{"id":"https://openalex.org/W2136954841","doi":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","title":"Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction: Possible Contribution of Endoplasmic Reticulum Stress to Cardiac Myocyte Apoptosis","display_name":"Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction: Possible Contribution of Endoplasmic Reticulum Stress to Cardiac Myocyte Apoptosis","publication_year":2004,"publication_date":"2004-08-03","ids":{"openalex":"https://openalex.org/W2136954841","doi":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","mag":"2136954841","pmid":"https://pubmed.ncbi.nlm.nih.gov/15289376"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000137836.95625.d4","doi":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000137836.95625.D4","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000137836.95625.D4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ken-ichiro Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichiro Okada","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113939848","display_name":"Tetsuo Minamino","orcid":"https://orcid.org/0000-0002-5424-4081","observed_orcids":["https://orcid.org/0000-0002-5424-4081"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Minamino","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028698358","display_name":"Yoshitane Tsukamoto","orcid":"https://orcid.org/0000-0001-7766-3505","observed_orcids":["https://orcid.org/0000-0001-7766-3505"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitane Tsukamoto","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029741432","display_name":"Yulin Liao","orcid":"https://orcid.org/0000-0001-5961-390X","observed_orcids":["https://orcid.org/0000-0001-5961-390X"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yulin Liao","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066544282","display_name":"Osamu Tsukamoto","orcid":"https://orcid.org/0000-0002-9504-8001","observed_orcids":["https://orcid.org/0000-0002-9504-8001"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Tsukamoto","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102866064","display_name":"Seiji Takashima","orcid":"https://orcid.org/0000-0003-1625-493X","observed_orcids":["https://orcid.org/0000-0003-1625-493X"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Takashima","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108201327","display_name":"Akio Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Hirata","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101801547","display_name":"Masashi Fujita","orcid":"https://orcid.org/0000-0002-3808-4292","observed_orcids":["https://orcid.org/0000-0002-3808-4292"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Fujita","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoko Nagamachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Nagamachi","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069159764","display_name":"Takeshi Nakatani","orcid":"https://orcid.org/0000-0002-6067-1135","observed_orcids":["https://orcid.org/0000-0002-6067-1135"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Nakatani","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004572838","display_name":"Chikao Yutani","orcid":"https://orcid.org/0000-0002-1132-0208","observed_orcids":["https://orcid.org/0000-0002-1132-0208"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikao Yutani","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020735059","display_name":"Kentaro Ozawa","orcid":"https://orcid.org/0000-0002-3648-4639","observed_orcids":["https://orcid.org/0000-0002-3648-4639"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Ozawa","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021711767","display_name":"Satoshi Ogawa","orcid":"https://orcid.org/0000-0002-4790-546X","observed_orcids":["https://orcid.org/0000-0002-4790-546X"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Ogawa","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110584302","display_name":"Hitonobu Tomoike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitonobu Tomoike","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800982","display_name":"Masatsugu Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatsugu Hori","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080293775","display_name":"Masafumi Kitakaze","orcid":"https://orcid.org/0000-0001-5157-4213","observed_orcids":["https://orcid.org/0000-0001-5157-4213"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Kitakaze","raw_affiliation_strings":["From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka (K. Okada, T.M., Y.L., O.T., S.T., A.H., M.F., Y.N., M.H.); Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.); Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.); and Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210151107","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroanatomy, Kanazawa University, Kanazawa, Ishikawa (K. Ozawa, S.O.)","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, (Y.T.)","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Departments of Cardiovascular Surgery (T.N.), Pathology (C.Y.), and Cardiovascular Medicine (H.T., M.K.), National Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6716,"has_fulltext":true,"cited_by_count":522,"citation_normalized_percentile":{"value":0.93892415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"110","issue":"6","first_page":"705","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.972000002861023},{"id":"https://openalex.org/keywords/transverse-aortic-constriction","display_name":"transverse aortic constriction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.8299999833106995},{"id":"https://openalex.org/keywords/er-chaperones","display_name":"ER