{"id":"https://openalex.org/W2136862494","doi":null,"title":"Regeneration in the adult brain after focal cerebral ischemia : exploration of neurogenesis and angiogenesis","display_name":"Regeneration in the adult brain after focal cerebral ischemia : exploration of neurogenesis and angiogenesis","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2136862494","mag":"2136862494"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-739","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-739","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101941006","display_name":"Wei Jiang","orcid":"https://orcid.org/0009-0007-5054-1306","observed_orcids":["https://orcid.org/0009-0007-5054-1306"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wei Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101941006"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spontaneous-reperfusion","display_name":"spontaneous reperfusion","score":0.8970000147819519},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cerebral-protein-synthesis","display_name":"cerebral protein synthesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.6019999980926514},{"id":"https://openalex.org/keywords/brdu-labeling","display_name":"BrdU labeling","score":0.546999990940094},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.3869999945163727},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.4880000054836273},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.5320000052452087},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.699999988079071},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8562096357345581},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6914810538291931},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6767966151237488},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6693582534790039},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.557226300239563},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5327779054641724},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.4592435657978058},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4517601430416107},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.435702919960022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3751487731933594},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19377323985099792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1638738512992859},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-739","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-739","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2136862494","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/record.jsf?pid=diva2:144368","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-739","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-739","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":132,"referenced_works":["https://openalex.org/W94373567","https://openalex.org/W180927739","https://openalex.org/W247746285","https://openalex.org/W292067595","https://openalex.org/W1487655984","https://openalex.org/W1489873347","https://openalex.org/W1517264384","https://openalex.org/W1592665312","https://openalex.org/W1667970511","https://openalex.org/W1879498419","https://openalex.org/W1963940970","https://openalex.org/W1968142349","https://openalex.org/W1969024031","https://openalex.org/W1971557664","https://openalex.org/W1972928390","https://openalex.org/W1974135000","https://openalex.org/W1974483939","https://openalex.org/W1974962627","https://openalex.org/W1976186811","https://openalex.org/W1976302746","https://openalex.org/W1979515609","https://openalex.org/W1979612418","https://openalex.org/W1979761775","https://openalex.org/W1980334508","https://openalex.org/W1980499453","https://openalex.org/W1980875076","https://openalex.org/W1984197891","https://openalex.org/W1987169758","https://openalex.org/W1987278634","https://openalex.org/W1987731290","https://openalex.org/W1988086690","https://openalex.org/W1992332979","https://openalex.org/W1994591232","https://openalex.org/W1996222694","https://openalex.org/W1997233104","https://openalex.org/W1998969072","https://openalex.org/W1999268673","https://openalex.org/W2000838270","https://openalex.org/W2001082025","https://openalex.org/W2001500938","https://openalex.org/W2002180317","https://openalex.org/W2004891705","https://openalex.org/W2005233270","https://openalex.org/W2006767153","https://openalex.org/W2010633131","https://openalex.org/W2011248088","https://openalex.org/W2012976938","https://openalex.org/W2014023829","https://openalex.org/W2015697901","https://openalex.org/W2016997675","https://openalex.org/W2018773565","https://openalex.org/W2023826599","https://openalex.org/W2025868911","https://openalex.org/W2027110288","https://openalex.org/W2028069038","https://openalex.org/W2028621484","https://openalex.org/W2030569690","https://openalex.org/W2031468048","https://openalex.org/W2031702150","https://openalex.org/W2034980302","https://openalex.org/W2035197701","https://openalex.org/W2036735419","https://openalex.org/W2038326029","https://openalex.org/W2041320147","https://openalex.org/W2045835005","https://openalex.org/W2046297960","https://openalex.org/W2048064609","https://openalex.org/W2048109276","https://openalex.org/W2049361332","https://openalex.org/W2051063727","https://openalex.org/W2051237347","https://openalex.org/W2052853635","https://openalex.org/W2057100984","https://openalex.org/W2060100969","https://openalex.org/W2065729329","https://openalex.org/W2066281989","https://openalex.org/W2069627208","https://openalex.org/W2070133351","https://openalex.org/W2071222108","https://openalex.org/W2072673889","https://openalex.org/W2073221687","https://openalex.org/W2073521129","https://openalex.org/W2074342738","https://openalex.org/W2076374640","https://openalex.org/W2079156156","https://openalex.org/W2079306550","https://openalex.org/W2079356804","https://openalex.org/W2081959240","https://openalex.org/W2086180819","https://openalex.org/W2089353787","https://openalex.org/W2090231093","https://openalex.org/W2090916915","https://openalex.org/W2092767384","https://openalex.org/W2093062161","https://openalex.org/W2096701071","https://openalex.org/W2102410705","https://openalex.org/W2102964293","https://openalex.org/W2105811963","https://openalex.org/W2107640283","https://openalex.org/W2108529838","https://openalex.org/W2109568753","https://openalex.org/W2109918847","https://openalex.org/W2110056217","https://openalex.org/W2112505121","https://openalex.org/W2115086792","https://openalex.org/W2117914751","https://openalex.org/W2118625836","https://openalex.org/W2119191600","https://openalex.org/W2119562338","https://openalex.org/W2123351961","https://openalex.org/W2123894485","https://openalex.org/W2125430425","https://openalex.org/W2125683177","https://openalex.org/W2126088489","https://openalex.org/W2129000249","https://openalex.org/W2129282529","https://openalex.org/W2145235967","https://openalex.org/W2152091665","https://openalex.org/W2152426226","https://openalex.org/W2152697120","https://openalex.org/W2153891187","https://openalex.org/W2157252680","https://openalex.org/W2160412538","https://openalex.org/W2167181354","https://openalex.org/W2169142949","https://openalex.org/W2194586608","https://openalex.org/W2314587883","https://openalex.org/W2403859991","https://openalex.org/W2410910353","https://openalex.org/W2414869747","https://openalex.org/W2415198084","https://openalex.org/W7125632127"],"related_works":["https://openalex.org/W2000838270","https://openalex.org/W1933713628","https://openalex.org/W2129000249","https://openalex.org/W273935787","https://openalex.org/W2002663490","https://openalex.org/W2757362149","https://openalex.org/W2891874945","https://openalex.org/W2061239191","https://openalex.org/W2025517705","https://openalex.org/W2075442039"],"abstract_inverted_index":{"Background:":[0],"Ischemic":[1],"stroke":[2,22,34,148],"ranks":[3],"as":[4,382,424,431,439,525,527],"the":[5,13,38,84,89,126,215,255,275,322,329,356,372,378,398,406,414,448,491,518,532],"third":[6],"major":[7],"cause":[8,15],"of":[9,16,30,42,83,235,274,364,405,409,442,482,540],"clinical":[10],"mortality":[11],"and":[12,40,63,72,79,105,115,125,156,167,172,308,335,377,402,421,457,479,487,503,515,521],"leading":[14],"handicap":[17],"in":[18,24,98,107,120,134,210,321,397,447,472,490,517,537],"adults.":[19],"Each":[20],"year,":[21],"occurs":[23],"about":[25],"30,000":[26],"Swedes.":[27],"The":[28,117,140,184,194,205,250,283],"severity":[29],"an":[31,233,262],"acute":[32,541],"ischemic":[33,449,542],"depends":[35],"mainly":[36],"on":[37],"degree":[39],"duration":[41],"local":[43,483],"cerebral":[44,59,112,128,494],"blood":[45],"flow":[46],"(lCBF)":[47],"reduction.":[48],"Prompt":[49],"reperfusion":[50,97,534],"improves":[51],"neurological":[52],"deficits,":[53],"spontaneous":[54,96,533],"electrical":[55],"activity,":[56],"energy":[57],"metabolism,":[58],"protein":[60],"synthesis":[61],"(CPS),":[62],"tissue":[64,488],"repair,":[65],"among":[66],"which":[67,410,443,529],"cell":[68,185,195],"proliferation":[69],"(neurogenesis,":[70],"gliosis)":[71],"revascularization":[73],"(angiogenesis)":[74],"may":[75],"have":[76],"important":[77],"functional":[78],"therapeutic":[80],"implications.":[81],"Aims":[82],"thesis:":[85],"(1)":[86],"To":[87,102