{"id":"https://openalex.org/W2136960413","doi":"https://doi.org/10.1161/circulationaha.108.838268","title":"Plasma Asymmetric Dimethylarginine and Incidence of Cardiovascular Disease and Death in the Community","display_name":"Plasma Asymmetric Dimethylarginine and Incidence of Cardiovascular Disease and Death in the Community","publication_year":2009,"publication_date":"2009-03-16","ids":{"openalex":"https://openalex.org/W2136960413","doi":"https://doi.org/10.1161/circulationaha.108.838268","mag":"2136960413","pmid":"https://pubmed.ncbi.nlm.nih.gov/19289633","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2742491"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.108.838268","doi":"https://doi.org/10.1161/circulationaha.108.838268","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.108.838268","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2742491","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038106053","display_name":"Rainer H. B\u00f6ger","orcid":"https://orcid.org/0000-0003-3770-5357","observed_orcids":["https://orcid.org/0000-0003-3770-5357"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Rainer H. Bo\u0308ger","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031278914","display_name":"LISA M. SULLIVAN","orcid":"https://orcid.org/0000-0003-0726-7149","observed_orcids":["https://orcid.org/0000-0003-0726-7149"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Lisa M. Sullivan","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","Lisa M. Sullivan From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Lisa M. Sullivan From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057764662","display_name":"Edzard Schwedhelm","orcid":"https://orcid.org/0000-0003-3597-6276","observed_orcids":["https://orcid.org/0000-0003-3597-6276"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Edzard Schwedhelm","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Edzard Schwedhelm From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Edzard Schwedhelm From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085451281","display_name":"Thomas J. Wang","orcid":"https://orcid.org/0000-0003-4063-6508","observed_orcids":["https://orcid.org/0000-0003-4063-6508","https://orcid.org/0000-0001-9182-9620"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Thomas J. Wang","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","Thomas J. Wang From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Thomas J. Wang From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004322058","display_name":"Renke Maas","orcid":"https://orcid.org/0000-0002-5498-9761","observed_orcids":["https://orcid.org/0000-0002-5498-9761"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Renke Maas","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","Renke Maas From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Renke Maas From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064309113","display_name":"Emelia J. Benjamin","orcid":"https://orcid.org/0000-0003-4076-2336","observed_orcids":["https://orcid.org/0000-0003-4076-2336"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Emelia J. Benjamin","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Emelia J. Benjamin From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Emelia J. Benjamin From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038205675","display_name":"Friedrich Schulze","orcid":"https://orcid.org/0000-0003-0277-8134","observed_orcids":["https://orcid.org/0000-0003-0277-8134"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Friedrich Schulze","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","Friedrich Schulze From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Friedrich Schulze From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061462830","display_name":"Vanessa Xanthakis","orcid":"https://orcid.org/0000-0002-7352-621X","observed_orcids":["https://orcid.org/0000-0002-7352-621X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Vanessa Xanthakis","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","Vanessa Xanthakis From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Vanessa Xanthakis From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091511539","display_name":"Ralf A. Benndorf","orcid":"https://orcid.org/0000-0001-6493-4521","observed_orcids":["https://orcid.org/0000-0001-6493-4521"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Ralf A. Benndorf","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","Ralf A. Benndorf From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Ralf A. Benndorf From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004656494","display_name":"Ramachandran