{"id":"https://openalex.org/W2136972522","doi":null,"title":"Regions of H- and K-ras that provide organ specificity/potency in mammary cancer induction.","display_name":"Regions of H- and K-ras that provide organ specificity/potency in mammary cancer induction.","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2136972522","mag":"2136972522","pmid":"https://pubmed.ncbi.nlm.nih.gov/11888883"},"language":"en","primary_location":{"id":"pmid:11888883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11888883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051905445","display_name":"Kwanghee Kim","orcid":"https://orcid.org/0000-0003-0544-6792","observed_orcids":["https://orcid.org/0000-0003-0544-6792"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwanghee Kim","raw_affiliation_strings":["McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040257835","display_name":"Mary J. Lindstrom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary J Lindstrom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102352016","display_name":"Michael N. Gould","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael N Gould","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5742,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.58104022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"5","first_page":"1241","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h-ras","display_name":"H-Ras","score":0.9729999899864197},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":1.0},{"id":"https://openalex.org/keywords/ras-isoforms","display_name":"Ras isoforms","score":0.6620000004768372},{"id":"https://openalex.org/keywords/organ-specificity","display_name":"organ specificity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hypervariable-region","display_name":"hypervariable region","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ras-oncogene-activation","display_name":"ras oncogene activation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/tissue-specificity","display_name":"tissue specificity","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7572146654129028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6439470052719116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5022165775299072},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4927401840686798},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.48133501410484314},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.4579138159751892},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4500357508659363},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.4389355182647705},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4346768856048584},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41128912568092346},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33897513151168823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27522674202919006},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19830617308616638},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.19806888699531555}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011920","descriptor_name":"Rats, Inbred WF","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11888883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11888883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2136972522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11888883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8001876664","display_name":"ONCOGENE SPECIFICITY IN ORGAN-DEFINED CANCERS","funder_award_id":"R01CA077527","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1498171831","https://openalex.org/W1560539518","https://openalex.org/W1575581877","https://openalex.org/W1753119423","https://openalex.org/W1799140375","https://openalex.org/W1982813290","https://openalex.org/W2000058321","https://openalex.org/W2001520967","https://openalex.org/W2003625629","https://openalex.org/W2010207338","https://openalex.org/W2035363409","https://openalex.org/W2056750804","https://openalex.org/W2083506343","https://openalex.org/W2098301486","https://openalex.org/W2131550937","https://openalex.org/W2133362776","https://openalex.org/W2133576136","https://openalex.org/W2152401699","https://openalex.org/W2156654096","https://openalex.org/W2159594827","https://openalex.org/W2173344695","https://openalex.org/W2399842723","https://openalex.org/W2970340375"],"related_works":["https://openalex.org/W2131550937","https://openalex.org/W4233059022","https://openalex.org/W4241459533","https://openalex.org/W7096351851","https://openalex.org/W2161693985","https://openalex.org/W1814635547","https://openalex.org/W2151366572","https://openalex.org/W7126246606","https://openalex.org/W3023712727","https://openalex.org/W2138089788"],"abstract_inverted_index":{"Organ-specific":[0],"cancers":[1],"with":[2,11,23],"activated":[3],"ras":[4,14],"oncogenes":[5],"most":[6],"often":[7],"are":[8],"associated":[9,22],"exclusively":[10],"only":[12,18],"one":[13],"isoform.":[15],"For":[16],"example,":[17],"H-ras":[19],"activation":[20],"is":[21,32,46],"rat":[24],"mammary":[25,94],"cancers.":[26],"The":[27],"mechanism":[28],"underlying":[29],"this":[30,40,86],"specificity":[31,42],"mostly":[33,104],"unknown.":[34],"We":[35],"have":[36],"shown":[37],"previously":[38],"that":[39,66,112],"tissue":[41],"of":[43,76,107,118],"Ras":[44,50,60,77,108],"isoforms":[45],"defined":[47],"by":[48,55],"the":[49,69,73,97,103,115],"protein":[51],"itself":[52],"and":[53],"not":[54],"differential":[56],"gene":[57],"expression":[58],"among":[59],"family":[61],"members.":[62],"Here":[63],"we":[64],"show":[65],"elements":[67],"in":[68,72,82,92,102],"known":[70],"domains":[71,101],"hypervariable":[74],"region":[75,106],"(amino":[78,109],"acids":[79,110],"170-189)":[80],"interact":[81],"part":[83],"to":[84],"control":[85],"mammary/H-Ras":[87],"specificity.":[88],"In":[89],"addition,":[90],"these":[91],"vivo":[93],"studies":[95],"for":[96],"first":[98],"time":[99],"identify":[100],"homologous":[105],"1-169)":[111],"strongly":[113],"influence":[114],"oncogenic":[116],"potency/specificity":[117],"H-Ras.":[119]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
