{"id":"https://openalex.org/W2136809991","doi":"https://doi.org/10.1093/nar/gki697","title":"Advances in mechanisms of genetic instability related to hereditary neurological diseases","display_name":"Advances in mechanisms of genetic instability related to hereditary neurological diseases","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2136809991","doi":"https://doi.org/10.1093/nar/gki697","mag":"2136809991","pmid":"https://pubmed.ncbi.nlm.nih.gov/16006624","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1174910"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gki697","doi":"https://doi.org/10.1093/nar/gki697","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gki697","pdf_url":"https://academic.oup.com/nar/article-pdf/33/12/3785/7124378/gki697.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/33/12/3785/7124378/gki697.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040500435","display_name":"Robert D. Wells","orcid":"https://orcid.org/0000-0002-7240-8473","observed_orcids":["https://orcid.org/0000-0002-7240-8473"]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]},{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. D. Wells","raw_affiliation_strings":["Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Texas Medical Center, 2121 W. Holcombe Blvd, Houston, TX 77030, USA. rwells@ibt.tamhsc.edu","Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Texas Medical Center, 2121 W. Holcombe Blvd, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Texas Medical Center, 2121 W. Holcombe Blvd, Houston, TX 77030, USA. rwells@ibt.tamhsc.edu","institution_ids":["https://openalex.org/I1337852284","https://openalex.org/I173268674"]},{"raw_affiliation_string":"Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Texas Medical Center, 2121 W. Holcombe Blvd, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1337852284","https://openalex.org/I173268674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040500435"],"corresponding_institution_ids":["https://openalex.org/I1337852284","https://openalex.org/I173268674"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.7081,"has_fulltext":true,"cited_by_count":208,"citation_normalized_percentile":{"value":0.84972216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"33","issue":"12","first_page":"3785","last_page":"3798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.451200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.451200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hereditary-neurological-disorders","display_name":"hereditary neurological disorders","score":0.8479999899864197},{"id":"https://openalex.org/keywords/trinucleotide-repeat-expansion","display_name":"trinucleotide repeat expansion","score":0.7379999756813049},{"id":"https://openalex.org/keywords/dna-slippage","display_name":"DNA slippage","score":0.7110000252723694},{"id":"https://openalex.org/keywords/non-b-dna","display_name":"non-B DNA structures","score":0.7459999918937683},{"id":"https://openalex.org/keywords/stem-loop-structure","display_name":"stem-loop structure","score":0.8289999961853027},{"id":"https://openalex.org/keywords/triplex","display_name":"triplex","score":0.8180000185966492},{"id":"https://openalex.org/keywords/replication-fork-pausing","display_name":"replication fork pausing","score":0.8600000143051147},{"id":"https://openalex.org/keywords/flap-endonuclease","display_name":"flap endonuclease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/methyl-directed-mismatch-repair","display_name":"methyl-directed mismatch repair","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":1.0},{"id":"https://openalex.org/keywords/genetic-recombination","display_name":"genetic recombination","score":0.9440000057220459},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.855918824672699},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6947754621505737},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6061312556266785},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5946505665779114},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5808027982711792},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.5278955101966858},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.4617055058479309},{"id":"https://openalex.org/C101434241","wikidata":"https://www.wikidata.org/wiki/Q211675","display_name":"Genetic recombination","level":4,"score":0.4473159909248352},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.4384566843509674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3612712323665619},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.29145389795303345}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042622","descriptor_name":"DNA Repeat Expansion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gki697","doi":"https://doi.org/10.1093/nar/gki697","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gki697","pdf_url":"https://academic.oup.com/nar/article-pdf/33/12/3785/7124378/gki697.