{"id":"https://openalex.org/W2136994899","doi":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","title":"Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice","display_name":"Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W2136994899","doi":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","mag":"2136994899","pmid":"https://pubmed.ncbi.nlm.nih.gov/21091850"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2516.2010.02397.x","doi":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2516.2010.02397.x","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2516.2010.02397.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035623733","display_name":"Mohammad Qadura","orcid":"https://orcid.org/0000-0003-0893-9920","observed_orcids":["https://orcid.org/0000-0003-0893-9920"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. QADURA","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111943229","display_name":"Braden Waters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. WATERS","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087122197","display_name":"Erin Burnett","orcid":"https://orcid.org/0000-0002-5361-3631","observed_orcids":["https://orcid.org/0000-0002-5361-3631"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"E. BURNETT","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059191079","display_name":"Rouzbeh Chegeni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. CHEGENI","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008809031","display_name":"Christine A. Hough","orcid":"https://orcid.org/0000-0001-5663-4801","observed_orcids":["https://orcid.org/0000-0001-5663-4801"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. HOUGH","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015421254","display_name":"Maha Othman","orcid":"https://orcid.org/0000-0001-7562-203X","observed_orcids":["https://orcid.org/0000-0001-7562-203X"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. OTHMAN","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061703162","display_name":"David Lillicrap","orcid":"https://orcid.org/0000-0003-2410-6312","observed_orcids":["https://orcid.org/0000-0003-2410-6312"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"D. LILLICRAP","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen\u2019s University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology & Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061703162"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":1.3738,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.81601662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"2","first_page":"288","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9829999804496765},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.6039999723434448},{"id":"https://openalex.org/keywords/anti-factor-viii-antibodies","display_name":"anti-factor VIII antibodies","score":0.8429999947547913},{"id":"https://openalex.org/keywords/factor-viii-inhibitors","display_name":"factor VIII inhibitors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antibody-isotypes","display_name":"antibody isotypes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/igg-subclasses","display_name":"IgG subclasses","score":0.671999990940094},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.5820000171661377},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9409999847412109},{"id":"https://openalex.org/keywords/genetic-strain-differences","display_name":"genetic strain differences","score":0.8009999990463257},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8640000224113464},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-and-secondary-immune-response","display_name":"primary and secondary immune response","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cytokine-microenvironment","display_name":"cytokine microenvironment","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7128496170043945},{"id":"https://openalex.org/C2777232031","wikidata":"https://www.wikidata.org/wiki/Q2092064","display_name":"Haemophilia A","level":3,"score":0.6911436319351196},{"id":"https://openalex.org/C2776529007","wikidata":"https://www.wikidata.org/wiki/Q9820","display_name":"BALB/c","level":3,"score":0.6028934121131897},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5469380617141724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.517466127872467},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5004556179046631},{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.47617048025131226},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.45166802406311035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4376016855239868},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3874295949935913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23881933093070984},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019774","descriptor_name":"Blood Coagulation Factor Inhibitors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2516.2010.02397.x","doi":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2516.2010.02397.x","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},{"id":"pmid:21091850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21091850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia : the official journal of the World Federation of Hemophilia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2516.2010.02397.x","doi":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2516.2010.02397.