{"id":"https://openalex.org/W2136973671","doi":"https://doi.org/10.1093/carcin/20.11.2117","title":"Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (\u2013)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production","display_name":"Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (\u2013)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2136973671","doi":"https://doi.org/10.1093/carcin/20.11.2117","mag":"2136973671","pmid":"https://pubmed.ncbi.nlm.nih.gov/10545414"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/20.11.2117","doi":"https://doi.org/10.1093/carcin/20.11.2117","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/20.11.2117","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036743590","display_name":"Santosh K. Katiyar","orcid":"https://orcid.org/0000-0001-5830-7652","observed_orcids":["https://orcid.org/0000-0001-5830-7652"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santosh K. Katiyar","raw_affiliation_strings":["Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland and University Hospitals of Cleveland and VA Hospital, Cleveland, OH 44106, USA. sxk32@po.cwru.edu","Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland and University Hospitals of Cleveland and VA Hospital, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland and University Hospitals of Cleveland and VA Hospital, Cleveland, OH 44106, USA. sxk32@po.cwru.edu","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland and University Hospitals of Cleveland and VA Hospital, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113532583","display_name":"Anjana Challa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjana Challa","raw_affiliation_strings":["Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081014269","display_name":"Thomas S. McCormick","orcid":"https://orcid.org/0000-0002-3294-0326","observed_orcids":["https://orcid.org/0000-0002-3294-0326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas S. McCormick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046056281","display_name":"Kevin D. Cooper","orcid":"https://orcid.org/0000-0002-1986-3602","observed_orcids":["https://orcid.org/0000-0002-1986-3602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin D. Cooper","raw_affiliation_strings":["VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082425428","display_name":"Hasan Mukhtar","orcid":"https://orcid.org/0000-0002-5358-077X","observed_orcids":["https://orcid.org/0000-0002-5358-077X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasan Mukhtar","raw_affiliation_strings":["Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":10.4653,"has_fulltext":false,"cited_by_count":193,"citation_normalized_percentile":{"value":0.98910955,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"20","issue":"11","first_page":"2117","last_page":"2124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.10939999669790268,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uvb-induced-immunosuppression","display_name":"UVB-induced immunosuppression","score":0.9620000123977661},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/green-tea-polyphenols","display_name":"green tea polyphenols","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7850000262260437},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":1.0},{"id":"https://openalex.org/keywords/contact-hypersensitivity","display_name":"contact hypersensitivity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/2-4-dinitrofluorobenzene","display_name":"2,4-dinitrofluorobenzene","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8769999742507935},{"id":"https://openalex.org/keywords/draining-lymph-nodes","display_name":"draining lymph nodes","score":0.7979999780654907},{"id":"https://openalex.org/keywords/photocarcinogenesis","display_name":"photocarcinogenesis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/topical-application","display_name":"topical application","score":0.5979999899864197},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2776960578","wikidata":"https://www.wikidata.org/wiki/Q3705873","display_name":"Photoaging","level":2,"score":0.5051794648170471},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5019717216491699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49533596634864807},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4879245460033417},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46891364455223083},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4457453489303589},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44278380274772644},{"id":"https://openalex.org/C2777926168","wikidata":"https://www.wikidata.org/wiki/Q484083","display_name":"Green tea extract","level":3,"score":0.43673887848854065},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40950027108192444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3394676446914673},{"id":"https://openalex.org/C2992814287","wikidata":"https://www.wikidata.org/wiki/Q484083","display_name":"Green tea","level":2,"score":0.2524529695510864},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.18042954802513123},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.07428285479545593}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013662","descriptor_name":"Tea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/20.11.2117","doi":"https://doi.org/10.1093/carcin/20.11.2117","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/20.11.2117","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:10545414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10545414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1753194528","display_name":"INTERACTION