{"id":"https://openalex.org/W2137168556","doi":"https://doi.org/10.1093/hmg/ddq511","title":"Collagen-related genes influence the glaucoma risk factor, central corneal thickness","display_name":"Collagen-related genes influence the glaucoma risk factor, central corneal thickness","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W2137168556","doi":"https://doi.org/10.1093/hmg/ddq511","mag":"2137168556","pmid":"https://pubmed.ncbi.nlm.nih.gov/21098505"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddq511","doi":"https://doi.org/10.1093/hmg/ddq511","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddq511","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085332370","display_name":"Eranga N. Vithana","orcid":"https://orcid.org/0000-0002-8898-0095","observed_orcids":["https://orcid.org/0000-0002-8898-0095"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Eranga N. Vithana","raw_affiliation_strings":["Singapore Eye Research Institute, Singapore. eranga.n.v@seri.com.sg","Department of Ophthalmology,","Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, Singapore. eranga.n.v@seri.com.sg","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Department of Ophthalmology,","institution_ids":[]},{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022464374","display_name":"Tin Aung","orcid":"https://orcid.org/0000-0002-7916-0589","observed_orcids":["https://orcid.org/0000-0002-7916-0589","https://orcid.org/0000-0002-4187-0788"]},"institutions":[{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Tin Aung","raw_affiliation_strings":["Department of Ophthalmology,","Singapore Eye Research Institute and","Singapore National Eye Centre, Singapore, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology,","institution_ids":[]},{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore National Eye Centre, Singapore, Singapore,","institution_ids":["https://openalex.org/I2799299286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080847227","display_name":"Chiea Chuen Khor","orcid":"https://orcid.org/0000-0002-1128-4729","observed_orcids":["https://orcid.org/0000-0002-1128-4729"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chiea Chuen Khor","raw_affiliation_strings":["Infectious Diseases, Genome Institute of Singapore, A*STAR, Singapore, Singapore,","NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Genome Institute of Singapore, A*STAR, Singapore, Singapore,","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I66068411"]},{"raw_affiliation_string":"NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076336397","display_name":"Belinda K. Cornes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Belinda K. Cornes","raw_affiliation_strings":["Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051282203","display_name":"Wan-Ting Tay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wan-Ting Tay","raw_affiliation_strings":["Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008481316","display_name":"Xueling Sim","orcid":"https://orcid.org/0000-0002-1233-7642","observed_orcids":["https://orcid.org/0000-0002-1233-7642"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xueling Sim","raw_affiliation_strings":["NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034635319","display_name":"Raghavan Lavanya","orcid":"https://orcid.org/0000-0003-2854-6526","observed_orcids":["https://orcid.org/0000-0003-2854-6526"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Raghavan Lavanya","raw_affiliation_strings":["Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075162983","display_name":"Renyi Wu","orcid":"https://orcid.org/0000-0002-5945-0124","observed_orcids":["https://orcid.org/0000-0002-5945-0124"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Renyi Wu","raw_affiliation_strings":["Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021782904","display_name":"Yingfeng Zheng","orcid":"https://orcid.org/0000-0002-0914-7864","observed_orcids":["https://orcid.org/0000-0002-0914-7864"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yingfeng Zheng","raw_affiliation_strings":["Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002784988","display_name":"Martin Lloyd Hibberd","orcid":"https://orcid.org/0000-0001-8587-1849","observed_orcids":["https://orcid.org/0000-0001-8587-1849"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Martin L. Hibberd","raw_affiliation_strings":["Infectious Diseases, Genome Institute of Singapore, A*STAR, Singapore, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Genome Institute of Singapore, A*STAR, Singapore, Singapore,","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075708255","display_name":"Kee Seng Chia","orcid":"https://orcid.org/0000-0002-0629-5570","observed_orcids":["https://orcid.org/0000-0002-0629-5570"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kee Seng Chia","raw_affiliation_strings":["Department of Epidemiology and Public Health and","NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Public Health and","institution_ids":[]},{"raw_affiliation_string":"NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074117254","display_name":"Mark