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1174910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1174910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:16006624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16006624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.512.6916","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.512.6916","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/33/12/3785.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.515.5976","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.515.5976","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/33/12/3785.full-text-lowres.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/nar/gki697","doi":"https://doi.org/10.1093/nar/gki697","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gki697","pdf_url":"https://academic.oup.com/nar/article-pdf/33/12/3785/7124378/gki697.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3324194030","display_name":"Mechanisms of Genetic Instabilites of Triplet Repeats","funder_award_id":"R01ES011347","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320306958","display_name":"Friedreich's Ataxia Research Alliance","ror":"https://ror.org/04edgdk70"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136809991.pdf","grobid_xml":"https://content.openalex.org/works/W2136809991.grobid-xml"},"referenced_works_count":169,"referenced_works":["https://openalex.org/W146312310","https://openalex.org/W386603110","https://openalex.org/W1492929429","https://openalex.org/W1496096031","https://openalex.org/W1513481287","https://openalex.org/W1516514485","https://openalex.org/W1517794590","https://openalex.org/W1522901791","https://openalex.org/W1528339501","https://openalex.org/W1532858692","https://openalex.org/W1545188340","https://openalex.org/W1548240020","https://openalex.org/W1557341471","https://openalex.org/W1559981481","https://openalex.org/W1561540396","https://openalex.org/W1605123732","https://openalex.org/W1779426053","https://openalex.org/W1787998249","https://openalex.org/W1967132986","https://openalex.org/W1970585122","https://openalex.org/W1971251049","https://openalex.org/W1971817747","https://openalex.org/W1975502500","https://openalex.org/W1980083127","https://openalex.org/W1981028631","https://openalex.org/W1983281057","https://openalex.org/W1984564889","https://openalex.org/W1984694497","https://openalex.org/W1985520143","https://openalex.org/W1986071629","https://openalex.org/W1986435856","https://openalex.org/W1987246047","https://openalex.org/W1987789275","https://openalex.org/W1988134095","https://openalex.org/W1990002392","https://openalex.org/W1990208477","https://openalex.org/W1991342096","https://openalex.org/W1994674028","https://openalex.org/W1995457826","https://openalex.org/W1996558420","https://openalex.org/W1996920141","https://openalex.org/W1998824244","https://openalex.org/W1999364887","https://openalex.org/W1999900311","https://openalex.org/W2002093858","https://openalex.org/W2003329456","https://openalex.org/W2004438438","https://openalex.org/W2007368142","https://openalex.org/W2008561777","https://openalex.org/W2008668090","https://openalex.org/W2009024472","https://openalex.org/W2009441234","https://openalex.org/W2009605330","https://openalex.org/W2010962019","https://openalex.org/W2014223000","https://openalex.org/W2015110613","https://openalex.org/W2015181216","https://openalex.org/W2017237069","https://openalex.org/W2019006170","https://openalex.org/W2019043328","https://openalex.org/W2020884359","https://openalex.org/W2021091954","https://openalex.org/W2026380481","https://openalex.org/W2026504273","https://openalex.org/W2028417441","https://openalex.org/W2029146269","https://openalex.org/W2033058075","https://openalex.org/W2033826591","https://openalex.org/W2033961411","https://openalex.org/W2034955342","https://openalex.org/W2035323777","https://openalex.org/W2036064747","https://openalex.org/W2038787000","https://openalex.org/W2041376177","https://openalex.org/W2042160009","https://openalex.org/W2044198642","https://openalex.org/W2047393064","https://openalex.org/W2049749605","https://openalex.org/W2050712839","https://openalex.org/W2051052655","https://openalex.org/W2052300085","https://openalex.org/W2052893592","https://openalex.org/W2053201040","https://openalex.org/W2057211837","https://openalex.org/W2057737922","https://openalex.org/W2057787531","https://openalex.org/W2059737494","https://openalex.org/W2059938757","https://openalex.org/W2060013127","https://openalex.org/W2060453248","https://openalex.org/W2063524071","https://openalex.org/W2064642497","https://openalex.org/W2067277044","https://openalex.org/W2069157381","https://openalex.org/W2075169657","https://openalex.org/W2075610789","https://openalex.org/W2076348042","https://openalex.org/W2076790103","https://openalex.org/W2079759384","https://openalex.org/W2085071152","https://