{"id":"https://openalex.org/W2137197237","doi":"https://doi.org/10.2174/13816128113199990407","title":"Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence","display_name":"Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2137197237","doi":"https://doi.org/10.2174/13816128113199990407","mag":"2137197237","pmid":"https://pubmed.ncbi.nlm.nih.gov/23448440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3782695"},"language":"en","primary_location":{"id":"doi:10.2174/13816128113199990407","doi":"https://doi.org/10.2174/13816128113199990407","is_oa":false,"landing_page_url":"https://doi.org/10.2174/13816128113199990407","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3782695","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074269717","display_name":"Jo\u00e3o Tom\u00e9\u2010Carneiro","orcid":"https://orcid.org/0000-0002-3597-9234","observed_orcids":["https://orcid.org/0000-0002-3597-9234"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210103709","display_name":"Centro de Edafolog\u00eda y Biolog\u00eda Aplicada del Segura","ror":"https://ror.org/01fah6g03","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210103709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joao Tom\u00e9-Carneiro","raw_affiliation_strings":["Research Group of Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain. jcespin@cebas.csic.es","Research Group of Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group of Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain. jcespin@cebas.csic.es","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210103709"]},{"raw_affiliation_string":"Research Group of Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain","institution_ids":["https://openalex.org/I4210103709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018115091","display_name":"Mar Larrosa","orcid":"https://orcid.org/0000-0002-8863-4686","observed_orcids":["https://orcid.org/0000-0002-8863-4686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar Larrosa","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070481752","display_name":"Antonio Gonz\u00e1lez\u2010Sarr\u00edas","orcid":"https://orcid.org/0000-0002-3407-0678","observed_orcids":["https://orcid.org/0000-0002-3407-0678"]},"institutions":[{"id":"https://openalex.org/I4403928277","display_name":"Bentham Science Publishers (United Arab Emirates)","ror":"https://ror.org/01866ja76","country_code":"AE","type":"company","lineage":["https://openalex.org/I4403928277"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Antonio Gonz\u00e1lez-Sarr\u00edas","raw_affiliation_strings":[",0","Bentham Science Publishers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]},{"raw_affiliation_string":"Bentham Science Publishers","institution_ids":["https://openalex.org/I4403928277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022785318","display_name":"Francisco Abraham Tom\u00e1s-Barber\u00e1n","orcid":"https://orcid.org/0000-0002-0790-1739","observed_orcids":["https://orcid.org/0000-0002-0790-1739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco Tom\u00e1s-Barber\u00e1n","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027248909","display_name":"Mar\u00eda\u2010Teresa Garc\u00eda\u2010Conesa","orcid":"https://orcid.org/0000-0002-4125-853X","observed_orcids":["https://orcid.org/0000-0002-4125-853X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Garc\u00eda-Conesa","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080054754","display_name":"Juan Carlos Esp\u0131\u0301n","orcid":"https://orcid.org/0000-0002-1068-8692","observed_orcids":["https://orcid.org/0000-0002-1068-8692"]},"institutions":[{"id":"https://openalex.org/I4210103709","display_name":"Centro de Edafolog\u00eda y Biolog\u00eda Aplicada del Segura","ror":"https://ror.org/01fah6g03","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210103709"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan Esp\u00edn","raw_affiliation_strings":["Research Group of Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group of Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain.,Spain","institution_ids":["https://openalex.org/I4210103709"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080054754"],"corresponding_institution_ids":["https://openalex.org/I4210103709"],"apc_list":null,"apc_paid":null,"fwci":30.9097,"has_fulltext":false,"cited_by_count":467,"citation_normalized_percentile":{"value":0.99864315,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"19","issue":"34","first_page":"6064","last_page":"6093"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8759999871253967},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5590000152587891},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.6650000214576721},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9539999961853027},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/atherogenic-profile","display_name":"atherogenic