{"id":"https://openalex.org/W2137059930","doi":"https://doi.org/10.1105/tpc.108.061879","title":"Multiple Mechanism\u2013Mediated Retention of a Defective Brassinosteroid Receptor in the Endoplasmic Reticulum of Arabidopsis","display_name":"Multiple Mechanism\u2013Mediated Retention of a Defective Brassinosteroid Receptor in the Endoplasmic Reticulum of Arabidopsis","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W2137059930","doi":"https://doi.org/10.1105/tpc.108.061879","mag":"2137059930","pmid":"https://pubmed.ncbi.nlm.nih.gov/19060110","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630446"},"language":"en","primary_location":{"id":"doi:10.1105/tpc.108.061879","doi":"https://doi.org/10.1105/tpc.108.061879","is_oa":false,"landing_page_url":"https://doi.org/10.1105/tpc.108.061879","pdf_url":null,"source":{"id":"https://openalex.org/S48849333","display_name":"The Plant Cell","issn_l":"1040-4651","issn":["1040-4651","1532-298X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630446","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhi Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi Hong","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089521694","display_name":"Hua Jin","orcid":"https://orcid.org/0000-0001-5478-4611","observed_orcids":["https://orcid.org/0000-0001-5478-4611"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Jin","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006209736","display_name":"Tzvi Tzfira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzvi Tzfira","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100386442","display_name":"Jianming Li","orcid":"https://orcid.org/0000-0003-3231-0778","observed_orcids":["https://orcid.org/0000-0003-3231-0778","https://orcid.org/0000-0002-1915-2659"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianming Li","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4934,"currency":"USD","value_usd":4934},"apc_paid":null,"fwci":4.3767,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.95407306,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"20","issue":"12","first_page":"3418","last_page":"3429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/brassinosteroid-receptor","display_name":"brassinosteroid receptor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/calnexin","display_name":"calnexin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/binding-proteins","display_name":"binding proteins","score":0.6840000152587891},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.6769999861717224},{"id":"https://openalex.org/keywords/proteasome-independent-degradation","display_name":"proteasome-independent degradation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8619999885559082},{"id":"https://openalex.org/keywords/protein-retention","display_name":"protein retention","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.902866005897522},{"id":"https://openalex.org/C130361206","wikidata":"https://www.wikidata.org/wiki/Q908443","display_name":"Calnexin","level":4,"score":0.9008448123931885},{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.8707118034362793},{"id":"https://openalex.org/C2778778573","wikidata":"https://www.wikidata.org/wiki/Q421976","display_name":"Brassinosteroid","level":5,"score":0.8004133701324463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.760800838470459},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.7245319485664368},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6010324954986572},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.5614010095596313},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4830808937549591},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.46891316771507263},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.44893041253089905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2788413166999817},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10272911190986633}],"mesh":[{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037281","descriptor_name":"Calnexin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1105/tpc.108.061879","doi":"https://doi.org/10.1105/tpc.108.061879","is_oa":false,"landing_page_url":"https://doi.org/10.1105/tpc.108.061879","pdf_url":null,"source":{"id":"https://openalex.org/S48849333","display_name":"The Plant Cell","issn_l":"1040-4651","issn":["1040-4651","1532-298X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2630446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630446","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell","raw_type":"Text"},{"id":"pmid:19060110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19060110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2630446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2630446","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.6735000014305115,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7960143107","display_name":"Molecular Genetic Studies of Plant Steroid Signaling","funder_award_id":"R01GM060519","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332140","display_name":"Arizona