{"id":"https://openalex.org/W2137144192","doi":"https://doi.org/10.1074/mcp.m110.002931","title":"Increased Selectivity, Analytical Precision, and Throughput in Targeted Proteomics","display_name":"Increased Selectivity, Analytical Precision, and Throughput in Targeted Proteomics","publication_year":2010,"publication_date":"2010-07-27","ids":{"openalex":"https://openalex.org/W2137144192","doi":"https://doi.org/10.1074/mcp.m110.002931","mag":"2137144192","pmid":"https://pubmed.ncbi.nlm.nih.gov/20664071","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3033677"},"language":"en","primary_location":{"id":"doi:10.1074/mcp.m110.002931","doi":"https://doi.org/10.1074/mcp.m110.002931","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m110.002931","pdf_url":"http://www.mcponline.org/article/S1535947620327845/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.mcponline.org/article/S1535947620327845/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071748194","display_name":"Reiko Kiyonami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reiko Kiyonami","raw_affiliation_strings":["ThermoFisher Scientific, San Jose, California 95134, USA","ThermoFisher Scientific, San Jose, California 95134"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ThermoFisher Scientific, San Jose, California 95134, USA","institution_ids":[]},{"raw_affiliation_string":"ThermoFisher Scientific, San Jose, California 95134","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065560634","display_name":"Alan E. Schoen","orcid":"https://orcid.org/0009-0002-3652-1089","observed_orcids":["https://orcid.org/0009-0002-3652-1089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Schoen","raw_affiliation_strings":["ThermoFisher Scientific, San Jose, California 95134"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ThermoFisher Scientific, San Jose, California 95134","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078204276","display_name":"Amol Prakash","orcid":"https://orcid.org/0000-0002-3997-6487","observed_orcids":["https://orcid.org/0000-0002-3997-6487"]},"institutions":[{"id":"https://openalex.org/I4210142480","display_name":"Thermo Fisher Scientific (United States)","ror":"https://ror.org/03x1ewr52","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142480"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amol Prakash","raw_affiliation_strings":["ThermoFisher Scientific Biomarker Research Initiative in Mass Spectrometry, Cambridge, Massachusetts 02139-4648"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ThermoFisher Scientific Biomarker Research Initiative in Mass Spectrometry, Cambridge, Massachusetts 02139-4648","institution_ids":["https://openalex.org/I4210142480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023989691","display_name":"Scott M. Peterman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Peterman","raw_affiliation_strings":["ThermoFisher Scientific, San Jose, California 95134"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ThermoFisher Scientific, San Jose, California 95134","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062806768","display_name":"Vlad Zabrouskov","orcid":"https://orcid.org/0000-0003-3567-9407","observed_orcids":["https://orcid.org/0000-0003-3567-9407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vlad Zabrouskov","raw_affiliation_strings":["ThermoFisher Scientific, San Jose, California 95134"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ThermoFisher Scientific, San Jose, California 95134","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084914720","display_name":"Paola Picotti","orcid":"https://orcid.org/0000-0002-4109-3552","observed_orcids":["https://orcid.org/0000-0002-4109-3552","https://orcid.org/0000-0003-1012-9994"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255907","display_name":"Institute for Molecular Systems Biology","ror":"https://ror.org/03j5gm982","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255907"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paola Picotti","raw_affiliation_strings":["Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule (ETH), CH-8093 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule (ETH), CH-8093 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053361384","display_name":"Ruedi H. Aebersold","orcid":"https://orcid.org/0000-0002-9576-3267","observed_orcids":["https://orcid.org/0000-0002-9576-3267","https://orcid.org/0000-0003-0827-3495"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255907","display_name":"Institute for Molecular Systems Biology","ror":"https://ror.org/03j5gm982","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255907"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ruedi Aebersold","raw_affiliation_strings":["Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule (ETH), CH-8093 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule (ETH), CH-8093 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027465075","display_name":"Andreas F. R. H\u00fchmer","orcid":"https://orcid.org/0009-0006-0825-9166","observed_orcids":["https://orcid.org/0009-0006-0825-9166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Huhmer","raw_affiliation_strings":["ThermoFisher Scientific, San Jose, California 95134"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ThermoFisher Scientific, San Jose, California 95134","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026064194","display_name":"Bruno Domon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255907","display_name":"Institute for Molecular Systems Biology","ror":"https://ror.org/03j5gm982","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255907"]},{"id":"https://openalex.org/I4405259354","display_name":"Centre de Recherche Public de la Sant\u00e9","ror":"https://ror.org/02485re30","country_code":"LU","type":"nonprofit","lineage":["https://openalex.org/I4210101141","https://openalex.org/I4405259354"]}],"countries":["CH","LU"],"is_corresponding":true,"raw_author_name":"Bruno Domon","raw_affiliation_strings":["Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule (ETH), CH-8093 Zurich, Switzerland","Luxembourg Clinical Proteomics Initiative, Centre de Recherche Public (CRP)-Sante, L-1445 Strassen, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Systems Biology, Eidgen\u00f6ssische Technische Hochschule (ETH), CH-8093 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]},{"raw_affiliation_string":"Luxembourg Clinical Proteomics Initiative, Centre de Recherche Public (CRP)-Sante, L-1445 Strassen, Luxembourg","institution_ids":["https://openalex.org/I4405259354"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026064194"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907","https://openalex.org/I4405259354"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":10.2598,"has_fulltext":true,"cited_by_count":189,"citation_normalized_percentile":{"value":0.99414836,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"10","issue":"2","first_page":"S1","last_page":"S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/targeted-proteomics","display_name":"targeted proteomics","score":0.9800000190734863},{"id":"https://openalex.org/keywords/multiple-reaction-monitoring","display_name":"multiple reaction monitoring","score":0.9950000047683716},{"id":"https://openalex.org/keywords/data-dependent-acquisition","display_name":"data-dependent acquisition","score":0.6140000224113464},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.6970000267028809},{"id":"https://openalex.org/keywords/peptide-identification","display_name":"peptide identification","score":0.4569999873638153},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.7490000128746033},{"id":"https://openalex.org/keywords/throughput","display_name":"throughput","score":0.453000009059906},{"id":"https://openalex.org/keywords/yeast-lysate","display_name":"yeast lysate","score":0.6209999918937683},{"id":"https://openalex.org/keywords/triple-quadrupole","display_name":"triple quadrupole","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6006235480308533},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5494579076766968},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5259823203086853},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5171353220939636},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5045918226242065},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5013189315795898},{"id":"https://openalex.org/C172493649","wikidata":"https://www.wikidata.org/wiki/Q7843529","display_name":"Triple quadrupole mass spectrometer","level":5,"score":0.4975915253162384},{"id":"https://openalex.org/C71043704","wikidata":"https://www.wikidata.org/wiki/Q17144692","display_name":"Selected reaction monitoring","level":4,"score":0.49502819776535034},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4602559804916382},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.45880308747291565},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4241114854812622},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.418077290058136},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.37882280349731445},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.35889267921447754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10372447967529297},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10234507918357849},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/mcp.m110.002931","doi":"https://doi.org/10.1074/mcp.m110.002931","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m110.002931","pdf_url":"http://www.mcponline.org/article/S1535947620327845/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},{"id":"pmid:20664071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20664071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & cellular proteomics : MCP","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3033677","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3033677/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Proteomics","raw_type":"Text"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/29975","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/29975","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics, 10 (2)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-c-000029975","doi":"https://doi.org/10.3929/ethz-c-000029975","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-c-000029975","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1074/mcp.m110.002931","doi":"https://doi.org/10.1074/mcp.m110.002931","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m110.002931","pdf_url":"http://www.mcponline.org/article/S1535947620327845/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137144192.pdf","grobid_xml":"https://content.openalex.org/works/W2137144192.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1965017740","https://openalex.org/W1974500649","https://openalex.org/W2007070415","https://openalex.org/W2013947447","https://openalex.org/W2023096047","https://openalex.org/W2031095666","https://openalex.org/W2035037428","https://openalex.org/W2037837681","https://openalex.org/W2049727081","https://openalex.org/W2054887015","https://openalex.org/W2056467018","https://openalex.org/W2065353443","https://openalex.org/W2068481474","https://openalex.org/W2085630110","https://openalex.org/W2113766156","https://openalex.org/W2117365920","https://openalex.org/W2124940471","https://openalex.org/W2126869418","https://openalex.org/W2133258252"],"related_works":["https://openalex.org/W2337184773","https://openalex.org/W2111865342","https://openalex.org/W7099477326","https://openalex.org/W2225308512","https://openalex.org/W4403887838","https://openalex.org/W6946116207","https://openalex.org/W2105167594","https://openalex.org/W1988049110","https://openalex.org/W2155298453","https://openalex.org/W2055254611"],"abstract_inverted_index":{"Proteomics":[0],"is":[1,69,76,98,121],"gradually":[2],"complementing":[3],"large":[4,217],"shotgun":[5],"qualitative":[6],"studies":[7],"with":[8],"hypothesis-driven":[9],"quantitative":[10],"experiments.":[11],"Targeted":[12],"analyses":[13],"performed":[14,77],"on":[15],"triple":[16],"quadrupole":[17],"instruments":[18],"in":[19,71,78,123,195],"selected":[20,73],"reaction":[21,74],"monitoring":[22,75],"mode":[23],"are":[24,140],"characterized":[25],"by":[26],"a":[27,61,102,114,124,134,167,179,190,204],"high":[28],"degree":[29],"of":[30,35,41,48,51,88,95,116,153,166,174,181,186],"selectivity":[31,56],"and":[32,84,189,213],"low":[33],"limit":[34,180],"detection;":[36],"however,":[37],"the":[38,46,86,89,130,151,154,163,172,175],"concurrent":[39],"analysis":[40],"multiple":[42],"analytes":[43],"occurs":[44],"at":[45],"expense":[47],"sensitivity":[49],"because":[50],"reduced":[52],"dwell":[53],"time":[54,105],"and/or":[55],"due":[57],"to":[58,60,81,107,118,142,148,161,170,184],"limitation":[59],"few":[62],"transitions.":[63],"A":[64,92],"new":[65],"data":[66,211,214],"acquisition":[67],"paradigm":[68],"presented":[70],"which":[72],"two":[79],"ways":[80],"simultaneously":[82],"quantify":[83,109],"confirm":[85,150],"identity":[87,152],"targeted":[90,155],"peptides.":[91,156],"first":[93],"set":[94,115],"primary":[96,131],"transitions":[97,120,132,139,194],"continuously":[99],"monitored":[100],"during":[101],"predetermined":[103],"elution":[104],"window":[106],"precisely":[108],"each":[110],"peptide.":[111],"In":[112],"addition,":[113],"six":[117],"eight":[119],"acquired":[122],"data-dependent":[125],"event,":[126],"triggered":[127],"when":[128],"all":[129],"exceed":[133],"preset":[135],"threshold.":[136],"These":[137],"additional":[138],"used":[141],"generate":[143],"composite":[144],"tandem":[145],"mass":[146],"spectra":[147],"formally":[149],"This":[157],"technique":[158,200],"was":[159,201],"applied":[160],"analyze":[162],"tryptic":[164],"digest":[165],"yeast":[168],"lysate":[169],"demonstrate":[171],"performance":[173],"technique.":[176],"We":[177],"showed":[178],"detection":[182],"down":[183],"tens":[185],"attomoles":[187],"injected":[188],"throughput":[191],"exceeding":[192],"6000":[193],"one":[196],"60-min":[197],"experiment.":[198],"The":[199],"integrated":[202],"into":[203],"linear":[205],"work":[206],"flow,":[207],"including":[208],"experimental":[209],"design,":[210],"acquisition,":[212],"evaluation,":[215],"enabling":[216],"scale":[218],"proteomic":[219],"studies.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}