{"id":"https://openalex.org/W21372174","doi":null,"title":"[Nosocomial candidemia: new challenges of an emergent problem].","display_name":"[Nosocomial candidemia: new challenges of an emergent problem].","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W21372174","mag":"21372174","pmid":"https://pubmed.ncbi.nlm.nih.gov/21191553"},"language":"es","primary_location":{"id":"pmid:21191553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21191553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110450209","display_name":"Joaqu\u00edn G\u00f3mez G\u00f3mez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J G\u00f3mez","raw_affiliation_strings":["Servicio de MI, Infecciosas,Hospital Universitario Virgen de la Arrixaca, Carretera Madrid-Cartagena sn, El Palmar, Murcia, Spain. joagomez@um.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de MI, Infecciosas,Hospital Universitario Virgen de la Arrixaca, Carretera Madrid-Cartagena sn, El Palmar, Murcia, Spain. joagomez@um.es","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111393694","display_name":"Elisa Garc\u00eda V\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Garc\u00eda-V\u00e1zquez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109005680","display_name":"A. Hern\u00e1ndez","orcid":"https://orcid.org/0009-0008-8477-624X","observed_orcids":["https://orcid.org/0009-0008-8477-624X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108649325","display_name":"C Espinosa","orcid":"https://orcid.org/0009-0002-3613-9672","observed_orcids":["https://orcid.org/0009-0002-3613-9672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Espinosa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017530243","display_name":"Jos\u00e9 Ruiz Pardo","orcid":"https://orcid.org/0000-0003-3805-6432","observed_orcids":["https://orcid.org/0000-0003-3805-6432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ruiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0458,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75375714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"23","issue":"4","first_page":"158","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candidemia","display_name":"candidemia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.6930000185966492},{"id":"https://openalex.org/keywords/non-albicans-candida","display_name":"non-albicans Candida","score":0.8450000286102295},{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":0.9760000109672546},{"id":"https://openalex.org/keywords/candida-krusei","display_name":"Candida krusei","score":0.9959999918937683},{"id":"https://openalex.org/keywords/candida-parapsilosis","display_name":"Candida parapsilosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.8059999942779541},{"id":"https://openalex.org/keywords/fluconazole-resistance","display_name":"fluconazole resistance","score":0.7400000095367432},{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":0.8429999947547913},{"id":"https://openalex.org/keywords/echinocandins","display_name":"echinocandins","score":0.8939999938011169},{"id":"https://openalex.org/keywords/empiric-antifungal-therapy","display_name":"empirical antifungal therapy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/central-venous-catheter-removal","display_name":"central venous catheter removal","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.375},{"id":"https://openalex.org/keywords/idsa-guidelines","display_name":"IDSA guidelines","score":0.5699999928474426},{"id":"https://openalex.org/keywords/neutropenic-patients","display_name":"neutropenic patients","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5013952255249023},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.4222319722175598},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.41259557008743286},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.38882017135620117},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.21770310401916504},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.03220176696777344}],"mesh":[{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025141","descriptor_name":"Drug Resistance, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21191553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21191553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","raw_type":"Journal Article"},{"id":"mag:21372174","doi":null,"is_oa":false,"landing_page_url":"https://seq.es/seq/0214-3429/23/4/gomez.