Biomedical Research Commission","ror":"https://ror.org/01smpj292"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W200640938","https://openalex.org/W1565824301","https://openalex.org/W1569627963","https://openalex.org/W1620028706","https://openalex.org/W1745204207","https://openalex.org/W1964606590","https://openalex.org/W1967517791","https://openalex.org/W1971195114","https://openalex.org/W1978014671","https://openalex.org/W1978179863","https://openalex.org/W1992395246","https://openalex.org/W1992563874","https://openalex.org/W1994207647","https://openalex.org/W1998292202","https://openalex.org/W2000319181","https://openalex.org/W2000350495","https://openalex.org/W2006690805","https://openalex.org/W2008849865","https://openalex.org/W2010127283","https://openalex.org/W2021268189","https://openalex.org/W2023397454","https://openalex.org/W2023692919","https://openalex.org/W2023849539","https://openalex.org/W2026357888","https://openalex.org/W2028629349","https://openalex.org/W2028903821","https://openalex.org/W2029237063","https://openalex.org/W2031391689","https://openalex.org/W2033191061","https://openalex.org/W2035171866","https://openalex.org/W2040666005","https://openalex.org/W2041749209","https://openalex.org/W2043825401","https://openalex.org/W2044564213","https://openalex.org/W2046407819","https://openalex.org/W2051129188","https://openalex.org/W2059744667","https://openalex.org/W2061619931","https://openalex.org/W2073223481","https://openalex.org/W2075491039","https://openalex.org/W2078530966","https://openalex.org/W2078895980","https://openalex.org/W2087111038","https://openalex.org/W2097435739","https://openalex.org/W2098115340","https://openalex.org/W2098428749","https://openalex.org/W2098941202","https://openalex.org/W2100474316","https://openalex.org/W2105393355","https://openalex.org/W2106488895","https://openalex.org/W2106778710","https://openalex.org/W2106982848","https://openalex.org/W2113835577","https://openalex.org/W2115019415","https://openalex.org/W2116122104","https://openalex.org/W2116466301","https://openalex.org/W2119482976","https://openalex.org/W2121474812","https://openalex.org/W2129992480","https://openalex.org/W2131931976","https://openalex.org/W2135513925","https://openalex.org/W2141474312","https://openalex.org/W2141970640","https://openalex.org/W2147776651","https://openalex.org/W2156541025","https://openalex.org/W2156571174","https://openalex.org/W2159116474","https://openalex.org/W2160756310","https://openalex.org/W2161577497","https://openalex.org/W2168195126","https://openalex.org/W2171838717","https://openalex.org/W2286262771","https://openalex.org/W4300702414"],"related_works":["https://openalex.org/W915607665","https://openalex.org/W2002580292","https://openalex.org/W2899770670","https://openalex.org/W2107278263","https://openalex.org/W2730134734","https://openalex.org/W2000284905","https://openalex.org/W1968912868","https://openalex.org/W2075520229","https://openalex.org/W1969571467","https://openalex.org/W7128860867"],"abstract_inverted_index":{"Endoplasmic":[0],"reticulum-mediated":[1],"quality":[2,24,133],"control":[3,25],"(ERQC)":[4],"is":[5,30,47,77,145],"a":[6,37,44,80,155],"well-studied":[7],"process":[8],"in":[9,49,87,136,154],"yeast":[10],"and":[11,15,72,76,126],"mammals":[12],"that":[13,36,42,64],"retains":[14],"disposes":[16],"misfolded/unassembled":[17],"polypeptides.":[18],"By":[19,107],"contrast,":[20,108],"how":[21],"plants":[22],"exert":[23],"over":[26],"their":[27],"secretory":[28],"proteins":[29],"less":[31],"clear.":[32],"Here,":[33],"we":[34],"report":[35],"mutated":[38],"brassinosteroid":[39],"receptor,":[40],"bri1-5,":[41,111],"carries":[43],"Cys69Tyr":[45],"mutation,":[46],"retained":[48],"the":[50,90,97,100,140],"ER":[51,69],"by":[52,79],"an":[53,114,146],"overvigilant":[54],"ERQC":[55,103],"system":[56],"involving":[57],"three":[58],"different":[59],"retention":[60],"mechanisms.":[61],"We":[62],"demonstrate":[63],"bri1-5":[65,105,141,144],"interacts":[66],"with":[67,113],"two":[68],"chaperones,":[70],"calnexin":[71],"binding":[73],"protein":[74,149],"(BiP),":[75],"degraded":[78],"proteasome-independent":[81],"endoplasmic":[82],"reticulum-associated":[83],"degradation":[84],"(ERAD).":[85],"Mutations":[86],"components":[88],"of":[89,99,110,124,139],"calnexin/calreticulin":[91],"cycle":[92],"had":[93],"little":[94],"effect":[95],"on":[96],"fidelity":[98],"Arabidopsis":[101],"thaliana":[102],"for":[104],"retention.":[106],"overexpression":[109],"treatment":[112],"ERAD":[115],"inhibitor,":[116],"RNA":[117],"interference-mediated":[118],"BiP":[119],"silencing,":[120],"or":[121],"simultaneous":[122],"mutations":[123],"Cys-69":[125],"its":[127],"partner":[128],"Cys-62":[129],"can":[130],"mitigate":[131],"this":[132],"control,":[134],"resulting":[135],"significant":[137],"suppression":[138],"phenotype.":[142],"Thus,":[143],"excellent":[147],"model":[148,156],"to":[150],"investigate":[151],"plant":[152],"ERQC/ERAD":[153],"organism.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