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2516.2010.02397.x","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3365076421","display_name":null,"funder_award_id":"MOP10912","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136994899.pdf","grobid_xml":"https://content.openalex.org/works/W2136994899.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1535156928","https://openalex.org/W1556987335","https://openalex.org/W1615447620","https://openalex.org/W1929136736","https://openalex.org/W1964975805","https://openalex.org/W1976302929","https://openalex.org/W2003230234","https://openalex.org/W2006359291","https://openalex.org/W2040816526","https://openalex.org/W2057863801","https://openalex.org/W2087685677","https://openalex.org/W2088251038","https://openalex.org/W2092415751","https://openalex.org/W2112982398","https://openalex.org/W2128653791","https://openalex.org/W2132127523","https://openalex.org/W2148267426","https://openalex.org/W2150613126","https://openalex.org/W2157530588","https://openalex.org/W2163175900","https://openalex.org/W2163449096","https://openalex.org/W2166141110","https://openalex.org/W2171211031","https://openalex.org/W2225119179","https://openalex.org/W2243590771","https://openalex.org/W2413723832","https://openalex.org/W2417891395","https://openalex.org/W2566878621","https://openalex.org/W6731261165"],"related_works":["https://openalex.org/W2410247943","https://openalex.org/W2983912791","https://openalex.org/W4249609309","https://openalex.org/W2551888988","https://openalex.org/W2576993890","https://openalex.org/W69001209","https://openalex.org/W4280573922","https://openalex.org/W157872429","https://openalex.org/W2056676912","https://openalex.org/W2117902695"],"abstract_inverted_index":{"Previous":[0],"studies":[1,196],"have":[2],"demonstrated":[3],"that":[4,179,198,213],"genetic":[5,231],"factors":[6],"play":[7],"an":[8],"important":[9],"role":[10],"in":[11,22,29,47,68,111,134,155,166,222,241],"determining":[12],"the":[13,31,38,107,119,125,159,180,191,214],"likelihood":[14],"of":[15,17,33,171,175,244],"formation":[16,36],"anti-factor":[18],"VIII":[19],"(FVIII)":[20],"antibodies":[21,73,115,131],"haemophilia":[23,52,63,245],"A":[24,53,64],"patients.":[25],"We":[26,211],"were":[27,66,77,89,102,132,153,164],"interested":[28],"characterizing":[30],"spectrum":[32],"FVIII":[34,45,72,75,96,109,127,207],"antibody":[35],"and":[37,40,57,60,74,81,86,93,121,144,161,187,217],"primary":[39],"secondary":[41],"immune":[42,204],"responses":[43],"after":[44,106],"administration":[46],"two":[48],"different":[49],"exon":[50],"16-disrupted":[51],"mouse":[54,136,242],"strains,":[55],"Balb/c":[56,59,138,193,209],"C57BL/6.":[58],"C57BL/6":[61,145,167,182,199,223],"E16":[62],"mice":[65,183,200,224],"used":[67],"all":[69],"experiments.":[70],"Total":[71],"inhibitors":[76,101],"measured":[78],"using":[79,91],"ELISA":[80,92],"Bethesda":[82],"assays":[83],"respectively.":[84],"T-":[85],"B-cell":[87],"cytokines":[88,189],"quantified":[90],"flow":[94],"cytometry.":[95],"antibodies,":[97],"but":[98,158],"not":[99],"functional":[100],"detectable":[103],"1":[104],"week":[105],"first":[108],"treatment":[110],"both":[112,135,156],"strains.":[113],"These":[114,195],"mainly":[116],"belonged":[117],"to":[118],"IgM":[120],"IgA":[122],"isotypes.":[123],"After":[124],"fourth":[126],"treatment,":[128],"neutralizing":[129],"anti-FVIII":[130],"detected":[133],"strains:":[137],"(mean":[139,146],"inhibitory":[140,147],"titer":[141,148],"58":[142],"BU)":[143],"82":[149],"BU).":[150],"IgG1":[151],"levels":[152],"similar":[154],"strains":[157],"IgG2A":[160],"IgG2B":[162],"subclasses":[163],"higher":[165],"mice.":[168,194,210],"The":[169],"results":[170],"intracellular":[172],"cytokine":[173,219],"staining":[174],"T":[176],"cells":[177],"indicated":[178],"FVIII-treated":[181,192],"produced":[184],"more":[185],"IL10":[186,218],"Th1":[188,216],"than":[190,208],"show":[197],"develop":[201],"a":[202],"stronger":[203],"response":[205],"towards":[206],"propose":[212],"enhanced":[215],"micro-environment":[220],"induced":[221],"is":[225],"responsible":[226],"for":[227],"this":[228],"difference.":[229],"Therefore,":[230],"strain-dependent":[232],"differences":[233],"must":[234],"be":[235],"considered":[236],"when":[237],"evaluating":[238],"immunological":[239],"outcomes":[240],"models":[243],"A.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}