{"id":"https://openalex.org/W2136861985","doi":"https://doi.org/10.2337/db06-s018","title":"Brain Adipocytokine Action and Metabolic Regulation","display_name":"Brain Adipocytokine Action and Metabolic Regulation","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2136861985","doi":"https://doi.org/10.2337/db06-s018","mag":"2136861985","pmid":"https://pubmed.ncbi.nlm.nih.gov/17130638"},"language":"en","primary_location":{"id":"doi:10.2337/db06-s018","doi":"https://doi.org/10.2337/db06-s018","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db06-s018","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073521153","display_name":"Rexford S. Ahima","orcid":"https://orcid.org/0000-0002-3479-1942","observed_orcids":["https://orcid.org/0000-0002-3479-1942"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rexford S. Ahima","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042748112","display_name":"Yong Qi","orcid":"https://orcid.org/0000-0002-2653-1307","observed_orcids":["https://orcid.org/0000-0002-2653-1307"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Qi","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090237810","display_name":"Neel S. Singhal","orcid":"https://orcid.org/0000-0003-1605-4444","observed_orcids":["https://orcid.org/0000-0003-1605-4444"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neel S. Singhal","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039802730","display_name":"Malaka B. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malaka B. Jackson","raw_affiliation_strings":["Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077747436","display_name":"Philipp E. Scherer","orcid":"https://orcid.org/0000-0003-0680-3392","observed_orcids":["https://orcid.org/0000-0003-0680-3392"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philipp E. Scherer","raw_affiliation_strings":["Department of Cell Biology and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1303,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.77508961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"55","issue":"Supplement_2","first_page":"S145","last_page":"S154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.49900001287460327,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.49900001287460327,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.49799999594688416,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9559999704360962},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9380000233650208},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.7850000262260437},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.640999972820282},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.777999997138977},{"id":"https://openalex.org/keywords/hyperphagia","display_name":"hyperphagia","score":0.6549999713897705},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7080000042915344},{"id":"https://openalex.org/keywords/adipose-tissue-hormones","display_name":"adipose tissue hormones","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7843469381332397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.760391116142273},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7383377552032471},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.6700040102005005},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6231708526611328},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.5895271301269531},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5174456238746643},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.497724324464798},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4897015392780304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4719984531402588},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.466667115688324},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3857429325580597},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.26002633571624756},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.23468416929244995},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2209157645702362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20433074235916138},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.12424597144126892},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10927459597587585}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/db06-s018","doi":"https://doi.org/10.2337/db06-s018","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db06-s018","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:17130638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17130638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6095495639","display_name":"Adiponectin, A Protein Secreted From Adipose Tissue","funder_award_id":"R01DK055758","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6173302592","display_name":"Integrative Metabolic Adaptations to Enviromental and Nutritional Challenge","funder_award_id":"P01DK049210","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G654473320","display_name":"CNS action of appetite suppressant aminosterol","funder_award_id":"R01DK062348","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6853246807","display_name":"Adiponectin: Effects on Graves'Optalmopathy","funder_award_id":"R03EY014935","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7263301401","display_name":"Adiponectin & Resistin: Structure, Function & Effects","funder_award_id":"R24DK071030","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000878197","display_name":"University of Pennsylvania Diabetes Research