BETWEEN PSORIATIC KERATINOCYTES AND T CELLS","funder_award_id":"R01AR041707","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G449388283","display_name":"Green Tea in Chemoprevention of Prostate Cancer","funder_award_id":"R01CA078809","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6579298273","display_name":"PHTHALOCYANINE PHOTODYNAMIC THERAPY OF SKIN TUMORS","funder_award_id":"R01CA051802","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306231","display_name":"American Institute for Cancer Research","ror":"https://ror.org/03b3akj74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W19143241","https://openalex.org/W59605368","https://openalex.org/W1492171082","https://openalex.org/W1515615230","https://openalex.org/W1516863427","https://openalex.org/W1572210960","https://openalex.org/W1587718614","https://openalex.org/W1590561990","https://openalex.org/W1617731458","https://openalex.org/W1805764019","https://openalex.org/W1905885279","https://openalex.org/W1925204255","https://openalex.org/W1931057000","https://openalex.org/W1967936513","https://openalex.org/W1969888545","https://openalex.org/W1969927222","https://openalex.org/W1975943298","https://openalex.org/W1978824132","https://openalex.org/W1979514172","https://openalex.org/W1993358791","https://openalex.org/W1996693750","https://openalex.org/W1998079753","https://openalex.org/W1999065283","https://openalex.org/W2004927075","https://openalex.org/W2018750367","https://openalex.org/W2030824690","https://openalex.org/W2032090998","https://openalex.org/W2036805524","https://openalex.org/W2043060387","https://openalex.org/W2065300519","https://openalex.org/W2068306606","https://openalex.org/W2072059088","https://openalex.org/W2076438363","https://openalex.org/W2081291884","https://openalex.org/W2082851306","https://openalex.org/W2089778507","https://openalex.org/W2091357966","https://openalex.org/W2095835949","https://openalex.org/W2096152012","https://openalex.org/W2101771134","https://openalex.org/W2102156468","https://openalex.org/W2134188156","https://openalex.org/W2144111899","https://openalex.org/W2147231692","https://openalex.org/W2150195134","https://openalex.org/W2158046602","https://openalex.org/W2158240118","https://openalex.org/W2161485037","https://openalex.org/W2163526297","https://openalex.org/W2165382073","https://openalex.org/W2318943984","https://openalex.org/W4237200631"],"related_works":["https://openalex.org/W1890625981","https://openalex.org/W4294960717","https://openalex.org/W4237200631","https://openalex.org/W1975943298","https://openalex.org/W1967143802","https://openalex.org/W2373357267","https://openalex.org/W1564709089","https://openalex.org/W2143134644","https://openalex.org/W2023593059","https://openalex.org/W2129806196"],"abstract_inverted_index":{"UV":[0],"exposure":[1,70,99,132],"of":[2,52,61,79,95,103,128,136,154,167,203],"the":[3,80,88,101,121,137,207],"skin,":[4],"particularly":[5],"UVB":[6,69,98,131,181],"(290-320":[7],"nm),":[8],"causes":[9],"adverse":[10],"biological":[11],"effects,":[12],"including":[13],"alterations":[14],"in":[15,41,142,147,176,213,218,225],"cutaneous":[16],"immune":[17],"cells,":[18],"photoaging":[19],"and":[20,39,84,106,163,195],"photocarcinogenesis.":[21,240],"Several":[22],"studies":[23],"have":[24],"shown":[25],"that":[26,49,189],"polyphenolic":[27,59],"compounds":[28],"isolated":[29],"from":[30],"green":[31,62],"tea":[32],"afford":[33],"protection":[34,237],"against":[35,192,228,238],"UVB-induced":[36,77,134,193,201,229,239],"inflammatory":[37,111],"responses":[38],"photocarcinogenesis":[40],"murine":[42],"models.":[43],"In":[44,125],"this":[45],"study":[46],"we":[47],"show":[48],"topical":[50],"application":[51,94,127],"(-)-epigallocatechin-3-gallate":[53],"(EGCG)":[54],"(3":[55],"mg/mouse),":[56],"a":[57,65,161],"major":[58],"component":[60],"tea,":[63],"before":[64,97,130],"single":[66],"low":[67],"dose":[68],"(72":[71],"mJ/cm(2))":[72],"to":[73,87,116,159,172],"C3H/HeN":[74],"mice":[75],"prevented":[76],"inhibition":[78],"contact":[81,89,168],"hypersensitivity":[82],"response":[83],"tolerance":[85,196],"induction":[86,166,197],"sensitizer":[90],"2,":[91],"4-dinitrofluorobenzene.":[92],"Topical":[93],"EGCG":[96,129,190,232],"reduced":[100],"number":[102],"CD11b+":[104,204],"monocytes/macrophages":[105],"neutrophils":[107],"infiltrating":[108],"into":[109,206],"skin":[110,143,214],"lesions,":[112],"which":[113,156],"are":[114],"considered":[115,158],"be":[117,160,173,234],"responsible":[118],"for":[119,165],"creating":[120],"UV-induced":[122],"immunosuppressive":[123],"state.":[124],"addition,":[126],"decreased":[133],"production":[135,153,212,224],"immunomodulatory":[138],"cytokine":[139],"interleukin":[140],"(IL)-10":[141],"as":[144,146,215,217],"well":[145,216],"draining":[148],"lymph":[149],"nodes":[150],"(DLN),":[151],"whereas":[152],"IL-12,":[155],"is":[157],"mediator":[162],"adjuvant":[164],"sensitivity,":[169],"was":[170],"found":[171],"markedly":[174,221],"increased":[175],"DLN":[177],"when":[178],"compared":[179],"with":[180,236],"alone-exposed":[182],"mice.":[183],"Taken":[184],"together,":[185],"our":[186],"data":[187],"demonstrate":[188],"protects":[191],"immunosuppression":[194,230],"by:":[198],"(i)":[199],"blocking":[200],"infiltration":[202],"cells":[205],"skin;":[208],"(ii)":[209],"reducing":[210],"IL-10":[211],"DLN;":[219],"(iii)":[220],"increasing":[222],"IL-12":[223],"DLN.":[226],"Protection":[227],"by":[231],"may":[233],"associated":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}