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S976986303","display_name":"Revista espa\u00f1ola de quimioterapia. Suplemento","issn_l":"1130-331X","issn":["1130-331X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista espa\u00f1ola de quimioterapia. Suplemento","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3462169433","display_name":"A novel approach to cell adhesion/cytoskeleton research for exploring the epithelia cell system","funder_award_id":"19GS0313","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7670953379","display_name":"Functional analysis of nuclear envelope targeting plasma membrane Proteins : using EGF family proteins","funder_award_id":"21570196","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W45162501","https://openalex.org/W207096567","https://openalex.org/W1549507729","https://openalex.org/W1567535025","https://openalex.org/W1595367033","https://openalex.org/W1816216051","https://openalex.org/W1979683372","https://openalex.org/W1986506708","https://openalex.org/W2000115360","https://openalex.org/W2024731091","https://openalex.org/W2036793245","https://openalex.org/W2040139427","https://openalex.org/W2042181648","https://openalex.org/W2042566612","https://openalex.org/W2047659549","https://openalex.org/W2047682827","https://openalex.org/W2049489136","https://openalex.org/W2050427285","https://openalex.org/W2064056766","https://openalex.org/W2064665222","https://openalex.org/W2075254976","https://openalex.org/W2075899867","https://openalex.org/W2078654597","https://openalex.org/W2078788694","https://openalex.org/W2081823113","https://openalex.org/W2082335793","https://openalex.org/W2083121860","https://openalex.org/W2084008476","https://openalex.org/W2095153363","https://openalex.org/W2098156485","https://openalex.org/W2098731984","https://openalex.org/W2103519964","https://openalex.org/W2105896831","https://openalex.org/W2110563594","https://openalex.org/W2111240123","https://openalex.org/W2112605123","https://openalex.org/W2113287546","https://openalex.org/W2118236446","https://openalex.org/W2118489318","https://openalex.org/W2124679111","https://openalex.org/W2124847922","https://openalex.org/W2126147032","https://openalex.org/W2126319933","https://openalex.org/W2132582794","https://openalex.org/W2133328722","https://openalex.org/W2136218127","https://openalex.org/W2137575148","https://openalex.org/W2138433856","https://openalex.org/W2141563676","https://openalex.org/W2149606831","https://openalex.org/W2150428940","https://openalex.org/W2152667558","https://openalex.org/W2156803121","https://openalex.org/W2156902146","https://openalex.org/W2162221318","https://openalex.org/W2167143090","https://openalex.org/W2171665367"],"related_works":["https://openalex.org/W135574571","https://openalex.org/W49756577","https://openalex.org/W2119540955","https://openalex.org/W4200135795","https://openalex.org/W2884221847","https://openalex.org/W2196820144","https://openalex.org/W2095153363","https://openalex.org/W4311539997","https://openalex.org/W2397900245","https://openalex.org/W2315548682"],"abstract_inverted_index":{"Candida":[0],"spp.":[1,41],"are":[2,94],"currently":[3],"one":[4],"of":[5,10,29,35,38,67,90,108,130,165,169,185,189],"the":[6,16,33,64,71,91,95,126,162],"most":[7],"common":[8],"causes":[9],"bloodstream":[11],"infections":[12],"in":[13,114,167],"hospitals.":[14],"Over":[15],"last":[17],"two":[18],"decades":[19],"there":[20],"has":[21],"been":[22],"a":[23,26,159],"shift":[24],"towards":[25],"greater":[27],"involvement":[28],"non-Candida":[30],"albicans":[31],"as":[32,70,85,87,136],"cause":[34],"candidemia.":[36,121,191],"Several":[37],"these":[39,112],"non-albicans":[40],"(e.g.,":[42],"C.":[43,46,170],"glabrata":[44],"and":[45,55,81,119,151],"krusei)":[47],"exhibit":[48],"resistance":[49],"to":[50,99,105,148,180],"traditional":[51],"triazole":[52],"antifungals":[53,68],"(fluconazole),":[54],"cross-resistance":[56],"with":[57,116,145,158],"newer":[58],"triazoles":[59],"(voriconazole),":[60],"focusing":[61],"attention":[62],"on":[63],"first-line":[65],"use":[66],"such":[69],"echinocandins,":[72],"which":[73],"possess":[74],"improved":[75],"activity":[76],"against":[77],"fluconazole-resistant":[78],"strains.":[79],"Early":[80],"adequate":[82],"empirical":[83,109],"treatment":[84,110,123,184],"well":[86],"early":[88,182],"removing":[89],"central":[92],"catheters":[93],"main":[96],"factors":[97,118],"related":[98],"mortality;":[100],"thus":[101],"it":[102],"is":[103],"necessary":[104],"implement":[106],"guidelines":[107,124],"(including":[111],"aspects)":[113],"patients":[115,144,153,186],"risk":[117,155,188],"possible":[120],"Recent":[122],"from":[125],"Infectious":[127],"Diseases":[128],"Society":[129],"America":[131],"(IDSA)":[132],"recommend":[133],"an":[134,173],"echinocandin":[135],"primary":[137],"therapy":[138],"for":[139,152,156],"non":[140],"neutropenic":[141,143],"or":[142],"moderately":[146],"severe":[147,149],"candidiasis":[150],"at":[154,187],"infection":[157],"triazole-resistant":[160],"strain;":[161],"increasing":[163],"MIC":[164],"echinocandins":[166],"case":[168],"parapsilosisis":[171],"also":[172],"emerging":[174],"concern.":[175],"Clinicians":[176],"should":[177],"remain":[178],"vigilant":[179],"prescribe":[181],"empiric":[183],"having":[190]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}