profile","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9660000205039978},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":1.0},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.8859999775886536},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.3580000102519989},{"id":"https://openalex.org/keywords/red-wine","display_name":"red wine","score":0.6980000138282776},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.9517189264297485},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.6986335515975952},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.57093745470047},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5475469827651978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47463759779930115},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4699428677558899},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.45010799169540405},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2166220247745514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10743555426597595},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2174/13816128113199990407","doi":"https://doi.org/10.2174/13816128113199990407","is_oa":false,"landing_page_url":"https://doi.org/10.2174/13816128113199990407","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2772922","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3782695","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3782695","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3782695","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Pharm Des","raw_type":"Text"},{"id":"pmid:23448440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23448440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.872.3067","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.872.3067","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3782695%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/152150","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/152150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2772922","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3782695","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":325,"referenced_works":["https://openalex.org/W65269860","https://openalex.org/W154564172","https://openalex.org/W160922265","https://openalex.org/W184199012","https://openalex.org/W1481670920","https://openalex.org/W1498633852","https://openalex.org/W1511966243","https://openalex.org/W1522207988","https://openalex.org/W1526691072","https://openalex.org/W1538172273","https://openalex.org/W1548494899","https://openalex.org/W1571086446","https://openalex.org/W1606511543","https://openalex.org/W1731618434","https://openalex.org/W1909321451","https://openalex.org/W1925901205","https://openalex.org/W1964097221","https://openalex.org/W1964986597","https://openalex.org/W1965523204","https://openalex.org/W1965919582","https://openalex.org/W1966577891","https://openalex.org/W1967495700","https://openalex.org/W1969408132","https://openalex.org/W1969752278","https://openalex.org/W1970276547","https://openalex.org/W1970396523","https://openalex.org/W1971943164","https://openalex.org/W1972621206","https://openalex.org/W1972700281","https://openalex.org/W1973761281","https://openalex.org/W1974269714","https://openalex.org/W1974431794","https://openalex.org/W1975828757","https://openalex.org/W1977819886","https://openalex.org/W1978611438","https://openalex.org/W1978778821","https://openalex.org/W1978875327","https://openalex.org/W1979657807","https://openalex.org/W1980687166","https://openalex.org/W1981634237","https://openalex.org/W1982726639","https://openalex.org/W1983470498","https://openalex.org/W1983979341","https://openalex.org/W1984225039","https://openalex.org/W1985148856","https://openalex.org/W1985506214","https://openalex.org/W1986757653","https://openalex.org/W1987129577","https://openalex.org/W1988786880","https://openalex.org/W1989581783","https://openalex.org/W1989969820","https://openalex.org/W1990034595","https://openalex.org/W1990545720","https://openalex.org/W1990882347","https://openalex.org/W1991165055","https://openalex.org/W1992371392","https://openalex.org/W1993519646","https://openalex.org/W1994724398