{"id":"https://openalex.org/W2136994151","doi":"https://doi.org/10.1002/jms.3298","title":"Specificity enhancement by electrospray ionization multistage mass spectrometry \u2013 a valuable tool for differentiation and identification of \u2018V\u2019\u2010type chemical warfare agents","display_name":"Specificity enhancement by electrospray ionization multistage mass spectrometry \u2013 a valuable tool for differentiation and identification of \u2018V\u2019\u2010type chemical warfare agents","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2136994151","doi":"https://doi.org/10.1002/jms.3298","mag":"2136994151","pmid":"https://pubmed.ncbi.nlm.nih.gov/24338889"},"language":"en","primary_location":{"id":"doi:10.1002/jms.3298","doi":"https://doi.org/10.1002/jms.3298","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jms.3298","pdf_url":null,"source":{"id":"https://openalex.org/S37349105","display_name":"Journal of Mass Spectrometry","issn_l":"1076-5174","issn":["1076-5174","1096-9888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061006203","display_name":"Avi Weissberg","orcid":"https://orcid.org/0000-0002-1398-5246","observed_orcids":["https://orcid.org/0000-0002-1398-5246"]},"institutions":[{"id":"https://openalex.org/I104146711","display_name":"Israel Institute for Biological Research","ror":"https://ror.org/05atez085","country_code":"IL","type":"facility","lineage":["https://openalex.org/I104146711"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Avi Weissberg","raw_affiliation_strings":["Analytical Chemistry Department Israel Institute for Biological Research (IIBR) P.O.B. 19 Ness-Ziona Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department Israel Institute for Biological Research (IIBR) P.O.B. 19 Ness-Ziona Israel","institution_ids":["https://openalex.org/I104146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013970335","display_name":"Nitzan Tzanani","orcid":"https://orcid.org/0009-0004-5708-2374","observed_orcids":["https://orcid.org/0009-0004-5708-2374"]},"institutions":[{"id":"https://openalex.org/I104146711","display_name":"Israel Institute for Biological Research","ror":"https://ror.org/05atez085","country_code":"IL","type":"facility","lineage":["https://openalex.org/I104146711"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nitzan Tzanani","raw_affiliation_strings":["Analytical Chemistry Department Israel Institute for Biological Research (IIBR) P.O.B. 19 Ness-Ziona Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department Israel Institute for Biological Research (IIBR) P.O.B. 19 Ness-Ziona Israel","institution_ids":["https://openalex.org/I104146711"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shai Dagan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104146711","display_name":"Israel Institute for Biological Research","ror":"https://ror.org/05atez085","country_code":"IL","type":"facility","lineage":["https://openalex.org/I104146711"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shai Dagan","raw_affiliation_strings":["Analytical Chemistry Department Israel Institute for Biological Research (IIBR) P.O.B. 19 Ness-Ziona Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Chemistry Department Israel Institute for Biological Research (IIBR) P.O.B. 19 Ness-Ziona Israel","institution_ids":["https://openalex.org/I104146711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061006203"],"corresponding_institution_ids":["https://openalex.org/I104146711"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.7483,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.6613373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"48","issue":"12","first_page":"1340","last_page":"1348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vx","display_name":"VX","score":0.5419999957084656},{"id":"https://openalex.org/keywords/structural-isomers","display_name":"structural isomers","score":0.7929999828338623},{"id":"https://openalex.org/keywords/fragmentation-pathways","display_name":"fragmentation pathways","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9461808204650879},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.70722895860672},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6392961144447327},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.5992785692214966},{"id":"https://openalex.org/C194451485","wikidata":"https://www.wikidata.org/wiki/Q1327575","display_name":"Electrospray","level":3,"score":0.5728424787521362},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.49793314933776855},{"id":"https://openalex.org/C51884965","wikidata":"https://www.wikidata.org/wiki/Q471254","display_name":"Chemical ionization","level":4,"score":0.47389617562294006},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.3886585831642151},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.3620096743106842},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3617936074733734},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24833300709724426},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002619","descriptor_name":"Chemical Warfare Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002619","descriptor_name":"Chemical