{"id":"https://openalex.org/W2137123783","doi":"https://doi.org/10.1186/gb-2004-5-10-r76","title":"A scale of functional divergence for yeast duplicated genes revealed from analysis of the protein-protein interaction network","display_name":"A scale of functional divergence for yeast duplicated genes revealed from analysis of the protein-protein interaction network","publication_year":2004,"publication_date":"2004-09-15","ids":{"openalex":"https://openalex.org/W2137123783","doi":"https://doi.org/10.1186/gb-2004-5-10-r76","mag":"2137123783","pmid":"https://pubmed.ncbi.nlm.nih.gov/15461795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/545596"},"language":"en","primary_location":{"id":"doi:10.1186/gb-2004-5-10-r76","doi":"https://doi.org/10.1186/gb-2004-5-10-r76","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2004-5-10-r76","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2004-5-10-r76","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2004-5-10-r76","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082003101","display_name":"Ana\u0131\u0308s Baudot","orcid":"https://orcid.org/0000-0003-0885-7933","observed_orcids":["https://orcid.org/0000-0003-0885-7933"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ana\u00efs Baudot","raw_affiliation_strings":["Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France. baudot@ibdm.univ-mrs.fr","Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France. baudot@ibdm.univ-mrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210120427"]},{"raw_affiliation_string":"Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105413680","display_name":"Bernard Jacq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Jacq","raw_affiliation_strings":["Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288, Marseille Cedex 9, France","Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Marseille Cedex 9, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288, Marseille Cedex 9, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210120427"]},{"raw_affiliation_string":"Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Marseille Cedex 9, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210120427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060161630","display_name":"Christine Brun","orcid":"https://orcid.org/0000-0002-5563-6765","observed_orcids":["https://orcid.org/0000-0002-5563-6765"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Christine Brun","raw_affiliation_strings":["Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288, Marseille Cedex 9, France","CNRS-INSERM-Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, IBDM, CNRS INSERM Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy, Case 907, 13288, Marseille Cedex 9, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210120427"]},{"raw_affiliation_string":"CNRS-INSERM-Universit\u00e9 de la M\u00e9diterran\u00e9e, Parc Scientifique de Luminy","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060161630"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210120427"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":1.1712,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.74706188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"10","first_page":"R76","last_page":"R76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.9169999957084656},{"id":"https://openalex.org/keywords/functional-divergence","display_name":"functional divergence","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7519999742507935},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8610000014305115},{"id":"https://openalex.org/keywords/whole-genome-doubling","display_name":"whole-genome duplication","score":0.9710000157356262},{"id":"https://openalex.org/keywords/protein-function-classification","display_name":"protein function classification","score":0.7609999775886536},{"id":"https://openalex.org/keywords/functional-evolution","display_name":"functional evolution","score":0.7110000252723694},{"id":"https://openalex.org/keywords/gene-function-conservation","display_name":"gene function conservation","score":0.49900001287460327},{"id":"https://openalex.org/keywords/gene-ontology-annotation","display_name":"gene ontology annotation","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.6293186545372009},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6246911287307739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6020225286483765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5847885608673096},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.5604029893875122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49524250626564026},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.47779518365859985},{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.43697112798690796},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.42092591524124146},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4058476686477661},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3535086512565613},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.1334993541240692},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0968661904335022},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0935857892036438},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020131","descriptor_name":"Genes, Duplicate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/gb-2004-5-10-r76","doi":"https://doi.org/10.1186/gb-2004-5-10-r76","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2004-5-10-r76","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