","https://openalex.org/W1996457804","https://openalex.org/W1996502167","https://openalex.org/W1996585783","https://openalex.org/W1996882516","https://openalex.org/W1998171278","https://openalex.org/W1998410775","https://openalex.org/W1998920288","https://openalex.org/W1999373749","https://openalex.org/W1999481655","https://openalex.org/W2000400362","https://openalex.org/W2000862243","https://openalex.org/W2000991417","https://openalex.org/W2000998536","https://openalex.org/W2001265042","https://openalex.org/W2002658591","https://openalex.org/W2003286160","https://openalex.org/W2003679920","https://openalex.org/W2005219606","https://openalex.org/W2005704233","https://openalex.org/W2006536349","https://openalex.org/W2007492343","https://openalex.org/W2007586888","https://openalex.org/W2007903566","https://openalex.org/W2010147545","https://openalex.org/W2010505710","https://openalex.org/W2012175434","https://openalex.org/W2013142897","https://openalex.org/W2016645610","https://openalex.org/W2016847030","https://openalex.org/W2017944964","https://openalex.org/W2018274913","https://openalex.org/W2019079558","https://openalex.org/W2019490742","https://openalex.org/W2019521754","https://openalex.org/W2020433921","https://openalex.org/W2020476652","https://openalex.org/W2020707728","https://openalex.org/W2021337133","https://openalex.org/W2022109431","https://openalex.org/W2022172419","https://openalex.org/W2022856465","https://openalex.org/W2023476241","https://openalex.org/W2024400555","https://openalex.org/W2024703353","https://openalex.org/W2024897628","https://openalex.org/W2025599495","https://openalex.org/W2026523078","https://openalex.org/W2026984649","https://openalex.org/W2027943537","https://openalex.org/W2028319504","https://openalex.org/W2028735844","https://openalex.org/W2028933526","https://openalex.org/W2029654654","https://openalex.org/W2031213396","https://openalex.org/W2031449777","https://openalex.org/W2031646169","https://openalex.org/W2033665108","https://openalex.org/W2034864293","https://openalex.org/W2035006578","https://openalex.org/W2036011023","https://openalex.org/W2037238246","https://openalex.org/W2037345578","https://openalex.org/W2037863187","https://openalex.org/W2038317187","https://openalex.org/W2039451247","https://openalex.org/W2039701298","https://openalex.org/W2040160147","https://openalex.org/W2040580331","https://openalex.org/W2040695610","https://openalex.org/W2041284941","https://openalex.org/W2041490167","https://openalex.org/W2041579457","https://openalex.org/W2041586952","https://openalex.org/W2043243971","https://openalex.org/W2044067781","https://openalex.org/W2045670568","https://openalex.org/W2045697440","https://openalex.org/W2046178358","https://openalex.org/W2046452636","https://openalex.org/W2048138223","https://openalex.org/W2048227382","https://openalex.org/W2048837202","https://openalex.org/W2049816300","https://openalex.org/W2049990134","https://openalex.org/W2050110236","https://openalex.org/W2050306133","https://openalex.org/W2050625990","https://openalex.org/W2050720508","https://openalex.org/W2050837407","https://openalex.org/W2051303822","https://openalex.org/W2051990086","https://openalex.org/W2052266208","https://openalex.org/W2053083199","https://openalex.org/W2053462924","https://openalex.org/W2053545242","https://openalex.org/W2054003772","https://openalex.org/W2055228213","https://openalex.org/W2057164724","https://openalex.org/W2057355419","https://openalex.org/W2059498912","https://openalex.org/W2060240527","https://openalex.org/W2060814375","https://openalex.org/W2062269191","https://openalex.org/W2062372651","https://openalex.org/W2062747831","https://openalex.org/W2064079175","https://openalex.org/W2064357607","https://openalex.org/W2064607195","https://openalex.org/W2066492523","https://openalex.org/W2068033649","https://openalex.org/W2068383276","https://openalex.org/W2069175454","https://openalex.org/W2070124969","https://openalex.org/W2070586971","https://openalex.org/W2070815033","https://openalex.org/W2070830478","https://openalex.org/W2071228656","https://openalex.org/W2071706440","https://openalex.org/W2072873673","https://openalex.org/W2072995534","https://openalex.org/W2073487625","https://openalex.org/W2074297759","https://openalex.org/W2074318214","https://openalex.org/W2074916731","https://openalex.org/W2074974899","https://openalex.org/W2074997140","https://openalex.org/W2075028389","https://openalex.org/W2076720853","https://openalex.org/W2078575160","https://openalex.org/W2079102359","https://openalex.org/W2079354947","https://openalex.org/W2080644780","https://openalex.org/W2082454497","https://openalex.org/W2082709188","https://openalex.org/W2084560940","https://openalex.org/W2084603699","https://openalex.org/W2085567788","https://openalex.org/W2085572455","https://openalex.org/W2088355928","https://openalex.org/W2088381487","https://openalex.org/W2088934129","https://openalex.org/W2089363473","https://openalex.org/W2089633892","https://openalex.org/W2089802889","https://openalex.org/W2090234441","https://openalex.org/W2091484442","https://openalex.org/W2091640850","https://openalex.org/W2092114539","https://openalex.org/W2092187231","https://openalex.org/W2096715073","https://openalex.org/W2096913256","https://openalex.org/W2097681801","https://openalex.org/W2097950928","https://openalex.org/W2098448061","https://openalex.org/W2099862699","https://openalex.org/W2099947030","https://openalex.org/W2100327177","https://openalex.org/W2101669302","https://openalex.org/W2101676131","https://openalex.org/W2102470188","https://openalex.org/W2102946509","https://openalex.org/W2103037064","https://openalex.org/W2103196111","https://openalex.org/W2103425923","https://openalex.org/W2104158890","https://openalex.org/W2104525350","https://openalex.org/W2104999225","https://openalex.org/W2105234557","https://openalex.org/W2106032666","https://openalex.org/W2106125934","https://openalex.org/W2110385920","https://openalex.org/W2111092938","https://openalex.org/W2111274588","https://openalex.org/W2111442478","https://openalex.org/W2111822142","https://openalex.org/W2111950527","https://openalex.org/W2112277318","https://openalex.org/W2112708877","https://openalex.org/W2114605941","https://openalex.org/W2114738050","https://openalex.org/W2114845975","https://openalex.org/W2114968425","https://openalex.org/W2115658663","https://openalex.org/W2116468636","https://openalex.org/W2117499294","https://openalex.org/W2117759551","https://openalex.org/W2117859871","https://openalex.org/W2119898601","https://openalex.org/W2120007830","https://openalex.org/W2120061094","https://openalex.org/W2123383348","https://openalex.org/W2123511852","https://openalex.org/W2124062217","https://openalex.org/W2124603426","https://openalex.org/W2124604057","https://openalex.org/W2125114619","https://openalex.org/W2125121177","https://openalex.org/W2125659422","https://openalex.org/W2127089149","https://openalex.org/W2127218748","https://openalex.org/W2127775273","https://openalex.org/W2127860658","https://openalex.org/W2128126753","https://openalex.org/W2128425403","https://openalex.org/W2129761592","https://openalex.org/W2129795601","https://openalex.org/W2131385716","https://openalex.org/W2132539868","https://openalex.org/W2132833611","https://openalex.org/W2133897047","https://openalex.org/W2134181109","https://openalex.org/W2135801831","https://openalex.org/W2136478232","https://openalex.org/W2136830554","https://openalex.org/W2137232154","https://openalex.org/W2138134399","https://openalex.org/W2141018935","https://openalex.org/W2141228362","https://openalex.org/W2142272708","https://openalex.org/W2143017085","https://openalex.org/W2143685079","https://openalex.org/W2143706492","https://openalex.org/W2144224364","https://openalex.org/W2144367247","https://openalex.org/W2144600435","https://openalex.org/W2144618543","https://openalex.org/W2144770293","https://openalex.org/W2146350175","https://openalex.org/W2148078723","https://openalex.org/W2148588414","https://openalex.org/W2150783039","https://openalex.org/W2151089147","https://openalex.org/W2152036317","https://openalex.org/W2152791120","https://openalex.org/W2153059926","https://openalex.org/W2154587590","https://openalex.org/W2154870817","https://openalex.org/W2154949516","https://openalex.org/W2155590575","https://openalex.org/W2155939414","https://openalex.org/W2156090275","https://openalex.org/W2156849286","https://openalex.org/W2157108841","https://openalex.org/W2158518544","https://openalex.org/W2158735110","https://openalex.org/W2158902191","https://openalex.org/W2159245434","https://openalex.org/W2160532649","https://openalex.org/W2162118340","https://openalex.org/W2162931896","https://openalex.org/W2163667551","https://openalex.org/W2164620829","https://openalex.org/W2165722123","https://openalex.org/W2166566484","https://openalex.org/W2167985455","https://openalex.org/W2170667061","https://openalex.org/W2171178744","https://openalex.org/W2223295563","https://openalex.org/W2277636392","https://openalex.org/W2297204985","https://openalex.org/