chaperones","score":0.9700000286102295},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.8569999933242798},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9138140678405762},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.813723087310791},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.6476356387138367},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6307677626609802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6017615795135498},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10625624656677246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068557","descriptor_name":"Olmesartan Medoxomil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014415","descriptor_name":"Tunicamycin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019284","descriptor_name":"Thapsigargin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.0000137836.95625.d4","doi":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000137836.95625.D4","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:15289376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15289376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"mag:2885883264","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/01.cir.0000137836.95625.d4?cited-by=yes%3B110%2F6%2F705","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.cir.0000137836.95625.d4","doi":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.0000137836.95625.d4","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000137836.95625.D4","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136954841.pdf","grobid_xml":"https://content.openalex.org/works/W2136954841.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W117817469","https://openalex.org/W172455299","https://openalex.org/W185505243","https://openalex.org/W1514223875","https://openalex.org/W1522763255","https://openalex.org/W1570888466","https://openalex.org/W1975969451","https://openalex.org/W2002958873","https://openalex.org/W2010160555","https://openalex.org/W2012393741","https://openalex.org/W2018054508","https://openalex.org/W2025518316","https://openalex.org/W2029642537","https://openalex.org/W2034213169","https://openalex.org/W2044256491","https://openalex.org/W2047201865","https://openalex.org/W2064776807","https://openalex.org/W2069924169","https://openalex.org/W2072881240","https://openalex.org/W2078006089","https://openalex.org/W2090839709","https://openalex.org/W2104918369","https://openalex.org/W2105162027","https://openalex.org/W2107601804","https://openalex.org/W2115205812","https://openalex.org/W2116380331","https://openalex.org/W2118157159","https://openalex.org/W2131954858","https://openalex.org/W2133771702","https://openalex.org/W2137755719","https://openalex.org/W2142297495","https://openalex.org/W2160035613","https://openalex.org/W2164669872"],"related_works":["https://openalex.org/W2270568939","https://openalex.org/W2108826379","https://openalex.org/W2061714252","https://openalex.org/W2389293454","https://openalex.org/W2076254810","https://openalex.org/W1981720408","https://openalex.org/W135534259","https://openalex.org/W2037563295","https://openalex.org/W3193866942","https://openalex.org/W2091236573"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,18,124,169],"endoplasmic":[2],"reticulum":[3],"(ER)":[4],"is":[5],"recognized":[6],"as":[7],"an":[8],"organelle":[9],"that":[10,65,94,230],"participates":[11],"in":[12,43,121,139,154,187,202,215],"folding":[13],"secretory":[14],"and":[15,68,76,88,117,137,151,199],"membrane":[16],"proteins.":[17],"ER":[19,25,31,41,82,101,135,149,176,193,197,210,237],"responds":[20],"to":[21,34,54,242,251],"stress":[22,32,42,194],"by":[23,97,175,190,233],"upregulating":[24],"chaperones,":[26],"but":[27,178],"prolonged":[28,100,236],"and/or":[29],"excess":[30],"leads":[33],"apoptosis.":[35,168],"However,":[36],"the":[37,105,143],"potential":[38],"role":[39],"of":[40,81,107,126,134,209,218],"pathophysiological":[44],"hearts":[45,189,217],"remains":[46],"unclear.":[47],"METHODS":[48],"AND":[49],"RESULTS:":[50],"Mice":[51],"were":[52,212],"subjected":[53],"transverse":[55],"aortic":[56],"constriction":[57],"(TAC)":[58],"or":[59,181],"sham":[60],"operation.":[61],"Echocardiographic":[62],"analysis":[63],"demonstrated":[64],"mice":[66],"1":[67,87,130],"4":[69,89],"weeks":[70,90],"after":[71,91],"TAC":[72,98,234],"had":[73],"cardiac":[74,158,204,243,249],"hypertrophy":[75,250],"failure,":[77],"respectively.":[78],"Cardiac":[79],"expression":[80],"chaperones":[83,136,150,198,211],"was":[84,119,185],"significantly":[85],"increased":[86,214],"TAC,":[92],"indicating":[93],"pressure":[95,231],"overload":[96,232],"induced":[99,152,174,200],"stress.":[102],"In":[103],"addition,":[104],"number":[106],"terminal":[108],"deoxynucleotidyl":[109],"transferase-mediated":[110],"dUTP":[111],"nick-end":[112],"labeling":[113],"(TUNEL)-positive":[114],"cells":[115],"increased,":[116],"caspase-3":[118],"cleaved":[120],"failing":[122,140,188,216],"hearts.":[123,141],"antagonism":[125],"angiotensin":[127,146],"II":[128,147],"type":[129],"receptor":[131],"prevented":[132],"upregulation":[133],"apoptosis":[138,153,201,245],"On":[142],"other":[144],"hand,":[145],"upregulated":[148,196],"cultured":[155,203],"adult":[156],"rat":[157],"myocytes.":[159,205],"We":[160],"also":[161],"investigated":[162],"possible":[163],"signaling":[164],"pathways":[165],"for":[166],"ER-initiated":[167],"CHOP-":[170],"(a":[171],"transcription":[172],"factor":[173],"stress),":[177],"not":[179],"JNK-":[180],"caspase-12-,":[182],"dependent":[183],"pathway":[184],"activated":[186],"TAC.":[191],"Pharmacological":[192],"inducers":[195],"Finally,":[206],"mRNA":[207],"levels":[208],"markedly":[213],"patients":[219],"with":[220],"elevated":[221],"brain":[222],"natriuretic":[223],"peptide":[224],"levels.":[225],"CONCLUSIONS:":[226],"These":[227],"findings":[228],"suggest":[229],"induces":[235],"stress,":[238],"which":[239],"may":[240],"contribute":[241],"myocyte":[244],"during":[246],"progression":[247],"from":[248],"failure.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":38},{"year":2014,"cited_by_count":43},{"year":2013,"cited_by_count":48},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}