Srini Vasan","orcid":"https://orcid.org/0000-0001-7357-5970","observed_orcids":["https://orcid.org/0000-0001-7357-5970"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Ramachandran S. Vasan","raw_affiliation_strings":["From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","Ramachandran S. Vasan From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.); Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.); Department of Biostatistics (L.M.S., V.X.) and Cardiology Division and Preventive Medicine (E.J.B., R.S.V.), Boston University School of Public Health, Boston, Mass; and Cardiology Division, Massachusetts General Hospital, Boston (T.J","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210108711","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston (T.J.W.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Framingham Heart Study, Framingham, Mass (L.M.S., T.J.W., E.J.B., V.X., R.S.V.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Ramachandran S. Vasan From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.H.B., E.S., R.M., F.S., R.A.B.)","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":22.5431,"has_fulltext":false,"cited_by_count":350,"citation_normalized_percentile":{"value":0.9981777,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"119","issue":"12","first_page":"1592","last_page":"1600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":1.0},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cardiovascular-disease-incidence","display_name":"cardiovascular disease incidence","score":0.8560000061988831},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.39500001072883606},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5960000157356262},{"id":"https://openalex.org/keywords/framingham-offspring-study","display_name":"Framingham Offspring Study","score":0.8370000123977661},{"id":"https://openalex.org/keywords/community-based-cohort","display_name":"community-based cohort","score":0.4729999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.925960898399353},{"id":"https://openalex.org/C2779877776","wikidata":"https://www.wikidata.org/wiki/Q752685","display_name":"Asymmetric dimethylarginine","level":4,"score":0.7787085771560669},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.577144205570221},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5377163887023926},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5189368724822998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4670770466327667},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37361377477645874},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.07821765542030334},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/circulationaha.108.838268","doi":"https://doi.org/10.1161/circulationaha.108.838268","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.108.838268","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:19289633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19289633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2742491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2742491","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.566.896","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.566.896","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.uke.de/der-vorstand/dekanat/downloads/geschaeftsfuehrung-dekanat/pom0904-3.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2742491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2742491","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1123540438","display_name":null,"funder_award_id":"K23 HL074077-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2808771873","display_name":null,"funder_award_id":"K23-HL-074077","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2833335","display_name":"Natriuretic Peptides, Genes, and Diastolic Heart Failure","funder_award_id":"5k23hl074077-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3665864103","display_name":"Aldosterone in Vascular Remodeling and Dysfunction","funder_award_id":"K24HL004334","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5164707915","display_name":null,"funder_award_id":"N01-HC-025195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5402081587","display_name":null,"funder_award_id":"N01-HV-028178","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6997205903","display_name":"NHLBI PROTEOMICS