{"id":"https://openalex.org/W2136754094","doi":"https://doi.org/10.1152/ajpgi.00403.2010","title":"Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells","display_name":"Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2136754094","doi":"https://doi.org/10.1152/ajpgi.00403.2010","mag":"2136754094","pmid":"https://pubmed.ncbi.nlm.nih.gov/21596996","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3154606"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00403.2010","doi":"https://doi.org/10.1152/ajpgi.00403.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00403.2010","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3154606/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043921996","display_name":"Phil\u2010Sun Oh","orcid":"https://orcid.org/0000-0002-0711-7514","observed_orcids":["https://orcid.org/0000-0002-0711-7514"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phil-Sun Oh","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077278335","display_name":"Vaishali B. Patel","orcid":"https://orcid.org/0009-0006-7951-3838","observed_orcids":["https://orcid.org/0009-0006-7951-3838"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaishali B. Patel","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109800379","display_name":"Matthew A. Sanders","orcid":"https://orcid.org/0009-0001-5183-4545","observed_orcids":["https://orcid.org/0009-0001-5183-4545"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Sanders","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041412748","display_name":"Shailender S. Kanwar","orcid":"https://orcid.org/0000-0002-1146-2927","observed_orcids":["https://orcid.org/0000-0002-1146-2927"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shailender S. Kanwar","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103095815","display_name":"Yingjie Yu","orcid":"https://orcid.org/0000-0002-2060-7390","observed_orcids":["https://orcid.org/0000-0002-2060-7390"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingjie Yu","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082661808","display_name":"Jyoti Nautiyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jyoti Nautiyal","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020988215","display_name":"Bhaumik B. Patel","orcid":"https://orcid.org/0000-0002-6618-4004","observed_orcids":["https://orcid.org/0000-0002-6618-4004"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhaumik B. Patel","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Karmanos Cancer Institute, and","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Karmanos Cancer Institute, and","institution_ids":["https://openalex.org/I4210090317"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029214095","display_name":"Adhip P.N. Majumdar","orcid":"https://orcid.org/0000-0002-6413-5102","observed_orcids":["https://orcid.org/0000-0002-6413-5102"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adhip P. N. Majumdar","raw_affiliation_strings":["Department of Internal Medicine, Wayne State University, Detroit, Michigan","Karmanos Cancer Institute, and","Veterans Affairs Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State University, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Karmanos Cancer Institute, and","institution_ids":["https://openalex.org/I4210090317"]},{"raw_affiliation_string":"Veterans Affairs Medical Center,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029214095"],"corresponding_institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"],"apc_list":null,"apc_paid":null,"fwci":2.919,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91748036,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"301","issue":"2","first_page":"G347","last_page":"G355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.890999972820282},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.628000020980835},{"id":"https://openalex.org/keywords/intestinal-differentiation","display_name":"intestinal differentiation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.906000018119812},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd166","display_name":"CD166","score":1.0},{"id":"https://openalex.org/keywords/aldh1","display_name":"ALDH1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.7960000038146973},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.7856445908546448},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.615799069404602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6099610328674316},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5491533279418945},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5179492235183716},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.5051453709602356},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.46314072608947754},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4617498219013214},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.43255630135536194},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4301791489124298},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37608346343040466},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37574541568756104},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3491683602333069},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3079577088356018},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21120193600654602},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18529441952705383},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.17550882697105408},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06906816363334656}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071916","descriptor_name":"AC133 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080924","descriptor_name":"Aldehyde Dehydrogenase 1 Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005326","descriptor_name":"Fetal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020410","descriptor_name":"Activated-Leukocyte Cell Adhesion Molecule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050697","descriptor_name":"Retinal Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00403.2010","doi":"https://doi.org/10.1152/ajpgi.00403.