{"id":"https://openalex.org/W2136993432","doi":"https://doi.org/10.1111/j.1398-9995.1986.tb00272.x","title":"Ipratropium Bromide (Atrovent\u00ae) as Inhalation Powder","display_name":"Ipratropium Bromide (Atrovent\u00ae) as Inhalation Powder","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2136993432","doi":"https://doi.org/10.1111/j.1398-9995.1986.tb00272.x","mag":"2136993432","pmid":"https://pubmed.ncbi.nlm.nih.gov/2938515"},"language":"en","primary_location":{"id":"doi:10.1111/j.1398-9995.1986.tb00272.x","doi":"https://doi.org/10.1111/j.1398-9995.1986.tb00272.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.1986.tb00272.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110036549","display_name":"Francis P.V. Maesen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115793","display_name":"De Wever-Ziekenhuis","ror":"https://ror.org/0285m5c69","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210115793"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"F. P. V. Maesen","raw_affiliation_strings":["Department of Respiratory Diseases, De Wever Hospital, Heerlen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Diseases, De Wever Hospital, Heerlen","institution_ids":["https://openalex.org/I4210115793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038556807","display_name":"J.J. Smeets","orcid":"https://orcid.org/0000-0002-1397-8871","observed_orcids":["https://orcid.org/0000-0002-1397-8871"]},"institutions":[{"id":"https://openalex.org/I4210115793","display_name":"De Wever-Ziekenhuis","ror":"https://ror.org/0285m5c69","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210115793"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. J. Smeets","raw_affiliation_strings":["Department of Respiratory Diseases, De Wever Hospital, Heerlen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Diseases, De Wever Hospital, Heerlen","institution_ids":["https://openalex.org/I4210115793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108127279","display_name":"R. M. D. Bernsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150011","display_name":"Boehringer Ingelheim (Netherlands)","ror":"https://ror.org/04fh1gw55","country_code":"NL","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210150011"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. Bernsen","raw_affiliation_strings":["Medical Department, Bochringer Ingelheim b.v., Alkmaar, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Bochringer Ingelheim b.v., Alkmaar, The Netherlands","institution_ids":["https://openalex.org/I4210150011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110075277","display_name":"P. J. G. Cornelissen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150011","display_name":"Boehringer Ingelheim (Netherlands)","ror":"https://ror.org/04fh1gw55","country_code":"NL","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210150011"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. J. G. Cornelissen","raw_affiliation_strings":["Medical Department, Bochringer Ingelheim b.v., Alkmaar, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Bochringer Ingelheim b.v., Alkmaar, The Netherlands","institution_ids":["https://openalex.org/I4210150011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110036549"],"corresponding_institution_ids":["https://openalex.org/I4210115793"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.22398108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"1","first_page":"37","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.14139999449253082,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ipratropium-bromide","display_name":"ipratropium bromide","score":1.0},{"id":"https://openalex.org/keywords/inhalation-powder","display_name":"inhalation powder","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bronchodilators","display_name":"bronchodilators","score":0.6470000147819519},{"id":"https://openalex.org/keywords/aerosol-formulation","display_name":"aerosol formulation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/drug-formulation-comparison","display_name":"drug formulation comparison","score":0.6269999742507935},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2780532441","wikidata":"https://www.wikidata.org/wiki/Q424294","display_name":"Ipratropium