INITIATIVE","funder_award_id":"n01hv28178-12-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1970161435","https://openalex.org/W1970629667","https://openalex.org/W1979877104","https://openalex.org/W1989697162","https://openalex.org/W1994950364","https://openalex.org/W1998155352","https://openalex.org/W2004688216","https://openalex.org/W2010079762","https://openalex.org/W2012627116","https://openalex.org/W2030477074","https://openalex.org/W2037655806","https://openalex.org/W2042800607","https://openalex.org/W2052893052","https://openalex.org/W2055864845","https://openalex.org/W2057116025","https://openalex.org/W2058385357","https://openalex.org/W2061976121","https://openalex.org/W2072531665","https://openalex.org/W2088632030","https://openalex.org/W2093634293","https://openalex.org/W2105082749","https://openalex.org/W2106478344","https://openalex.org/W2110420172","https://openalex.org/W2117058217","https://openalex.org/W2122545929","https://openalex.org/W2123178954","https://openalex.org/W2124718979","https://openalex.org/W2126037923","https://openalex.org/W2129050578","https://openalex.org/W2133685977","https://openalex.org/W2146852777","https://openalex.org/W2148531805","https://openalex.org/W2150110134","https://openalex.org/W2153110646","https://openalex.org/W2157261119","https://openalex.org/W2166937516","https://openalex.org/W2166969544","https://openalex.org/W2169513794","https://openalex.org/W2211287272","https://openalex.org/W3147894994","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7099102486","https://openalex.org/W2885534268","https://openalex.org/W2169513794","https://openalex.org/W2056621811","https://openalex.org/W2378110055","https://openalex.org/W2308496329","https://openalex.org/W2083059992","https://openalex.org/W2062801753","https://openalex.org/W7098030390","https://openalex.org/W2782153628"],"abstract_inverted_index":{"BACKGROUND:":[0],"Asymmetric":[1],"dimethylarginine":[2],"(ADMA),":[3],"an":[4,21],"endogenous":[5],"inhibitor":[6],"of":[7,24,36,58,65,105,110,113,152,249],"nitric":[8],"oxide":[9],"synthase,":[10],"induces":[11],"endothelial":[12],"dysfunction.":[13],"Although":[14],"elevated":[15],"ADMA":[16,37,61,148,155,207,252,267],"has":[17,41],"been":[18,43],"associated":[19,158,209,255,270],"with":[20,159,210,231,256,271],"increased":[22],"risk":[23,132],"cardiovascular":[25,66,114,120,257],"disease":[26,67,115,258],"events":[27],"and":[28,55,87,122,134,145,149,174,246],"death":[29,88,211],"in":[30,38,89,212,229,275],"referral":[31],"samples,":[32],"the":[33,39,56,63,150,247],"prognostic":[34],"significance":[35],"community":[40],"not":[42,189,228,254],"adequately":[44],"evaluated.":[45],"METHODS":[46],"AND":[47],"RESULTS:":[48],"We":[49,200],"related":[50],"plasma":[51],"ADMA,":[52,244],"l-arginine":[53],"(Arg),":[54],"ratio":[57,151,163,248],"Arg":[59,153,187,250],"to":[60,62,154,172,183,198,225,242,251],"incidence":[64,259],"(fatal":[68],"or":[69,78,84],"nonfatal":[70],"myocardial":[71],"infarction,":[72],"coronary":[73],"insufficiency,":[74],"angina":[75],"pectoris,":[76],"stroke":[77],"transient":[79],"ischemic":[80],"attack,":[81],"intermittent":[82],"claudication,":[83],"heart":[85],"failure)":[86],"3320":[90],"Framingham":[91],"Offspring":[92],"Study":[93],"participants":[94,124],"(1769":[95],"women;":[96],"mean":[97],"age,":[98],"59":[99],"years).":[100],"Over":[101],"a":[102],"follow-up":[103],"period":[104],"10.9":[106],"years,":[107],"281":[108],"individuals":[109,213,230],"2956":[111],"free":[112],"at":[116],"baseline":[117],"developed":[118],"incident":[119],"disease,":[121],"285":[123],"died.":[125],"In":[126,262],"multivariable":[127],"models":[128],"adjusting":[129],"for":[130],"established":[131],"factors":[133],"other":[135],"biomarkers":[136],"(B-type":[137],"natriuretic":[138],"peptide,":[139],"renin,":[140],"homocysteine,":[141],"urine":[142],"albumin":[143],"excretion,":[144],"C-reactive":[146],"protein),":[147],"were":[156,253],"significantly":[157,269],"all-cause":[160,272],"mortality":[161],"(adjusted-hazard":[162],"[HR]":[164],"per":[165,176,191,218,235],"1-SD":[166,177,192,219,236],"increment,":[167,178,193,220,237],"1.21;":[168],"95%":[169,180,195,222,239],"CI,":[170,181,196,223,240],"1.07":[171],"1.37;":[173],"HR":[175,217,234],"0.80;":[179],"0.69":[182],"0.93,":[184],"respectively),":[185],"whereas":[186],"was":[188,208,268],"(HR":[190],"0.89;":[194],"0.77":[197],"1.02).":[199],"noted":[201],"effect":[202],"modification":[203],"by":[204],"diabetes":[205,215,232],"status;":[206],"without":[214],"(adjusted":[216,233],"1.30;":[221],"1.13":[224],"1.50)":[226],"but":[227],"0.85;":[238],"0.62":[241],"1.16).":[243],"Arg,":[245],"(P>0.10).":[260],"CONCLUSIONS:":[261],"our":[263],"large":[264],"community-based":[265],"sample,":[266],"mortality,":[273],"particularly":[274],"nondiabetic":[276],"individuals.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}