T. Seielstad","orcid":"https://orcid.org/0000-0001-5783-1401","observed_orcids":["https://orcid.org/0000-0001-5783-1401"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Seielstad","raw_affiliation_strings":["Department of Laboratory Medicine, Institute for Human Genetics, University of California, San Francisco, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Institute for Human Genetics, University of California, San Francisco, USA,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110388572","display_name":"Liang Kee Goh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Liang Kee Goh","raw_affiliation_strings":["Duke-NUS Graduate Medical School, Singapore, Singapore and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke-NUS Graduate Medical School, Singapore, Singapore and","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064124202","display_name":"Seang\u2010Mei Saw","orcid":"https://orcid.org/0000-0001-7166-796X","observed_orcids":["https://orcid.org/0000-0001-7166-796X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Seang-Mei Saw","raw_affiliation_strings":["Department of Epidemiology and Public Health and","Department of Ophthalmology,","NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,","Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Public Health and","institution_ids":[]},{"raw_affiliation_string":"Department of Ophthalmology,","institution_ids":[]},{"raw_affiliation_string":"NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049068947","display_name":"E Shyong Tai","orcid":"https://orcid.org/0000-0003-2929-8966","observed_orcids":["https://orcid.org/0000-0003-2929-8966"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"E. Shyong Tai","raw_affiliation_strings":["Department of Epidemiology and Public Health and","Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore,","NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Public Health and","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore,","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"NUS-GIS Center for Molecular Epidemiology, Singapore, Singapore,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072258594","display_name":"Tien Yin Wong","orcid":"https://orcid.org/0000-0002-8448-1264","observed_orcids":["https://orcid.org/0000-0002-8448-1264"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105949","display_name":"Centre for Eye Research Australia","ror":"https://ror.org/01sqdef20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210105949"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["AU","SG"],"is_corresponding":false,"raw_author_name":"Tien Y. Wong","raw_affiliation_strings":["Centre for Eye Research Australia, University of Melbourne, Victoria, Australia","Department of Epidemiology and Public Health and","Department of Ophthalmology,","Singapore Eye Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Eye Research Australia, University of Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105949"]},{"raw_affiliation_string":"Department of Epidemiology and Public Health and","institution_ids":[]},{"raw_affiliation_string":"Department of Ophthalmology,","institution_ids":[]},{"raw_affiliation_string":"Singapore Eye Research Institute and","institution_ids":["https://openalex.org/I4210116917"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5085332370"],"corresponding_institution_ids":["https://openalex.org/I4210116917"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.0233,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.88408851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"20","issue":"4","first_page":"649","last_page":"658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.35249999165534973,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-corneal-thickness","display_name":"central corneal thickness","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8460000157356262},{"id":"https://openalex.org/keywords/collagen-genes","display_name":"collagen genes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/col8a2","display_name":"COL8A2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/col5a1","display_name":"COL5A1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/retinoid-x-receptor-alpha","display_name":"retinoid X receptor alpha","score":0.781000018119812},{"id":"https://openalex.org/keywords/znf469","display_name":"ZNF469","score":0.9890000224113464},{"id":"https://openalex.org/keywords/brittle-cornea-syndrome","display_name":"brittle cornea syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5630000233650208},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.7329999804496765},{"id":"https://openalex.org/keywords/singapore","display_name":"Singapore","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8584698438644409},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7248640060424805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5009217262268066},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4952808916568756},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4344298839569092},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3821972906589508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1669594943523407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08245259523391724},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008296","descriptor_name":"Malaysia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012846","descriptor_name":"Singapore","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024102","descriptor_name":"Collagen