bromide","level":4,"score":0.9939027428627014},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.8130674362182617},{"id":"https://openalex.org/C2778088044","wikidata":"https://www.wikidata.org/wiki/Q279330","display_name":"Bronchospasm","level":3,"score":0.7906040549278259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.765239953994751},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7038664221763611},{"id":"https://openalex.org/C2909577894","wikidata":"https://www.wikidata.org/wiki/Q424294","display_name":"Ipratropium","level":4,"score":0.6913681626319885},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.5728662610054016},{"id":"https://openalex.org/C2776291473","wikidata":"https://www.wikidata.org/wiki/Q3363684","display_name":"Parasympatholytic","level":4,"score":0.47237566113471985},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.46026068925857544},{"id":"https://openalex.org/C2777419714","wikidata":"https://www.wikidata.org/wiki/Q1334805","display_name":"Dry-powder inhaler","level":4,"score":0.43470245599746704},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.37167322635650635},{"id":"https://openalex.org/C2780261241","wikidata":"https://www.wikidata.org/wiki/Q1394363","display_name":"Inhaler","level":3,"score":0.2540266811847687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11992362141609192},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001286","descriptor_name":"Atropine Derivatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005280","descriptor_name":"Fenoterol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005280","descriptor_name":"Fenoterol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009241","descriptor_name":"Ipratropium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009241","descriptor_name":"Ipratropium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1398-9995.1986.tb00272.x","doi":"https://doi.org/10.1111/j.1398-9995.1986.tb00272.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.1986.tb00272.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:2938515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2938515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1985836655","https://openalex.org/W1999976801","https://openalex.org/W2030518682","https://openalex.org/W2051720100","https://openalex.org/W2073370777","https://openalex.org/W2082661485","https://openalex.org/W2084613369","https://openalex.org/W2094646199","https://openalex.org/W2095491619","https://openalex.org/W2136861449"],"related_works":["https://openalex.org/W2405727413","https://openalex.org/W2467907059","https://openalex.org/W2415634624","https://openalex.org/W2425996986","https://openalex.org/W2408432725","https://openalex.org/W2416499209","https://openalex.org/W2523150658","https://openalex.org/W1965314661","https://openalex.org/W1973882487","https://openalex.org/W2132457952"],"abstract_inverted_index":{"The":[0,91,131],"bronchospasmolytic":[1,121],"effects":[2,92,122,135],"of":[3,16,64,79,82,93,97,114,127,133,174,185],"40":[4,65],"micrograms":[5,66],"ipratropium":[6,67,98,175],"bromide":[7,68,99,176],"(Atrovent)":[8],"given":[9,38],"either":[10],"as":[11,20,69],"an":[12,70,73],"aerosol":[13,71],"(2":[14],"puffs":[15],"20":[17,44],"micrograms)":[18],"or":[19,187],"a":[21,27,32,150,195],"powder":[22,173],"inhalation":[23],"were":[24,100,123,182],"compared":[25],"in":[26,49,125,153],"double-blind":[28],"cross-over":[29],"study.":[30],"Following":[31],"randomisation":[33],"list":[34],"the":[35,57,76,80,94,115,128,134,142,156,165,168,199],"drug":[36,89],"was":[37,60,136,148,160,177],"on":[39],"2":[40],"successive":[41],"days":[42],"to":[43,109,193,198],"patients":[45],"with":[46,155,167],"stable":[47],"bronchospasm":[48],"whom":[50],"it":[51],"had":[52],"previously":[53],"been":[54],"shown":[55],"that":[56],"bronchial":[58],"obstruction":[59],"reversible":[61],"after":[62,88,112,141],"administration":[63,113],"(with":[72],"increase":[74],"over":[75],"baseline":[77,157],"value":[78],"FEV1":[81],"at":[83],"least":[84],"15%":[85],"1":[86,139],"h":[87,111,140],"administration).":[90],"two":[95,169],"presentations":[96],"followed":[101],"by":[102],"respiratory":[103],"function":[104],"tests":[105],"from":[106],"15":[107],"min":[108],"6":[110],"drug.":[116],"With":[117],"both":[118],"formulations":[119],"excellent":[120],"noted":[124,137],"each":[126],"parameters":[129],"measured.":[130],"peak":[132],"approximately":[138],"inhalations.":[143],"Six":[144],"hours":[145],"later":[146],"there":[147,181],"still":[149],"significant":[151,162],"improvement":[152],"comparison":[154],"values.":[158],"There":[159],"no":[161,183],"difference":[163],"between":[164],"results":[166],"different":[170],"formulations.":[171],"Inhalation":[172],"well":[178],"tolerated":[179],"and":[180],"complaints":[184],"irritation":[186],"coughing.":[188],"It":[189],"would":[190],"appear,":[191],"therefore,":[192],"be":[194],"valuable":[196],"alternative":[197],"pressure":[200],"aerosol.":[201]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}