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00403.2010","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:21596996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21596996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3154606","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3154606/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3154606","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3154606/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Gastrointest Liver Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5852701817","display_name":"The Aging Gut: Regulation of Cell Proliferation","funder_award_id":"R01AG014343","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1816158752","https://openalex.org/W1846418786","https://openalex.org/W1968834525","https://openalex.org/W1977480736","https://openalex.org/W1980539309","https://openalex.org/W1983469440","https://openalex.org/W1983961550","https://openalex.org/W2001540193","https://openalex.org/W2006434892","https://openalex.org/W2010867021","https://openalex.org/W2012495753","https://openalex.org/W2019199359","https://openalex.org/W2020695289","https://openalex.org/W2021658503","https://openalex.org/W2023316892","https://openalex.org/W2034185792","https://openalex.org/W2056598800","https://openalex.org/W2059972525","https://openalex.org/W2062069198","https://openalex.org/W2063933465","https://openalex.org/W2064047613","https://openalex.org/W2068961038","https://openalex.org/W2074637014","https://openalex.org/W2080761304","https://openalex.org/W2081447858","https://openalex.org/W2082057023","https://openalex.org/W2084564750","https://openalex.org/W2087675944","https://openalex.org/W2089542859","https://openalex.org/W2089762788","https://openalex.org/W2099366431","https://openalex.org/W2107880288","https://openalex.org/W2111724542","https://openalex.org/W2125311914","https://openalex.org/W2129644533","https://openalex.org/W2130177169","https://openalex.org/W2135925682","https://openalex.org/W2136441460","https://openalex.org/W2142024216","https://openalex.org/W2143138560","https://openalex.org/W2143995836","https://openalex.org/W2151393604","https://openalex.org/W2156149964","https://openalex.org/W2161344850","https://openalex.org/W2167553081","https://openalex.org/W2167564369","https://openalex.org/W2171648963","https://openalex.org/W3148398312"],"related_works":["https://openalex.org/W1989917232","https://openalex.org/W4407292081","https://openalex.org/W2581719334","https://openalex.org/W2999245248","https://openalex.org/W7095089490","https://openalex.org/W3150187609","https://openalex.org/W3112753550","https://openalex.org/W2140408888","https://openalex.org/W2891440355","https://openalex.org/W2803805668"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"demonstrated":[3],"that":[4,58,191],"expression":[5,139,166,193,222],"of":[6,50,68,79,85,94,99,123,129,138,140,150,167,197,205,218],"the":[7,100,141,165],"novel":[8],"gene":[9],"schlafen-3":[10],"(Slfn-3)":[11],"correlates":[12],"with":[13],"intestinal":[14,86],"epithelial":[15],"cell":[16,134],"differentiation":[17,49,206],"(Patel":[18],"VB,":[19],"Yu":[20],"Y,":[21],"Das":[22],"JK,":[23],"Patel":[24],"BB,":[25],"Majumdar":[26],"AP.":[27],"Biochem":[28],"Biophys":[29],"Res":[30],"Commun":[31],"388:":[32],"752-756,":[33],"2009).":[34],"The":[35],"present":[36],"investigation":[37],"was":[38,118],"undertaken":[39],"to":[40,182,229],"examine":[41],"whether":[42],"Slfn-3":[43,69,89,148,162,192,221],"plays":[44],"a":[45,83],"role":[46],"in":[47,62,70,77,92,110,126,132,171,180,209],"regulating":[48],"FOLFOX-resistant":[51,71,112,151,173,199],"(5-fluorouracil":[52],"+":[53],"oxaliplatin)":[54],"colon":[55,72,174,200,225],"cancer":[56,63,73,175,201,230],"cells":[57,65,75,155],"are":[59],"highly":[60],"enriched":[61],"stem":[64,133],"(CSCs).":[66],"Transfection":[67],"HCT-116":[74,113,152],"resulted":[76,91],"increase":[78],"alkaline":[80],"phosphatase":[81],"activity,":[82,214],"marker":[84],"differentiation.":[87],"Additionally,":[88,147],"transfection":[90,149,163],"reduction":[93,208],"mRNA":[95],"and":[96,106,114,136,153,207,215],"protein":[97,145],"levels":[98],"CSC":[101],"markers":[102],"CD44,":[103],"CD133,":[104],"CD166,":[105],"aldehyde":[107],"dehydrogenase":[108],"1":[109],"both":[111,172],"HT-29":[115,154],"cells.":[116],"This":[117],"accompanied":[119],"by":[120],"decreased":[121],"formation":[122],"tumorosphere/colonosphere":[124,210],"(an":[125],"vitro":[127],"model":[128],"tumor":[130],"growth)":[131],"medium":[135],"inhibition":[137],"chemotherapeutic":[142],"drug":[143,212],"transporter":[144,213],"ABCG2.":[146],"reduced":[156],"Hoechst":[157],"33342":[158],"dye":[159],"exclusion.":[160],"Finally,":[161],"inhibited":[164],"transforming":[168],"growth":[169],"factor-\u03b1":[170],"cells,":[176,202],"but":[177],"stimulated":[178],"apoptosis":[179],"response":[181],"additional":[183],"FOLFOX":[184],"treatment.":[185],"In":[186],"summary,":[187],"our":[188],"data":[189],"demonstrate":[190],"inhibits":[194],"multiple":[195],"characteristics":[196],"CSC-enriched,":[198],"including":[203],"induction":[204],"formation,":[211],"autocrine":[216],"stimulation":[217],"proliferation.":[219],"Thus":[220],"may":[223],"render":[224],"CSCs":[226],"more":[227],"susceptible":[228],"chemotherapeutics.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