2004-5-10-r76","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:103596","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC545596","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:545596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/545596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmid:15461795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15461795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.285.1063","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.285.1063","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3b/35/Genome_Biol_2004_Sep_15_5(10)_R76.tar.gz","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00311016v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00311016","pdf_url":null,"source":{"id":"https://openalex.org/S4406922393","display_name":"HAL AMU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, 2004, 5, pp.R76","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/gb-2004-5-10-r76","doi":"https://doi.org/10.1186/gb-2004-5-10-r76","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2004-5-10-r76","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2004-5-10-r76","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137123783.pdf","grobid_xml":"https://content.openalex.org/works/W2137123783.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W78816759","https://openalex.org/W1486817521","https://openalex.org/W1497994697","https://openalex.org/W1550202981","https://openalex.org/W1617947194","https://openalex.org/W1641544182","https://openalex.org/W1750603985","https://openalex.org/W1815753558","https://openalex.org/W1847593574","https://openalex.org/W1849896953","https://openalex.org/W1956694423","https://openalex.org/W1965941177","https://openalex.org/W1968482168","https://openalex.org/W1980041175","https://openalex.org/W1996835973","https://openalex.org/W2011986160","https://openalex.org/W2017651048","https://openalex.org/W2019591778","https://openalex.org/W2021142940","https://openalex.org/W2029158589","https://openalex.org/W2040282448","https://openalex.org/W2040880974","https://openalex.org/W2056433290","https://openalex.org/W2081933515","https://openalex.org/W2082143788","https://openalex.org/W2094780854","https://openalex.org/W2101220662","https://openalex.org/W2103017472","https://openalex.org/W2106013076","https://openalex.org/W2107817133","https://openalex.org/W2132518731","https://openalex.org/W2135123683","https://openalex.org/W2137786672","https://openalex.org/W2152075687","https://openalex.org/W2169074268","https://openalex.org/W4230428902","https://openalex.org/W4236956086","https://openalex.org/W4244421882"],"related_works":["https://openalex.org/W7095812746","https://openalex.org/W4244421882","https://openalex.org/W7095849841","https://openalex.org/W2303957209","https://openalex.org/W2096246686","https://openalex.org/W2151144604","https://openalex.org/W2167680767","https://openalex.org/W2007148892","https://openalex.org/W2008383476","https://openalex.org/W7098802496"],"abstract_inverted_index":{"BACKGROUND:":[0],"Studying":[1],"the":[2,5,15,30,55,63,81,97,119,130,151,163,176,210,218],"evolution":[3,57,212],"of":[4,7,14,17,24,34,50,58,80,90,102,148,197,213,221],"function":[6,33,52,223],"duplicated":[8,59,98,115,125,152,214],"genes":[9,35,60,215],"usually":[10],"implies":[11],"an":[12,103],"estimation":[13],"extent":[16],"functional":[18,56,78,146,164,181,211],"conservation/divergence":[19,149],"between":[20],"duplicates":[21],"from":[22,109],"comparison":[23,89],"actual":[25],"sequences.":[26],"This":[27],"only":[28],"reveals":[29,180],"possible":[31],"molecular":[32],"without":[36],"taking":[37],"into":[38,45],"account":[39],"their":[40,69,135],"cellular":[41],"function(s).":[42],"We":[43,122],"took":[44],"consideration":[46],"this":[47],"latter":[48],"dimension":[49],"gene":[51],"to":[53,134,143,162,208],"approach":[54],"by":[61,167,187],"analyzing":[62],"protein-protein":[64,228],"interaction":[65,156,177],"network":[66,178],"in":[67,129,195],"which":[68,183],"products":[70],"are":[71,184],"involved.":[72],"For":[73],"this,":[74],"we":[75,112,173,191],"derived":[76],"a":[77,85,145,205],"classification":[79,131],"proteins":[82],"using":[83],"PRODISTIN,":[84],"bioinformatics":[86],"method":[87],"allowing":[88],"protein":[91,116,222],"function.":[92],"Our":[93,201],"work":[94],"focused":[95],"on":[96,155,227],"yeast":[99],"genes,":[100,153],"remnants":[101],"ancient":[104],"whole-genome":[105],"duplication.":[106],"RESULTS:":[107],"Starting":[108],"4,143":[110],"interactions,":[111],"analyzed":[113],"41":[114],"pairs":[117,126],"with":[118,132],"PRODISTIN":[120],"method.":[121],"showed":[123,174],"that":[124,175],"behaved":[127],"differently":[128],"respect":[133],"interactors.":[136],"The":[137],"different":[138],"observed":[139],"behaviors":[140],"allowed":[141],"us":[142],"propose":[144],"scale":[147],"for":[150],"based":[154,226],"data.":[157],"By":[158],"comparing":[159],"our":[160,193],"results":[161,194],"information":[165],"carried":[166],"GO":[168],"annotations":[169],"and":[170,216],"sequence":[171],"comparisons,":[172],"analysis":[179,202],"subtleties,":[182],"not":[185],"discernible":[186],"other":[188],"means.":[189],"Finally,":[190],"interpreted":[192],"terms":[196],"evolutionary":[198,224],"scenarios.":[199],"CONCLUSIONS:":[200],"might":[203],"provide":[204],"new":[206],"way":[207],"analyse":[209],"constitutes":[217],"first":[219],"attempt":[220],"comparisons":[225],"interactions.":[229]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}