Center","funder_award_id":"P30DK019525","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W1506453366","https://openalex.org/W1527986744","https://openalex.org/W1582721451","https://openalex.org/W1590709474","https://openalex.org/W1675830194","https://openalex.org/W1896220440","https://openalex.org/W1970205234","https://openalex.org/W1971452427","https://openalex.org/W1972275518","https://openalex.org/W1972586753","https://openalex.org/W1978088424","https://openalex.org/W1978496847","https://openalex.org/W1979101494","https://openalex.org/W1980497699","https://openalex.org/W1984795858","https://openalex.org/W1993661677","https://openalex.org/W1994479220","https://openalex.org/W1996713062","https://openalex.org/W2007161557","https://openalex.org/W2007194743","https://openalex.org/W2007867899","https://openalex.org/W2008647639","https://openalex.org/W2008869160","https://openalex.org/W2010188590","https://openalex.org/W2011033553","https://openalex.org/W2012067669","https://openalex.org/W2014163208","https://openalex.org/W2015479739","https://openalex.org/W2015684603","https://openalex.org/W2018868819","https://openalex.org/W2019803851","https://openalex.org/W2022464927","https://openalex.org/W2024734221","https://openalex.org/W2026614701","https://openalex.org/W2028395411","https://openalex.org/W2041553669","https://openalex.org/W2042621509","https://openalex.org/W2042893069","https://openalex.org/W2049965571","https://openalex.org/W2057528564","https://openalex.org/W2059105920","https://openalex.org/W2060982742","https://openalex.org/W2061128822","https://openalex.org/W2063086702","https://openalex.org/W2063271924","https://openalex.org/W2064437942","https://openalex.org/W2066958828","https://openalex.org/W2069685389","https://openalex.org/W2071589836","https://openalex.org/W2072013523","https://openalex.org/W2075019242","https://openalex.org/W2076905303","https://openalex.org/W2081393100","https://openalex.org/W2084310603","https://openalex.org/W2087408139","https://openalex.org/W2087482176","https://openalex.org/W2091087465","https://openalex.org/W2092136583","https://openalex.org/W2095022880","https://openalex.org/W2096032494","https://openalex.org/W2098025594","https://openalex.org/W2101680331","https://openalex.org/W2103270369","https://openalex.org/W2106891780","https://openalex.org/W2107940713","https://openalex.org/W2109674969","https://openalex.org/W2109742508","https://openalex.org/W2113392334","https://openalex.org/W2115904465","https://openalex.org/W2117268230","https://openalex.org/W2121330405","https://openalex.org/W2121492052","https://openalex.org/W2125312207","https://openalex.org/W2127764698","https://openalex.org/W2127818104","https://openalex.org/W2129008449","https://openalex.org/W2134414477","https://openalex.org/W2136024338","https://openalex.org/W2140855423","https://openalex.org/W2141060229","https://openalex.org/W2142042418","https://openalex.org/W2154972651","https://openalex.org/W2156260257","https://openalex.org/W2157510059","https://openalex.org/W2161324995","https://openalex.org/W2162188338","https://openalex.org/W2164198629","https://openalex.org/W2165708021","https://openalex.org/W2166280318","https://openalex.org/W2168761911","https://openalex.org/W2182306574","https://openalex.org/W2311400861","https://openalex.org/W2319361543","https://openalex.org/W2334545156","https://openalex.org/W2399381335","https://openalex.org/W2883656871","https://openalex.org/W3140109418","https://openalex.org/W4212849655","https://openalex.org/W4233349015","https://openalex.org/W4238663920","https://openalex.org/W4254261652","https://openalex.org/W4321162519"],"related_works":["https://openalex.org/W2158574701","https://openalex.org/W2036519287","https://openalex.org/W1553584907","https://openalex.org/W3178836078","https://openalex.org/W1978496847","https://openalex.org/W1534839528","https://openalex.org/W1567175289","https://openalex.org/W1999343895","https://openalex.org/W2788781113","https://openalex.org/W2042444876"],"abstract_inverted_index":{"Adipose":[0,133],"tissue":[1,134],"secretes":[2,141],"factors":[3],"that":[4],"control":[5],"various":[6],"physiological":[7],"systems.":[8],"The":[9],"fall":[10],"in":[11,34,57,72,88,99,109],"leptin":[12,32,52],"during":[13],"fasting":[14],"mediates":[15,135],"hyperphagia":[16],"and":[17,21,24,44,60,79,82,96,107,111,122,129,140,146,148,163,167],"suppresses":[18],"thermogenesis,":[19],"thyroid":[20],"reproductive":[22],"hormones,":[23],"immune":[25],"system.":[26],"On":[27],"the":[28,35,58,67,89,152,161],"other":[29,61],"hand,":[30],"rising":[31],"levels":[33],"fed":[36],"state":[37],"stimulate":[38],"fatty":[39,93],"acid":[40,94],"oxidation,":[41],"decrease":[42],"appetite,":[43],"limit":[45],"weight":[46],"gain.":[47],"These":[48,125],"divergent":[49],"effects":[50,126],"of":[51,69,137,154,165],"occur":[53],"through":[54],"neuronal":[55],"circuits":[56],"hypothalamus":[59],"brain":[62],"areas.":[63],"Leptin":[64],"also":[65,83],"regulates":[66],"activities":[68],"enzymes":[70],"involved":[71],"lipid":[73,123],"metabolism,":[74],"e.g.,":[75],"AMP-activated":[76,103],"protein":[77,104],"kinase":[78,105],"stearoyl-CoA":[80],"desaturase-1,":[81],"interacts":[84],"with":[85],"insulin":[86,97],"signaling":[87],"brain.":[90],"Adiponectin":[91],"enhances":[92],"oxidation":[95],"sensitivity,":[98],"part":[100],"by":[101,118],"stimulating":[102],"phosphorylation":[106],"activity":[108],"liver":[110],"muscle.":[112],"Moreover,":[113],"adiponectin":[114],"decreases":[115],"body":[116],"fat":[117],"increasing":[119],"energy":[120],"expenditure":[121],"catabolism.":[124],"involve":[127],"peripheral":[128],"possibly":[130],"central":[131],"mechanisms.":[132],"interconversion":[136],"steroid":[138],"hormones":[139],"proinflammatory":[142],"cytokines,":[143],"vasoactive":[144],"peptides,":[145],"coagulation":[147],"complement":[149],"proteins.":[150],"Understanding":[151],"actions":[153],"these":[155],"\"adipocytokines\"":[156],"will":[157],"provide":[158],"insight":[159],"into":[160],"pathogenesis":[162],"treatment":[164],"obesity":[166],"related":[168],"diseases.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}