openalex.org/W2085617522","https://openalex.org/W2086181830","https://openalex.org/W2086646899","https://openalex.org/W2090337838","https://openalex.org/W2091660221","https://openalex.org/W2092007922","https://openalex.org/W2092117608","https://openalex.org/W2094502358","https://openalex.org/W2098421525","https://openalex.org/W2105329904","https://openalex.org/W2105564521","https://openalex.org/W2106629363","https://openalex.org/W2107419622","https://openalex.org/W2110811750","https://openalex.org/W2111045117","https://openalex.org/W2111202021","https://openalex.org/W2112035003","https://openalex.org/W2113194569","https://openalex.org/W2113629413","https://openalex.org/W2115237139","https://openalex.org/W2115477513","https://openalex.org/W2115616515","https://openalex.org/W2118542999","https://openalex.org/W2118767483","https://openalex.org/W2121874696","https://openalex.org/W2123702933","https://openalex.org/W2123859383","https://openalex.org/W2125289455","https://openalex.org/W2126149307","https://openalex.org/W2132695846","https://openalex.org/W2133167492","https://openalex.org/W2133318968","https://openalex.org/W2134573093","https://openalex.org/W2135180107","https://openalex.org/W2136218692","https://openalex.org/W2137770909","https://openalex.org/W2139864835","https://openalex.org/W2139865784","https://openalex.org/W2141798197","https://openalex.org/W2142409171","https://openalex.org/W2142440824","https://openalex.org/W2142710492","https://openalex.org/W2146764723","https://openalex.org/W2147156824","https://openalex.org/W2147233024","https://openalex.org/W2147334667","https://openalex.org/W2148649115","https://openalex.org/W2151387833","https://openalex.org/W2153430850","https://openalex.org/W2154252071","https://openalex.org/W2154287511","https://openalex.org/W2157458103","https://openalex.org/W2159203886","https://openalex.org/W2159337192","https://openalex.org/W2164191257","https://openalex.org/W2165377218","https://openalex.org/W2168244130","https://openalex.org/W2168936357","https://openalex.org/W2169710836","https://openalex.org/W2170783097","https://openalex.org/W2171824895","https://openalex.org/W2173267258","https://openalex.org/W2314008219","https://openalex.org/W2619616726","https://openalex.org/W3146601741","https://openalex.org/W3198167246","https://openalex.org/W4249141508","https://openalex.org/W4298198812","https://openalex.org/W7098835656"],"related_works":["https://openalex.org/W7098254406","https://openalex.org/W2159203886","https://openalex.org/W386603110","https://openalex.org/W1549538159","https://openalex.org/W2087505473","https://openalex.org/W1996924520","https://openalex.org/W3209489198","https://openalex.org/W2621571490","https://openalex.org/W2220058702","https://openalex.org/W1970806530"],"abstract_inverted_index":{"Substantial":[0],"progress":[1],"has":[2],"been":[3],"realized":[4],"in":[5,10,52,79,151],"the":[6,14,19,58,70,108,113,118,126,161],"past":[7],"several":[8],"years":[9],"our":[11],"understanding":[12],"of":[13,25,37,57,69,107,112,117,137,165],"molecular":[15],"mechanisms":[16,102],"responsible":[17],"for":[18],"expansions":[20],"and":[21,29,47,87,95,125,135,146,155],"deletions":[22],"(genetic":[23],"instabilities)":[24],"repeating":[26,31,72],"tri-,":[27],"tetra-":[28],"pentanucleotide":[30],"sequences":[32,120,169],"associated":[33],"with":[34],"a":[35,76],"number":[36],"hereditary":[38],"neurological":[39],"diseases.":[40],"These":[41],"instabilities":[42],"occur":[43],"by":[44,105,140],"replication,":[45],"recombination":[46,145],"repair":[48,136,149],"processes,":[49],"probably":[50],"acting":[51],"concert,":[53],"due":[54],"to":[55,63,122,170],"slippage":[56],"DNA":[59,83,90],"complementary":[60],"strands":[61,74],"relative":[62,121],"each":[64],"other.":[65],"The":[66,100],"biophysical":[67],"properties":[68],"folded-back":[71],"sequence":[73],"play":[75],"critical":[77],"role":[78],"these":[80],"instabilities.":[81],"Non-B":[82],"structural":[84],"elements":[85],"(hairpins":[86],"slipped":[88],"structures,":[89],"unwinding":[91],"elements,":[92],"tetraplexes,":[93],"triplexes":[94],"sticky":[96],"DNA)":[97],"are":[98,103,142,158,175],"described.":[99],"replication":[101,109,123],"influenced":[104],"pausing":[106],"fork,":[110],"orientation":[111],"repeat":[114,119,168],"strands,":[115],"location":[116],"origins":[124],"flap":[127],"endonuclease.":[128],"Methyl-directed":[129],"mismatch":[130],"repair,":[131,134],"nucleotide":[132],"excision":[133],"damage":[138],"caused":[139],"mutagens":[141],"discussed.":[143,176],"Genetic":[144],"double-strand":[147],"break":[148],"advances":[150],"Escherichia":[152],"coli,":[153],"yeast":[154],"mammalian":[156],"models":[157],"reviewed.":[159],"Furthermore,":[160],"newly":[162],"discovered":[163],"capacities":[164],"certain":[166],"triplet":[167],"cause":[171],"gross":[172],"chromosomal":[173],"rearrangements":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