Type VIII","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/hmg/ddq511","doi":"https://doi.org/10.1093/hmg/ddq511","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddq511","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:21098505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21098505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/108305","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/108305","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W17268869","https://openalex.org/W52053813","https://openalex.org/W93966645","https://openalex.org/W1514409988","https://openalex.org/W1602611466","https://openalex.org/W1604876728","https://openalex.org/W1812952512","https://openalex.org/W1969761972","https://openalex.org/W1972027633","https://openalex.org/W1981821954","https://openalex.org/W1983880505","https://openalex.org/W1989399186","https://openalex.org/W1992210537","https://openalex.org/W1995954566","https://openalex.org/W2005304369","https://openalex.org/W2013748019","https://openalex.org/W2015593839","https://openalex.org/W2016750941","https://openalex.org/W2021047349","https://openalex.org/W2030831433","https://openalex.org/W2037056548","https://openalex.org/W2043389398","https://openalex.org/W2048738817","https://openalex.org/W2053404076","https://openalex.org/W2054750812","https://openalex.org/W2055577456","https://openalex.org/W2057266151","https://openalex.org/W2059436289","https://openalex.org/W2062598900","https://openalex.org/W2077037485","https://openalex.org/W2078528120","https://openalex.org/W2079819761","https://openalex.org/W2091151219","https://openalex.org/W2093952772","https://openalex.org/W2100298873","https://openalex.org/W2106433994","https://openalex.org/W2108986293","https://openalex.org/W2120711134","https://openalex.org/W2136084577","https://openalex.org/W2136188592","https://openalex.org/W2141713414","https://openalex.org/W2142642125","https://openalex.org/W2143156606","https://openalex.org/W2149791927","https://openalex.org/W2151292542","https://openalex.org/W2157752701","https://openalex.org/W2160479367","https://openalex.org/W2161526538","https://openalex.org/W2161633633","https://openalex.org/W2162530578","https://openalex.org/W2168889968","https://openalex.org/W2328081052","https://openalex.org/W6636257454"],"related_works":["https://openalex.org/W2023849652","https://openalex.org/W2100298873","https://openalex.org/W7099704402","https://openalex.org/W7096247342","https://openalex.org/W2059436289","https://openalex.org/W2126377392","https://openalex.org/W1986387103","https://openalex.org/W3035510112","https://openalex.org/W1983880505","https://openalex.org/W17268869"],"abstract_inverted_index":{"Central":[0],"corneal":[1],"thickness":[2],"(CCT)":[3],"is":[4],"a":[5,103],"risk":[6],"factor":[7],"of":[8,14,20,47,90,102,128,179,189],"glaucoma,":[9,41],"the":[10,26,33,36,45,100,131,177,187],"most":[11],"common":[12],"cause":[13],"irreversible":[15],"blindness":[16],"worldwide.":[17],"The":[18],"identification":[19],"genetic":[21,76],"determinants":[22],"affecting":[23],"CCT":[24,39,57,81,108,183],"in":[25,58,66],"normal":[27],"population":[28],"will":[29],"provide":[30],"insights":[31],"into":[32],"mechanisms":[34],"underlying":[35],"association":[37,54,129],"between":[38],"and":[40,70,73,109,120,184],"as":[42,44],"well":[43],"pathogenesis":[46,188],"glaucoma":[48],"itself.":[49],"We":[50,98],"conducted":[51],"two":[52,63],"genome-wide":[53,135],"studies":[55],"for":[56,107,134],"5080":[59],"individuals":[60],"drawn":[61],"from":[62,148],"ethnic":[64],"populations":[65],"Singapore":[67],"(2538":[68],"Indian":[69],"2542":[71],"Malays)":[72],"identified":[74],"novel":[75],"loci":[77],"significantly":[78],"associated":[79],"with":[80,160],"(COL8A2":[82],"rs96067,":[83],"p(meta)":[84,93],"=":[85,94,116,123,152,155,170],"5.40":[86],"\u00d7":[87,96,118,125,172],"10\u207b\u00b9\u00b3,":[88],"interval":[89],"RXRA-COL5A1":[91],"rs1536478,":[92],"3.05":[95],"10\u207b\u2079).":[97,173],"confirmed":[99],"involvement":[101,178],"previously":[104],"reported":[105],"gene":[106],"brittle":[110],"cornea":[111],"syndrome":[112],"(ZNF469)":[113],"[rs9938149":[114],"(p(meta)":[115,122],"1.63":[117],"10\u207b\u00b9\u2076)":[119],"rs12447690":[121],"1.92":[124],"10\u207b\u00b9\u2074)].":[126],"Evidence":[127],"exceeding":[130],"formal":[132],"threshold":[133],"significance":[136],"was":[137],"observed":[138],"at":[139],"rs7044529,":[140],"an":[141,165],"SNP":[142],"located":[143],"within":[144],"COL5A1":[145],"when":[146],"data":[147,163],"this":[149],"study":[150],"(n":[151],"5080,":[153],"P":[154],"0.0012)":[156],"were":[157],"considered":[158],"together":[159],"all":[161],"published":[162],"(reflecting":[164],"additional":[166],"7349":[167],"individuals,":[168],"p(Fisher)":[169],"1.5":[171],"These":[174],"findings":[175],"implicate":[176],"collagen":[180],"genes":[181],"influencing":[182],"thus,":[185],"possibly":[186],"glaucoma.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
