{"id":"https://openalex.org/W2136785877","doi":"https://doi.org/10.1124/dmd.104.002253","title":"tert-BUTYLHYDROQUINONE IS A NOVEL ARYL HYDROCARBON RECEPTOR LIGAND","display_name":"tert-BUTYLHYDROQUINONE IS A NOVEL ARYL HYDROCARBON RECEPTOR LIGAND","publication_year":2004,"publication_date":"2004-12-18","ids":{"openalex":"https://openalex.org/W2136785877","doi":"https://doi.org/10.1124/dmd.104.002253","mag":"2136785877","pmid":"https://pubmed.ncbi.nlm.nih.gov/15608132"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.104.002253","doi":"https://doi.org/10.1124/dmd.104.002253","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.104.002253","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039214452","display_name":"Negar Gharavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Negar Gharavi","raw_affiliation_strings":["Faculty of Pharmacy and Pharmaceutical Sciences, 3118 Dentistry/Pharmacy Centre, University of Alberta, Edmonton, AB, Canada T6G 2N8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy and Pharmaceutical Sciences, 3118 Dentistry/Pharmacy Centre, University of Alberta, Edmonton, AB, Canada T6G 2N8","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053384151","display_name":"Ayman O.S. El\u2010Kadi","orcid":"https://orcid.org/0000-0002-8692-0400","observed_orcids":["https://orcid.org/0000-0002-8692-0400"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ayman O.S. El-Kadi","raw_affiliation_strings":["University of Alberta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alberta","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.17,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.85328098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"33","issue":"3","first_page":"365","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.46779999136924744,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.46779999136924744,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.447299987077713,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tert-butylhydroquinone","display_name":"tert-butylhydroquinone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cyp1a1-induction","display_name":"CYP1A1 induction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.46299999952316284},{"id":"https://openalex.org/keywords/hepatoma-cells","display_name":"hepatoma cells","score":0.5370000004768372},{"id":"https://openalex.org/keywords/hepa-1c1c7-cells","display_name":"Hepa1c1c7 cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.8159999847412109},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/phenolic-antioxidants","display_name":"phenolic antioxidants","score":0.6970000267028809},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/protein-synthesis-dependence","display_name":"protein synthesis dependence","score":0.5210000276565552},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.9343439340591431},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.8403069972991943},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.719602108001709},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5726539492607117},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5467717051506042},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5195510983467102},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5055344104766846},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47140029072761536},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.4574441611766815},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.44452449679374695},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.44263532757759094},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4127451181411743},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34277409315109253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19071370363235474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1764877438545227},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.145381897687912}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1124/dmd.104.002253","doi":"https://doi.org/10.1124/dmd.104.002253","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.104.002253","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmid:15608132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15608132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.903.9199","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.903.9199","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dmd.aspetjournals.org/content/33/3/365.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W94341715","https://openalex.org/W198065351","https://openalex.org/W569951484","https://openalex.org/W1488985346","https://openalex.org/W1540649785","https://openalex.org/W1935479846","https://openalex.org/W1969656285","https://openalex.org/W1970051475","https://openalex.org/W1974175122","https://openalex.org/W1975124499","https://openalex.org/W1976234994","https://openalex.org/W1985754063","https://openalex.org/W1996954653","https://openalex.org/W1996995800","https://openalex.org/W2002372954","https://openalex.org/W2005891669","https://openalex.org/W2012410951","https://openalex.org/W2040657528","https://openalex.org/W2045931107","https://openalex.org/W2051982486","https://openalex.org/W2053236035","https://openalex.org/W2058224429","https://openalex.org/W2058586837","https://openalex.org/W2059349834","https://openalex.org/W2087332917","https://openalex.org/W2092617266","https://openalex.org/W2093177850","https://openalex.org/W2114629114","https://openalex.org/W2118688982","https://openalex.org/W2141306531","https://openalex.org/W2144634347","https://openalex.org/W2145337751","https://openalex.org/W2152468739","https://openalex.org/W2162067613","https://openalex.org/W2164930070","https://openalex.org/W2166454597","https://openalex.org/W2167128153","https://openalex.org/W2170264506","https://openalex.org/W6682212051","https://openalex.org/W6685150213"],"related_works":["https://openalex.org/W7099627519","https://openalex.org/W2171129583","https://openalex.org/W2132865838","https://openalex.org/W2116598568","https://openalex.org/W1818467859","https://openalex.org/W2132762752","https://openalex.org/W2152195908","https://openalex.org/W6926503723","https://openalex.org/W2552305737","https://openalex.org/W2083993637"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