W2323170397","https://openalex.org/W2325766772","https://openalex.org/W2328229204","https://openalex.org/W2337341934","https://openalex.org/W2338264314","https://openalex.org/W2404578968","https://openalex.org/W4294309179"],"related_works":["https://openalex.org/W7096667137","https://openalex.org/W2031213396","https://openalex.org/W4390672306","https://openalex.org/W3102019461","https://openalex.org/W2314216502","https://openalex.org/W1986877767","https://openalex.org/W1983245123","https://openalex.org/W2952610681","https://openalex.org/W2011040305","https://openalex.org/W1481670920"],"abstract_inverted_index":{"Resveratrol":[0,22],"(3,5,4'-trihydroxy-trans-stilbene)":[1],"is":[2,107,177,208,233,304],"a":[3,11,28,65,124,209,294,307,312],"non-flavonoid":[4],"polyphenol":[5],"that":[6,185,236,303],"may":[7],"be":[8,187],"present":[9],"in":[10,43,64,69,101,144,175,195,214,267],"limited":[12],"number":[13,165],"of":[14,30,37,52,68,98,114,166,171,244,262],"foodstuffs":[15],"such":[16],"as":[17],"grapes":[18],"and":[19,41,71,139,169,251],"red":[20],"wine.":[21],"has":[23,62,226],"been":[24,118,229],"reported":[25],"to":[26,127,162,189,311],"exert":[27],"plethora":[29],"health":[31],"benefits":[32,100,168,240],"through":[33,103,241],"many":[34,53,80,183],"different":[35],"mechanisms":[36,170],"action.":[38],"This":[39,270],"versatility":[40],"presence":[42],"the":[44,49,57,88,96,164,216,223,242,275],"human":[45],"diet":[46],"have":[47,117,160],"drawn":[48],"worldwide":[50],"attention":[51],"research":[54,299],"groups":[55],"over":[56,87],"past":[58],"twenty":[59],"years,":[60],"which":[61,215],"resulted":[63],"huge":[66],"output":[67],"vitro":[70,145],"animal":[72],"(preclinical)":[73],"studies.":[74],"In":[75,94,289],"line":[76],"with":[77,90,123,133,149],"this":[78,301],"expectation,":[79],"resveratrol-":[81],"based":[82],"nutraceuticals":[83],"are":[84,182],"consumed":[85],"all":[86,156],"world":[89],"questionable":[91,125],"clinical/scientific":[92],"support.":[93],"fact,":[95],"confirmation":[97,174],"these":[99,157],"humans":[102,176,283],"randomized":[104,286],"clinical":[105,287],"trials":[106],"still":[108],"very":[109,178],"limited.":[110,179],"The":[111,198],"vast":[112],"majority":[113],"preclinical":[115],"studies":[116,159],"performed":[119],"using":[120],"assay":[121],"conditions":[122],"extrapolation":[126],"humans,":[128],"i.e.":[129],"too":[130],"high":[131,206,263],"concentrations":[132],"potential":[134],"safety":[135,255],"concerns":[136,256],"(adverse":[137],"effects":[138,225,281],"drug":[140],"interactions),":[141],"short-term":[142],"exposures,":[143],"tests":[146],"carried":[147],"out":[148],"non-physiological":[150],"metabolites":[151],"and/or":[152],"concentrations,":[153],"etc.":[154],"Unfortunately,":[155],"hypothesis-generating":[158],"contributed":[161],"increased":[163],"'potential'":[167],"resveratrol":[172,196,237],"but":[173,205],"Therefore,":[180],"there":[181],"issues":[184],"should":[186],"addressed":[188],"avoid":[190],"an":[191],"apparent":[192],"endless":[193],"loop":[194],"research.":[197],"so-called":[199],"'Resveratrol":[200],"Paradox',":[201],"i.e.,":[202],"low":[203],"bioavailability":[204],"bioactivity,":[207],"conundrum":[210],"not":[211,227],"yet":[212,228],"solved":[213],"final":[217],"responsible":[218],"actor":[219],"(if":[220],"any)":[221],"for":[222,297],"exerted":[224],"unequivocally":[230],"identified.":[231],"It":[232],"becoming":[234],"evident":[235],"exerts":[238],"cardioprotective":[239],"improvement":[243],"inflammatory":[245],"markers,":[246],"atherogenic":[247],"profile,":[248],"glucose":[249],"metabolism":[250],"endothelial":[252],"function.":[253],"However,":[254],"remain":[257],"unsolved":[258],"regarding":[259,279],"chronic":[260],"consumption":[261],"RES":[264],"doses,":[265],"specially":[266],"medicated":[268],"people.":[269],"review":[271],"will":[272,292],"focus":[273],"on":[274,282,300],"currently":[276],"available":[277],"evidence":[278],"resveratrol's":[280],"obtained":[284],"from":[285,306],"trials.":[288],"addition,":[290],"we":[291],"provide":[293],"critical":[295],"outlook":[296],"further":[298],"molecule":[302],"evolving":[305],"minor":[308],"dietary":[309],"compound":[310],"possible":[313],"multi-target":[314],"therapeutic":[315],"drug.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":37},{"year":2019,"cited_by_count":49},{"year":2018,"cited_by_count":50},{"year":2017,"cited_by_count":52},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":46},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}