Nanjing, China E-mail : mapleqh@126.com","institution_ids":["https://openalex.org/I4210118317"]},{"raw_affiliation_string":"Department of Clinical Lab, the 81th Hospital of PLA, Nanjing, China E-mail :","institution_ids":["https://openalex.org/I4210118317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101786005","display_name":"Yujie He","orcid":"https://orcid.org/0000-0001-5740-8726","observed_orcids":["https://orcid.org/0000-0001-5740-8726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Jie He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077002457","display_name":"Ying-Xing Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying-Xing Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047765280","display_name":"Rui\u2010Ning Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui-Ning Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111943680","display_name":"Yuerong Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue-Rong Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Hong Qiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":2.7849,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.91781262,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"22","first_page":"9611","last_page":"9614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lung-cancer-diagnosis","display_name":"lung cancer diagnosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.8220000267028809},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cyfra-21-1","display_name":"CYFRA21-1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/combined-tumor-marker-detection","display_name":"combined tumor marker detection","score":0.7919999957084656},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8199999928474426},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/small-cell-carcinoma","display_name":"small cell carcinoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.8336406946182251},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7756882905960083},{"id":"https://openalex.org/C2781447364","wikidata":"https://www.wikidata.org/wiki/Q584992","display_name":"Tumor marker","level":3,"score":0.7210875153541565},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6765967011451721},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.6740511059761047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.665486752986908},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.651671826839447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48724785447120667},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.480114221572876},{"id":"https://openalex.org/C192638826","wikidata":"https://www.wikidata.org/wiki/Q908357","display_name":"Tumor M2-PK","level":4,"score":0.4667428135871887},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4380408823490143},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4324053227901459},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4315013885498047},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36866915225982666},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36260920763015747},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1978340446949005}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006242","descriptor_name":"Haptoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053539","descriptor_name":"Keratin-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7314/apjcp.2014.15.22.9611","doi":"https://doi.org/10.7314/apjcp.2014.15.22.9611","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2014.15.22.9611","pdf_url":"http://koreascience.or.kr:80/article/JAKO201405458144820.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmid:25520076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25520076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7314/apjcp.2014.15.22.9611","doi":"https://doi.org/10.7314/apjcp.2014.15.22.9611","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2014.15.22.9611","pdf_url":"http://koreascience.or.kr:80/article/JAKO201405458144820.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137294173.pdf","grobid_xml":"https://content.openalex.org/works/W2137294173.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1926159205","https://openalex.org/W1930514129","https://openalex.org/W1940357650","https://openalex.org/W1972889533","https://openalex.org/W1996201543","https://openalex.org/W1997159731","https://openalex.org/W2009494587","https://openalex.org/W2010341706","https://openalex.org/W2020851102","https://openalex.org/W2098682109","https://openalex.org/W2119412894","https://openalex.org/W2123030952","https://openalex.org/W2146124805","https://openalex.org/W2164939674","https://openalex.org/W2326665525"],"related_works":["https://openalex.org/W2347804992","https://openalex.org/W2389819788","https://openalex.org/W2385904647","https://openalex.org/W584413908","https://openalex.org/W2394254835","https://openalex.org/W2386794912","https://openalex.org/W2387676240","https://openalex.org/W2361668460","https://openalex.org/W2367640405","https://openalex.org/W2378285823"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"investigate":[2],"the":[3,29,82,158,174,178,195,253],"clinical":[4],"value":[5],"in":[6,51,94,213,220,257],"lung":[7,55,61,85,97,106,240,260],"cancer":[8,86,98],"of":[9,12,68,77,84,114,128,145,151,170,182,188,199,211,244,259],"a":[10,141,234],"combination":[11],"four":[13],"serum":[14,236],"tumor":[15,79,91,135,237],"markers,":[16],"haptoglobin":[17],"(Hp),":[18],"carcinoembryonic":[19],"antigen":[20],"(CEA),":[21],"neuron":[22],"specific":[23],"enolase":[24],"(NSE)":[25],"as":[26,28,233],"well":[27],"cytokeratin":[30],"19":[31],"fragment":[32],"(CYFRA21-1).":[33],"MATERIALS":[34],"AND":[35],"METHODS:":[36],"Serum":[37,90],"Hp":[38,163,212,229],"(with":[39,45],"immune-turbidimetric":[40],"method),":[41],"CEA,":[42,116,246],"NSE,":[43],"CYFRA21-1":[44,119,165,249],"chemiluminescence":[46],"method)":[47],"level":[48],"were":[49,70,87,99,120,166],"assessed":[50],"193":[52],"patients":[53,58,95],"with":[54,59,96,104,126,162],"cancer,":[56,261],"87":[57],"benign":[60,105],"disease":[62,107],"and":[63,74,108,118,124,132,164,223,248,255,262],"150":[64],"healthy":[65],"controls.":[66],"Differences":[67],"expression":[69],"compared":[71],"among":[72],"groups,":[73],"joint":[75],"effects":[76],"these":[78],"markers":[80,136],"for":[81,239,266],"diagnosis":[83,258],"analyzed.":[88],"RESULTS:":[89],"marker":[92,238],"levels":[93],"obviously":[100],"higher":[101,148,167,185,218],"than":[102,149,168,186,219],"those":[103],"normal":[109],"controls":[110],"(p<0.01).":[111],"The":[112,203],"sensitivities":[113],"Hp,":[115,245],"NSE":[117,200,247],"43.5%,":[121],"40.9%,":[122],"23.3%":[123],"41.5%,":[125],"specificities":[127],"90.7%,":[129],"99.2%,":[130],"97.9%":[131],"97.9%.":[133],"Four":[134],"combined":[137],"together":[138],"could":[139,250,263],"produce":[140],"positive":[142,159,179,196],"detection":[143,160,180,197,243],"rate":[144,181,198],"85.0%,":[146],"significantly":[147,251],"that":[150,169,187],"any":[152],"single":[153],"test.":[154],"With":[155],"squamous":[156,214],"carcinomas,":[157,194],"rates":[161],"other":[171,189],"markers.":[172,190],"In":[173],"adenocarcinoma":[175,221],"case":[176],",":[177],"CEA":[183],"was":[184,201,217],"For":[191],"small":[192,224],"cell":[193,225],"highest.":[202],"area":[204],"under":[205],"receiver":[206],"operating":[207],"characteristic":[208],"curve":[209],"(AUCROC)":[210],"carcinoma":[215,226],"(0.805)":[216],"(0.664)":[222],"(0.665).":[227],"CONCLUSIONS:":[228],"can":[230],"be":[231,264],"used":[232],"new":[235],"cancer.":[241],"Combination":[242],"improve":[252],"sensitivity":[254],"specificity":[256],"useful":[265],"pathological":[267],"typing.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}