],"establish":[88],"photothrombotic":[90],"ring":[91,224,256],"stroke(PRS)":[92],"model":[93,119,133,207,471],"with":[94,199,218,240,509],"late":[95],"adult":[99,108,123,135,211,388,473,507],"mice;":[100],"(2)":[101],"explore":[103],"angiogenesis":[104],"neurogenesis":[106,502,511],"brain":[109],"after":[110,147,467,498],"focal":[111],"ischemia.":[113,297],"Materials":[114],"Methods:":[116],"PRS":[118,206,470],"C57":[121],"BL":[122],"mice":[124,212,474],"middle":[127],"artery":[129],"suture":[130],"occlusion":[131],"(MCAO)":[132],"Wistar":[136],"rats":[137,389,508],"were":[138,160,178,331,351,367,411,437,463],"used.":[139],"5-bromodeoxyuridine":[141],"(BrdU)":[142],"was":[143,188,197,208,258,309],"delivered":[144],"into":[145],"animal":[146],"induction":[149],"to":[150,180,272,286,371,391,531],"label":[151],"DNA":[152],"duplication.":[153],"CBF,":[154,484],"CPS":[155,290],"adenosine":[157],"triphosphate":[158],"(ATP)":[159],"measured":[161],"by":[162,190,213,261,353,384,413,426],"laser-Doppler":[163],"flowmetry":[164],"(LDF),":[165],"[14C]\u2013Iodoantipyrine":[166],"[3H]-Leucine":[168],"double":[169],"tracer":[170],"autoradiography,":[171],"bioluminescence,":[173],"respectively.":[174],"Immunocytochemistry":[175],"/":[176],"immunofluoresence":[177],"performed":[179,198],"detect":[181],"different":[182],"proteins.":[183],"marker":[186,358,374,380],"colocalization":[187],"analyzed":[189,383,425],"three-dimension":[191],"(3-D)":[192],"confocal.":[193,386,428],"counting":[196,202],"a":[200,219,476],"stereological":[201],"system.":[203],"Results:":[204],"established":[209],"irradiating":[214],"exposed":[216,390],"skull":[217],"514.5":[220],"nm":[221],"argon":[222],"laser":[223],"beam":[225],"(3":[226],"mm":[227,230],"diameter,":[228],"0.21":[229],"thick)":[231],"at":[232,278,294,300,306,312,317,327,342,465,496,513],"intensity":[234],"0.65":[236],"W/cm2":[237],"for":[238,248],"60s,":[239],"concurrent":[241],"erythrosin":[242],"B":[243],"(4.25":[244],"mg/kg)":[245],"intravenous":[246],"infusion":[247],"15s.":[249],"central":[251],"cortical":[252,349,501],"region":[253,323],"within":[254],"locus":[257],"progressively":[259],"encroached":[260],"annular":[263],"ring-shaped":[264],"perfusion":[265],"deficit,":[266],"where":[267,289,452,500],"lCBF":[268],"LDF":[269],"declined":[270,299],"promptly":[271],"43%":[273],"baseline":[276],"value":[277],"30":[279,514],"min":[280],"post":[281,296,345],"irradiation.":[282],"lCBF-IAP":[284],"amounted":[285],"46-17-58":[287],"ml/100g/min,":[288],"varied":[291],"from":[292],"57-38-112%":[293],"4h-48h-7days":[295],"ATP":[298,486],"4h,":[301],"achieved":[302],"its":[303],"maximum":[304],"level":[305],"48h":[307,328],"markedly":[310],"reduced":[311],"7":[313,343],"days":[314,344],"postischemia.":[315],"Morphologically,":[316],"4h":[318],"some":[319,441],"neurons":[320],"at-risk":[324],"appeared":[325,396],"swollen,":[326,333],"majority":[330],"severely":[332],"eosinophilic":[334],"pyknotic.":[336],"Tissue":[337],"morphology":[338,489],"became":[339],"partly":[340],"restored":[341],"stroke,":[346,499],"when":[347],"numerous":[348],"cells":[350,366,395,436],"immunolabeled":[352],"BrdU":[354],"or":[355],"mitosis-specific":[357],"phosphorylated":[359],"histone":[360],"H3":[361],"(Phos-H3).":[362],"Some":[363,408],"these":[365],"even":[368],"doubly":[369],"immunopositive":[370],"neuron-specific":[373],"Neu":[375,422],"N":[376,423],"astrocyte":[379],"GFAP,":[381],"3-D":[385,427],"In":[387,506],"MCAO,":[392,510],"widespread":[393],"BrdU-immunolabeled":[394],"cortex,":[399],"ipsilateral":[400],"striatum":[401],"dentate":[403],"gyrus":[404],"hippocampus.":[407],"doubleimmunolabeled":[412],"neuron":[415],"specific":[416],"markers":[417],"Map-2,":[418],"\u03b2-tubulin":[419],"III":[420],"As":[429],"early":[430,526],"24h":[432],"postischemia,":[433],"BrdU-immunopositive":[434],"endothelial":[435],"aligned":[438],"microvessels,":[440],"exhibited":[444],"distinguishable":[445],"lumens":[446],"boundary":[450],"zone,":[451],"VEGF-A,":[453],"B,":[454],"C":[455],"proteins":[456],"their":[458],"receptors":[459],"flt-1,":[460],"fik-1,":[461],"flt-4":[462],"overexpressed":[464],"72h":[466],"MCAO.":[468],"Conclusion:":[469],"elicits":[475],"dynamic":[477],"deterioration":[478],"then":[480],"restoration":[481],"CPS,":[485],"spontaneously":[492],"reperfused":[493],"cortex":[495,520],"7d":[497],"gliosis":[504],"occurred.":[505],"occurred":[512,524],"60d":[516],"penumbral":[519],"striatum.":[522],"Angiogenesis":[523],"24h,":[528],"contributed":[530],"frequently":[535],"observed":[536],"this":[538],"setting":[539],"stroke.":[543]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