Warfare Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009946","descriptor_name":"Organothiophosphorus Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009946","descriptor_name":"Organothiophosphorus Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jms.3298","doi":"https://doi.org/10.1002/jms.3298","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jms.3298","pdf_url":null,"source":{"id":"https://openalex.org/S37349105","display_name":"Journal of Mass Spectrometry","issn_l":"1076-5174","issn":["1076-5174","1096-9888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:24338889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24338889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of mass spectrometry : JMS","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.5}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1854436188","https://openalex.org/W1910602216","https://openalex.org/W1970853696","https://openalex.org/W1977313074","https://openalex.org/W1990350964","https://openalex.org/W2003353773","https://openalex.org/W2007994699","https://openalex.org/W2012821461","https://openalex.org/W2015312262","https://openalex.org/W2025910293","https://openalex.org/W2026429638","https://openalex.org/W2042261881","https://openalex.org/W2061736512","https://openalex.org/W2064723006","https://openalex.org/W2073232987","https://openalex.org/W2078676624","https://openalex.org/W2078976567","https://openalex.org/W2105851824","https://openalex.org/W2130580741","https://openalex.org/W2159660198","https://openalex.org/W2170083749","https://openalex.org/W2334391019"],"related_works":["https://openalex.org/W3211185388","https://openalex.org/W3041488728","https://openalex.org/W2953804091","https://openalex.org/W2032521716","https://openalex.org/W4283828106","https://openalex.org/W1973964777","https://openalex.org/W2119568728","https://openalex.org/W2080676659","https://openalex.org/W1985490102","https://openalex.org/W2159660198"],"abstract_inverted_index":{"The":[0,236],"use":[1],"of":[2,10,14,20,36,41,80,86,144,149,170,195,201,217,223,225,228],"chemical":[3,25,151],"warfare":[4,152],"agents":[5,153,251],"has":[6],"become":[7],"an":[8],"issue":[9],"emerging":[11],"concern.":[12],"One":[13],"the":[15,21,49,57,78,81,129,140,171,183,196,202,215,221],"challenges":[16],"in":[17,66,77,241],"analytical":[18],"monitoring":[19],"extremely":[22],"toxic":[23],"'V'-type":[24,88,150,250],"weapons":[26],"[O-alkyl":[27],"S-(2-dialkylamino)ethyl":[28],"alkylphosphonothiolates]":[29],"is":[30],"to":[31,74],"distinguish":[32],"and":[33,70,99,120,136,142,147,191,213,220,252],"identify":[34],"compounds":[35,43],"similar":[37,62],"structure.":[38],"MS":[39],"analysis":[40],"these":[42],"reveals":[44],"mostly":[45],"fragment/product":[46],"ions":[47,173,190,226,239],"representing":[48],"amine-containing":[50],"residue.":[51],"Hence,":[52],"isomers":[53,146],"or":[54],"derivatives":[55,148],"with":[56],"same":[58],"amine":[59],"residue":[60],"exhibit":[61],"mass":[63,113],"spectral":[64],"patterns":[65],"both":[67],"classical":[68],"EI/MS":[69],"electrospray":[71],"ionization-MS,":[72],"leading":[73],"unavoidable":[75],"ambiguity":[76],"identification":[79,143],"phosphonate":[82,198],"moiety.":[83],"A":[84],"set":[85],"five":[87],"agents,":[89],"including":[90],"O-ethyl":[91,100],"S-(2-diisopropylamino)ethyl":[92],"methylphosphonothiolate":[93,97,102],"(VX),":[94],"O-isobutyl":[95],"S-(2-diethylamino)ethyl":[96,101],"(RVX)":[98],"(VM)":[103],"were":[104,124,134,175],"studied":[105],"by":[106],"liquid":[107],"chromatography/electrospray":[108],"ionization/MS,":[109],"utilizing":[110,255],"a":[111,137],"QTRAP":[112],"detector.":[114],"MS/MS":[115,156],"enhanced":[116,157,182],"product":[117,158,172,189],"ion":[118,159,257],"scans":[119,160],"multistage":[121],"MS(3)":[122,180],"experiments":[123,181],"carried":[125,211],"out.":[126],"Based":[127],"on":[128],"results,":[130],"possible":[131],"fragmentation":[132,203],"pathways":[133],"proposed,":[135],"method":[138],"for":[139,185,231,247],"differentiation":[141],"structural":[145],"was":[154,210],"obtained.":[155],"at":[161,176],"various":[162],"collision":[163],"energies":[164],"provided":[165,192],"information-rich":[166],"spectra,":[167],"although":[168],"many":[169],"obtained":[174],"low":[177,187],"abundance.":[178],"Employing":[179],"selectivity":[184],"those":[186],"abundance":[188],"spectra":[193],"indicative":[194],"different":[197],"groups.":[199],"Study":[200],"pathways,":[204],"revealing":[205],"some":[206],"less":[207],"expected":[208],"structures,":[209],"out":[212],"allowed":[214],"formulation":[216],"mechanistic":[218],"rules":[219],"determination":[222],"sets":[224],"typical":[227],"specific":[229],"groups,":[230],"example,":[232],"methylphosphonothiolates":[233],"versus":[234],"ethylphosphonothiolates.":[235],"new":[237],"group-specific":[238],"elucidated":[240],"this":[242],"work":[243],"are":[244],"also":[245],"useful":[246],"screening":[248],"unknown":[249],"related":[253],"compounds,":[254],"precursor":[256],"scan":[258],"experiments.":[259]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}